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  1. Article ; Online: Size precision in insect eyes.

    Milán, Marco

    PLoS biology

    2024  Volume 22, Issue 1, Page(s) e3002471

    Abstract: The building of fully functional and well-proportioned individuals relies on the precise regulation of the size of each of their constituting organs. A new study unravels a mechanism that confers precision to size regulation of the adult Drosophila eye ... ...

    Abstract The building of fully functional and well-proportioned individuals relies on the precise regulation of the size of each of their constituting organs. A new study unravels a mechanism that confers precision to size regulation of the adult Drosophila eye through morphogen-mediated modulation of cell survival.
    MeSH term(s) Animals ; Humans ; Drosophila/metabolism ; Drosophila Proteins/metabolism ; Feedback ; Organ Size ; Gene Expression Regulation, Developmental ; Bone Morphogenetic Protein 2
    Chemical Substances Drosophila Proteins ; BMP2 protein, human ; Bone Morphogenetic Protein 2
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3002471
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  2. Article ; Online: Organogenesis: Cell death matters in size and shape regulation.

    Milán, Marco

    Current biology : CB

    2024  Volume 34, Issue 2, Page(s) R62–R64

    Abstract: Anisotropic growth and large-scale morphogenetic movements contribute to the final size and shape of the adult Drosophila wing. A new study unravels an unexpected contribution of cell death, which follows a spatial and temporal pattern, to the growth of ... ...

    Abstract Anisotropic growth and large-scale morphogenetic movements contribute to the final size and shape of the adult Drosophila wing. A new study unravels an unexpected contribution of cell death, which follows a spatial and temporal pattern, to the growth of the wing and the acquisition of its elongated shape.
    MeSH term(s) Animals ; Organogenesis ; Anisotropy ; Cell Death ; Drosophila ; Morphogenesis
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.12.011
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  3. Article ; Online: Wing regeneration: Single-cell analysis sheds new light.

    Milán, Marco

    Current biology : CB

    2022  Volume 32, Issue 15, Page(s) R842–R844

    Abstract: The developing wing primordium of Drosophila displays a remarkable capacity to regenerate in response to different types of damage. A new study shows that this capacity relies on the activation of a pro-regenerative gene regulatory network in two ... ...

    Abstract The developing wing primordium of Drosophila displays a remarkable capacity to regenerate in response to different types of damage. A new study shows that this capacity relies on the activation of a pro-regenerative gene regulatory network in two distinct cell populations within the blastema.
    MeSH term(s) Animals ; Drosophila/genetics ; Drosophila Proteins/genetics ; Single-Cell Analysis ; Wings, Animal/physiology
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2022.06.068
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  4. Article ; Online: Tissue growth: Basement membrane degradation triggers cell proliferation.

    Milán, Marco

    Current biology : CB

    2022  Volume 32, Issue 6, Page(s) R276–R279

    Abstract: Building of the Drosophila abdomen relies on the removal of larval cells and expansion, through proliferation, of a population of progenitor epithelial cells. A new study shows that matrix metalloproteinases produced by larval cells drive basement ... ...

    Abstract Building of the Drosophila abdomen relies on the removal of larval cells and expansion, through proliferation, of a population of progenitor epithelial cells. A new study shows that matrix metalloproteinases produced by larval cells drive basement membrane degradation and proliferative growth of the progenitor epithelial population.
    MeSH term(s) Basement Membrane/metabolism ; Cell Proliferation ; Epithelial Cells/metabolism ; Stem Cells
    Language English
    Publishing date 2022-03-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2022.01.081
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  5. Article ; Online: Aneuploidy-induced cellular behaviors: Insights from Drosophila.

    Joy, Jery / Fusari, Elena / Milán, Marco

    Developmental cell

    2024  Volume 59, Issue 3, Page(s) 295–307

    Abstract: A balanced gene complement is crucial for proper cell function. Aneuploidy, the condition of having an imbalanced chromosome set, alters the stoichiometry of gene copy numbers and protein complexes and has dramatic consequences at the cellular and ... ...

    Abstract A balanced gene complement is crucial for proper cell function. Aneuploidy, the condition of having an imbalanced chromosome set, alters the stoichiometry of gene copy numbers and protein complexes and has dramatic consequences at the cellular and organismal levels. In humans, aneuploidy is associated with different pathological conditions including cancer, microcephaly, mental retardation, miscarriages, and aging. Over the last century, Drosophila has provided a valuable system for studying the consequences of systemic aneuploidies. More recently, it has contributed to the identification and molecular dissection of aneuploidy-induced cellular behaviors and their impact at the tissue and organismal levels. In this perspective, we review this active field of research, first by comparing knowledge from yeast, mouse, and human cells, then by highlighting the contributions of Drosophila. The aim of these discussions was to further our understanding of the functional interplay between aneuploidy, cell physiology, and tissue homeostasis in human development and disease.
    MeSH term(s) Humans ; Animals ; Mice ; Drosophila ; Aneuploidy ; Gene Dosage ; Cell Physiological Phenomena ; Saccharomyces cerevisiae
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2023.12.009
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    Zs.MG 76: Show issues

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  6. Article: Leaching of Glyphosate and AMPA from Field Lysimeters

    Milan, Marco / Vidotto, Francesco / Fogliatto, Silvia

    Agronomy. 2022 Jan. 27, v. 12, no. 2

    2022  

    Abstract: Leaching of glyphosate and AMPA as affected by the time elapsed between the spraying and first leaching event was studied on large-scale lysimeters in a two-year study. The leaching events were induced by irrigation interventions able to deliver 336 L, ... ...

    Abstract Leaching of glyphosate and AMPA as affected by the time elapsed between the spraying and first leaching event was studied on large-scale lysimeters in a two-year study. The leaching events were induced by irrigation interventions able to deliver 336 L, equivalent to a rainfall of 40 mm. Four groups of three lysimeters were randomly selected between the 12 lysimeters available. They were irrigated on either one day after herbicide treatment (1 DAT), 7 DAT, 14 DAT or 28 DAT. The same group of lysimeters were irrigated a second time 14 days after the first irrigation, corresponding to a period of time of 15 DAT (1 + 14), 21 DAT (7 + 14), 28 DAT (14 + 14) and 42 DAT (28 + 14). In both years, lysimeters were sprayed with glyphosate (360 L ha⁻¹) at a rate of 12 L ha⁻¹, the maximum field rate allowed on the label. Our results pointed out that the leaching of glyphosate and AMPA is effectively event-driven and highlighted the importance of the first rainfall event in moving glyphosate through the soil, increasing the potential risk of water contamination. Overall, both chemicals showed a risk of water contamination. Glyphosate may persist more than usually considered, and its residues were found in leached waters from lysimeters treated 30 days before the leaching event. Other factors may affect the movement of these two compounds through the soil profile after spraying: temperature pattern and soil moisture. Finally, the results of this study refer to a very high application rate of glyphosate. Hence, at lower field rates, observed concentrations can likely be minor.
    Keywords agronomy ; application rate ; glyphosate ; irrigation ; lysimeters ; rain ; risk ; soil profiles ; soil water ; temperature ; water pollution
    Language English
    Dates of publication 2022-0127
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2607043-1
    ISSN 2073-4395
    ISSN 2073-4395
    DOI 10.3390/agronomy12020328
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: A new and integrated approach to evaluate the environmental and ecotoxicological impact of herbicide mixtures: A case study in maize

    Vidotto, Francesco / Fogliatto, Silvia / Milan, Marco

    Science of the total environment. 2022 June 17,

    2022  

    Abstract: An index-based approach for a comprehensive evaluation of the potential risk for active substances and their mixtures to impact the environment was developed. Some of the indices considered already exist (PRISW-1, Priority Index), while others were ... ...

    Abstract An index-based approach for a comprehensive evaluation of the potential risk for active substances and their mixtures to impact the environment was developed. Some of the indices considered already exist (PRISW-1, Priority Index), while others were created ex novo from indicators available on open-source platforms (PESTi, ECOi, AGROi). These indices maybe used for an evaluation before use of pesticides by farmers and advisers. The present approach was initially validated for herbicides in maize crops, but it can readily be applied to other PPPs and crops. PESTi index underline the physical and chemical characteristics as a whole, not considering the impact of other factors such as application rate or period of application. Hence, this index may underestimate the risk associated to a certain chemical. AGROi has a precautionary approach. The risk associated to a specific mixture derives from a combination of intrinsic characteristics of the chemicals, agronomic impacts, regulation restrictions and potential hazard to water compartment. The ECOi index is focused on the ecotoxicological impact against non-target organisms. The helpfulness of this index stands in its ability to easily discriminate the ecotoxicological impact of chemicals using indicators commonly available in literature and without making complex calculations. PRISW-1 Index discriminate active substances according to their risk against three representative non-target organisms. However, due to the intrinsic characteristics of each pesticide, a high PRISW-1 value could not always mean an easy movement of the chemical via runoff waters. The information deriving from Priority index may certainly help public authorities to select chemicals to be detected in water monitoring campaigns. The application of these indices may represent a valid decision tool for public stakeholders in defining agricultural measures to reduce the externalities of pest control.
    Keywords application rate ; case studies ; corn ; ecotoxicology ; environment ; pest control ; risk ; runoff ; stakeholders
    Language English
    Dates of publication 2022-0617
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.156862
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  8. Article ; Online: Gene-Regulatory Logic to Induce and Maintain a Developmental Compartment.

    Milán, Marco

    PLoS genetics

    2015  Volume 11, Issue 10, Page(s) e1005543

    MeSH term(s) Animals ; Developmental Biology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Epigenomics ; Gene Expression Regulation, Developmental ; Genes, Regulator ; Humans ; Transcription Factors/genetics ; Vertebrates/genetics ; Vertebrates/growth & development
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2015-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1005543
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  9. Article ; Online: A new and integrated approach to evaluate the environmental and ecotoxicological impact of herbicide mixtures: A case study in maize.

    Vidotto, Francesco / Fogliatto, Silvia / Milan, Marco

    The Science of the total environment

    2022  Volume 842, Page(s) 156862

    Abstract: An index-based approach for a comprehensive evaluation of the potential risk for active substances and their mixtures to impact the environment was developed. Some of the indices considered already exist (PRISW-1, Priority Index), while others were ... ...

    Abstract An index-based approach for a comprehensive evaluation of the potential risk for active substances and their mixtures to impact the environment was developed. Some of the indices considered already exist (PRISW-1, Priority Index), while others were created ex novo from indicators available on open-source platforms (PESTi, ECOi, AGROi). These indices maybe used for an evaluation before use of pesticides by farmers and advisers. The present approach was initially validated for herbicides in maize crops, but it can readily be applied to other PPPs and crops. PESTi index underline the physical and chemical characteristics as a whole, not considering the impact of other factors such as application rate or period of application. Hence, this index may underestimate the risk associated to a certain chemical. AGROi has a precautionary approach. The risk associated to a specific mixture derives from a combination of intrinsic characteristics of the chemicals, agronomic impacts, regulation restrictions and potential hazard to water compartment. The ECOi index is focused on the ecotoxicological impact against non-target organisms. The helpfulness of this index stands in its ability to easily discriminate the ecotoxicological impact of chemicals using indicators commonly available in literature and without making complex calculations. PRISW-1 Index discriminate active substances according to their risk against three representative non-target organisms. However, due to the intrinsic characteristics of each pesticide, a high PRISW-1 value could not always mean an easy movement of the chemical via runoff waters. The information deriving from Priority index may certainly help public authorities to select chemicals to be detected in water monitoring campaigns. The application of these indices may represent a valid decision tool for public stakeholders in defining agricultural measures to reduce the externalities of pest control.
    MeSH term(s) Environmental Monitoring ; Herbicides/toxicity ; Pesticides/analysis ; Risk Assessment ; Water/chemistry ; Water Pollutants, Chemical/analysis ; Zea mays
    Chemical Substances Herbicides ; Pesticides ; Water Pollutants, Chemical ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-06-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.156862
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    Zs.A 949: Show issues Location:
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  10. Article ; Online: Regulation of Anisotropic Tissue Growth by Two Orthogonal Signaling Centers.

    Barrio, Lara / Milán, Marco

    Developmental cell

    2020  Volume 52, Issue 5, Page(s) 659–672.e3

    Abstract: The Drosophila wing has served as a paradigm to mechanistically characterize the role of morphogens in patterning and growth. Wingless (Wg) and Decapentaplegic (Dpp) are expressed in two orthogonal signaling centers, and their gradients organize ... ...

    Abstract The Drosophila wing has served as a paradigm to mechanistically characterize the role of morphogens in patterning and growth. Wingless (Wg) and Decapentaplegic (Dpp) are expressed in two orthogonal signaling centers, and their gradients organize patterning by regulating the expression of well-defined target genes. By contrast, graded activity of these morphogens is not an absolute requirement for wing growth. Despite their permissive role in regulating growth, here we show that Wg and Dpp are utilized in a non-interchangeable manner by the two existing orthogonal signaling centers to promote preferential growth along the two different axes of the developing wing. Our data indicate that these morphogens promote anisotropic growth by making use of distinct and non-interchangeable molecular mechanisms. Whereas Dpp drives growth along the anterior-posterior axis by maintaining Brinker levels below a growth-repressing threshold, Wg exerts its action along the proximal-distal axis through a double repression mechanism involving T cell factor (TCF).
    MeSH term(s) Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Morphogenesis ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Signal Transduction ; TCF Transcription Factors/metabolism ; Wings, Animal/growth & development ; Wings, Animal/metabolism ; Wnt1 Protein/genetics ; Wnt1 Protein/metabolism
    Chemical Substances Drosophila Proteins ; Repressor Proteins ; TCF Transcription Factors ; Wnt1 Protein ; brk protein, Drosophila ; dpp protein, Drosophila ; wg protein, Drosophila
    Language English
    Publishing date 2020-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2020.01.017
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