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Article ; Online: Effect of Air Pollution on the Basal DNA Damage of Mother-Newborn Couples of México City.

Valverde, Mahara / Granados, Adriana / Milić, Mirta / Ceppi, Marcello / Sollano, Leticia / Bonassi, Stefano / Rojas, Emilio

Toxics

2023 Volume 11, Issue 9

Abstract: Environmental pollution of megacities can cause early biological damage such as DNA strand breaks and micronuclei formation. Comet assay tail length (TL) reflects exposure in the uterus to high levels of air pollution, primarily ozone and air particles ( ... ...

Abstract	Environmental pollution of megacities can cause early biological damage such as DNA strand breaks and micronuclei formation. Comet assay tail length (TL) reflects exposure in the uterus to high levels of air pollution, primarily ozone and air particles (PM
Language	English
Publishing date	2023-09-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics11090766
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Article ; Online: Brain DNA damaging effects of volatile anesthetics and 1 and 2 Gy gamma irradiation

Benković, Vesna / Milić, Mirta / Oršolić, Nada / Horvat Knežević, Anica / Brozović, Gordana / Borojević, Nikola

Toxicology and industrial health

2023 Volume 39, Issue 2, Page(s) 67–80

Abstract: Although both can cause DNA damage, the combined impact of volatile anesthetics halothane/sevoflurane/isoflurane and radiotherapeutic exposure on sensitive brain ... ...

Abstract	Although both can cause DNA damage, the combined impact of volatile anesthetics halothane/sevoflurane/isoflurane and radiotherapeutic exposure on sensitive brain cells
MeSH term(s)	Mice ; Animals ; Sevoflurane/pharmacology ; Isoflurane/pharmacology ; Anesthetics, Inhalation/pharmacology ; Halothane/pharmacology ; Methyl Ethers/pharmacology ; Gamma Rays/adverse effects ; Brain
Chemical Substances	Sevoflurane (38LVP0K73A) ; Isoflurane (CYS9AKD70P) ; Anesthetics, Inhalation ; Halothane (UQT9G45D1P) ; Methyl Ethers
Language	English
Publishing date	2023-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	56831-4
ISSN	1477-0393 ; 0748-2337
ISSN (online)	1477-0393
ISSN	0748-2337
DOI	10.1177/07482337221145599
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Article ; Online: The effect of low doses of chlorpyrifos on blood and bone marrow cells in Wistar rats.

Kašuba, Vilena / Micek, Vedran / Milić, Mirta / Želježić, Davor / Katić, Anja

Arhiv za higijenu rada i toksikologiju

2022 Volume 73, Issue 3, Page(s) 223–232

Abstract: The aim of this study was to investigate the genotoxic potential of low doses of chlorpyrifos (CPF) on blood and bone marrow cells in adult male Wistar rats. CPF was administered by oral gavage at daily doses of 0.010, 0.015, and 0.160 mg/kg of body ... ...

Abstract	The aim of this study was to investigate the genotoxic potential of low doses of chlorpyrifos (CPF) on blood and bone marrow cells in adult male Wistar rats. CPF was administered by oral gavage at daily doses of 0.010, 0.015, and 0.160 mg/kg of body weight (bw) for 28 consecutive days. Positive control (PC) was administered 300 mg/kg bw/day of ethyl methane sulphonate (EMS) for the final three days of the experiment. Toxic outcomes of exposure were determined with the
MeSH term(s)	Animals ; Body Weight ; Bone Marrow Cells ; Chlorpyrifos/toxicity ; Comet Assay/methods ; DNA Damage ; Male ; Methane ; Micronucleus Tests/methods ; Rats ; Rats, Wistar
Chemical Substances	Chlorpyrifos (JCS58I644W) ; Methane (OP0UW79H66)
Language	English
Publishing date	2022-09-30
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	127289-5
ISSN	1848-6312 ; 0004-1254
ISSN (online)	1848-6312
ISSN	0004-1254
DOI	10.2478/aiht-2022-73-3665
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Article ; Online: Different damaging effects of volatile anaesthetics alone or in combination with 1 and 2 Gy gamma-irradiation

Benković, Vesna / Milić, Mirta / Oršolić, Nada / Knežević, Anica Horvat / Brozović, Gordana / Borojević, Nikola

Arhiv za higijenu rada i toksikologiju

2023 Volume 74, Issue 1, Page(s) 22–33

Abstract: As the number of radiotherapy and radiology diagnostic procedures increases from year to year, so does the use of general volatile anaesthesia (VA). Although considered safe, VA exposure can cause different adverse effects and, in combination with ... ...

Abstract	As the number of radiotherapy and radiology diagnostic procedures increases from year to year, so does the use of general volatile anaesthesia (VA). Although considered safe, VA exposure can cause different adverse effects and, in combination with ionising radiation (IR), can also cause synergistic effects. However, little is known about DNA damage incurred by this combination at doses applied in a single radiotherapy treatment. To learn more about it, we assessed DNA damage and repair response in the liver tissue of Swiss albino male mice following exposure to isoflurane (I), sevoflurane (S), or halothane (H) alone or in combination with 1 or 2 Gy irradiation using the comet assay. Samples were taken immediately (0 h) and 2, 6, and 24 h after exposure. Compared to control, the highest DNA damage was found in mice receiving halothane alone or in combination with 1 or 2 Gy IR treatments. Sevoflurane and isoflurane displayed protective effects against 1 Gy IR, while with 2 Gy IR the first adverse effects appeared at 24 h post-exposure. Although VA effects depend on liver metabolism, the detection of unrepaired DNA damage 24 h after combined exposure with 2 Gy IR indicates that we need to look further into the combined effects of VA and IR on genome stability and include a longer time frame than 24 h for single exposure as well as repeated exposure as a more realistic scenario in radiotherapy treatment.
MeSH term(s)	Animals ; Mice ; Isoflurane ; Sevoflurane/pharmacology ; Halothane/toxicity ; DNA Damage ; Anesthetics, Inhalation/toxicity ; Liver
Chemical Substances	Isoflurane (CYS9AKD70P) ; Sevoflurane (38LVP0K73A) ; Halothane (UQT9G45D1P) ; Anesthetics, Inhalation
Language	English
Publishing date	2023-04-04
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	127289-5
ISSN	1848-6312 ; 0004-1254
ISSN (online)	1848-6312
ISSN	0004-1254
DOI	10.2478/aiht-2023-74-3692
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Article ; Online: Skin Characteristics of Hairdresser Apprentices at the Beginning of Vocational Training.

Franić, Zrinka / Babić, Željka / Milić, Mirta / Macan, Jelena

Dermatitis : contact, atopic, occupational, drug

2021 Volume 32, Issue 6, Page(s) 437–443

Abstract: Background: Hairdresser apprentices (HAs) are at high risk of developing occupational contact dermatitis.: Objectives: To assess skin characteristics of HAs, using genotyping, clinically observed and self-reported skin symptoms, and skin ... ...

Abstract	Background: Hairdresser apprentices (HAs) are at high risk of developing occupational contact dermatitis. Objectives: To assess skin characteristics of HAs, using genotyping, clinically observed and self-reported skin symptoms, and skin bioengineering methods at the beginning of apprenticeship. Methods: During the screening phase of a prospective cohort study, we recruited 352 HAs in 24 Croatian towns. The protocol included the following: questionnaires with self-reported skin and atopy symptoms evaluation, Osnabrueck Hand Eczema Severity Index (OHSI) for clinical skin assessment, genotyping FLG (filaggrin) gene mutations, skin pH, and transepidermal water loss (TEWL) measurements. Results: Self-reported skin symptoms were reported by 12%, history of dry hands by 29%, and history of atopy by 46% of HAs. Skin changes were found at the clinical examination in 18% of the HA. The OHSI score was positively correlated with hand TEWL and hand skin pH in multiple regression linear models. An FLG gene mutation was found in 1 apprentice. Conclusions: Significant prevalence of clinically observed skin signs on the hands was observed in HAs at the beginning of training. The OHSI score was found to be an independent predictor of higher hand TEWL and skin pH values. The need to ameliorate preventive examinations before the enrolment to hairdressing schools was indicated.
MeSH term(s)	Barbering ; Dermatitis, Allergic Contact/diagnosis ; Dermatitis, Occupational/diagnosis ; Dermatitis, Occupational/etiology ; Eczema/diagnosis ; Follow-Up Studies ; Hand Dermatoses/diagnosis ; Hand Dermatoses/etiology ; Humans ; Occupational Exposure/adverse effects ; Prospective Studies ; Vocational Education
Language	English
Publishing date	2021-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2144723-8
ISSN	2162-5220 ; 1532-8163 ; 1710-3568
ISSN (online)	2162-5220 ; 1532-8163
ISSN	1710-3568
DOI	10.1097/DER.0000000000000718
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Article ; Online: Changes in anthropometric, biochemical, oxidative, and DNA damage parameters after 3-weeks-567-kcal-hospital-controlled-VLCD in severely obese patients with BMI ≥ 35 kg m−2

Ožvald, Ivan / Božičević, Dragan / Duh, Lidija / Vinković Vrček, Ivana / Domijan, Ana-Marija / Milić, Mirta

European Society for Clinical Nutrition and Metabolism Clinical Nutrition ESPEN. 2022 June, v. 49 p.319-327

2022

Abstract: Severe obesity and its comorbidities relate to increased genomic instability/cancer risk. Obesity in Croatia is rapidly increasing, and long diets are sometimes the reason for obese to quit health improvement programs. A shorter diet with more strict ... ...

Abstract	Severe obesity and its comorbidities relate to increased genomic instability/cancer risk. Obesity in Croatia is rapidly increasing, and long diets are sometimes the reason for obese to quit health improvement programs. A shorter diet with more strict calorie reduction could also lead to weight reduction and health improvements, but data are scarce. We tested for the first time if a very low-calorie diet (VLCD) can improve anthropometric, biochemical and genomic stability parameters in severely obese with BMI ≥ 35 kg m⁻². 22 participants were chosen among those regularly attending the hospital for obesity control, with no other previous treatment for bodyweight reduction. Under 24 h medical surveillance, patients received 3-weeks-567-kcal-hospital-controlled-VLCD composed of 50–60% complex carbohydrates, 20–25% proteins, and 25–30% fat, with the attention to food carbo-glycemic index, in 3 meals freshly prepared in hospital. We analyzed changes in body weight, BMI, basal metabolism rate, waist–hip ratio, visceral fat level, body fat mass, percent body fat, skeletal muscle mass, basal metabolism, energy intake, lipid profile, thyroid hormones, TSH, and genomic instability (alkaline and oxidative FPG comet assay) before and on the last VLCD day. Diet caused BMI reduction (in average 3–4 BMI units' loss), excessive weight loss (between 10 and 35%), significant weight loss (average 9 kg, range 4.8–14.4 kg) and a significant decrease in glucose, insulin, urea, cholesterol, HDL-c, LDL-c, oxidative (FPG) and DNA damage (alkaline comet assay) levels. The diet can lead to ≥10% excessive weight loss, significant health, and genomic stability improvement, and keep severely obese interest in maintaining healthy habits. The study was registered at ClinicalTrials.gov as NCT05007171 (10.08.2021).
Keywords	DNA damage ; basal metabolism ; cholesterol ; clinical nutrition ; comet assay ; energy intake ; genetic instability ; genomics ; glucose ; hospitals ; insulin ; lipid composition ; monitoring ; obesity ; risk ; skeletal muscle ; urea ; very low calorie diet ; visceral fat ; waist-to-hip ratio ; weight loss ; Croatia ; Alkaline comet assay ; FPG oxidative comet assay ; VLCD ; TL ; TI ; FPG NET ; FPG ; W-HR ; SMM ; BFM ; PBF ; BMR ; VFL ; c ; TG ; fT3 ; fT4 ; TSH ; CRP ; HOMA-IR
Language	English
Dates of publication	2022-06
Size	p. 319-327.
Publishing place	Elsevier Ltd
Document type	Article ; Online
ISSN	2405-4577
DOI	10.1016/j.clnesp.2022.03.028
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Kidney cell DNA damage caused by combined exposure to volatile anaesthetics and 1 Gy or 2 Gy radiotherapy dose

Benković, Vesna / Oršolić, Nada / Knežević, Anica Horvat / Borojević, Nikola / Brozović, Gordana / Milić, Mirta

Arhiv za higijenu rada i toksikologiju

2022 Volume 73, Issue 1, Page(s) 62–70

Abstract: Patient immobilisation with volatile anaesthetics (VA) during radiotherapy is sometimes unavoidable. Although it is known that both VAs and ionising radiation can have nephrotoxic effects, there are no studies of their combined effects on DNA damage. The ...

Abstract	Patient immobilisation with volatile anaesthetics (VA) during radiotherapy is sometimes unavoidable. Although it is known that both VAs and ionising radiation can have nephrotoxic effects, there are no studies of their combined effects on DNA damage. The aim of this
MeSH term(s)	Anesthetics, Inhalation/toxicity ; Animals ; Comet Assay ; DNA Damage ; Halothane/toxicity ; Humans ; Isoflurane/toxicity ; Kidney ; Mice ; Radiation Dosage ; Sevoflurane/toxicity
Chemical Substances	Anesthetics, Inhalation ; Sevoflurane (38LVP0K73A) ; Isoflurane (CYS9AKD70P) ; Halothane (UQT9G45D1P)
Language	English
Publishing date	2022-04-07
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	127289-5
ISSN	1848-6312 ; 0004-1254
ISSN (online)	1848-6312
ISSN	0004-1254
DOI	10.2478/aiht-2022-73-3600
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Article ; Online: Changes in anthropometric, biochemical, oxidative, and DNA damage parameters after 3-weeks-567-kcal-hospital-controlled-VLCD in severely obese patients with BMI ≥ 35 kg m

Ožvald, Ivan / Božičević, Dragan / Duh, Lidija / Vinković Vrček, Ivana / Domijan, Ana-Marija / Milić, Mirta

Clinical nutrition ESPEN

2022 Volume 49, Page(s) 319–327

Abstract: Background & aims: Severe obesity and its comorbidities relate to increased genomic instability/cancer risk. Obesity in Croatia is rapidly increasing, and long diets are sometimes the reason for obese to quit health improvement programs. A shorter diet ... ...

Abstract	Background & aims: Severe obesity and its comorbidities relate to increased genomic instability/cancer risk. Obesity in Croatia is rapidly increasing, and long diets are sometimes the reason for obese to quit health improvement programs. A shorter diet with more strict calorie reduction could also lead to weight reduction and health improvements, but data are scarce. We tested for the first time if a very low-calorie diet (VLCD) can improve anthropometric, biochemical and genomic stability parameters in severely obese with BMI ≥ 35 kg m Methods: 22 participants were chosen among those regularly attending the hospital for obesity control, with no other previous treatment for bodyweight reduction. Under 24 h medical surveillance, patients received 3-weeks-567-kcal-hospital-controlled-VLCD composed of 50-60% complex carbohydrates, 20-25% proteins, and 25-30% fat, with the attention to food carbo-glycemic index, in 3 meals freshly prepared in hospital. We analyzed changes in body weight, BMI, basal metabolism rate, waist-hip ratio, visceral fat level, body fat mass, percent body fat, skeletal muscle mass, basal metabolism, energy intake, lipid profile, thyroid hormones, TSH, and genomic instability (alkaline and oxidative FPG comet assay) before and on the last VLCD day. Results: Diet caused BMI reduction (in average 3-4 BMI units' loss), excessive weight loss (between 10 and 35%), significant weight loss (average 9 kg, range 4.8-14.4 kg) and a significant decrease in glucose, insulin, urea, cholesterol, HDL-c, LDL-c, oxidative (FPG) and DNA damage (alkaline comet assay) levels. Conclusions: The diet can lead to ≥10% excessive weight loss, significant health, and genomic stability improvement, and keep severely obese interest in maintaining healthy habits. The study was registered at ClinicalTrials.gov as NCT05007171 (10.08.2021).
MeSH term(s)	Body Mass Index ; DNA Damage ; Genomic Instability ; Hospitals ; Humans ; Obesity/complications ; Obesity, Morbid/complications ; Oxidative Stress ; Weight Loss
Language	English
Publishing date	2022-03-26
Publishing country	England
Document type	Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2022.03.028
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Article ; Online: Genomska nestabilnost i test osjetljivosti na bleomicin.

Milić, Mirta

Arhiv za higijenu rada i toksikologiju

2010 Volume 61, Issue 2, Page(s) 257–266

Abstract: Estimation of individual susceptibility to mutagens is often a part of epidemiological studies monitoring the appearance of malignant disease in different populations. Genome exposure to mutagens can lead to DNA damage. The rate of damage depends on ... ...

Title translation	Genome instability and bleomycin sensitivity test.
Abstract	Estimation of individual susceptibility to mutagens is often a part of epidemiological studies monitoring the appearance of malignant disease in different populations. Genome exposure to mutagens can lead to DNA damage. The rate of damage depends on individual differences in response, which are usually associated with differences in DNA repair capacity. Cytogenetic studies have shown that the genome of tumour cells is less stable than normal cells and therefore accumulates more damage. Tumour patients show a higher frequency of chromatid and chromosomal aberrations and a predisposition to certain types of tumours. One of the common biomarkers used in monitoring tumour appearance and changed response to DNA damage is the bleomycin test. In its active form, bleomycin (glycopeptid) is a radiomimetic cytostatic that can damage the DNA molecule and cause multiple single and double strands. The bleomycin test is simple and inexpensive, and is based on scoring chromatid breaks in lymphocytes in vitro exposed to bleomycin during the late G2 phase of the cell cycle. This review looks into different factors that may affect test results and discusses its wide implementation in studies of genome instability usually caused by a combination of factors.
MeSH term(s)	Bleomycin/pharmacology ; Chromatids/drug effects ; DNA Repair/drug effects ; Genomic Instability/drug effects ; Humans ; Mutagenicity Tests ; Mutagens/pharmacology ; Neoplasms/genetics ; Polymorphism, Single Nucleotide/drug effects ; Translocation, Genetic/drug effects
Chemical Substances	Mutagens ; Bleomycin (11056-06-7)
Language	Croatian
Publishing date	2010-06
Publishing country	Croatia
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	127289-5
ISSN	1848-6312 ; 0004-1254
ISSN (online)	1848-6312
ISSN	0004-1254
DOI	10.2478/10004-1254-61-2010-2003
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Article ; Online: Combined Approach: FFQ, DII, Anthropometric, Biochemical and DNA Damage Parameters in Obese with BMI ≥ 35 kg m

Milić, Mirta / Ožvald, Ivan / Matković, Katarina / Radašević, Hrvoje / Nikolić, Maja / Božičević, Dragan / Duh, Lidija / Matovinović, Martina / Bituh, Martina

Nutrients

2023 Volume 15, Issue 4

Abstract: Although obesity with its comorbidities is linked with higher cancer risk, the data on genome stability in the obese/severely obese are scarce. This is the first study with three DNA damage assessment assays (Fpg-modified and alkaline comet assays and ... ...

Abstract	Although obesity with its comorbidities is linked with higher cancer risk, the data on genome stability in the obese/severely obese are scarce. This is the first study with three DNA damage assessment assays (Fpg-modified and alkaline comet assays and micronucleus
MeSH term(s)	Humans ; Body Mass Index ; Diet ; DNA Damage ; Obesity/metabolism ; Comet Assay
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15040899
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