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  1. Article ; Online: Blood Glucose Control Strategy for Type 2 Diabetes Patients With COVID-19

    Hiroyuki Futatsugi / Masato Iwabu / Miki Okada-Iwabu / Koh Okamoto / Yosuke Amano / Yutaka Morizaki / Takashi Kadowaki / Toshimasa Yamauchi

    Frontiers in Cardiovascular Medicine, Vol

    2020  Volume 7

    Abstract: Since December 2019, coronavirus disease 2019 (COVID-19) caused by a novel coronavirus has spread all over the world affecting tens of millions of people. Another pandemic affecting the modern world, type 2 diabetes mellitus is among the major risk ... ...

    Abstract Since December 2019, coronavirus disease 2019 (COVID-19) caused by a novel coronavirus has spread all over the world affecting tens of millions of people. Another pandemic affecting the modern world, type 2 diabetes mellitus is among the major risk factors for mortality from COVID-19. Current evidence, while limited, suggests that proper blood glucose control may help prevent exacerbation of COVID-19 even in patients with type 2 diabetes mellitus. Under current circumstances where the magic bullet for the disease remains unavailable, it appears that the role of blood glucose control cannot be stressed too much. In this review the profile of each anti-diabetic agent is discussed in relation to COVID-19.
    Keywords COVID-19 ; diabetes mellitus ; antidiabetic agents ; healthy diet ; exercise ; Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Effects of lifelong intake of lemon polyphenols on aging and intestinal microbiome in the senescence-accelerated mouse prone 1 (SAMP1)

    Chikako Shimizu / Yoshihisa Wakita / Takashi Inoue / Masanori Hiramitsu / Miki Okada / Yutaka Mitani / Shuichi Segawa / Youichi Tsuchiya / Toshitaka Nabeshima

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 11

    Abstract: Abstract Polyphenols have been examined for their beneficial effects on health, particularly in rodents, but their lifelong effects are unclear. Lemons (Citrus limon), containing lemon polyphenols (LPP), are widely consumed but the effects of LPP on ... ...

    Abstract Abstract Polyphenols have been examined for their beneficial effects on health, particularly in rodents, but their lifelong effects are unclear. Lemons (Citrus limon), containing lemon polyphenols (LPP), are widely consumed but the effects of LPP on aging are unknown. Therefore, we examined the effects of LPP on aging such as aging-related scores, locomotor activity, cognitive functions, and intestinal microbiome using senescence-accelerated mouse prone 1 (SAMP1) and senescence-accelerated resistant mouse 1 (SAMR1). All mice had ad libitum access to water (P1_water group, SAMR1) or 0.1% LPP (P1_LPP group). In the P1_LPP group, LPP intake prolonged the lifespan by approximately 3 weeks and delayed increases in aging-related scores (e.g., periophthalmic lesions) and locomotor atrophy. The P1_water group showed large changes in the intestinal microbiome structure, while the R1 and P1_LPP groups did not. The phylum Bacteroidetes/Firmicutes, which is associated with obesity, in the P1_water group was significantly lower and higher than that in the P1_LPP and R1 groups, respectively. Although the relative abundance of Lactobacillus significantly increased in both P1 groups with aging, the P1_LPP group showed a significantly lower increase than the P1_water group. Thus, lifelong intake of LPP may have anti-aging effects on both phenotypes and the intestinal environment.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice

    Masato Iwabu / Miki Okada-Iwabu / Hiroaki Tanabe / Nozomi Ohuchi / Keiko Miyata / Toshiko Kobori / Sara Odawara / Yuri Kadowaki / Shigeyuki Yokoyama / Toshimasa Yamauchi / Takashi Kadowaki

    Communications Biology, Vol 4, Iss 1, Pp 1-

    2021  Volume 11

    Abstract: Masato Iwabu and Miki Okada-Iwabu et al. investigate whether diabetic phenotypes associated ...

    Abstract Masato Iwabu and Miki Okada-Iwabu et al. investigate whether diabetic phenotypes associated with disruption of the adiponectin receptor (AdipoR1) can be reversed in diabetic mice by upregulation of the receptor. They show that overexpressing human AdipoR1 in the muscles of diabetic mice increased insulin sensitivity and exercise endurance, suggesting a possible route for future clinical therapies.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Human adiponectin receptor AdipoR1 assumes closed and open structures

    Hiroaki Tanabe / Yoshifumi Fujii / Miki Okada-Iwabu / Masato Iwabu / Kuniyuki Kano / Hiroki Kawana / Masakatsu Hato / Yoshihiro Nakamura / Takaho Terada / Tomomi Kimura-Someya / Mikako Shirouzu / Yoshiaki Kawano / Masaki Yamamoto / Junken Aoki / Toshimasa Yamauchi / Takashi Kadowaki / Shigeyuki Yokoyama

    Communications Biology, Vol 3, Iss 1, Pp 1-

    2020  Volume 11

    Abstract: Tanabe, Fujii, Okada-Iwabu, Iwabu et al. report the crystal structures of the D208A variant of human adiponectin receptor AdipoR1 as well as the revised structures of the wild-type AdipoR1. These structures clarify the interconversion between the open ... ...

    Abstract Tanabe, Fujii, Okada-Iwabu, Iwabu et al. report the crystal structures of the D208A variant of human adiponectin receptor AdipoR1 as well as the revised structures of the wild-type AdipoR1. These structures clarify the interconversion between the open and closed states of this protein, which may be relevant to its function.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Discovery of a transdermally deliverable pentapeptide for activating AdipoR1 to promote hair growth

    Jungyoon Ohn / Kyung Wook Been / Jin Yong Kim / Eun Ju Kim / Taeyong Park / Hye‐Jin Yoon / Jeong Seok Ji / Miki Okada‐Iwabu / Masato Iwabu / Toshimasa Yamauchi / Yeon Kyung Kim / Chaok Seok / Ohsang Kwon / Kyu Han Kim / Hyung Ho Lee / Jin Ho Chung

    EMBO Molecular Medicine, Vol 13, Iss 10, Pp n/a-n/a (2021)

    2021  

    Abstract: Abstract Alopecia induced by aging or side effects of medications affects millions of people worldwide and impairs the quality of life; however, there is a limit to the current medications. Here, we identify a small transdermally deliverable 5‐mer ... ...

    Abstract Abstract Alopecia induced by aging or side effects of medications affects millions of people worldwide and impairs the quality of life; however, there is a limit to the current medications. Here, we identify a small transdermally deliverable 5‐mer peptide (GLYYF; P5) that activates adiponectin receptor 1 (AdipoR1) and promotes hair growth. P5 sufficiently reproduces the biological effect of adiponectin protein via AMPK signaling pathway, increasing the expression of hair growth factors in the dermal papilla cells of human hair follicle. P5 accelerates hair growth ex vivo and induces anagen hair cycle in mice in vivo. Furthermore, we elucidate a key spot for the binding between AdipoR1 and adiponectin protein using docking simulation and mutagenesis studies. This study suggests that P5 could be used as a topical peptide drug for alleviating pathological conditions, which can be improved by adiponectin protein, such as alopecia.
    Keywords adiponectin ; adiponectin receptor 1 ; adiponectin receptor 1 agonist ; hair growth ; peptide ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Subject code 612
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
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  6. Article: De Novo Genome Assembly of the Economically Important Weed Horseweed Using Integrated Data from Multiple Sequencing Platforms

    Peng, Yanhui / C. Neal Stewart / Henriette O’Geen / Loren H. Rieseberg / Madhugiri Nageswara-Rao / Marie Jasieniuk / Miki Okada / R. Douglas Sammons / Ryan W. Kim / Thomas Lane / Zhao Lai

    Plant physiology. 2014 Nov., v. 166, no. 3

    2014  

    Abstract: De novo genome assembly and genomic resources of horseweed will be useful to understand the genetic and molecular bases of weediness . ... Horseweed ( Conyza canadensis ), a member of the Compositae (Asteraceae) family, was the first broadleaf weed to ... ...

    Abstract De novo genome assembly and genomic resources of horseweed will be useful to understand the genetic and molecular bases of weediness .

    Horseweed ( Conyza canadensis ), a member of the Compositae (Asteraceae) family, was the first broadleaf weed to evolve resistance to glyphosate. Horseweed, one of the most problematic weeds in the world, is a true diploid (2 n = 2 x = 18), with the smallest genome of any known agricultural weed (335 Mb). Thus, it is an appropriate candidate to help us understand the genetic and genomic bases of weediness. We undertook a draft de novo genome assembly of horseweed by combining data from multiple sequencing platforms (454 GS-FLX, Illumina HiSeq 2000, and PacBio RS) using various libraries with different insertion sizes (approximately 350 bp, 600 bp, 3 kb, and 10 kb) of a Tennessee-accessed, glyphosate-resistant horseweed biotype. From 116.3 Gb (approximately 350× coverage) of data, the genome was assembled into 13,966 scaffolds with 50% of the assembly = 33,561 bp. The assembly covered 92.3% of the genome, including the complete chloroplast genome (approximately 153 kb) and a nearly complete mitochondrial genome (approximately 450 kb in 120 scaffolds). The nuclear genome is composed of 44,592 protein-coding genes. Genome resequencing of seven additional horseweed biotypes was performed. These sequence data were assembled and used to analyze genome variation. Simple sequence repeat and single-nucleotide polymorphisms were surveyed. Genomic patterns were detected that associated with glyphosate-resistant or -susceptible biotypes. The draft genome will be useful to better understand weediness and the evolution of herbicide resistance and to devise new management strategies. The genome will also be useful as another reference genome in the Compositae. To our knowledge, this article represents the first published draft genome of an agricultural weed.
    Keywords Conyza ; genome assembly ; weed biology ; weeds
    Language English
    Dates of publication 2014-11
    Size p. 1241-1254.
    Publishing place American Society of Plant Biologists
    Document type Article
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1104/pp.114.247668
    Database NAL-Catalogue (AGRICOLA)

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