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  1. Book ; Thesis: Synthetic magnetic resonance image reconstruction based on parametric weighted images for contrast enhancement at high field MRI

    Milford, David

    2013  

    Author's details vorgelegt von David Milford
    Language English
    Size VIII, 99 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2014
    HBZ-ID HT018727458
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 E 1364 order for loan Magazin

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  2. Book ; Online ; E-Book: Understanding kidney diseases

    Rayner, Hugh C. / Thomas, Mark E. / Milford, David V.

    2020  

    Author's details Hugh C. Rayner, Mark E. Thomas, David V. Milford,
    Language English
    Size 1 Online-Ressource (xii, 396 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020482242
    ISBN 978-3-030-43027-6 ; 9783030430269 ; 3-030-43027-8 ; 303043026X
    DOI 10.1007/978-3-030-43027-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Response to "Susceptibility to diabetic nephropathy".

    Howie, Alexander J / Milford, David V

    Pediatric nephrology (Berlin, Germany)

    2024  Volume 39, Issue 6, Page(s) 1959

    MeSH term(s) Humans ; Diabetic Nephropathies ; Genetic Predisposition to Disease ; Genotype ; Diabetes Mellitus
    Language English
    Publishing date 2024-01-19
    Publishing country Germany
    Document type Letter
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-024-06298-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Kidney transplantation in low- and middle-income countries: the Transplant Links experience.

    Roberts, Lydia E / Kaur, Amrit / Jewitt-Harris, Jennie / Ready, Andrew / Milford, David V

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 39, Issue 5, Page(s) 1347–1353

    Abstract: Paediatric kidney failure is a global problem responsible for significant childhood morbidity and mortality. The gold-standard treatment is kidney transplantation. However, the availability of kidney transplantation remains limited in some low- and ... ...

    Abstract Paediatric kidney failure is a global problem responsible for significant childhood morbidity and mortality. The gold-standard treatment is kidney transplantation. However, the availability of kidney transplantation remains limited in some low- and middle-income countries (LMICs). Transplant Links Community (TLC) is a UK-based charity that mentors units in LMICs wishing to start kidney transplantation; the ultimate goal is for these units to become self-sufficient. TLC provides this support through in-person training visits and skill transfer, plus direct mentorship from the UK that is maintained over many years. From such mentoring programmes, it is evident that there are numerous challenges in the initial establishment and long-term maintenance of kidney transplant services, with specific and unique barriers applying to setting up paediatric transplant programmes compared to their adult counterparts. This review summarises TLC's first-hand experience of developing paediatric kidney transplantation services in LMICs over the past 15 years, the challenges encountered, and the major ongoing barriers that must be addressed to facilitate further progress in delivering transplantation services to children globally.
    MeSH term(s) Adult ; Humans ; Child ; Developing Countries ; Kidney Transplantation ; Mentoring ; Mentors
    Language English
    Publishing date 2023-09-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-06129-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Kidney biopsy findings in children with diabetes mellitus.

    Weerasooriya, Lasanthi / Howie, Alexander J / Wakeman, Matthew P / Cavanagh, Susan / Milford, David V

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 39, Issue 6, Page(s) 1865–1873

    Abstract: Background: Diabetic nephropathy may begin in childhood, but clinical kidney disease ascribable to this is uncommon in children with type 1 (insulin dependent) diabetes mellitus.: Methods: We reviewed our experience of kidney biopsies in children ... ...

    Abstract Background: Diabetic nephropathy may begin in childhood, but clinical kidney disease ascribable to this is uncommon in children with type 1 (insulin dependent) diabetes mellitus.
    Methods: We reviewed our experience of kidney biopsies in children with type 1 diabetes mellitus.
    Results: Between 1995 and 2022, there were biopsies in 17 children, with various clinical indications for kidney biopsy, making this the largest series of biopsies in diabetic children with clinical kidney abnormalities. Four biopsies showed diabetic nephropathy, three showed the combination of diabetic nephropathy and IgA nephropathy, and ten showed a variety of conditions other than diabetic nephropathy: minimal change disease (2), membranous nephropathy (2), thin glomerular basement membrane lesion (2), non-glomerular chronic damage in Wolcott-Rallison syndrome (2), acute pauciimmune necrotizing crescentic glomerulonephritis (1) and IgA nephropathy (1). Clinical clues of something other than diabetic nephropathy included acute kidney injury, microscopic haematuria or chronic kidney impairment with little or no proteinuria and the nephrotic syndrome after a short duration of diabetes.
    Conclusions: We confirm that changes better known in adults with either type 1 or type 2 diabetes mellitus can occur in children with type 1 diabetes mellitus: overt diabetic nephropathy either on its own or combined with other conditions and kidney disorders other than diabetic nephropathy.
    MeSH term(s) Adult ; Child ; Humans ; Diabetic Nephropathies/pathology ; Diabetes Mellitus, Type 1/pathology ; Glomerulonephritis, IGA/pathology ; Diabetes Mellitus, Type 2 ; Kidney/pathology ; Kidney Diseases/pathology ; Proteinuria/pathology ; Biopsy
    Language English
    Publishing date 2023-12-21
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-06254-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2196: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: A novel method for T2 quantification in presence of B1 inhomogeneities.

    Milford, David / Bendszus, Martin / Heiland, Sabine

    Zeitschrift fur medizinische Physik

    2017  Volume 28, Issue 1, Page(s) 63–72

    Abstract: Introduction: T2 relaxometry as a quantitative MRI technique offers a more precise characterization of tissue, compared with qualitative T2 weighted imaging. The issue, however, is that in typically used T2 relaxometry sequences such as a multi-spin ... ...

    Abstract Introduction: T2 relaxometry as a quantitative MRI technique offers a more precise characterization of tissue, compared with qualitative T2 weighted imaging. The issue, however, is that in typically used T2 relaxometry sequences such as a multi-spin echo sequences, incorrect refocussing flip angles and B1 inhomogeneities cause inaccuracies in T2 determination. The work presented here within presents a new technique for modelling T2 decay curves and thereby correcting T2 times altered by inhomogeneities.
    Materials and methods: The proposed technique models the signal decay acquired by multi-spin echo sequences based on extended phase graph theory. We have then put this new correction technique to test under both noise free and noise affected simulated signal and compared it to other previously introduced correction methods. To compare the efficacy of the T2 correction techniques, it was applied to MRI data acquired at 9.4Tesla.
    Results and conclusion: The results show that the proposed technique is able to minimize the systematic error in T2 relaxometry for a wide range of T2 times. Beyond that, the technique reveals the actual refocussing pulse angle in the respective voxel and reduces the error in S
    MeSH term(s) Algorithms ; Computer Simulation ; Humans ; Image Interpretation, Computer-Assisted/standards ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/standards ; Reproducibility of Results
    Language English
    Publishing date 2017-08-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1104517-6
    ISSN 1876-4436 ; 0939-3889 ; 0040-5973
    ISSN (online) 1876-4436
    ISSN 0939-3889 ; 0040-5973
    DOI 10.1016/j.zemedi.2017.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3525: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Levamisole Induced Pauci Immune Focal Necrotizing and Crescentic Glomerulonephritis.

    Ranawaka, Randula / Gamage, Manoji P / Lokuge, Kalpani / Milford, David V

    Indian journal of pediatrics

    2018  Volume 85, Issue 7, Page(s) 599

    MeSH term(s) Acute Disease ; Adjuvants, Immunologic/adverse effects ; Glomerulonephritis/chemically induced ; Glomerulonephritis, Membranoproliferative ; Humans ; Levamisole/adverse effects
    Chemical Substances Adjuvants, Immunologic ; Levamisole (2880D3468G)
    Language English
    Publishing date 2018-01-02
    Publishing country India
    Document type Letter
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-017-2584-x
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    Zs.A 826: Show issues Location:
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  8. Article ; Online: Effect of contrast agent dosage on longitudinal relaxation time, signal and apparent tumor volume in glioblastoma at 9.4T.

    Nickel, Alina / Milford, David / Fischer, Manuel / Bendszus, Martin / Heiland, Sabine

    Zeitschrift fur medizinische Physik

    2018  Volume 29, Issue 3, Page(s) 206–215

    Abstract: Introduction: Glioblastoma multiforme is the most frequent innate brain tumor and still yields an unfavorable prognosis of 15 months of survival after diagnosis. Animal models play an important role in the investigation of therapeutic strategies of ... ...

    Abstract Introduction: Glioblastoma multiforme is the most frequent innate brain tumor and still yields an unfavorable prognosis of 15 months of survival after diagnosis. Animal models play an important role in the investigation of therapeutic strategies of brain tumors. Thereby, MRI is substantial to individual follow-up examination for therapeutic response. Contrast agent dosage at 1.5 and 3T MRI has been thoroughly tested, while there is hardly any data for 9.4T. Therefore, the aim of this study was to find the optimal contrast agent dosage at 9.4T for examination of T1 relaxation time and apparent tumor volume in an animal model.
    Material and methods: Six animals with a U-87 glioblastoma were part of this study. Scans were performed on a 9.4T MRI. The MRI protocol contained a standard T1w sequence, which was employed for tumor volumetry and signal intensity measurement after single, double and triple contrast agent dosage injections and a T2w sequence for volumetry of tumor and edema. From a T1 map, T1 relaxation times and tumor area were measured. Histologic tumor size measurements were also performed for two animals.
    Results: The mean apparent tumor volume in T1w MRI increased significantly with each additional contrast agent injection, mainly due to the increase of the hyperintense tumor rim. Volumetry based on T2w MRI resulted in a higher tumor volume than in T1w volumetry, whereas the tumor volume in T1w MRI approached the volume in T2w MRI with increasing contrast agent dosage. Histology revealed an apparent tumor volume that corresponded to the volume of the hypointense center in T1w MRI. In contrast, T1 time decrease and T1w signal increase occurred mainly in the tumor rim.
    Conclusion: Increasing the contrast agent dosage led to an increase in apparent tumor volume. High-dose T1 MRI, however, overestimated the tumor volume that was determined by histology. Thereby, it can be concluded that standard contrast agent dosage is sufficient to visualize the core tumor volume in T1w MRI. Measurement of tumor volume after increasing contrast agent dosage depicts tumor core and edema, which can be due to diffusion or accumulation or both. Tumor core and edema, however, can be visualized by T2w MRI without need of additional contrast agent.
    MeSH term(s) Animals ; Cell Line, Tumor ; Contrast Media ; Female ; Glioblastoma/diagnostic imaging ; Glioblastoma/pathology ; Humans ; Magnetic Resonance Imaging/methods ; Rats ; Tumor Burden
    Chemical Substances Contrast Media
    Language English
    Publishing date 2018-11-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1104517-6
    ISSN 1876-4436 ; 0939-3889 ; 0040-5973
    ISSN (online) 1876-4436
    ISSN 0939-3889 ; 0040-5973
    DOI 10.1016/j.zemedi.2018.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3525: Show issues Location:
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  9. Book: Understanding kidney diseases

    Rayner, Hugh / Thomas, Mark / Milford, David

    2016  

    Author's details Hugh Rayner, Mark Thomas, David Milford
    MeSH term(s) Kidney Diseases/diagnosis ; Kidney Diseases/physiopathology ; Diagnostic Techniques, Urological ; Disease Progression ; Renal Replacement Therapy
    Language English
    Size xxi, 300 pages :, illustrations
    Document type Book
    ISBN 9783319234571 ; 9783319234588 ; 3319234579 ; 3319234587
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: Mono-Exponential Fitting in T2-Relaxometry: Relevance of Offset and First Echo.

    Milford, David / Rosbach, Nicolas / Bendszus, Martin / Heiland, Sabine

    PloS one

    2015  Volume 10, Issue 12, Page(s) e0145255

    Abstract: Introduction: T2 relaxometry has become an important tool in quantitative MRI. Little focus has been put on the effect of the refocusing flip angle upon the offset parameter, which was introduced to account for a signal floor due to noise or to long T2 ... ...

    Abstract Introduction: T2 relaxometry has become an important tool in quantitative MRI. Little focus has been put on the effect of the refocusing flip angle upon the offset parameter, which was introduced to account for a signal floor due to noise or to long T2 components. The aim of this study was to show that B1 imperfections contribute significantly to the offset. We further introduce a simple method to reduce the systematic error in T2 by discarding the first echo and using the offset fitting approach.
    Materials and methods: Signal curves of T2 relaxometry were simulated based on extended phase graph theory and evaluated for 4 different methods (inclusion and exclusion of the first echo, while fitting with and without the offset). We further performed T2 relaxometry in a phantom at 9.4T magnetic resonance imaging scanner and used the same methods for post-processing as in the extended phase graph simulated data. Single spin echo sequences were used to determine the correct T2 time.
    Results: The simulation data showed that the systematic error in T2 and the offset depends on the refocusing pulse, the echo spacing and the echo train length. The systematic error could be reduced by discarding the first echo. Further reduction of the systematic T2 error was reached by using the offset as fitting parameter. The phantom experiments confirmed these findings.
    Conclusion: The fitted offset parameter in T2 relaxometry is influenced by imperfect refocusing pulses. Using the offset as a fitting parameter and discarding the first echo is a fast and easy method to minimize the error in T2, particularly for low to intermediate echo train length.
    MeSH term(s) Algorithms ; Data Interpretation, Statistical ; Magnetic Resonance Imaging/methods ; Phantoms, Imaging
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0145255
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