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  1. Article ; Online: Massive Pulmonary Artery Dilatation in a Case of Chronic Thromboembolic Pulmonary Hypertension.

    Miles, Jeremy A / Wan, Ningxin / Murthy, Sandhya

    The American journal of medicine

    2019  Volume 132, Issue 9, Page(s) 1050–1052

    MeSH term(s) Computed Tomography Angiography ; Dilatation, Pathologic/diagnostic imaging ; Echocardiography ; Female ; Humans ; Hypertension, Pulmonary/diagnosis ; Middle Aged ; Pulmonary Artery/diagnostic imaging ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Valve Insufficiency/diagnostic imaging ; Syncope/etiology
    Language English
    Publishing date 2019-04-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2019.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Elevated red cell distribution width is associated with negative P wave amplitude in lead V1: national health and nutrition examination survey (NHANES III).

    Katamreddy, Adarsh / Kokkinidis, Damianos G / Miles, Jeremy A / Faillace, Robert T

    American journal of cardiovascular disease

    2020  Volume 10, Issue 4, Page(s) 356–361

    Abstract: Introduction: Red cell distribution (RDW) is associated with atrial fibrillation (AF) incidence. However, its relationship with precursors of AF has not been established. We aim to investigate if association exists between RDW and negative P wave ... ...

    Abstract Introduction: Red cell distribution (RDW) is associated with atrial fibrillation (AF) incidence. However, its relationship with precursors of AF has not been established. We aim to investigate if association exists between RDW and negative P wave amplitude in V1, a marker of left atrial abnormality.
    Methods: NHANES III is a complex, multistage, clustered design survey of noninstitutionalized United States population between 1988-94. A Sample of 6403 individuals was extracted after excluding missing demographic, laboratory, anthropometric and ECG data and major ECG abnormalities. Variables were selected and univariate analysis was done first with a level of significance at P<0.01 (99% confidence). All the significant variables were included in a multivariate linear regression model.
    Results: 53.58% of subjects were female. Racial distribution was caucasian 50.2%, hispanic 23.9% and african american 21.7%. Age, PR interval, heart rate, systolic blood pressure, red cell distribution width, glycated hemoglobin, serum cholesterol, serum ferritin, and body mass index showed a significant correlation with negative P wave amplitude in V1 (P<0.001). After including all these variables in a multivariate regression model, only age, body mass index, systolic blood pressure, PR interval, heart rate and red cell distribution width had a P≤0.001.
    Conclusions: Increased RDW is independently associated with negative P wave amplitude in V1 after correcting for other cardiovascular risk factors. Further studies are required to analyze the reason for this correlation.
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2616844-3
    ISSN 2160-200X
    ISSN 2160-200X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association of Transthoracic Echocardiography Findings and Long-Term Outcomes in Patients Undergoing Workup of Stroke.

    Miles, Jeremy A / Garber, Leonid / Ghosh, Subha / Spevack, Daniel M

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2018  Volume 27, Issue 11, Page(s) 2943–2950

    Abstract: Background: Transthoracic echocardiography (TTE) has become routine as part of initial stroke workup to assess for sources of emboli. Few studies have looked at other TTE findings such as ejection fraction, wall motion abnormalities, valve disease, ... ...

    Abstract Background: Transthoracic echocardiography (TTE) has become routine as part of initial stroke workup to assess for sources of emboli. Few studies have looked at other TTE findings such as ejection fraction, wall motion abnormalities, valve disease, pulmonary hypertension and left ventricular hypertrophy and their association with various subtypes of stroke, long-term outcomes of recurrent stroke, and all-cause mortality.
    Methods and results: Computed tomography and magnetic resonance imaging brain imaging and TTE reports were reviewed for 2464 consecutive patients referred for TTE as part of a workup for acute stroke between 1/1/01 and 9/30/07. Study patients were 67 ± 15years, 60% female, 75% minorities and had hypertension (76%), diabetes (41%), chronic kidney disease (27%) and atrial fibrillation (18%). On TTE, a mass, thrombus, or vegetation was identified in only 4 cases (0.2%), whereas a clinically significant abnormality (ejection fraction < 50%, left ventricle or right ventricle wall motion abnormalities, severe valve disease, pulmonary hypertension, or left ventricular hypertrophy) was identified in 16%. Those with an abnormal TTE had increased risk for death at 10years (hazard ratio [HR] 1.8; 95% confidence interval [CI]: 1.6, 2.0; P < .01), although risk for readmission with stroke was not increased. Abnormal TTE remained associated with increased risk of death at 10years after adjustment for age, sex, race, and cardiovascular risk factors (HR 1.4; 95% CI: 1.2, 1.7; P < .01).
    Conclusions: TTE performed as part of an initial workup for stroke had minimal yield for identifying sources of embolism. Clinically important abnormalities found on TTE were independently associated with increased long-term mortality, but not recurrent stroke.
    MeSH term(s) Aged ; Aged, 80 and over ; Echocardiography ; Female ; Heart Diseases/diagnostic imaging ; Heart Diseases/mortality ; Heart Diseases/physiopathology ; Heart Diseases/therapy ; Humans ; Intracranial Embolism/diagnostic imaging ; Intracranial Embolism/mortality ; Intracranial Embolism/physiopathology ; Intracranial Embolism/therapy ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Patient Readmission ; Predictive Value of Tests ; Prognosis ; Recurrence ; Retrospective Studies ; Risk Factors ; Stroke/diagnostic imaging ; Stroke/mortality ; Stroke/physiopathology ; Stroke/therapy ; Time Factors ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-07-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2018.06.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Torsemide versus furosemide and intermediate-term outcomes in patients with heart failure: an updated meta-analysis.

    Miles, Jeremy A / Hanumanthu, Balaram K / Patel, Kavisha / Chen, Michelle / Siegel, Robert M / Kokkinidis, Damianos G

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2019  Volume 20, Issue 6, Page(s) 379–388

    Abstract: Aims: Loop diuretics have become a mainstay of chronic heart failure management. Furosemide and torsemide are the two most common loop diuretics; nevertheless, there is inconsistent evidence regarding the optimal choice of loop diuretic with respect to ... ...

    Abstract Aims: Loop diuretics have become a mainstay of chronic heart failure management. Furosemide and torsemide are the two most common loop diuretics; nevertheless, there is inconsistent evidence regarding the optimal choice of loop diuretic with respect to clinical outcomes.
    Methods: Medline and Cochrane Databases were systemically reviewed for randomized and observational studies comparing patients with chronic heart failure on oral torsemide versus oral furosemide and their association with intermediate-term outcomes (5-12 months) through May 2018. Odds ratios with corresponding 95% confidence intervals (CIs) were used for outcomes. A random effect model was used to account for heterogeneity among studies. Heterogeneity was assessed with the Higgins I-square statistic.
    Results: A total of 8127 patients were included in the analysis from a total of 14 studies (10 randomized, four observational); 5729 patients were prescribed furosemide and 2398 were given torsemide. There was no significant difference in intermediate-term mortality among heart failure patients on furosemide compared with torsemide [odds ratio (OR) 1.01, CI 0.64-1.59, I = 65.8%]; however, furosemide was associated with an increased risk of heart failure readmissions (OR 2.16, CI 1.28-2.64, I = 0.0%). Heart failure patients taking torsemide were more likely to have an improvement in New York Heart Association class compared with those on furosemide (OR 0.73, CI 0.58-0.93, I = 19.6%).
    Conclusion: Torsemide is associated with a reduction in intermediate-term heart failure readmissions and improvement in New York Heart Association class compared with furosemide but is not associated with a reduced mortality risk. Additional randomized trials are needed to examine the impact of loop diuretics on clinical outcomes in patients with heart failure.
    MeSH term(s) Furosemide/adverse effects ; Furosemide/therapeutic use ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/mortality ; Heart Failure/physiopathology ; Humans ; Observational Studies as Topic ; Patient Readmission ; Randomized Controlled Trials as Topic ; Recovery of Function ; Sodium Potassium Chloride Symporter Inhibitors/adverse effects ; Sodium Potassium Chloride Symporter Inhibitors/therapeutic use ; Time Factors ; Torsemide/adverse effects ; Torsemide/therapeutic use ; Treatment Outcome
    Chemical Substances Sodium Potassium Chloride Symporter Inhibitors ; Furosemide (7LXU5N7ZO5) ; Torsemide (W31X2H97FB)
    Language English
    Publishing date 2019-04-04
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000000794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Statin Use in Hospitalized Patients with COVID-19: A Comprehensive Analysis of the New York City Public Hospital System.

    Li, Weijia / Rios, Saul / Nagraj, Sanjana / Hajra, Adrija / Saralidze, Tinatin / Varrias, Dimitrios / Mathai, Sheetal Vasundara / Novakovic, Marko / Hupart, Kenneth H / Miles, Jeremy A / Katamreddy, Adarsh / Palaiodimos, Leonidas / Faillace, Robert T

    The American journal of medicine

    2022  Volume 135, Issue 7, Page(s) 897–905

    Abstract: Introduction: Statins have been commonly used for primary and secondary cardiovascular prevention. We hypothesized that statins may improve in-hospital outcomes for hospitalized patients with Coronavirus disease 2019 (COVID-19) due to its known anti- ... ...

    Abstract Introduction: Statins have been commonly used for primary and secondary cardiovascular prevention. We hypothesized that statins may improve in-hospital outcomes for hospitalized patients with Coronavirus disease 2019 (COVID-19) due to its known anti-inflammatory effects.
    Methods: We conducted a retrospective study at the largest municipal health care system in the United States, including adult patients who were hospitalized for COVID-19 between March 1 and December 1, 2020. The primary endpoint was in-hospital death. Propensity score matching was conducted to balance possible confounding variables between patients receiving statins during hospitalization (statin group) and those not receiving statins (non-statin group). Multivariate logistic regression was used to evaluate the association of statin use and other variables with in-hospital outcomes.
    Results: There were 8897 patients eligible for study enrollment, with 3359 patients in the statin group and 5538 patients in the non-statin group. After propensity score matching, both the statin and non-statin groups included 2817 patients. Multivariate logistic regression analysis showed that the statin group had a significantly lower risk of in-hospital mortality (odds ratio 0.71; 95% confidence interval, 0.63-0.80; P < .001) and mechanical ventilation (OR 0.80; 95% confidence interval, 0.71-0.90; P < .001) compared with the non-statin group.
    Conclusion: Statin use was associated with lower likelihood of in-hospital mortality and invasive mechanical ventilation in hospitalized patients with COVID-19.
    MeSH term(s) Adult ; COVID-19 ; Hospital Mortality ; Hospitals, Public ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; New York City/epidemiology ; Retrospective Studies ; United States
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2022.02.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Racial differences and mortality risk in patients with heart failure and hyponatremia.

    Miles, Jeremy A / Quispe, Renato / Mehlman, Yonatan / Patel, Kavisha / Lama Von Buchwald, Claudia / You, Jee Young / Sokol, Seth / Faillace, Robert T

    PloS one

    2019  Volume 14, Issue 6, Page(s) e0218504

    Abstract: Background: Hyponatremia is a well-established poor prognostic marker in patients with heart failure. Whether the mortality risk is comparable among different races of patients with heart failure and hyponatremia is unknown.: Materials and methods: ... ...

    Abstract Background: Hyponatremia is a well-established poor prognostic marker in patients with heart failure. Whether the mortality risk is comparable among different races of patients with heart failure and hyponatremia is unknown.
    Materials and methods: Consecutive patients admitted with acute decompensated heart failure and an admission sodium level<135 mEq/L from 1/1/2001 through 12/31/10 were identified. Patients were divided into four groups based on self-reported race: white, African American, Hispanic and other. African Americans were used as the reference group for statistical analysis. The primary outcome was all-cause mortality.
    Results: We included 4,343 patients, from which 1,356 (31%) identified as white, 1,248 (29%) as African American, 780 (18%) as Hispanic and 959 (22%) as other. During a median follow-up of 23 months, a total of 2,384 patients died: 678 were African American, 820 were white, 298 were Hispanic and 588 were other. After adjusting for baseline demographics, comorbidities and medication use, Hispanic patients had a 45% less risk of death as compared to African Americans (HR .55, CI .48-.64, p<0.05). There was no difference in mortality between white and African American patients (HR 1.04, CI .92-1.2, p = 0.79).
    Conclusion: Hispanic patients admitted for heart failure and who were hyponatremic on admission had an independent lower risk of mortality compared to other groups. These findings may be due to the disparate activity of the renin-angiotensin-aldosterone system among various racial groups. This observational study is hypothesis generating and suggests that treatment of patients with heart failure and hyponatremia should perhaps be focused more on renin-angiotensin-aldosterone system reduction in certain racial groups, yet less in others.
    MeSH term(s) African Americans/genetics ; Aged ; Atrial Fibrillation/genetics ; Atrial Fibrillation/mortality ; Atrial Fibrillation/physiopathology ; Comorbidity ; European Continental Ancestry Group/genetics ; Female ; Heart Failure/genetics ; Heart Failure/mortality ; Heart Failure/physiopathology ; Hispanic Americans/genetics ; Hospitalization ; Humans ; Hyponatremia/genetics ; Hyponatremia/mortality ; Hyponatremia/physiopathology ; Middle Aged ; Myocardial Infarction/genetics ; Myocardial Infarction/mortality ; Myocardial Infarction/physiopathology ; Peripheral Vascular Diseases/genetics ; Peripheral Vascular Diseases/mortality ; Peripheral Vascular Diseases/physiopathology ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0218504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Systematic Review of the Incidence and Outcomes of In-Hospital Cardiac Arrests in Patients With Coronavirus Disease 2019.

    Lim, Zheng Jie / Ponnapa Reddy, Mallikarjuna / Curtis, J Randall / Afroz, Afsana / Billah, Baki / Sheth, Vishad / Hayek, Salim S / Leaf, David E / Miles, Jeremy A / Shah, Priyank / Yuriditsky, Eugene / Jones, Daryl / Shekar, Kiran / Subramaniam, Ashwin

    Critical care medicine

    2021  Volume 49, Issue 6, Page(s) 901–911

    Abstract: Objectives: To investigate the incidence, characteristics, and outcomes of in-hospital cardiac arrest in patients with coronavirus disease 2019 and to describe the characteristics and outcomes for patients with in-hospital cardiac arrest within the ICU, ...

    Abstract Objectives: To investigate the incidence, characteristics, and outcomes of in-hospital cardiac arrest in patients with coronavirus disease 2019 and to describe the characteristics and outcomes for patients with in-hospital cardiac arrest within the ICU, compared with non-ICU patients with in-hospital cardiac arrest. Finally, we evaluated outcomes stratified by age.
    Data sources: A systematic review of PubMed, EMBASE, and preprint websites was conducted between January 1, 2020, and December 10, 2020. Prospective Register of Systematic Reviews identification: CRD42020203369.
    Study selection: Studies reporting on consecutive in-hospital cardiac arrest with a resuscitation attempt among patients with coronavirus disease 2019.
    Data extraction: Two authors independently performed study selection and data extraction. Study quality was assessed with the Newcastle-Ottawa Scale. Data were synthesized according to the Preferred Reporting Items for Systematic Reviews guidelines. Discrepancies were resolved by consensus or through an independent third reviewer.
    Data synthesis: Eight studies reporting on 847 in-hospital cardiac arrest were included. In-hospital cardiac arrest incidence varied between 1.5% and 5.8% among hospitalized patients and 8.0-11.4% among patients in ICU. In-hospital cardiac arrest occurred more commonly in older male patients. Most initial rhythms were nonshockable (83.9%, [asystole = 36.4% and pulseless electrical activity = 47.6%]). Return of spontaneous circulation occurred in 33.3%, with a 91.7% in-hospital mortality. In-hospital cardiac arrest events in ICU had higher incidence of return of spontaneous circulation (36.6% vs 18.7%; p < 0.001) and relatively lower mortality (88.7% vs 98.1%; p < 0.001) compared with in-hospital cardiac arrest in non-ICU locations. Patients greater than or equal to 60 years old had significantly higher in-hospital mortality than those less than 60 years (93.1% vs 87.9%; p = 0.019).
    Conclusions: Approximately, one in 20 patients hospitalized with coronavirus disease 2019 received resuscitation for an in-hospital cardiac arrest. Hospital survival after in-hospital cardiac arrest within the ICU was higher than non-ICU locations and seems comparable with prepandemic survival for nonshockable rhythms. Although the data provide guidance surrounding prognosis after in-hospital cardiac arrest, it should be interpreted cautiously given the paucity of information surrounding treatment limitations and resource constraints during the pandemic. Further research is into actual causative mechanisms is needed.
    MeSH term(s) COVID-19/mortality ; COVID-19/therapy ; Cause of Death ; Heart Arrest/mortality ; Heart Arrest/therapy ; Hospital Mortality ; Humans ; Incidence ; Treatment Outcome
    Language English
    Publishing date 2021-04-01
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Characteristics and Outcomes of In-Hospital Cardiac Arrest Events During the COVID-19 Pandemic: A Single-Center Experience From a New York City Public Hospital.

    Miles, Jeremy A / Mejia, Mateo / Rios, Saul / Sokol, Seth I / Langston, Matthew / Hahn, Steven / Leiderman, Ephraim / Salgunan, Reka / Soghier, Israa / Gulani, Perminder / Joshi, Keval / Chung, Virginia / Morante, Joaquin / Maggiore, Diane / Uppal, Dipan / Friedman, Ari / Katamreddy, Adarsh / Abittan, Nathaniel / Ramani, Gokul /
    Irfan, Wakil / Liaqat, Wasla / Grushko, Michael / Krouss, Mona / Cho, Hyung J / Bradley, Steven M / Faillace, Robert T

    Circulation. Cardiovascular quality and outcomes

    2020  Volume 13, Issue 11, Page(s) e007303

    Abstract: Background: Patients hospitalized for severe coronavirus disease 2019 (COVID-19) infection are at risk for in-hospital cardiac arrest (IHCA). It is unknown whether certain characteristics of cardiac arrest care and outcomes of IHCAs during the COVID-19 ... ...

    Abstract Background: Patients hospitalized for severe coronavirus disease 2019 (COVID-19) infection are at risk for in-hospital cardiac arrest (IHCA). It is unknown whether certain characteristics of cardiac arrest care and outcomes of IHCAs during the COVID-19 pandemic differed compared with a pre-COVID-19 period.
    Methods: All patients who experienced an IHCA at our hospital from March 1, 2020 through May 15, 2020, during the peak of the COVID-19 pandemic, and those who had an IHCA from January 1, 2019 to December 31, 2019 were identified. All patient data were extracted from our hospital's Get With The Guidelines-Resuscitation registry, a prospective hospital-based archive of IHCA data. Baseline characteristics of patients, interventions, and overall outcomes of IHCAs during the COVID-19 pandemic were compared with IHCAs in 2019, before the COVID-19 pandemic.
    Results: There were 125 IHCAs during a 2.5-month period at our hospital during the peak of the COVID-19 pandemic compared with 117 IHCAs in all of 2019. IHCAs during the COVID-19 pandemic occurred more often on general medicine wards than in intensive care units (46% versus 33%; 19% versus 60% in 2019;
    Conclusions: Patients who experienced an IHCA during the COVID-19 pandemic had overall worse survival compared with those who had an IHCA before the COVID-19 pandemic. Our findings highlight important differences between these 2 time periods. Further study is needed on cardiac arrest care in patients with COVID-19.
    MeSH term(s) Aged ; COVID-19 ; Cardiology Service, Hospital ; Coronavirus Infections/diagnosis ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Female ; Heart Arrest/diagnosis ; Heart Arrest/mortality ; Heart Arrest/therapy ; Hospitalization ; Hospitals, Public ; Humans ; Male ; Middle Aged ; New York City ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Retrospective Studies ; Severity of Illness Index ; Time Factors ; Treatment Outcome
    Keywords covid19
    Language English
    Publishing date 2020-09-25
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2483197-9
    ISSN 1941-7705 ; 1941-7713
    ISSN (online) 1941-7705
    ISSN 1941-7713
    DOI 10.1161/CIRCOUTCOMES.120.007303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Characteristics and Outcomes of In-Hospital Cardiac Arrest Events During the COVID-19 Pandemic

    Miles, Jeremy A. / Mejia Saldarriaga, Mateo / Rios, Saul / Sokol, Seth I. / Langston, Matthew / Hahn, Steven / Leiderman, Ephraim / Salgunan, Reka / Soghier, Israa / Gulani, Perminder / Joshi, Keval / Chung, Virginia / Morante, Joaquin / Maggiore, Diane / Uppal, Dipan / Friedman, Ari / Katamreddy, Adarsh / Abittan, Nathaniel / Ramani, Gokul /
    Irfan, Wakil / Liaqat, Wasla / Grushko, Michael / Krouss, Mona / Cho, Hyung J. / Bradley, Steven M. / Faillace, Robert T.

    Circulation: Cardiovascular Quality and Outcomes ; ISSN 1941-7713 1941-7705

    A Single Center Experience from a New York City Public Hospital

    2020  

    Abstract: Background : Patients hospitalized for severe COVID-19 infection are at risk for in-hospital cardiac arrest (IHCA). It is unknown whether certain characteristics of cardiac arrest care and outcomes of IHCAs during the COVID-19 pandemic differed compared ... ...

    Abstract Background : Patients hospitalized for severe COVID-19 infection are at risk for in-hospital cardiac arrest (IHCA). It is unknown whether certain characteristics of cardiac arrest care and outcomes of IHCAs during the COVID-19 pandemic differed compared to a pre-COVID-19 period. Methods : All patients who experienced an IHCA at our hospital from March 1st through May 15th 2020, during the peak of the COVID-19 pandemic, and those who had an IHCA from January 1st 2019 to December 31st 2019 were identified. All patient data was extracted from our hospital's Get With The Guidelines-Resuscitation (GWTG-R) registry, a prospective hospital-based archive of IHCA data. Baseline characteristics of patients, interventions and overall outcomes of IHCAs during the COVID-19 pandemic were compared to IHCAs in 2019, prior to the COVID-19 pandemic. Results : There were 125 IHCAs during a 2.5-month period at our hospital during the peak of the COVID-19 pandemic compared to 117 IHCAs in all of 2019. IHCAs during the COVID-19 pandemic occurred more often on general medicine wards than in intensive care units (46% vs 33%; 19% vs 60% in 2019, p<0.001), were overall shorter in duration (median time of 11 min (8.5-26.5) vs 15 min (7.0-20.0), p=0.001), led to fewer endotracheal intubations (52% vs 85%, p<0.001) and had overall worse survival rates (3% vs 13%, p=0.007) compared to IHCAs prior to the COVID-19 pandemic. Conclusions : Patients who experienced an IHCA during the COVID-19 pandemic had overall worse survival compared to those who had an IHCA prior to the COVID-19 pandemic. Our findings highlight important differences between these two time periods. Further study is needed on cardiac arrest care in patients with COVID-19.
    Keywords Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    DOI 10.1161/circoutcomes.120.007303
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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