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Article ; Online: A Review of the Prevalence of Ophthalmologic Diseases in Native American Populations.

Miller, Alyssa M / Gill, Manjot K

2023 Volume 254, Page(s) 54–61

Abstract: Purpose: Compared with the general population in North America, Native American/American Indian and Alaska Native (AI/AN) populations experience a disparate prevalence of eye diseases. Visual impairment is a barrier to communication, interferes with ... ...

Abstract	Purpose: Compared with the general population in North America, Native American/American Indian and Alaska Native (AI/AN) populations experience a disparate prevalence of eye diseases. Visual impairment is a barrier to communication, interferes with academic and social success, and decreases overall quality of life. The prevalence of ocular pathology could serve as an indicator of health and social disparities. Therefore, the objective of this research was to perform a thorough review comparing the prevalence of common ophthalmological pathologies between AI/AN and non-AI/AN individuals in North America. Design: Retrospective, cross-sectional study. Methods: A total of 57 articles were retrieved and reviewed, and 14 met the criteria outlined for inclusion. These articles were retrieved from PubMed, MEDLINE, and ISI Web of Knowledge. Only studies that were peer reviewed in the last 25 years and reported on the prevalence of eye diseases in AI/AN compared with a non-AI/AN population met criteria. Results: Rates of retinopathy, cataracts, visual impairment, and blindness were clearly higher for AI/AN compared with non-AI/AN counterparts. Although rates of macular degeneration and glaucoma were similar between AI/AN and non-AI/AN populations, the treatment rates were lower and associated with poorer outcomes in AI/AN individuals. Conclusions: There are considerable inequities in the prevalence and treatment rates of ophthalmologic conditions in AI/AN individuals. A likely explanation is the barrier of lack of access to adequate health and eye care. Because of substantial underinsurance and geographic variability, attention needs to be brought to expanding eye care access to AI/AN communities. The results are subject to the availability of appropriate technology, health literacy, and language.
MeSH term(s)	Humans ; American Indian or Alaska Native ; Cross-Sectional Studies ; Indians, North American ; Prevalence ; Quality of Life ; Retrospective Studies ; United States/epidemiology ; Vision Disorders/epidemiology ; Vision Disorders/ethnology ; Vision Disorders/therapy ; Health Status Disparities ; Healthcare Disparities/ethnology
Language	English
Publishing date	2023-06-17
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2023.06.010
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Article ; Online: Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils.

Miller, Alyssa / Chia, Sean / Klimont, Ewa / Knowles, Tuomas P J / Vendruscolo, Michele / Ruggeri, Francesco Simone

Communications biology

2024 Volume 7, Issue 1, Page(s) 153

Abstract: Many proteins self-assemble to form amyloid fibrils, which are highly organized structures stabilized by a characteristic cross-β network of hydrogen bonds. This process underlies a variety of human diseases and can be exploited to develop versatile ... ...

Abstract	Many proteins self-assemble to form amyloid fibrils, which are highly organized structures stabilized by a characteristic cross-β network of hydrogen bonds. This process underlies a variety of human diseases and can be exploited to develop versatile functional biomaterials. Thus, protein self-assembly has been widely studied to shed light on the properties of fibrils and their intermediates. A still open question in the field concerns the microscopic processes that underlie the long-time behaviour and properties of amyloid fibrillar assemblies. Here, we use atomic force microscopy with angstrom-sensitivity to observe that amyloid fibrils undergo a maturation process, associated with an increase in both fibril length and thickness, leading to a decrease of their density, and to a change in their cross-β sheet content. These changes affect the ability of the fibrils to catalyse the formation of new aggregates. The identification of these changes helps us understand the fibril maturation processes, facilitate the targeting of amyloid fibrils in drug discovery, and offer insight into the development of biocompatible and sustainable protein-based materials.
MeSH term(s)	Humans ; Amyloid/metabolism ; Protein Conformation, beta-Strand ; Microscopy, Atomic Force
Chemical Substances	Amyloid
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-05858-7
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Article ; Online: Combined Sewer Overflows and Gastrointestinal Illness in Atlanta, 2002-2013: Evaluating the Impact of Infrastructure Improvements.

Miller, Alyssa G / Ebelt, Stefanie / Levy, Karen

Environmental health perspectives

2022 Volume 130, Issue 5, Page(s) 57009

Abstract: Background: Combined sewer overflows (CSOs) discharge untreated sewage into surface and recreational water, often following heavy precipitation. Given projected increases in frequency and intensity of precipitation due to climate change, it is important ...

Abstract	Background: Combined sewer overflows (CSOs) discharge untreated sewage into surface and recreational water, often following heavy precipitation. Given projected increases in frequency and intensity of precipitation due to climate change, it is important to understand the health impacts of CSOs and mediating effects of sewerage systems. Objectives: In this study we estimate associations of CSO events and emergency department (ED) visits for gastrointestinal (GI) illness among City of Atlanta, Georgia, residents and explore how these associations vary with sewerage improvements. Methods: We estimate associations using Poisson generalized linear models, controlling for time trends. We categorized CSOs by overflow volume and assessed effects of CSO events prior to ED visits with 1-, 2- and 3-wk lags. Similarly, we evaluated effects of weekly cumulative precipitation greater than the 90th percentile at the same lags. We also evaluated effect modification by ZIP Code Tabulation Area (ZCTA)-level poverty and infrastructure improvement period using interaction terms. Results: Occurrence of a large volume CSO in the previous week was associated with a 9% increase in daily ED visits for GI illness. We identified significant interaction by ZCTA-level poverty, with stronger CSO-GI illness associations in low than high poverty areas. Among areas with low poverty, we observed associations at 1-wk and longer lags, following both large and lower volume CSO events. We did not observe significant interaction by infrastructure improvement period for CSO- nor precipitation-GI illness associations; however, the number of CSO events decreased from 2.31 per week before improvements to 0.49 after improvements. Discussion: Our findings suggest that CSOs contribute to acute GI illness burden in Atlanta and that the magnitude of this risk may be higher among populations living in areas of low poverty. We did not find a protective effect of sewerage system improvements. Nonetheless, observed reductions in CSO frequency may lower the absolute burden of GI illness attributable to these events. https://doi.org/10.1289/EHP10399.
MeSH term(s)	Climate Change ; Emergency Service, Hospital ; Environmental Monitoring ; Georgia/epidemiology ; Sewage/analysis
Chemical Substances	Sewage
Language	English
Publishing date	2022-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP10399
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Article ; Online: Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils

Miller, Alyssa / Chia, Sean / Klimont, Ewa / Knowles, Tuomas P.J. / Vendruscolo, Michele / Ruggeri, Francesco Simone

Communications Biology

2024 Volume 7

Abstract	Many proteins self-assemble to form amyloid fibrils, which are highly organized structures stabilized by a characteristic cross-β network of hydrogen bonds. This process underlies a variety of human diseases and can be exploited to develop versatile functional biomaterials. Thus, protein self-assembly has been widely studied to shed light on the properties of fibrils and their intermediates. A still open question in the field concerns the microscopic processes that underlie the long-time behaviour and properties of amyloid fibrillar assemblies. Here, we use atomic force microscopy with angstrom-sensitivity to observe that amyloid fibrils undergo a maturation process, associated with an increase in both fibril length and thickness, leading to a decrease of their density, and to a change in their cross-β sheet content. These changes affect the ability of the fibrils to catalyse the formation of new aggregates. The identification of these changes helps us understand the fibril maturation processes, facilitate the targeting of amyloid fibrils in drug discovery, and offer insight into the development of biocompatible and sustainable protein-based materials.
Keywords	Life Science
Language	English
Publishing country	nl
Document type	Article ; Online
ISSN	2399-3642
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Article ; Online: Unraveling the Physicochemical Determinants of Protein Liquid-liquid Phase Separation by Nanoscale Infrared Vibrational Spectroscopy.

Ruggeri, Francesco S / Miller, Alyssa M / Vendruscolo, Michele / Knowles, Tuomas P J

Bio-protocol

2021 Volume 11, Issue 16, Page(s) e4122

Abstract: The phenomenon of reversible liquid-liquid phase separation of proteins underlies the formation of membraneless organelles, which are crucial for cellular processes such as signalling and transport. In addition, it is also of great interest to uncover ... ...

Abstract	The phenomenon of reversible liquid-liquid phase separation of proteins underlies the formation of membraneless organelles, which are crucial for cellular processes such as signalling and transport. In addition, it is also of great interest to uncover the mechanisms of further irreversible maturation of the functional dense liquid phase into aberrant insoluble assemblies due to its implication in human disease. Recent advances in methods based on atomic force microscopy (AFM) have made it possible to study protein condensates at the nanometer level, providing unprecedented information on the nature of the intermolecular interactions governing phase separation. Here, we provide an in-depth description of a protocol for the characterisation of the morphology, stiffness, and chemical properties of protein condensates using infrared nanospectroscopy (AFM-IR).
Language	English
Publishing date	2021-08-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325 ; 2331-8325
ISSN (online)	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.4122
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Article ; Online: Changing the firing threshold for normal optic nerve axons by the application of infra-red laser light.

Austerschmidt, Lavinia J / Schottler, Nadine I / Miller, Alyssa M / Baker, Mark D

Scientific reports

2021 Volume 11, Issue 1, Page(s) 20528

Abstract: Normal optic nerve axons exhibit a temperature dependence, previously explained by a membrane potential hyperpolarization on warming. We now report that near infra-red laser light, delivered via a fibre optic light guide, also affects axonal membrane ... ...

Abstract	Normal optic nerve axons exhibit a temperature dependence, previously explained by a membrane potential hyperpolarization on warming. We now report that near infra-red laser light, delivered via a fibre optic light guide, also affects axonal membrane potential and threshold, at least partly through a photo-thermal effect. Application of light to optic nerve, at the recording site, gave rise to a local membrane potential hyperpolarization over a period of about a minute, and increased the size of the depolarizing after potential. Application near the site of electrical stimulation reversibly raised current-threshold, and the change in threshold recorded over minutes of irradiation was significantly increased by the application of the I
MeSH term(s)	Animals ; Axons/metabolism ; Axons/radiation effects ; Female ; Infrared Rays ; Male ; Membrane Potentials/radiation effects ; Optic Nerve/metabolism ; Optic Nerve/radiation effects ; Rats, Sprague-Dawley ; Rats, Wistar ; Sodium/metabolism ; Temperature ; Rats
Chemical Substances	Sodium (9NEZ333N27)
Language	English
Publishing date	2021-10-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-00084-1
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Article: The role of ethnicity, biological sex, and psychotropic agents in early and late onset Alzheimer's disease.

Miller, Alyssa / Desai, Ashna / Roley, Laurie Theriot / Goodwin, Richard L / Nathaniel, Adebobola I / Nathaniel, Thomas I

Frontiers in aging neuroscience

2022 Volume 14, Page(s) 1052330

Abstract: Objective: This study investigates differences in pharmacological and demographic factors among male and female patients with Late-onset Alzheimer's disease (LOAD) and Early-onset Alzheimer's disease (EOAD).: Method: Data are from 10,126 AD patients, ...

Abstract	Objective: This study investigates differences in pharmacological and demographic factors among male and female patients with Late-onset Alzheimer's disease (LOAD) and Early-onset Alzheimer's disease (EOAD). Method: Data are from 10,126 AD patients, 9,290 were diagnosed with LOAD, while 836 were diagnosed with EOAD. Data were collected from the Prisma Health Upstate Alzheimer's patients' registry between 2016 and 2021. The logistic regression analysis was used to assess the association between pharmacological and demographic factors in males and females with LOAD and EOAD. Results: In the adjusted analysis for males, patients that were administered memantine [odd ratio (OR) = 1.588, 95% CI, 1.175-2.145, Conclusion: Our findings identified specific demographic and pharmacological factors associated with males and females with LOAD and EOAD. These findings suggest the need to develop strategies to eliminate disparity in the care of LOAD or EOAD patients.
Language	English
Publishing date	2022-12-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2022.1052330
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Article ; Online: In Vivo and Ex Vivo View of Newt Lens Regeneration.

Tsissios, Georgios / Sallese, Anthony / Chen, Weihao / Miller, Alyssa / Wang, Hui / Del Rio-Tsonis, Katia

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2562, Page(s) 197–208

Abstract: Lens regeneration in the adult newt illustrates a unique example of naturally occurring cell transdifferentiation. During this process, iris pigmented epithelial cells (iPECs) reprogram into a lens, a tissue that is derived from a different embryonic ... ...

Abstract	Lens regeneration in the adult newt illustrates a unique example of naturally occurring cell transdifferentiation. During this process, iris pigmented epithelial cells (iPECs) reprogram into a lens, a tissue that is derived from a different embryonic source. Several methodologies both in vivo and in culture have been utilized over the years to observe this phenomenon. Most recently, Optical Coherence Tomography (OCT) has been identified as an effective tool to study the lens regeneration process in continuity through noninvasive, real-time imaging of the same animal. Described in this chapter are three different methodologies that can be used to observe the newt lens regeneration process both in vivo and ex vivo.
MeSH term(s)	Animals ; Lens, Crystalline ; Salamandridae ; Cell Transdifferentiation ; Epithelial Cells
Language	English
Publishing date	2022-10-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2659-7_13
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Article ; Online: The tibial tubercle-trochlear groove distance: a comparison study between EOS and MRI in the paediatric population.

Murphy, Geoffrey T / Rudraraju, Ravi / Mathews, Timothy / Sidhu, Verinder / Miller, Alyssa / Brown, Kylie / Nicholls, Alex

Skeletal radiology

2023 Volume 53, Issue 1, Page(s) 85–91

Abstract: Objective: This study aims to compare the relative reliability and accuracy of TT-TG measurements in EOS with that of MRI in a paediatric population.: Methods: Patients were included if they underwent both an MRI and EOS scans and were under the age ... ...

Abstract	Objective: This study aims to compare the relative reliability and accuracy of TT-TG measurements in EOS with that of MRI in a paediatric population. Methods: Patients were included if they underwent both an MRI and EOS scans and were under the age of 16. Two authors recorded the TT-TG distances on each modality at two separate time points. In the EOS images, the distance between the two points was measured in the horizontal 2D plane. In the MRI images, it was done in the plane referenced by posterior femoral condylar axis. The intra- and inter-rater reliability was assessed in each modality and between modalities. Results: Twenty-seven patients (30 knees), 14 males, and 13 females with an average age of 13 years (range: 7-16 years) were included in the study. The mean TT-TG distance on EOS scan and MRI scan was 14 mm. On inter- and intra-observer analysis, both imaging modalities had excellent reliability (0.97 ICC for EOS and 0.98 ICC for MRI inter-observer) and repeatability (0.98-0.99 ICC for EOS and 0.99 ICC for MRI for intra-observer). However, on comparing the two imaging modalities (EOS vs MRI), the ICC was fair (0.56 ICC for rater 1 and 0.65 ICC for rater 2). Conclusion: While the EOS TT-TG measurements were precise and reproducible, they were only moderately comparable to MRI TT-TG measurements. Consequently, EOS TT-TG measurements should not be used for decision-making without the development of EOS-specific TT-TG values that indicate the need for distal realignment surgery. Level of evidence: Level II.
MeSH term(s)	Female ; Male ; Child ; Humans ; Adolescent ; Reproducibility of Results ; Tibia/diagnostic imaging ; Femur ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-06-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-023-04385-6
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Article ; Online: FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells.

Danopoulos, Soula / Belgacemi, Randa / Hein, Renee F C / Miller, Alyssa J / Deutsch, Gail H / Glass, Ian / Spence, Jason R / Al Alam, Denise

American journal of physiology. Lung cellular and molecular physiology

2023 Volume 324, Issue 4, Page(s) L433–L444

Abstract: Fibroblast growth factor (FGF) signaling is known to play an important role in lung organogenesis. However, we recently demonstrated that FGF10 fails to induce branching in human fetal lungs as is observed in mouse. Our previous human fetal lung RNA ... ...

Abstract	Fibroblast growth factor (FGF) signaling is known to play an important role in lung organogenesis. However, we recently demonstrated that FGF10 fails to induce branching in human fetal lungs as is observed in mouse. Our previous human fetal lung RNA sequencing data exhibited increased FGF18 during the pseudoglandular stage of development, suggestive of its importance in human lung branching morphogenesis. Whereas it has been previously reported that FGF18 is critical during alveologenesis, few studies have described its implication in lung branching, specifically in human. Therefore, we aimed to determine the role of FGF18 in human lung branching morphogenesis. Human fetal lung explants within the pseudoglandular stage of development were treated with recombinant human FGF18 in air-liquid interface culture. Explants were analyzed grossly to assess differences in branching pattern, as well as at the cellular and molecular levels. FGF18 treatment promoted branching in explant cultures and demonstrated increased epithelial proliferation as well as maintenance of the double positive SOX2/SOX9 distal bud progenitor cells, confirming its role in human lung branching morphogenesis. In addition, FGF18 treated explants displayed increased expression of SOX9, FN1, and COL2A1 within the mesenchyme, all factors that are important to chondrocyte differentiation. In humans, cartilaginous airways extend deep into the lung up to the 12th generation of branching whereas in mouse these are restricted to the trachea and main bronchi. Therefore, our data suggest that FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells.
MeSH term(s)	Animals ; Humans ; Mice ; Fibroblast Growth Factors/genetics ; Lung/metabolism ; Mesenchymal Stem Cells ; Morphogenesis/physiology ; Organogenesis/genetics
Chemical Substances	Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 18
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1013184-x
ISSN	1522-1504 ; 1040-0605
ISSN (online)	1522-1504
ISSN	1040-0605
DOI	10.1152/ajplung.00316.2022
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