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  1. Article ; Online: Yolk sac steps up to the plate.

    Mikkola, Hanna K A

    The Journal of experimental medicine

    2022  Volume 219, Issue 3

    Abstract: Atkins et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20211924) create a PSC differentiation model for human yolk sac hematopoiesis and discover multipotent progenitors with erythro-myeloid and T lymphoid potential. The multipotent progenitors ... ...

    Abstract Atkins et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20211924) create a PSC differentiation model for human yolk sac hematopoiesis and discover multipotent progenitors with erythro-myeloid and T lymphoid potential. The multipotent progenitors emerge via hemogenic endothelium and share origin with primitive erythroid wave in KDR+CD235a/b+ mesoderm.
    MeSH term(s) Hematopoiesis ; Humans ; Mesoderm ; Yolk Sac
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20212315
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  2. Article ; Online: The genesis of human hematopoietic stem cells.

    Calvanese, Vincenzo / Mikkola, Hanna K A

    Blood

    2023  Volume 142, Issue 6, Page(s) 519–532

    Abstract: Developmental hematopoiesis consists of multiple, partially overlapping hematopoietic waves that generate the differentiated blood cells required for embryonic development while establishing a pool of undifferentiated hematopoietic stem cells (HSCs) for ... ...

    Abstract Developmental hematopoiesis consists of multiple, partially overlapping hematopoietic waves that generate the differentiated blood cells required for embryonic development while establishing a pool of undifferentiated hematopoietic stem cells (HSCs) for postnatal life. This multilayered design in which active hematopoiesis migrates through diverse extra and intraembryonic tissues has made it difficult to define a roadmap for generating HSCs vs non-self-renewing progenitors, especially in humans. Recent single-cell studies have helped in identifying the rare human HSCs at stages when functional assays are unsuitable for distinguishing them from progenitors. This approach has made it possible to track the origin of human HSCs to the unique type of arterial endothelium in the aorta-gonad-mesonephros region and document novel benchmarks for HSC migration and maturation in the conceptus. These studies have delivered new insights into the intricate process of HSC generation and provided tools to inform the in vitro efforts to replicate the physiological developmental journey from pluripotent stem cells via distinct mesodermal and endothelial intermediates to HSCs.
    MeSH term(s) Female ; Pregnancy ; Humans ; Hematopoietic Stem Cells ; Embryo, Mammalian ; Hematopoiesis/physiology ; Mesonephros
    Language English
    Publishing date 2023-06-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022017934
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  3. Article ; Online: Tracking HSC Origin: From Bench to Placenta.

    Calvanese, Vincenzo / Mikkola, Hanna K A

    Developmental cell

    2016  Volume 36, Issue 5, Page(s) 479–480

    Abstract: Reporting in Developmental Cell, Pereira et al. (2016) use in vitro lineage reprogramming insights to inform understanding of hematopoietic stem cell (HSC) development in vivo. They find Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors, akin to ... ...

    Abstract Reporting in Developmental Cell, Pereira et al. (2016) use in vitro lineage reprogramming insights to inform understanding of hematopoietic stem cell (HSC) development in vivo. They find Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors, akin to fibroblast-derived hemato-vascular precursors, in mouse placenta and embryo. The cells mature into transplantable HSCs in culture.
    MeSH term(s) Animals ; Cell Differentiation/physiology ; Cell Lineage/physiology ; Cellular Reprogramming ; Female ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/cytology ; Mouse Embryonic Stem Cells/cytology ; Pregnancy
    Language English
    Publishing date 2016-03-07
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2016.02.022
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  4. Article ; Online: Return to youth with Sox17.

    Chhabra, Akanksha / Mikkola, Hanna K A

    Genes & development

    2011  Volume 25, Issue 15, Page(s) 1557–1562

    Abstract: Maturation of hematopoietic stem cells (HSCs) from fetal to adult state and differentiation to progenitors are thought to follow a one-way street. In this issue of Genes & Development, He and colleagues (pp. 1613-1627) show that overexpression of Sox17 ... ...

    Abstract Maturation of hematopoietic stem cells (HSCs) from fetal to adult state and differentiation to progenitors are thought to follow a one-way street. In this issue of Genes & Development, He and colleagues (pp. 1613-1627) show that overexpression of Sox17 can convert adult multipotential progenitors to self-renewing HSCs that possess fetal properties. These findings challenge the irreversibility of hematopoietic development, and open up new perspectives to understand the different forms of HSC self-renewal at distinct stages of ontogeny and during transformation.
    MeSH term(s) Animals ; Cell Differentiation ; Fetus ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Humans ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; SOXF Transcription Factors/metabolism
    Chemical Substances SOXF Transcription Factors
    Language English
    Publishing date 2011-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.17328611
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  5. Article ; Online: Sex hormone drives blood stem cell reproduction.

    Calvanese, Vincenzo / Lee, Lydia K / Mikkola, Hanna K A

    The EMBO journal

    2014  Volume 33, Issue 6, Page(s) 534–535

    Abstract: Stem cells ensure the maintenance of tissue homeostasis throughout life by tightly regulating their self-renewal and differentiation. In a recent study published in Nature, Nakada et al, 2014 unveil an unexpected endocrine mechanism that regulates ... ...

    Abstract Stem cells ensure the maintenance of tissue homeostasis throughout life by tightly regulating their self-renewal and differentiation. In a recent study published in Nature, Nakada et al, 2014 unveil an unexpected endocrine mechanism that regulates hematopoietic stem cell (HSC) self-renewal.
    MeSH term(s) Animals ; Estrogens/metabolism ; Female ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Male ; Pregnancy
    Chemical Substances Estrogens
    Language English
    Publishing date 2014-02-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.1002/embj.201487976
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  6. Article ; Online: Hematopoietic stem cells in transit--where's the niche?

    Magnusson, Mattias / Mikkola, Hanna K A

    Cell stem cell

    2008  Volume 2, Issue 4, Page(s) 302–304

    Abstract: In this issue of Cell Stem Cell, Min et al. (2008) identify Egr1 as a novel hematopoietic stem cell (HSC) transcription factor that regulates proliferation and mobilization of these cells. An improved understanding of Egr1 targets may lead to better ... ...

    Abstract In this issue of Cell Stem Cell, Min et al. (2008) identify Egr1 as a novel hematopoietic stem cell (HSC) transcription factor that regulates proliferation and mobilization of these cells. An improved understanding of Egr1 targets may lead to better strategies to expand populations of HSCs ex vivo for therapeutic applications.
    MeSH term(s) Animals ; Cell Movement/physiology ; Cell Proliferation ; Early Growth Response Protein 1/physiology ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/physiology ; Humans
    Chemical Substances EGR1 protein, human ; Early Growth Response Protein 1 ; Egr1 protein, mouse
    Language English
    Publishing date 2008-04-10
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2008.03.017
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  7. Article ; Online: Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells.

    Grace, Clea S / Mikkola, Hanna K A / Dou, Diana R / Calvanese, Vincenzo / Ronn, Roger E / Purton, Louise E

    Experimental hematology

    2018  Volume 65, Page(s) 1–16

    Abstract: Hematopoietic stem cells (HSCs) are multipotent cells responsible for the maintenance of the hematopoietic system throughout life. Dysregulation of the balance in HSC self-renewal, death, and differentiation can have serious consequences such as ... ...

    Abstract Hematopoietic stem cells (HSCs) are multipotent cells responsible for the maintenance of the hematopoietic system throughout life. Dysregulation of the balance in HSC self-renewal, death, and differentiation can have serious consequences such as myelodysplastic syndromes or leukemia. All-trans retinoic acid (ATRA), the biologically active metabolite of vitamin A/RA, has been shown to have pleiotropic effects on hematopoietic cells, enhancing HSC self-renewal while also increasing differentiation of more mature progenitors. Furthermore, ATRA has been shown to have key roles in regulating the specification and formation of hematopoietic cells from pluripotent stem cells including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Here, we summarize the known roles of vitamin A and RA receptors in the regulation of hematopoiesis from HSCs, ES, and iPSCs.
    MeSH term(s) Cell Differentiation/physiology ; Hematopoiesis ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/physiology ; Humans ; Models, Biological ; Pluripotent Stem Cells/cytology ; Receptors, Retinoic Acid/physiology ; Retinoids/metabolism ; Signal Transduction
    Chemical Substances Receptors, Retinoic Acid ; Retinoids
    Language English
    Publishing date 2018-07-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 185107-x
    ISSN 1873-2399 ; 0531-5573 ; 0301-472X
    ISSN (online) 1873-2399
    ISSN 0531-5573 ; 0301-472X
    DOI 10.1016/j.exphem.2018.06.287
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  8. Article ; Online: Mapping human haematopoietic stem cells from haemogenic endothelium to birth.

    Calvanese, Vincenzo / Capellera-Garcia, Sandra / Ma, Feiyang / Fares, Iman / Liebscher, Simone / Ng, Elizabeth S / Ekstrand, Sophia / Aguadé-Gorgorió, Júlia / Vavilina, Anastasia / Lefaudeux, Diane / Nadel, Brian / Li, Jacky Y / Wang, Yanling / Lee, Lydia K / Ardehali, Reza / Iruela-Arispe, M Luisa / Pellegrini, Matteo / Stanley, Ed G / Elefanty, Andrew G /
    Schenke-Layland, Katja / Mikkola, Hanna K A

    Nature

    2022  Volume 604, Issue 7906, Page(s) 534–540

    Abstract: The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the inability to identify HSCs as they emerge and mature at different haematopoietic ... ...

    Abstract The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the inability to identify HSCs as they emerge and mature at different haematopoietic sites
    MeSH term(s) Cell Differentiation ; Endothelial Cells ; Endothelium ; Female ; Hematopoiesis ; Hematopoietic Stem Cells ; Humans ; Mesonephros ; Pregnancy
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-04571-x
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  9. Article ; Online: Targeting leukemia stem cells.

    Mikkola, Hanna K A / Radu, Caius G / Witte, Owen N

    Nature biotechnology

    2010  Volume 28, Issue 3, Page(s) 237–238

    MeSH term(s) Animals ; Drug Delivery Systems ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; Mice ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/pathology ; Xenograft Model Antitumor Assays
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2010-03
    Publishing country United States
    Document type Comment ; News
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/nbt0310-237
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  10. Article ; Online: DNA methylation is a guardian of stem cell self-renewal and multipotency.

    Gereige, Laurraine-Marcelle / Mikkola, Hanna K A

    Nature genetics

    2009  Volume 41, Issue 11, Page(s) 1164–1166

    MeSH term(s) Animals ; Cell Differentiation ; DNA (Cytosine-5-)-Methyltransferase 1 ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA Methylation ; Epigenesis, Genetic ; Erythroid Cells/cytology ; Erythroid Cells/metabolism ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Mice ; Multipotent Stem Cells/cytology ; Multipotent Stem Cells/metabolism
    Chemical Substances DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37) ; DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37)
    Language English
    Publishing date 2009-09-29
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/ng1109-1164
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