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  1. Article ; Online: Tumor-Mediated Neutrophil Polarization and Therapeutic Implications.

    Raftopoulou, Sofia / Valadez-Cosmes, Paulina / Mihalic, Zala Nikita / Schicho, Rudolf / Kargl, Julia

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: Neutrophils are immune cells with reported phenotypic and functional plasticity. Tumor-associated neutrophils display many roles during cancer progression. Several tumor microenvironment (TME)-derived factors orchestrate neutrophil release from the bone ... ...

    Abstract Neutrophils are immune cells with reported phenotypic and functional plasticity. Tumor-associated neutrophils display many roles during cancer progression. Several tumor microenvironment (TME)-derived factors orchestrate neutrophil release from the bone marrow, recruitment and functional polarization, while simultaneously neutrophils are active stimulators of the TME by secreting factors that affect immune interactions and subsequently tumor progression. Successful immunotherapies for many cancer types and stages depend on the targeting of tumor-infiltrating lymphocytes. Neutrophils impact the success of immunotherapies, such as immune checkpoint blockade therapies, by displaying lymphocyte suppressive properties. The identification and characterization of distinct neutrophil subpopulations or polarization states with pro- and antitumor phenotypes and the identification of the major TME-derived factors of neutrophil polarization would allow us to harness the full potential of neutrophils as complementary targets in anticancer precision therapies.
    MeSH term(s) Humans ; Immunotherapy ; Lymphocytes, Tumor-Infiltrating/pathology ; Neoplasms/pathology ; Neutrophils ; Tumor Microenvironment
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target.

    Valadez-Cosmes, Paulina / Raftopoulou, Sofia / Mihalic, Zala Nikita / Marsche, Gunther / Kargl, Julia

    Pharmacology & therapeutics

    2021  Volume 236, Page(s) 108052

    Abstract: Myeloperoxidase is a heme-peroxidase which makes up approximately 5% of the total dry cell weight of neutrophils where it is predominantly found in the primary (azurophilic) granules. Other cell types, such as monocytes and certain macrophage ... ...

    Abstract Myeloperoxidase is a heme-peroxidase which makes up approximately 5% of the total dry cell weight of neutrophils where it is predominantly found in the primary (azurophilic) granules. Other cell types, such as monocytes and certain macrophage subpopulations also contain myeloperoxidase, but to a much lesser extent. Initially, the function of myeloperoxidase had been mainly associated with its ability as a catalyzer of reactive oxidants that help to clear pathogens. However, over the past years non-canonical functions of myeloperoxidase have been described both in health and disease. Attention has been specially focused on inflammatory diseases, in which an exacerbate infiltration of leukocytes can favor a poorly-controlled production and release of myeloperoxidase and its oxidants. There is compelling evidence that myeloperoxidase derived oxidants contribute to tissue damage and the development and propagation of acute and chronic vascular inflammation. Recently, neutrophils have attracted much attention within the large diversity of innate immune cells that are part of the tumor microenvironment. In particular, neutrophil-derived myeloperoxidase may play an important role in cancer development and progression. This review article aims to provide a comprehensive overview of the roles of myeloperoxidase in the development and progression of cancer. We propose future research approaches and explore prospects of inhibiting myeloperoxidase as a strategy to fight against cancer.
    MeSH term(s) Humans ; Inflammation/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neutrophils ; Oxidants/metabolism ; Peroxidase/metabolism ; Tumor Microenvironment
    Chemical Substances Oxidants ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2021-12-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2021.108052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1183: Show issues Location:
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  3. Article ; Online: The human placenta shapes the phenotype of decidual macrophages.

    Vondra, Sigrid / Höbler, Anna-Lena / Lackner, Andreas Ian / Raffetseder, Johanna / Mihalic, Zala Nikita / Vogel, Andrea / Saleh, Leila / Kunihs, Victoria / Haslinger, Peter / Wahrmann, Markus / Husslein, Heinrich / Oberle, Raimund / Kargl, Julia / Haider, Sandra / Latos, Paulina / Schabbauer, Gernot / Knöfler, Martin / Ernerudh, Jan / Pollheimer, Jürgen

    Cell reports

    2023  Volume 42, Issue 1, Page(s) 111977

    Abstract: During human pregnancy, placenta-derived extravillous trophoblasts (EVTs) invade the decidua and communicate with maternal immune cells. The decidua distinguishes into basalis (decB) and parietalis (decP). The latter remains unaffected by EVT invasion. ... ...

    Abstract During human pregnancy, placenta-derived extravillous trophoblasts (EVTs) invade the decidua and communicate with maternal immune cells. The decidua distinguishes into basalis (decB) and parietalis (decP). The latter remains unaffected by EVT invasion. By defining a specific gating strategy, we report the accumulation of macrophages in decB. We describe a decidua basalis-associated macrophage (decBAM) population with a differential transcriptome and secretome compared with decidua parietalis-associated macrophages (decPAMs). decBAMs are CD11c
    MeSH term(s) Pregnancy ; Female ; Humans ; Pregnancy Trimester, First/physiology ; Decidua/metabolism ; Trophoblasts/metabolism ; Phenotype ; Macrophages/metabolism
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.111977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The human placenta shapes the phenotype of decidual macrophages.

    Vondra, Sigrid / Höbler, Anna-Lena / Lackner, Andreas Ian / Raffetseder, Johanna / Mihalic, Zala Nikita / Vogel, Andrea / Saleh, Leila / Kunihs, Victoria / Haslinger, Peter / Wahrmann, Markus / Husslein, Heinrich / Oberle, Raimund / Kargl, Julia / Haider, Sandra / Latos, Paulina / Schabbauer, Gernot / Knöfler, Martin / Ernerudh, Jan / Pollheimer, Jürgen

    Cell reports

    2023  Volume 42, Issue 3, Page(s) 112285

    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The fate of human SUSD2+ endometrial mesenchymal stem cells during decidualization.

    Gorsek Sparovec, Tina / Markert, Udo R / Reif, Philipp / Schoell, Wolfgang / Moser, Gerit / Feichtinger, Julia / Mihalic, Zala Nikita / Kargl, Julia / Gargett, Caroline E / Gold, Daniela

    Stem cell research

    2022  Volume 60, Page(s) 102671

    Abstract: Regeneration of the endometrial stromal compartment in premenopausal women is likely maintained by the perivascular endometrial mesenchymal stem/stromal cells (eMSC) expressing sushi domain containing 2 (SUSD2). The fate of SUSD2+ eMSC during pregnancy ... ...

    Abstract Regeneration of the endometrial stromal compartment in premenopausal women is likely maintained by the perivascular endometrial mesenchymal stem/stromal cells (eMSC) expressing sushi domain containing 2 (SUSD2). The fate of SUSD2+ eMSC during pregnancy and their role in decidualization is not fully known. The aim of our study was to determine the effect of progesterone on the stemness of the SUSD2+ eMSC isolated from non-pregnant uterine samples. Secondary objectives were to characterize the functional capacity including differentiation and clonogenicity assays of SUSD2+ eMSC isolated from decidua at full term and compare it to the capacity of those isolated from non-pregnant uterine samples. Progesterone treatment induced changes in the decidual gene expression profile in non-pregnant SUSD2+ eMSC. Data analysis of a publicly available single cell RNA-seq data set revealed differential expression of several mesenchymal and epithelial signature genes between the SUSD2+ eMSC and the decidual stromal cells, suggesting mesenchymal-to-epithelial transition occurs during decidualization. Histological analysis revealed a significantly lower abundance of SUSD2+ eMSC in 1
    MeSH term(s) Cell Differentiation ; Endometrium/metabolism ; Female ; Humans ; Membrane Glycoproteins/metabolism ; Mesenchymal Stem Cells/metabolism ; Pregnancy ; Progesterone/metabolism ; Progesterone/pharmacology ; Stromal Cells
    Chemical Substances Membrane Glycoproteins ; SUSD2 protein, human ; Progesterone (4G7DS2Q64Y)
    Language English
    Publishing date 2022-01-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2393143-7
    ISSN 1876-7753 ; 1873-5061
    ISSN (online) 1876-7753
    ISSN 1873-5061
    DOI 10.1016/j.scr.2022.102671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Identification of Novel Low-Density Neutrophil Markers Through Unbiased High-Dimensional Flow Cytometry Screening in Non-Small Cell Lung Cancer Patients.

    Valadez-Cosmes, Paulina / Maitz, Kathrin / Kindler, Oliver / Raftopoulou, Sofia / Kienzl, Melanie / Santiso, Ana / Mihalic, Zala Nikita / Brcic, Luka / Lindenmann, Jörg / Fediuk, Melanie / Pichler, Martin / Schicho, Rudolf / Houghton, A McGarry / Heinemann, Akos / Kargl, Julia

    Frontiers in immunology

    2021  Volume 12, Page(s) 703846

    Abstract: Neutrophils have been described as a phenotypically heterogeneous cell type that possess both pro- and anti-tumor properties. Recently, a subset of neutrophils isolated from the peripheral blood mononuclear cell (PBMC) fraction has been described in ... ...

    Abstract Neutrophils have been described as a phenotypically heterogeneous cell type that possess both pro- and anti-tumor properties. Recently, a subset of neutrophils isolated from the peripheral blood mononuclear cell (PBMC) fraction has been described in cancer patients. These low-density neutrophils (LDNs) show a heterogeneous maturation state and have been associated with pro-tumor properties in comparison to mature, high-density neutrophils (HDNs). However, additional studies are necessary to characterize this cell population. Here we show new surface markers that allow us to discriminate between LDNs and HDNs in non-small cell lung cancer (NSCLC) patients and assess their potential as diagnostic/prognostic tool. LDNs were highly enriched in NSCLC patients (median=20.4%, range 0.3-76.1%; n=26) but not in healthy individuals (median=0.3%, range 0.1-3.9%; n=14). Using a high-dimensional human cell surface marker screen, we identified 12 surface markers that were downregulated in LDNs when compared to HDNs, while 41 surface markers were upregulated in the LDN subset. Using flow cytometry, we confirmed overexpression of CD36, CD41, CD61 and CD226 in the LDN fraction. In summary, our data support the notion that LDNs are a unique neutrophil population and provide novel targets to clarify their role in tumor progression and their potential as diagnostic and therapeutic tool.
    MeSH term(s) Aged ; Aged, 80 and over ; Antigens, CD/blood ; Antigens, CD/immunology ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/immunology ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/immunology ; Female ; Flow Cytometry ; Humans ; Lung Neoplasms/blood ; Lung Neoplasms/immunology ; Male ; Middle Aged ; Neoplasm Proteins/blood ; Neoplasm Proteins/immunology ; Neutrophils/immunology ; Neutrophils/metabolism
    Chemical Substances Antigens, CD ; Biomarkers, Tumor ; Neoplasm Proteins
    Language English
    Publishing date 2021-08-13
    Publishing country Switzerland
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.703846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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