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  1. Article: Innate lymphoid cells in neuroinflammation.

    Kveštak, Daria / Mihalić, Andrea / Jonjić, Stipan / Brizić, Ilija

    Frontiers in cellular neuroscience

    2024  Volume 18, Page(s) 1364485

    Abstract: Innate lymphoid cells (ILCs) are largely tissue-resident cells that participate in the maintenance of tissue homeostasis and react early to inflammatory events. Mature ILCs are divided into three major groups based on the transcription factors required ... ...

    Abstract Innate lymphoid cells (ILCs) are largely tissue-resident cells that participate in the maintenance of tissue homeostasis and react early to inflammatory events. Mature ILCs are divided into three major groups based on the transcription factors required for their development and function. Under physiological conditions, ILCs are present within the choroid plexus and meninges while the CNS parenchyma is almost devoid of these cells. However, pathological conditions such as autoimmune neuroinflammation and viral infections of the CNS result in the infiltration of ILCs into parenchyma. In this article, we provide an overview of the involvement and function of the ILCs within the CNS during physiological conditions and in infections, autoimmune diseases, neurodegeneration, and injury.
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2024.1364485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.

    Rožmanić, Carmen / Lisnić, Berislav / Pribanić Matešić, Marina / Mihalić, Andrea / Hiršl, Lea / Park, Eugene / Lesac Brizić, Ana / Indenbirken, Daniela / Viduka, Ina / Šantić, Marina / Adler, Barbara / Yokoyama, Wayne M / Krmpotić, Astrid / Juranić Lisnić, Vanda / Jonjić, Stipan / Brizić, Ilija

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6412

    Abstract: Infections in early life can elicit substantially different immune responses and pathogenesis than infections in adulthood. Here, we investigate the consequences of murine cytomegalovirus infection in newborn mice on NK cells. We show that infection ... ...

    Abstract Infections in early life can elicit substantially different immune responses and pathogenesis than infections in adulthood. Here, we investigate the consequences of murine cytomegalovirus infection in newborn mice on NK cells. We show that infection severely compromised NK cell maturation and functionality in newborns. This effect was not due to compromised virus control. Inflammatory responses to infection dysregulated the expression of major transcription factors governing NK cell fate, such as Eomes, resulting in impaired NK cell function. Most prominently, NK cells from perinatally infected mice have a diminished ability to produce IFN-γ due to the downregulation of long non-coding RNA Ifng-as1 expression. Moreover, the bone marrow's capacity to efficiently generate new NK cells is reduced, explaining the prolonged negative effects of perinatal infection on NK cells. This study demonstrates that viral infections in early life can profoundly impact NK cell biology, including long-lasting impairment in NK cell functionality.
    MeSH term(s) Mice ; Animals ; Killer Cells, Natural ; Cytomegalovirus Infections/genetics ; Muromegalovirus
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-42182-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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