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  1. Article ; Online: Down's syndrome, breast cancer and COVID-19

    Miguel Ángel Lara Álvarez / Almudena Martín Marino / Mar Pérez Pérez

    Medicina Clínica Práctica, Vol 3, Iss 6, Pp 100153- (2020)

    2020  

    Abstract: The incidence of cancer in children and adults with Down's syndrome has a clearly differentiated presentation pattern with a higher frequency of lymphomas and leukaemias and a lower frequency of solid tumours. The incidence of breast cancer has ... ...

    Abstract The incidence of cancer in children and adults with Down's syndrome has a clearly differentiated presentation pattern with a higher frequency of lymphomas and leukaemias and a lower frequency of solid tumours. The incidence of breast cancer has especially decreased. In our setting, COVID-19 mortality in cancer patients has greatly increased. We present the case of a patient with Down's syndrome, breast cancer and COVID-19. Resumen: La incidencia de cáncer en niños y adultos con síndrome de Down tiene un patrón de presentación claramente diferenciado, con mayor frecuencia de linfomas y leucemias y menor de tumores sólidos. La incidencia de cáncer de mama está especialmente disminuida. En nuestro medio, la mortalidad por COVID-19 en pacientes con cáncer está incrementada sobremanera. Presentamos el caso de una paciente con síndrome de Down, cáncer de mama y COVID-19.
    Keywords Síndrome de Down ; Cáncer de mama ; COVID-19 ; Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Elsevier España
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain

    Ane Abad-motos / Jesús Troya / Eva Jiménez / Mario Fontán-Vela / Jorge Valencia / Ines Fernandez-Jimenez / Elena Alba Álvaro-Alonso / Elsa Izquierdo-García / Andrea Lazaro Cebas / Elisa Gallego Ruiz-Elvira / Ana Josefa Tebar-Martinez / Belén Garcia-Marina / Gabriela Peña-Lillo / Laura Macaya / Mario Pérez-Butragueño / Blanca Herrero Mendoza / Natividad Plazas Andreu / Liliana Vázquez Bol / Sandra María Gadin López /
    Álvaro Martínez Alcalá / Sonia Pérez Gonzalez / Amalia Martínez de la Gándara / Alejandro Zuazua Gonzalez / Javier Montoya Adarraga / Miguel Ángel Lara Álvarez / Enrique Calvo Aranda / Rosa M Lorente Ramos / María Alcantud / Roberto Alcázar Arroyo / Verónica Suberviola Sánchez-Caballero / Ariela Candelario Cáceres / Juan Churruca Sarasqueta / Juan Torres Macho / Ismael Escobar Rodríguez / Raquel Ruíz Páez / Alberto Esquivel López / Pablo de la Cueva Dobao / Natalia Blanca López / José García Hinojosa / Cristina Sevillano Collantes / Alfonso Camacho Aroca / Tamar Talaván Zañón / María Ángeles Sánchez Úriz / Carlos Bibiano Guillén / Miguel Ángel López Arenas / Margarita Gimeno Arández / Francisco Javier Quintero Gutiérrez del Álamo

    BMJ Open, Vol 10, Iss

    a retrospective case series study

    2020  Volume 11

    Abstract: Objectives To describe demographic, clinical, radiological and laboratory characteristics, as well as outcomes, of patients admitted for COVID-19 in a secondary hospital.Design and setting Retrospective case series of sequentially hospitalised patients ... ...

    Abstract Objectives To describe demographic, clinical, radiological and laboratory characteristics, as well as outcomes, of patients admitted for COVID-19 in a secondary hospital.Design and setting Retrospective case series of sequentially hospitalised patients with confirmed SARS-CoV-2, at Infanta Leonor University Hospital (ILUH) in Madrid, Spain.Participants All patients attended at ILUH testing positive to reverse transcriptase-PCR on nasopharyngeal swabs and diagnosed with COVID-19 between 1 March 2020 and 28 May 2020.Results A total of 1549 COVID-19 cases were included (median age 69 years (IQR 55.0–81.0), 57.5% men). 78.2% had at least one underlying comorbidity, the most frequent was hypertension (55.8%). Most frequent symptoms at presentation were fever (75.3%), cough (65.7%) and dyspnoea (58.1%). 81 (5.8%) patients were admitted to the intensive care unit (ICU) (median age 62 years (IQR 51–71); 74.1% men; median length of stay 9 days (IQR 5–19)) 82.7% of them needed invasive ventilation support. 1393 patients had an outcome at the end of the study period (case fatality ratio: 21.2% (296/1393)). The independent factors associated with fatality (OR; 95% CI): age (1.07; 1.06 to 1.09), male sex (2.86; 1.85 to 4.50), neurological disease (1.93; 1.19 to 3.13), chronic kidney disease (2.83; 1.40 to 5.71) and neoplasia (4.29; 2.40 to 7.67). The percentage of hospital beds occupied with COVID-19 almost doubled (702/361), with the number of patients in ICU quadrupling its capacity (32/8). Median length of stay was 9 days (IQR 6–14).Conclusions This study provides clinical characteristics, complications and outcomes of patients with COVID-19 admitted to a European secondary hospital. Fatal outcomes were similar to those reported by hospitals with a higher level of complexity.
    Keywords Medicine ; R
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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