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Article ; Online: Comprehensive insight into triclosan—from widespread occurrence to health outcomes

Milanović, Maja / Đurić, Larisa / Milošević, Nataša / Milić, Nataša

Environ Sci Pollut Res. 2023 Feb., v. 30, no. 10 p.25119-25140

2023

Abstract: Humans are exposed to the variety of emerging environmental pollutant in everyday life. The special concern is paid to endocrine disrupting chemicals especially to triclosan which could interfere with normal hormonal functions. Triclosan could be found ... ...

Abstract	Humans are exposed to the variety of emerging environmental pollutant in everyday life. The special concern is paid to endocrine disrupting chemicals especially to triclosan which could interfere with normal hormonal functions. Triclosan could be found in numerous commercial products such as mouthwashes, toothpastes and disinfectants due to its antibacterial and antifungal effects. Considering the excessive use and disposal, wastewaters are recognized as the main source of triclosan in the aquatic environment. As a result of the incomplete removal, triclosan residues reach surface water and even groundwater. Triclosan has potential to accumulate in sediment and aquatic organisms. Therefore, the detectable concentrations of triclosan in various environmental and biological matrices emerged concerns about the potential toxicity. Triclosan impairs thyroid homeostasis and could be associated with neurodevelopment impairment, metabolic disorders, cardiotoxicity and the increased cancer risk. The growing resistance of the vast groups of bacteria, the evidenced toxicity on different aquatic organisms, its adverse health effects observed in vitro, in vivo as well as the available epidemiological studies suggest that further efforts to monitor triclosan toxicity at environmental levels are necessary. The safety precaution measures and full commitment to proper legislation in compliance with the environmental protection are needed in order to obtain triclosan good ecological status. This paper is an overview of the possible negative triclosan effects on human health. Sources of exposure to triclosan, methods and levels of detection in aquatic environment are also discussed.
Keywords	aquatic environment ; cardiotoxicity ; compliance ; environmental protection ; groundwater ; homeostasis ; human health ; laws and regulations ; neurodevelopment ; pollutants ; risk ; sediments ; surface water ; toxicity ; triclosan ; wastewater
Language	English
Dates of publication	2023-02
Size	p. 25119-25140.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
Note	Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-17273-0
Database	NAL-Catalogue (AGRICOLA)

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Article: Chromium(VI) adsorption onto boehmite nanoparticles obtained by cost effective “green” synthesis

Milanović, M. / Stijepović, I. / Obrenović, Z. / Kukić, D. / Vasić, V. / Panić, S. / Šćiban, M.

International journal of environmental science and technology. 2022 Oct., v. 19, no. 10

2022

Abstract: Mesoporous boehmite nanopowder was prepared by a simple route and used as an efficient adsorbent for chromium(VI) removal. Chromium(VI) is considered to be potentially carcinogenic to humans, thus, removal of Cr(VI) ions from aqueous solution is of great ...

Abstract	Mesoporous boehmite nanopowder was prepared by a simple route and used as an efficient adsorbent for chromium(VI) removal. Chromium(VI) is considered to be potentially carcinogenic to humans, thus, removal of Cr(VI) ions from aqueous solution is of great importance. Batch adsorption experiments were conducted to study the effects of contact time and initial concentration of Cr(VI). The boehmite prepared by neutralization of sodium aluminate solution from Bayer liquor and glucose as nonionic surfactant is environmentally friendly material for potential industrial scale production. It has the high specific surface area (296 m²/g) and high adsorption capacity (32.92 mg/g after 72 h) for the removal of Cr(VI) from aqueous solutions. This high removal percentage is in an excellent agreement with the capacity calculated by the pseudo-second order model (33.11 mg/g). The equilibrium isotherm data fitted well with the Langmuir model (R² = 0.996), suggesting a uniform surface nature of the prepared nanoparticles.
Keywords	adsorbents ; adsorption ; aqueous solutions ; boehmite ; carcinogenicity ; chromium ; cost effectiveness ; environmental science ; glucose ; models ; nanoparticles ; neutralization ; nonionic surfactants ; porous media ; sodium ; sorption isotherms ; surface area
Language	English
Dates of publication	2022-10
Size	p. 10189-10198.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	2230399-6
ISSN	1735-2630 ; 1735-1472
ISSN (online)	1735-2630
ISSN	1735-1472
DOI	10.1007/s13762-021-03819-9
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Sensitivity and Accuracy of Dielectric Measurements of Liquids Significantly Improved by Coupled Capacitive-Dependent Quartz Crystals.

Matko, Vojko / Milanovič, Miro

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 10

Abstract: A method to measure complex permittivity of liquids by using a capacitive-dependent quartz crystal and two quartz oscillators for temperature compensation in the frequency range of 4-10 MHz is described. Complex permittivity can be detected with high ... ...

Abstract	A method to measure complex permittivity of liquids by using a capacitive-dependent quartz crystal and two quartz oscillators for temperature compensation in the frequency range of 4-10 MHz is described. Complex permittivity can be detected with high precision and sensitivity through a small change of capacitance and conductance, because a change in reactance in series with the quartz crystal impacts its resonant oscillation frequency. The temperature compensation in the range below 0.1 ppm is achieved by using two quartz oscillators that are made of elements of the same quality and have a temperature-frequency pair of quartz crystals. With the help of a reference oscillator, measurements of frequency are more accurate, because the frequency difference is in the kHz region, which also enables further processing of the signal by a microcontroller. With a proper calibration, the accuracy of this highly sensitive quartz crystal method is ±0.05%, which is an order of magnitude lower than that for a capacitance method without quartz crystals. The improved accuracy is of significant importance in the field of power engineering to monitor coolants and lubricants, oils, liquid fuels and other liquids, the dielectric properties of which are crucial for proper operation of devices.
Language	English
Publishing date	2021-05-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21103565
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exogenous α-ketoglutarate Modulates Redox Metabolism and Functions of Human Dendritic Cells, Altering Their Capacity to Polarise T Cell Response.

Milanović, Marijana / Bekić, Marina / Đokić, Jelena / Vučević, Dragana / Čolić, Miodrag / Tomić, Sergej

International journal of biological sciences

2024 Volume 20, Issue 3, Page(s) 1064–1087

Abstract: Alpha-ketoglutarate (αKG) emerged as a key regulator of energetic and redox metabolism in cells, affecting the immune response in various conditions. However, it remained unclear how the exogenous αKG modulates the functions of dendritic cells (DCs), key ...

Abstract	Alpha-ketoglutarate (αKG) emerged as a key regulator of energetic and redox metabolism in cells, affecting the immune response in various conditions. However, it remained unclear how the exogenous αKG modulates the functions of dendritic cells (DCs), key cells regulating T-cell response. Here we found that non-toxic doses of αKG display anti-inflammatory properties in human APC-T cell interaction models. In a model of monocyte-derived (mo)DCs, αKG impaired the differentiation, and the maturation of moDCs induced with lipopolysaccharide (LPS)/interferon (IFN)-γ, and decreased their capacity to induce Th1 cells. However, αKG also promoted IL-1β secretion by mature moDCs, despite inflammasome downregulation, potentiating their Th17 polarizing capacity. αKG induced the expression of anti-oxidative enzymes and hypoxia-induced factor (HIF)-1α in moDCs, activated Akt/FoxO1 pathway and increased autophagy flux, oxidative phosphorylation (OXPHOS) and glycolysis. This correlated with a higher capacity of immature αKG-moDCs to induce Th2 cells, and conventional regulatory T cells in an indolamine-dioxygenase (IDO)-1-dependent manner. Additionally, αKG increased moDCs' capacity to induce non-conventional T regulatory (Tr)-1 and IL-10-producing CD8+T cells via up-regulated immunoglobulin-like transcript (ILT3) expression in OXPHOS-dependent manner. These results suggested that exogenous αKG-altered redox metabolism in moDCs contributed to their tolerogenic properties, which could be relevant for designing more efficient therapeutic approaches in DCs-mediated immunotherapies.
MeSH term(s)	Humans ; Ketoglutaric Acids/metabolism ; Dendritic Cells/metabolism ; Th1 Cells ; Th2 Cells ; Cell Differentiation ; Monocytes ; Oxidation-Reduction ; Cells, Cultured
Chemical Substances	Ketoglutaric Acids
Language	English
Publishing date	2024-01-20
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.91109
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: When the microbiome helps the brain-current evidence.

Drljača, Jovana / Milošević, Nataša / Milanović, Maja / Abenavoli, Ludovico / Milić, Nataša

CNS neuroscience & therapeutics

2023 Volume 29 Suppl 1, Page(s) 43–58

Abstract: The gut microbiota-brain axis has been recognized as a network of connections that provides communication between the gut microflora and both central and autonomic nervous system. The gut microbiota alteration has been targeted for therapy in various ... ...

Abstract	The gut microbiota-brain axis has been recognized as a network of connections that provides communication between the gut microflora and both central and autonomic nervous system. The gut microbiota alteration has been targeted for therapy in various neurodegenerative and psychiatric disbalances. Psychobiotics are probiotics that contribute beneficially to the brain function and the host mental health as a result of an interaction with the commensal gut bacteria, although their mechanism of action has not been completely revealed. In this state-of-art review, the findings about the potential therapeutic effects of the psychobiotics alone or in combination with conventional medicine in the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, as well as in some psychiatric diseases like depression, schizophrenia, and bipolar disorder, have been summarized. The evidence of the psychobiotics therapeutic outcomes obtained in preclinical and clinical trials have been given respectively for the observed neurodegenerative and psychiatric disorders.
MeSH term(s)	Humans ; Brain ; Microbiota/physiology ; Gastrointestinal Microbiome/physiology ; Neurodegenerative Diseases/therapy ; Parkinson Disease
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2423461-8
ISSN	1755-5949 ; 1755-5930
ISSN (online)	1755-5949
ISSN	1755-5930
DOI	10.1111/cns.14076
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Magnetic Flux Density Measurement Platform for an Inductive Wireless Power Transmitter Coil Design.

Prosen, Nataša / Milanovič, Miro / Domajnko, Jure

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 2

Abstract: This paper presents a platform developed for automated magnetic flux density measurement. The platform was designed to be used to measure the magnetic flux density of the transmitter/receiver coil of an inductive wireless power transfer system. The ... ...

Abstract	This paper presents a platform developed for automated magnetic flux density measurement. The platform was designed to be used to measure the magnetic flux density of the transmitter/receiver coil of an inductive wireless power transfer system. The magnetic flux density of a transmitter was measured using a small, 3-axis search coil. The search coil was positioned in the 3D space above the transmitter coil using a 3D positioning mechanism and used to measure the magnetic flux density at a specific point. The data was then sent to a computer application to visualize the magnetic flux density. The measured magnetic field could be used in combination with electromagnetic field solvers to design and optimize transmitter coils for inductive wireless power transfer systems.
Language	English
Publishing date	2022-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22020479
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 3D Platform for Coupling Coefficient Evaluation of an Inductive Power Transfer Systems.

Domajnko, Jure / Milanovič, Miro / Prosen, Nataša

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 4

Abstract: This paper presents a custom-made, computer-connected, and controlled 3D platform that enables the evaluation of the coupling coefficient between the transmitter and receiver coil parts of an inductive wireless power transfer (IPT) system. The platform ... ...

Abstract	This paper presents a custom-made, computer-connected, and controlled 3D platform that enables the evaluation of the coupling coefficient between the transmitter and receiver coil parts of an inductive wireless power transfer (IPT) system. The platform includes a computer application, a 3D positioning mechanism, and an inductance measurement circuit. The positioning mechanism moves the coils to the point in 3D space, and the inductance circuit measures the mutual inductance between the transmitter and the receiver coil. The measured value can be used to calculate the coupling coefficient between the transmitter and the receiver coil. The data are sent to the computer for further visualisation. The transmitter and the receiver coil can be evaluated by measuring the coupling coefficient between them in multiple points in space. Measurements performed with the platform can be used in the design and evaluation phases of inductive wireless power transfer systems and to extrapolate the polynomial function of the coupling coefficient in relation to the distance between coils or their misalignment.
Language	English
Publishing date	2022-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22041445
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: On-Line Foreign Object Detection Using Double DD Coils in an Inductive Wireless Power Transfer System.

Prosen, Nataša / Milanovič, Miro / Domajnko, Jure

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 4

Abstract: This paper proposes an on-line method for foreign object detection in a double DD coil system. The foreign object is detected by real-time measurement of the mutual inductance between the transfer pads. Measurement of the mutual inductance between coils ... ...

Abstract	This paper proposes an on-line method for foreign object detection in a double DD coil system. The foreign object is detected by real-time measurement of the mutual inductance between the transfer pads. Measurement of the mutual inductance between coils can be performed at the start, during initialisation, or during the wireless power transfer. The coils in the double DD coil structure can be used separately; one coil can be used for power transfer and the other can be used for the mutual inductance measurement. The mutual inductance measurement is based on the voltage measurement across the open circuit receiver coil. The measured value of mutual inductance between the transmitter and the receiver pad can be used in a control algorithm and in a foreign object detection algorithm. Additionally, a 2DDq coil structure can be used as a replacement for the double DD coil structure, which increases the power transfer density. The DD coils in the double DD coil structure can also be driven using two phase-shifted voltages, which enables better location and detection of foreign objects. The method also helps to differentiate the mutual inductance change due to the distance change from the mutual inductance change due to the presence of a foreign object.
Language	English
Publishing date	2022-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22041637
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Detection Principles of Temperature Compensated Oscillators with Reactance Influence on Piezoelectric Resonator.

Matko, Vojko / Milanovič, Miro

Sensors (Basel, Switzerland)

2020 Volume 20, Issue 3

Abstract: This review presents various ways of detection of different physical quantities based on the frequency change of oscillators using piezoelectric crystals. These are influenced by the reactance changes modifying their electrical characteristics. Reactance ...

Abstract	This review presents various ways of detection of different physical quantities based on the frequency change of oscillators using piezoelectric crystals. These are influenced by the reactance changes modifying their electrical characteristics. Reactance in series, in parallel, or a combination of reactances can impact the electrical crystal substitute model by influencing its resonant oscillation frequency. In this way, various physical quantities near resonance can be detected with great sensitivity through a small change of capacitance or inductance. A piezoelectric crystal impedance circle and the mode of frequency changing around the resonant frequency change are shown. This review also presents the influence of reactance on the piezoelectric crystal, the way in which the capacitance lost among the crystal's electrodes is compensated, and how the mode of oscillators' output frequency is converted to lower frequency range (1-100 kHz). Finally, the review also explains the temperature-frequency compensation of the crystals' characteristics in oscillators that use temperature-frequency pair of crystals and the procedure of the compensation of crystals own temperature characteristics based on the method switching between the active and reference reactance. For the latter, the experimental results of the oscillator's output frequency stability (
Language	English
Publishing date	2020-02-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20030802
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comprehensive insight into triclosan-from widespread occurrence to health outcomes.

Milanović, Maja / Đurić, Larisa / Milošević, Nataša / Milić, Nataša

Environmental science and pollution research international

2021 Volume 30, Issue 10, Page(s) 25119–25140

Abstract	Humans are exposed to the variety of emerging environmental pollutant in everyday life. The special concern is paid to endocrine disrupting chemicals especially to triclosan which could interfere with normal hormonal functions. Triclosan could be found in numerous commercial products such as mouthwashes, toothpastes and disinfectants due to its antibacterial and antifungal effects. Considering the excessive use and disposal, wastewaters are recognized as the main source of triclosan in the aquatic environment. As a result of the incomplete removal, triclosan residues reach surface water and even groundwater. Triclosan has potential to accumulate in sediment and aquatic organisms. Therefore, the detectable concentrations of triclosan in various environmental and biological matrices emerged concerns about the potential toxicity. Triclosan impairs thyroid homeostasis and could be associated with neurodevelopment impairment, metabolic disorders, cardiotoxicity and the increased cancer risk. The growing resistance of the vast groups of bacteria, the evidenced toxicity on different aquatic organisms, its adverse health effects observed in vitro, in vivo as well as the available epidemiological studies suggest that further efforts to monitor triclosan toxicity at environmental levels are necessary. The safety precaution measures and full commitment to proper legislation in compliance with the environmental protection are needed in order to obtain triclosan good ecological status. This paper is an overview of the possible negative triclosan effects on human health. Sources of exposure to triclosan, methods and levels of detection in aquatic environment are also discussed.
MeSH term(s)	Humans ; Triclosan/analysis ; Risk ; Disinfectants/pharmacology ; Antifungal Agents/pharmacology ; Aquatic Organisms ; Outcome Assessment, Health Care ; Water Pollutants, Chemical/analysis
Chemical Substances	Triclosan (4NM5039Y5X) ; Disinfectants ; Antifungal Agents ; Water Pollutants, Chemical
Language	English
Publishing date	2021-11-06
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-17273-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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