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Article ; Online: Efecto del riesgo cardiovascular sobre la limpieza del ARN del SARS-CoV-2 en hisopos nasofaríngeos de pacientes con COVID-19.

Mazzaccaro, Daniela / Piccinni, Rosangela / Milani, Valentina / Righini, Paolo / Nano, Giovanni / Gobbo, Giulia Ml

2024 Volume 98, Page(s) e1–e4

Title translation	Effect of cardiovascular risk on SARS-CoV-2 RNA clearance in nasopharyngeal swabs from COVID-19 patients.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; RNA, Viral/genetics ; Cardiovascular Diseases/diagnosis ; Risk Factors ; Spain ; Nasopharynx ; Heart Disease Risk Factors
Chemical Substances	RNA, Viral
Language	Spanish
Publishing date	2024-03-01
Publishing country	Spain
Document type	Letter
ZDB-ID	1288657-9
ISSN	2173-9110 ; 0034-8899 ; 1135-5727
ISSN (online)	2173-9110
ISSN	0034-8899 ; 1135-5727
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Zs.A 483: Show issues

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Article ; Online: Does the Pittsburgh Severity Score Predict Patients' Outcomes in Benign Esophageal Perforations?

Andreatta, Erika / Lovece, Andrea / Milani, Valentina / Asti, Emanuele / Bonavina, Luigi

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2022 Volume 26, Issue 8, Page(s) 1757–1759

MeSH term(s)	Esophageal Perforation/diagnosis ; Esophageal Perforation/etiology ; Esophageal Perforation/surgery ; Esophagoscopy ; Humans ; Iatrogenic Disease ; Stents
Language	English
Publishing date	2022-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1007/s11605-022-05281-5
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Zs.A 5207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 354: Show issues

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Article ; Online: Comparative outcomes of Toupet fundoplication and magnetic sphincter augmentation.

Asti, Emanuele / Milito, Pamela / Froiio, Caterina / Milani, Valentina / Bonavina, Luigi

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

2022 Volume 36, Issue Supplement_1

Abstract: Laparoscopic fundoplication is the current surgical gold standard for the treatment of refractory gastroesophageal reflux disease (GERD). Magnetic sphincter augmentation (MSA) is a less invasive, standardized, and reversible option to restore competency ... ...

Abstract	Laparoscopic fundoplication is the current surgical gold standard for the treatment of refractory gastroesophageal reflux disease (GERD). Magnetic sphincter augmentation (MSA) is a less invasive, standardized, and reversible option to restore competency of the lower esophageal sphincter. A comparative cohort study was conducted at a tertiary-care referral center on patients with typical GERD symptoms treated with systematic crural repair combined with Toupet fundoplication or MSA. Primary study outcome was decrease of Gastroesophageal Reflux Disease-Health Related Quality of Life (GERD-HRQL) score. Between January 2014 and December 2021, a total of 199 patients (60.3% female, median [Q1-Q3] age: 51.0 [40.0-61.0]) underwent MSA (n = 130) or Toupet fundoplication (n = 69). Operative time and hospital stay were significantly shorter in MSA patients (P < 0.0001). At a median follow-up of 12.0 [12.0-24.0] months, there was a statistically significant decrease of GERD-HRQL score in both patient groups (P = 0.001). The mean delta values did not significantly differ between groups (P = 0.7373). The incidence of severe gas bloating symptoms was similar in the two groups (P = 0.7604), but the rate of persistent postoperative dysphagia was greater in MSA patients (P = 0.0009). Six (8.7%) patients in the Toupet group had recurrent hiatal hernia requiring revisional surgery in one (1.4%). In the MSA group, eight (7.9%) patients necessitated through-the-scope balloon dilation for relief of dysphagia, and six patients had the device removed (4.6%) because of persistent dysphagia (n = 3), device disconnection (n = 1), persistent reflux (n = 1) or need of magnetic resonance (n = 1). Toupet and MSA procedures provide similar clinical outcomes, but MSA is associated with a greater risk of reoperation. Randomized clinical trials comparing fundoplication and MSA are eagerly awaited.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Fundoplication/methods ; Cohort Studies ; Deglutition Disorders/etiology ; Deglutition Disorders/surgery ; Quality of Life ; Laparoscopy/methods ; Gastroesophageal Reflux/complications ; Esophageal Sphincter, Lower/surgery ; Treatment Outcome
Language	English
Publishing date	2022-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	639470-x
ISSN	1442-2050 ; 1120-8694
ISSN (online)	1442-2050
ISSN	1120-8694
DOI	10.1093/dote/doac090
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Zs.A 2378: Show issues

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Article: Surgical Ventricular Restoration for Ischemic Heart Failure: A Glance at a Real-World Population.

Castelvecchio, Serenella / Milani, Valentina / Ambrogi, Federico / Volpe, Marianna / Ramputi, Lucia / Soletti, Giovanni / Menicanti, Lorenzo

Journal of personalized medicine

2022 Volume 12, Issue 4

Abstract: Surgical ventricular restoration (SVR) has repeatedly been suggested as a viable therapeutic strategy for ischemic heart failure (HF) patients, although the survival benefit is still debated. We investigated a real-world population treated with SVR in a ... ...

Abstract	Surgical ventricular restoration (SVR) has repeatedly been suggested as a viable therapeutic strategy for ischemic heart failure (HF) patients, although the survival benefit is still debated. We investigated a real-world population treated with SVR in a single center with high case volumes. From July 2001 to June 2017, 648 patients (111 females) underwent SVR; coronary surgery was performed in 582 patients. Data were analyzed by dividing the population into two groups: Group I (371 patients operated between July 2001 and December 2007) and Group II (277 patients operated between January 2008 and June 2017). At baseline, Group I patients were more symptomatic for angina (47.4% versus 19.4%, p < 0.0001) and less symptomatic for HF (NYHA class III/IV, 46.3% versus 57%, p = 0.0071). The end-diastolic volume (106 mL/m2 versus 118.3 mL/m2, p < 0.0001) and the end-systolic volume (70.5 mL/m2 versus 81.5 mL/m2, p < 0.0001) were lower in Group I. The presence of 3-vessel coronary artery disease (CAD) was higher in Group I (73.3% versus 59.2%, p < 0.0001). Thirty-day mortality (6.64%) was similar in the two groups (p = 0.4475). The Kaplan−Meier estimate for all-cause mortality for the entire population was 13% at 2 years, 19.2% at 4 years and 36.6% at 8 years, and the probability was not different between groups (Log-rank = 0.11). In a real-world ischemic HF population, SVR may be carried out with favorable results; in patients with worse LV remodeling and less extensive CAD, SVR showed a trend toward a better outcome.
Language	English
Publishing date	2022-04-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12040567
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Article ; Online: Could fat distribution have a greater influence than BMI on the antibody titre after SARS-CoV-2 vaccine?

Basilico, Sara / Dubini, Carola / Milani, Valentina / Bertolini, Caterina / Malavazos, Alexis Elias

Obesity (Silver Spring, Md.)

2022 Volume 30, Issue 7, Page(s) 1321–1322

MeSH term(s)	Antibodies, Viral ; Body Mass Index ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; SARS-CoV-2
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines
Language	English
Publishing date	2022-06-15
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.23474
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Zs.A 4061: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 87: Show issues

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Article ; Online: Prognostic value of cardiopulmonary exercise testing in a European cohort with cardiovascular risk factors absent of a cardiovascular disease diagnosis.

Zannoni, Jessica / Guazzi, Marco / Milani, Valentina / Bandera, Francesco / Alfonzetti, Eleonora / Arena, Ross

International journal of cardiology

2022 Volume 370, Page(s) 402–404

Abstract: Introduction: Cardiorespiratory fitness (CRF) is now considered a vital sign. Cardiopulmonary exercise testing (CPET) is the gold-standard assessment of CRF; peak oxygen consumption (VO: Methods: 695 subjects (mean age: 62 ± 13 years, body mass index: ...

Abstract	Introduction: Cardiorespiratory fitness (CRF) is now considered a vital sign. Cardiopulmonary exercise testing (CPET) is the gold-standard assessment of CRF; peak oxygen consumption (VO Methods: 695 subjects (mean age: 62 ± 13 years, body mass index: 28.9 ± 5.3 kg/m Results: Mean peak VO Discussion: These results support the prognostic value of CPET prior to a CVD diagnosis. The prognostic value of the VE/VCO
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Aged ; Exercise Test ; Prognosis ; Oxygen Consumption ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Heart Failure/diagnosis ; Carbon Dioxide ; Risk Factors ; Heart Disease Risk Factors
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2022-10-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2022.10.016
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Zs.A 1673: Show issues

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Article ; Online: Phenotyping congestion in acute heart failure by renal flow and right heart to pulmonary circulation coupling.

Vella, Alessandro / Labate, Valentina / Carenini, Gianmarco / Alfonzetti, Eleonora / Milani, Valentina / Bandera, Francesco / Oliva, Omar / Guazzi, Marco

ESC heart failure

2023 Volume 10, Issue 6, Page(s) 3546–3558

Abstract: Aims: In acute heart failure (AHF), kidney congestion is basic to treatment and prognosis. Its aetiology is manifold and quite unexplored in details mainly regarding the right heart to pulmonary circulation (Pc) coupling. We investigated the right heart ...

Abstract	Aims: In acute heart failure (AHF), kidney congestion is basic to treatment and prognosis. Its aetiology is manifold and quite unexplored in details mainly regarding the right heart to pulmonary circulation (Pc) coupling. We investigated the right heart to kidney interrelationship by Doppler renal flow pattern, right atrial dynamics, and right ventricular (RV) function to Pc coupling in AHF. Methods and results: In 119 AHF patients, echocardiographic and renal Doppler data were analysed. Univariate and multivariate regression models were performed to define the determinants of a quantitative parameter of renal congestion, the renal venous stasis index (RVSI). When grouped according to different intra-renal venous flow patterns, no differences were observed in haemodynamics and baseline renal function. Nonetheless, patients with renal Doppler evidence of congestion showed a reduced RV function [tricuspid annular plane systolic excursion (TAPSE), S'-wave velocity, and fractional area change], impaired RV to Pc coupling [TAPSE/pulmonary artery systolic pressure (PASP) ratio], and right atrial peak longitudinal strain (RAPLS), along with signs of volume overload [increased inferior vena cava (IVC) diameters and estimated right atrial pressure]. Univariate and multivariate regression analyses confirmed TAPSE/PASP, RAPLS, and IVC diameter as independent determinants of the RVSI. RVSI was the only variable predicting the composite outcome (cardiac death, heart failure hospitalization, and haemodialysis). An easy-to-use echo-derived right heart score of four variables provided good accuracy in identifying kidney congestion. Conclusions: In AHF, the renal venous flow pattern combined with a right heart study phenotypes congestion and clinical evolution. Keys to renal flow disruption are an impaired right atrial dynamics and RV-Pc uncoupling. Integration of four right heart echocardiographic variables may be an effective tool for scoring the renal congestive phenotype in AHF.
MeSH term(s)	Humans ; Pulmonary Circulation ; Atrial Fibrillation ; Echocardiography, Doppler ; Prospective Studies ; Heart Failure/complications ; Heart Failure/diagnosis ; Vascular Diseases ; Kidney/diagnostic imaging ; Kidney/physiology
Language	English
Publishing date	2023-09-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14522
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Article ; Online: Factors associated with perioperative mortality after late open conversion for failed endovascular aortic repair.

Mazzaccaro, Daniela / Righini, Paolo / Giannetta, Matteo / Modafferi, Alfredo / Malacrida, Giovanni / Milani, Valentina / Ambrogi, Federico / Nano, Giovanni

The Journal of cardiovascular surgery

2023 Volume 64, Issue 3, Page(s) 297–303

Abstract: Introduction: The aim of this study was to perform a systematic review about the clinical and technical aspects of late open conversion for failed endovascular aortic repair (EVAR) of abdominal aortic aneurysms (AAA), and to investigate if the need for ... ...

Abstract	Introduction: The aim of this study was to perform a systematic review about the clinical and technical aspects of late open conversion for failed endovascular aortic repair (EVAR) of abdominal aortic aneurysms (AAA), and to investigate if the need for suprarenal aortic cross clamping, graft infection, urgent procedures, endoleaks and aortic rupture were associated with an increase of 30-days (perioperative) mortality. Evidence acquisition: A literature search was conducted on PubMed using the words "open conversion endovascular" on December 29 Evidence synthesis: The search retrieved 985 results on PubMed from 1994 to 2021. Among them, 40 papers were included in the study for the systematic review, and 5 of them for the meta-analysis. A total of 2297 patients from 1992 to 2020 were submitted to open conversion after a median of 40.4 months from the initial EVAR. Endoleak was the most frequent cause of open conversion (76.3%). Perioperative mortality was 23.5% for urgent and 5.3% for elective conversions. At meta-analysis, urgent procedures and aortic rupture were both associated with higher perioperative mortality (OR 5.27, 95% CI 2.90-9.57 and OR 5.61, 95% CI 3.09-10.19 respectively). Similarly, patients with infections and who needed suprarenal aortic clamping were at higher risk of 30-days postoperative death (OR 3.74, 95% CI 1.96-7.13) and OR 2.23, 95% CI 1.24-4.02), while the presence of a preoperative endoleaks was not associated with a higher 30-days mortality. Conclusions: Late open conversion after EVAR of AAA is burdened by a perioperative mortality rate of 23.5% for urgent and 5.3% for elective cases. Urgent treatment, presence of aortic rupture or infection, and the need for suprarenal aortic cross clamping were associated with increased perioperative mortality, while the presence of an endoleak did not affect perioperative mortality.
MeSH term(s)	Humans ; Endoleak/surgery ; Endovascular Aneurysm Repair ; Aortic Rupture/diagnostic imaging ; Aortic Rupture/surgery ; Aortic Rupture/etiology ; Blood Vessel Prosthesis Implantation ; Endovascular Procedures ; Postoperative Complications ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/surgery ; Aortic Aneurysm, Abdominal/complications ; Risk Factors ; Treatment Outcome
Language	English
Publishing date	2023-02-10
Publishing country	Italy
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	80143-4
ISSN	1827-191X ; 0021-9509
ISSN (online)	1827-191X
ISSN	0021-9509
DOI	10.23736/S0021-9509.22.12491-2
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Zs.A 469: Show issues

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Article ; Online: Low profile endografts for the endovascular treatment of abdominal aortic aneurysms.

Mazzaccaro, Daniela / Righini, Paolo / Giannetta, Matteo / Galligani, Marina / Milani, Valentina / Modafferi, Alfredo / Malacrida, Giovanni / Nano, Giovanni

Expert review of medical devices

2023 Volume 20, Issue 9, Page(s) 753–767

Abstract: Introduction: Favorable midterm outcomes have been reported with the use of low-profile endografts (LPE), but long-term data is still needed. Furthermore, it is unclear if each of these LPE may have advantages over the other, which may, in turn, affect ... ...

Abstract	Introduction: Favorable midterm outcomes have been reported with the use of low-profile endografts (LPE), but long-term data is still needed. Furthermore, it is unclear if each of these LPE may have advantages over the other, which may, in turn, affect the outcomes. We systematically reviewed the literature about complications and reintervention rates of patients submitted to endovascular aneurysm repair (EVAR) of abdominal aortic aneurysm (AAA) using LPE. Matherials and methods: A literature search was conducted including articles that reported 30-days and follow-up mortality, complications, and reintervention rates of patients treated with EVAR using Incraft (Cordis), Zenith LP/Alpha (Cook Medical Inc) and Ovation (Endologix) endografts. Results: 36 papers were evaluated, reporting results of 582 patients treated with Zenith device, 1211 with Incraft and 3449 with Ovation. During follow up, similar survival and freedom from reintervention rates were reported among the various types of endograft both at 1 and 3 years. The incidence of limb stenosis/kinking was significantly higher in patients treated with Zenith LP/Alpha (2.1%, Conclusions: Long-term survival and freedom from reintervention rates were comparable among the three LPEs. The Cook Zenith device had the highest rates of limb stenosis/kinking, while the Incraft device had the lowest occurrence of type III endoleak. Prospero: Registration number: CRD42022315875.
MeSH term(s)	Humans ; Blood Vessel Prosthesis/adverse effects ; Aortic Aneurysm, Abdominal/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Constriction, Pathologic/complications ; Treatment Outcome ; Risk Factors ; Endovascular Procedures ; Time Factors ; Endoleak/surgery ; Prosthesis Design ; Retrospective Studies
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2250857-0
ISSN	1745-2422 ; 1743-4440
ISSN (online)	1745-2422
ISSN	1743-4440
DOI	10.1080/17434440.2023.2239148
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Zs.A 6424: Show issues

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Article ; Online: Clopidogrel Resistance and Ticagrelor Replacement in Dual Antiplatelet Therapy for Carotid Artery Stenting.

Mazzaccaro, Daniela / Giannetta, Matteo / Ranucci, Marco / Righini, Paolo / Di Dedda, Umberto / Baryshnikova, Ekaterina / Milani, Valentina / Nano, Giovanni

Annals of vascular surgery

2022 Volume 90, Page(s) 128–136

Abstract: Backgrounds: Resistance to the pharmacological effect of clopidogrel in patients undergoing dual antiplatelet therapy for carotid stenting may increase the risk of periprocedural neurological events. The purpose of the study was to describe the ... ...

Abstract	Backgrounds: Resistance to the pharmacological effect of clopidogrel in patients undergoing dual antiplatelet therapy for carotid stenting may increase the risk of periprocedural neurological events. The purpose of the study was to describe the phenomenon of clopidogrel resistance in a series of patients undergoing carotid stenting. Methods: Data of patients who consecutively underwent carotid stenting from November 2016 to December 2020 for a significant stenosis and who underwent a dual antiplatelet therapy using acetyl-salicylic acid and clopidogrel were prospectively collected. Patients who were already taking a different thienopyridine were excluded. The effectiveness of antiplatelet drugs was assessed by the impedance aggregometry test. Primary endpoint was to evaluate the incidence of clopidogrel resistance and the effectiveness of ticagrelor as alternative therapy. P values < 0.05 were considered statistically significant. Results: Two-hundred patients (80 females, 40%) underwent stenting for carotid stenosis (94% asymptomatic). The phenomenon of clopidogrel resistance was observed in 38 patients (19%), in whom clopidogrel was replaced by ticagrelor (90 mg/bis in die) with 100% effectiveness at aggregometry test. Platelet counts was associated to clopidogrel resistance (P = 0.001). There was no stent thrombosis at 30 days, neither major hemorrhagic events; a total of 12/200 major adverse cardiovascular events occurred (6%), including 1 in the group of patients who took ticagrelor and 11 in group of patients under clopidogrel (2.6% versus 6.7%, P = 0.55). Conclusions: Clopidogrel was ineffective in 19% of patients undergoing carotid stenting. Platelet count seemed to affect this phenomenon. In these patients, clopidogrel was effectively replaced by ticagrelor.
MeSH term(s)	Female ; Humans ; Platelet Aggregation Inhibitors/therapeutic use ; Clopidogrel ; Ticagrelor/pharmacology ; Carotid Stenosis/therapy ; Stents ; Treatment Outcome ; Carotid Arteries ; Percutaneous Coronary Intervention
Chemical Substances	Platelet Aggregation Inhibitors ; Clopidogrel (A74586SNO7) ; Ticagrelor (GLH0314RVC)
Language	English
Publishing date	2022-10-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2022.09.063
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Zs.A 2882: Show issues

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