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  1. Article ; Online: COVID-19: Possible Impact of the Genetic Background in IFNL Genes on Disease Outcomes.

    Mihm, Sabine

    Journal of innate immunity

    2020  Volume 12, Issue 3, Page(s) 273–274

    MeSH term(s) Animals ; COVID-19 ; Coronavirus Infections/genetics ; Coronavirus Infections/immunology ; Humans ; Interferons/genetics ; Interferons/immunology ; Interleukins/genetics ; Interleukins/immunology ; Pandemics ; Pneumonia, Viral/genetics ; Pneumonia, Viral/immunology ; Receptors, Pattern Recognition/genetics
    Chemical Substances Interleukins ; Receptors, Pattern Recognition ; Interferons (9008-11-1)
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country Switzerland
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000508076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Danger-Associated Molecular Patterns (DAMPs): Molecular Triggers for Sterile Inflammation in the Liver.

    Mihm, Sabine

    International journal of molecular sciences

    2018  Volume 19, Issue 10

    Abstract: Inflammatory liver diseases in the absence of pathogens such as intoxication by xenobiotics, cholestatic liver injury, hepatic ischemia-reperfusion injury (I/R), non-alcoholic steatohepatitis (NASH), or alcoholic liver disease (ALD) remain threatening ... ...

    Abstract Inflammatory liver diseases in the absence of pathogens such as intoxication by xenobiotics, cholestatic liver injury, hepatic ischemia-reperfusion injury (I/R), non-alcoholic steatohepatitis (NASH), or alcoholic liver disease (ALD) remain threatening conditions demanding specific therapeutic options. Caused by various different noxae, all these conditions have been recognized to be triggered by danger- or death-associated molecular patterns (DAMPs), discompartmentalized self-structures released by dying cells. These endogenous, ectopic molecules comprise proteins, nucleic acids, adenosine triphosphate (ATP), or mitochondrial compounds, among others. This review resumes the respective modes of their release-passively by necrotic hepatocytes or actively by viable or apoptotic parenchymal cells-and their particular roles in sterile liver pathology. It addresses their sensors and the initial inflammatory responses they provoke. It further addresses a resulting second wave of parenchymal death that might be of different mode, boosting the release of additional, second-line DAMPs. Thus, triggering a more complex and pronounced response. Initial and secondary inflammatory responses comprise the activation of Kupffer cells (KCs), the attraction and activation of monocytes and neutrophil granulocytes, and the induction of type I interferons (IFNs) and their effectors. A thorough understanding of pathophysiology is a prerequisite for identifying rational therapeutic targets.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Alarmins/genetics ; Alarmins/metabolism ; Animals ; Biomarkers ; HMGB1 Protein/genetics ; HMGB1 Protein/metabolism ; Hepatitis/genetics ; Hepatitis/metabolism ; Humans ; Keratins/genetics ; Keratins/metabolism ; Mitochondria, Liver/metabolism ; Pathogen-Associated Molecular Pattern Molecules/metabolism
    Chemical Substances Alarmins ; Biomarkers ; HMGB1 Protein ; Pathogen-Associated Molecular Pattern Molecules ; Keratins (68238-35-7) ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2018-10-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19103104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19

    Mihm, Sabine

    Possible Impact of the Genetic Background in $IFNL$ Genes on Disease Outcomes

    2020  

    Abstract: Open-Access-Publikationsfonds 2020 ... ...

    Abstract Open-Access-Publikationsfonds 2020

    peerReviewed
    Keywords Immunology ; 610 ; covid19
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: COVID-19

    Mihm, Sabine

    Journal of Innate Immunity

    Possible Impact of the Genetic Background in IFNL Genes on Disease Outcomes

    2020  Volume 12, Issue 3, Page(s) 273–274

    Keywords Immunology and Allergy ; covid19
    Language English
    Publisher S. Karger AG
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000508076
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Hepatic

    Huschka, Henriette / Mihm, Sabine

    International journal of molecular sciences

    2021  Volume 22, Issue 15

    Abstract: Hepatocellular carcinoma (HCC) is a malignancy with a leading lethality. The etiology is quite diverse, ranging from viral infections to metabolic disorders or intoxications, and associates with specific somatic mutational patterns and specific host ... ...

    Abstract Hepatocellular carcinoma (HCC) is a malignancy with a leading lethality. The etiology is quite diverse, ranging from viral infections to metabolic disorders or intoxications, and associates with specific somatic mutational patterns and specific host immunological phenotypes. Particularly, hepatitis C virus (HCV)-infected liver is featured by an activation of interferon (IFN)-stimulated genes (ISGs; IFN signature), which we suppose is driven by type III
    MeSH term(s) Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Case-Control Studies ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Hepacivirus/isolation & purification ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/virology ; Humans ; Interleukins/genetics ; Interleukins/metabolism ; Liver Neoplasms/etiology ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Tumor Cells, Cultured
    Chemical Substances Biomarkers, Tumor ; IFNL4 protein, human ; Interleukins
    Language English
    Publishing date 2021-07-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22157803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Activation of Type I and Type III Interferons in Chronic Hepatitis C.

    Mihm, Sabine

    Journal of innate immunity

    2015  Volume 7, Issue 3, Page(s) 251–259

    Abstract: Infection with hepatitis C virus (HCV) results in chronic and progressive liver disease. Persistency rates add up to 85%. Despite recognition of the virus by the human host in peripheral blood and in the liver, immune response appears to be ineffective ... ...

    Abstract Infection with hepatitis C virus (HCV) results in chronic and progressive liver disease. Persistency rates add up to 85%. Despite recognition of the virus by the human host in peripheral blood and in the liver, immune response appears to be ineffective in clearing infection. The ability to spontaneously eradicate the virus as well as the outcome of infection upon therapy with human recombinant interferon-α (IFN-α) was found to correlate most closely with genetic variations within the region encoding the IFN-λ genes, as revealed by genome-wide association studies on main ethnic populations in 2009. This review summarizes the induction of type I and type III IFN genes and their effectors, the IFN-stimulated genes. It focusses on the in vivo situation in chronic HCV infection in man both in the peripheral blood compartment and in the liver. It also addresses the impact of genetic polymorphisms in the region of type III IFN genes on their activation. Finally, it discusses how antiviral drugs (i.e. IFN-α, ribavirin and the direct-acting antivirals) may complementarily control the activation of endogenous IFNs and succeed in combatting infections.
    MeSH term(s) Antiviral Agents/immunology ; Antiviral Agents/therapeutic use ; Female ; Genetic Variation ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/genetics ; Hepatitis C, Chronic/immunology ; Hepatitis C, Chronic/pathology ; Humans ; Interferon-alpha/genetics ; Interferon-alpha/immunology ; Interferon-alpha/therapeutic use ; Male
    Chemical Substances Antiviral Agents ; Interferon-alpha
    Language English
    Publishing date 2015-01-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000369973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6727: Show issues Location:
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  8. Book ; Online ; Thesis: The Effects of Conventional Chemotherapeutics on the Activation of Type I Interferons (IFN-α/β) in Hepatic Cancer Cells in vitro: The Significance of Endogenous Type III Interferons (IFN-λ)

    Grothe, Luca Maria [Verfasser] / Mihm, Sabine [Akademischer Betreuer] / Mihm, Sabine [Gutachter] / Kube, Dieter Prof [Gutachter]

    2023  

    Author's details Luca Maria Grothe ; Gutachter: Sabine Mihm, Dieter Prof Kube ; Betreuer: Sabine Mihm
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Niedersächsische Staats- und Universitätsbibliothek Göttingen
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article ; Online: Interferon-lambda (IFNL) germline variations and their significance for HCC and PDAC progression: an analysis of The Cancer Genome Atlas (TCGA) data.

    Huschka, Henriette / Mihm, Sabine

    BMC cancer

    2020  Volume 20, Issue 1, Page(s) 1131

    Abstract: Background: Hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) are malignancies with a leading lethality. With reference to interferons (IFNs) known to mediate antitumor activities, this study investigated the relationship ... ...

    Abstract Background: Hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) are malignancies with a leading lethality. With reference to interferons (IFNs) known to mediate antitumor activities, this study investigated the relationship between germline genetic variations in type III IFN genes and cancer disease progression from The Cancer Genome Atlas (TCGA) data. The genetic variations under study tag a gain-or-loss-of-function dinucleotide polymorphism within the IFNL4 gene, rs368234815 [TT/ΔG].
    Methods: The entirety of the TCGA sequencing data was used to assess genotypes of 187 patients with HCC and of 162 patients with PDAC matched for ethnicity. Stratified for IFNL genotypes, both cohorts were subjected to time-to-event analyses according to Kaplan-Meier with regard to the length of the specific progression free interval (PFI) and the overall survival (OS) time as two clinical endpoints for disease progression.
    Results: Logrank analysis revealed a significant relationship between IFNL genotypes and disease outcome for PDAC. This relationship was not found for HCC. A multiple Cox regression analysis employing patients' age, tumor grade and tumor stage as further covariates proved IFNL genotypes to be independent predictors for PDAC disease outcome.
    Conclusion: This repository-based approach unveiled clinical evidence suggestive for an impact of IFNL germline variations for PDAC progression with an IFNL haplotype predisposing for IFNL4 expression being favorable.
    MeSH term(s) Adenocarcinoma/genetics ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Pancreatic Ductal/genetics ; Disease Progression ; Female ; Genetic Variation/genetics ; Genome/genetics ; Germ Cells ; Humans ; Interferons/metabolism ; Interleukins/metabolism ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Male
    Chemical Substances interferon-lambda, human ; Interleukins ; Interferons (9008-11-1)
    Language English
    Publishing date 2020-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-020-07589-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Activation of Type I and Type III Interferons in Chronic Hepatitis C

    Mihm, Sabine

    Journal of Innate Immunity

    2015  Volume 7, Issue 3, Page(s) 251–259

    Abstract: Infection with hepatitis C virus (HCV) results in chronic and progressive liver disease. Persistency rates add up to 85%. Despite recognition of the virus by the human host in peripheral blood and in the liver, immune response appears to be ineffective ... ...

    Institution Department of Gastroenterology II, University Medical Center Goettingen, Goettingen, Germany
    Abstract Infection with hepatitis C virus (HCV) results in chronic and progressive liver disease. Persistency rates add up to 85%. Despite recognition of the virus by the human host in peripheral blood and in the liver, immune response appears to be ineffective in clearing infection. The ability to spontaneously eradicate the virus as well as the outcome of infection upon therapy with human recombinant interferon-α (IFN-α) was found to correlate most closely with genetic variations within the region encoding the IFN-λ genes, as revealed by genome-wide association studies on main ethnic populations in 2009. This review summarizes the induction of type I and type III IFN genes and their effectors, the IFN-stimulated genes. It focusses on the in vivo situation in chronic HCV infection in man both in the peripheral blood compartment and in the liver. It also addresses the impact of genetic polymorphisms in the region of type III IFN genes on their activation. Finally, it discusses how antiviral drugs (i.e. IFN-α, ribavirin and the direct-acting antivirals) may complementarily control the activation of endogenous IFNs and succeed in combatting infections.
    Keywords Host defense ; Virology ; Pattern recognition receptors
    Language English
    Publishing date 2015-01-28
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Review
    ZDB-ID 2454158-8
    ISSN 1662-8128 ; 1662-811X
    ISSN (online) 1662-8128
    ISSN 1662-811X
    DOI 10.1159/000369973
    Database Karger publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6727: Show issues Location:
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