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  1. Article ; Online: Hearing ability of prairie voles (Microtus ochrogaster).

    New, Emily M / Hurd, Jessica A / Alarcon, Genesis A / Miller, Cameron S / Williams, Peyton A / Greene, Nathaniel T / Sergott, Casey E / Li, Ben-Zheng / Lei, Tim C / McCullagh, Elizabeth A

    The Journal of the Acoustical Society of America

    2024  Volume 155, Issue 1, Page(s) 555–567

    Abstract: The hearing abilities of mammals are impacted by factors such as social cues, habitat, and physical characteristics. Despite being used commonly to study social behaviors, hearing of the monogamous prairie vole (Microtus ochrogaster) has never been ... ...

    Abstract The hearing abilities of mammals are impacted by factors such as social cues, habitat, and physical characteristics. Despite being used commonly to study social behaviors, hearing of the monogamous prairie vole (Microtus ochrogaster) has never been characterized. In this study, anatomical features are measured and auditory brainstem responses (ABRs) are used to measure auditory capabilities of prairie voles, characterizing monaural and binaural hearing and hearing range. Sexually naive male and female voles were measured to characterize differences due to sex. It was found that prairie voles show a hearing range with greatest sensitivity between 8 and 32 kHz, binaural hearing across interaural time difference ranges appropriate for their head sizes. No differences are shown between the sexes in binaural hearing or hearing range (except at 1 kHz), however, female voles have increased amplitude of peripheral ABR waves I and II and longer latency of waves III and IV compared to males. The results confirm that prairie voles have a broad hearing range, binaural hearing consistent with rodents of similar size, and differences in amplitudes and thresholds of monaural physiological measures between the sexes. These data further highlight the necessity to understand sex-specific differences in neural processing that may underly variability in responses between sexes.
    MeSH term(s) Female ; Male ; Animals ; Grassland ; Hearing ; Arvicolinae ; Cues
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 219231-7
    ISSN 1520-8524 ; 0001-4966
    ISSN (online) 1520-8524
    ISSN 0001-4966
    DOI 10.1121/10.0024357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Using a classroom-based deese roediger mcdermott paradigm to assess the effects of imagery on false memories

    Oliver, Merrin C / Bays, Rebecca B / Miller, Cameron

    Journal of visualized experiments. 2018 Nov. 14, , no. 141

    2018  

    Abstract: Associated word list procedures can elicit false memories in predictable ways by inducing associative processing, thus making it harder to monitor the accuracy of memories. The purpose of the method presented here was to induce false memories using lists ...

    Abstract Associated word list procedures can elicit false memories in predictable ways by inducing associative processing, thus making it harder to monitor the accuracy of memories. The purpose of the method presented here was to induce false memories using lists of either semantically or phonologically related words and to assess the effects of imagery instructions on the recall and recognition of those false memories. To do this, we used a modified version of the Deese Roediger McDermott (DRM) paradigm. We adapted word lists from previous DRM studies to suit imagery procedures and created an automated presentation to present the word lists in classroom settings. We then recruited undergraduate classes and instructed some of the classes to create mental images of the list words as they were being presented, while instructing the other classes to simply remember the words. The automated presentation presented word lists to participants, one word at a time, alternating between phonologically and semantically related lists. Participants used paper-pencil recall packets to immediately recall list items, complete a distractor activity, and take a subsequent final recognition test. Often, participants immediately recalled and later recognized words that were related to the list items but were not actually presented; these are known as critical lures and indicate a false memory. The protocol detailed here describes a four-step procedure - list presentation, immediate recall, distractor phase, and final recognition - that can assess the effects of list type and imagery instruction within the DRM paradigm on memory. The automated nature of the list presentation provides the ability to systematically vary variables of interest, and the paper and pencil method of data collection affords an easily accessible method for collecting data in classroom settings. The protocol also offers options to modify the procedure to a more traditional DRM paradigm without imagery and/or list type manipulations. The use of this protocol can provide results relevant to both classroom learning and cognitive science principles.
    Keywords automation ; cognition ; data collection ; memory
    Language English
    Dates of publication 2018-1114
    Size p. e58326.
    Publishing place Journal of Visualized Experiments
    Document type Article
    ISSN 1940-087X
    DOI 10.3791/58326
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Using a Classroom-Based Deese Roediger McDermott Paradigm to Assess the Effects of Imagery on False Memories.

    Oliver, Merrin C / Bays, Rebecca B / Miller, Cameron

    Journal of visualized experiments : JoVE

    2018  , Issue 141

    Abstract: Associated word list procedures can elicit false memories in predictable ways by inducing associative processing, thus making it harder to monitor the accuracy of memories. The purpose of the method presented here was to induce false memories using lists ...

    Abstract Associated word list procedures can elicit false memories in predictable ways by inducing associative processing, thus making it harder to monitor the accuracy of memories. The purpose of the method presented here was to induce false memories using lists of either semantically or phonologically related words and to assess the effects of imagery instructions on the recall and recognition of those false memories. To do this, we used a modified version of the Deese Roediger McDermott (DRM) paradigm. We adapted word lists from previous DRM studies to suit imagery procedures and created an automated presentation to present the word lists in classroom settings. We then recruited undergraduate classes and instructed some of the classes to create mental images of the list words as they were being presented, while instructing the other classes to simply remember the words. The automated presentation presented word lists to participants, one word at a time, alternating between phonologically and semantically related lists. Participants used paper-pencil recall packets to immediately recall list items, complete a distractor activity, and take a subsequent final recognition test. Often, participants immediately recalled and later recognized words that were related to the list items but were not actually presented; these are known as critical lures and indicate a false memory. The protocol detailed here describes a four-step procedure - list presentation, immediate recall, distractor phase, and final recognition - that can assess the effects of list type and imagery instruction within the DRM paradigm on memory. The automated nature of the list presentation provides the ability to systematically vary variables of interest, and the paper and pencil method of data collection affords an easily accessible method for collecting data in classroom settings. The protocol also offers options to modify the procedure to a more traditional DRM paradigm without imagery and/or list type manipulations. The use of this protocol can provide results relevant to both classroom learning and cognitive science principles.
    MeSH term(s) Data Collection ; Humans ; Imagination ; Memory, Short-Term ; Mental Recall ; Recognition (Psychology) ; Semantics
    Language English
    Publishing date 2018-11-14
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ISSN 1940-087X
    ISSN (online) 1940-087X
    DOI 10.3791/58326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Epitranscriptomic Reader YTHDF2 Regulates SEK1(

    Malovic, Emir / Ealy, Alyssa / Hsu, Phillip J / Sarkar, Souvarish / Miller, Cameron / Rokad, Dharmin / Goeser, Cody / Hartman, Aleah Kristen / Zhu, Allen / Palanisamy, Bharathi / Zenitsky, Gary / Jin, Huajun / Anantharam, Vellareddy / Kanthasamy, Arthi / He, Chuan / Kanthasamy, Anumantha G

    bioRxiv : the preprint server for biology

    2024  

    Abstract: As the most abundant glial cells in the CNS, astrocytes dynamically respond to neurotoxic stress, however, the key molecular regulators controlling the inflammatory status of these sentinels during neurotoxic stress have remained elusive. Herein, we ... ...

    Abstract As the most abundant glial cells in the CNS, astrocytes dynamically respond to neurotoxic stress, however, the key molecular regulators controlling the inflammatory status of these sentinels during neurotoxic stress have remained elusive. Herein, we demonstrate that the m6A epitranscriptomic mRNA modification tightly regulates the pro-inflammatory functions of astrocytes. Specifically, the astrocytic neurotoxic stresser, manganese (Mn), downregulated the m6A reader YTHDF2 in human and mouse astrocyte cultures and in the mouse brain. Functionally, YTHDF2 knockdown augmented, while its overexpression dampened, neurotoxic stress induced proinflammatory response, suggesting YTHDF2 serves as a key upstream regulator of inflammatory responses in astrocytes. Mechnistically, YTHDF2 RIP-sequencing identified
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.26.577106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pawn to save a chariot, or drawbridge into the fort?

    Toh, Puay Khoon / Miller, Cameron D

    Strategic management journal Vol. 38, No. 11 , p. 2213-2236

    firms' disclosure during standard setting and complementary technologies within ecosystems

    2017  Volume 38, Issue 11, Page(s) 2213–2236

    Author's details Puay Khoon Toh and Cameron D. Miller
    Keywords disclosure ; standard setting ; complementary technologies ; competition ; appropriation
    Language English
    Publisher Wiley
    Publishing place Chichester [u.a.]
    Document type Article
    ZDB-ID 164405-1 ; 1478912-7
    ISSN 1097-0266 ; 0143-2095
    ISSN (online) 1097-0266
    ISSN 0143-2095
    Database ECONomics Information System

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  6. Article: Automating a Process Convolution Approach to Account for Spatial Information in Imaging Mass Spectrometry Data.

    Miller, Cameron / Lawson, Andrew / Chung, Dongjun / Gebregziabher, Mulugeta / Yeh, Elizabeth / Drake, Richard / Hill, Elizabeth

    Spatial statistics

    2020  Volume 36

    Abstract: In the age of big data, imaging techniques such as imaging mass spectrometry (IMS) stand out due to the combination of data size and spatial referencing. However, the data analytic tools readily accessible to investigators often ignore the spatial ... ...

    Abstract In the age of big data, imaging techniques such as imaging mass spectrometry (IMS) stand out due to the combination of data size and spatial referencing. However, the data analytic tools readily accessible to investigators often ignore the spatial information or provide results with vague interpretations. We focus on imaging techniques like IMS that collect data along a regular grid and develop methods to automate the process of modeling spatially-referenced imaging data using a process convolution (PC) approach. The PC approach provides a flexible framework to model spatially-referenced geostatistical data, but to make it computationally efficient requires identification of model parameters. We perform simulation studies to define optimal methods for specifying PC parameters and then test those methods using simulations that spike in real spatial information. In doing so, we demonstrate that our methods concurrently account for the spatial information and provide clear interpretations of covariate effects, while maximizing power and maintaining type I error rates near the nominal level. To make these methods accessible, we detail the imagingPC R package. Our approach provides a framework that is flexible and scalable to the level required by many imaging techniques.
    Language English
    Publishing date 2020-02-19
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-6753
    ISSN 2211-6753
    DOI 10.1016/j.spasta.2020.100422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Transcriptional responses define dysregulated immune activation in Hepatitis C (HCV)-naïve recipients of HCV-infected donor kidneys.

    Steinbrink, Julie M / Miller, Cameron / Myers, Rachel A / Sanoff, Scott / Mazur, Anna / Burke, Thomas W / Byrns, Jennifer / Jackson, Annette M / Luo, Xunrong / McClain, Micah T

    PloS one

    2023  Volume 18, Issue 1, Page(s) e0280602

    Abstract: Renal transplantation from hepatitis C (HCV) nucleic acid amplification test-positive (NAAT-positive) donors to uninfected recipients has greatly increased the organ donation pool. However, there is concern for adverse outcomes in these recipients due to ...

    Abstract Renal transplantation from hepatitis C (HCV) nucleic acid amplification test-positive (NAAT-positive) donors to uninfected recipients has greatly increased the organ donation pool. However, there is concern for adverse outcomes in these recipients due to dysregulated immunologic activation secondary to active inflammation from acute viremia at the time of transplantation. This includes increased rates of cytomegalovirus (CMV) DNAemia and allograft rejection. In this study, we evaluate transcriptional responses in circulating leukocytes to define the character, timing, and resolution of this immune dysregulation and assess for biomarkers of adverse outcomes in transplant patients. We enrolled 67 renal transplant recipients (30 controls, 37 HCV recipients) and performed RNA sequencing on serial samples from one, 3-, and 6-months post-transplant. CMV DNAemia and allograft rejection outcomes were measured. Least absolute shrinkage and selection operator was utilized to develop gene expression classifiers predictive of clinical outcomes. Acute HCV incited a marked transcriptomic response in circulating leukocytes of renal transplant recipients in the acute post-transplant setting, despite the presence of immunosuppression, with 109 genes significantly differentially expressed compared to controls. These HCV infection-associated genes were reflective of antiviral immune pathways and generally resolved by the 3-month timepoint after sustained viral response (SVR) for HCV. Differential gene expression was also noted from patients who developed CMV DNAemia or allograft rejection compared to those who did not, although transcriptomic classifiers could not accurately predict these outcomes, likely due to sample size and variable time-to-event. Acute HCV infection incites evidence of immune activation and canonical antiviral responses in the human host even in the presence of systemic immunosuppression. After treatment of HCV with antiviral therapy and subsequent aviremia, this immune activation resolves. Changes in gene expression patterns in circulating leukocytes are associated with some clinical outcomes, although larger studies are needed to develop accurate predictive classifiers of these events.
    MeSH term(s) Humans ; Hepatitis C ; Hepacivirus/genetics ; Tissue Donors ; Antiviral Agents/therapeutic use ; Kidney ; Cytomegalovirus Infections/drug therapy ; Transplant Recipients
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0280602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Toward Preventing Enamel Hypoplasia: Modeling Maternal and Neonatal Biomarkers of Human Calcium Homeostasis.

    Reed, Susan G / Miller, Cameron S / Wagner, Carol L / Hollis, Bruce W / Lawson, Andrew B

    Caries research

    2019  Volume 54, Issue 1, Page(s) 55–67

    Abstract: Aim: The aim of this study was to assess biomarkers of calcium homeostasis and tooth development, in mothers during pregnancy and their children at birth, for enamel hypoplasia (EH) in the primary maxillary central incisor teeth.: Methods: Bayesian ... ...

    Abstract Aim: The aim of this study was to assess biomarkers of calcium homeostasis and tooth development, in mothers during pregnancy and their children at birth, for enamel hypoplasia (EH) in the primary maxillary central incisor teeth.
    Methods: Bayesian methodology was used for secondary data analyses from a randomized, controlled trial of prenatal vitamin D3 supplementation in healthy mothers (N = 350) and a follow-up study of a subset of the children. The biomarkers were serum calcium (Ca), phosphorus (P), intact parathyroid hormone (iPTH), total circulating 25-dihydroxyvitamin D (25(OH)D), and 1,25-dihydroxyvitamin D (1,25(OH)2D). The maternal biomarkers were assayed monthly during pregnancy, and the child's biomarkers were derived from cord blood. Digital images of the child's 2 teeth were scored for EH using Enamel Defects Index criteria for each of the incisal, middle, and cervical regions for an EH extent score.
    Results: The child EH prevalence was 41% (60/145), with most defects present in the incisal and middle tooth regions. Cord blood iPTH and 1,25(OH)2D levels were significantly associated with EH extent after controlling for maternal factors. For every 1 pg/mL increase in cord blood iPTH, the EH extent decreased by approximately 6%. For every 10 pg/mL increase in cord blood 1,25(OH)2D, the EH extent increased by almost 30% (holding all other terms constant and adjusting for subject-level heterogeneity). The relationship between maternal 25(OH)D and maternal mean iPTH varied significantly by EH extent.
    Conclusion: The results suggest possible modifiable relationships of maternal and neonatal factors of calcium homeostasis during pregnancy and at birth for EH, contributing to the frontier of knowledge regarding sound tooth development for dental caries prevention.
    MeSH term(s) Bayes Theorem ; Biomarkers ; Calcium ; Dental Caries ; Dental Enamel Hypoplasia/prevention & control ; Female ; Follow-Up Studies ; Homeostasis ; Humans ; Infant, Newborn ; Pregnancy
    Chemical Substances Biomarkers ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-10-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 390575-5
    ISSN 1421-976X ; 0008-6568
    ISSN (online) 1421-976X
    ISSN 0008-6568
    DOI 10.1159/000502793
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  9. Article ; Online: HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search.

    Lee, Yi-Yuan / Guler, Mustafa / Chigumba, Desnor N / Wang, Shen / Mittal, Neel / Miller, Cameron / Krummenacher, Benjamin / Liu, Haodong / Cao, Liu / Kannan, Aditya / Narayan, Keshav / Slocum, Samuel T / Roth, Bryan L / Gurevich, Alexey / Behsaz, Bahar / Kersten, Roland D / Mohimani, Hosein

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 4219

    Abstract: Recent analyses of public microbial genomes have found over a million biosynthetic gene clusters, the natural products of the majority of which remain unknown. Additionally, GNPS harbors billions of mass spectra of natural products without known ... ...

    Abstract Recent analyses of public microbial genomes have found over a million biosynthetic gene clusters, the natural products of the majority of which remain unknown. Additionally, GNPS harbors billions of mass spectra of natural products without known structures and biosynthetic genes. We bridge the gap between large-scale genome mining and mass spectral datasets for natural product discovery by developing HypoRiPPAtlas, an Atlas of hypothetical natural product structures, which is ready-to-use for in silico database search of tandem mass spectra. HypoRiPPAtlas is constructed by mining genomes using seq2ripp, a machine-learning tool for the prediction of ribosomally synthesized and post-translationally modified peptides (RiPPs). In HypoRiPPAtlas, we identify RiPPs in microbes and plants. HypoRiPPAtlas could be extended to other natural product classes in the future by implementing corresponding biosynthetic logic. This study paves the way for large-scale explorations of biosynthetic pathways and chemical structures of microbial and plant RiPP classes.
    MeSH term(s) Ribosomes/metabolism ; Biological Products/chemistry ; Peptides/chemistry ; Databases, Factual ; Tandem Mass Spectrometry ; Protein Processing, Post-Translational
    Chemical Substances Biological Products ; Peptides
    Language English
    Publishing date 2023-07-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-39905-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Review of Sterilization Techniques for Medical and Personal Protective Equipment Contaminated With SARS-CoV-2.

    Jinia, Abbas Johar / Sunbul, Noora Ba / Meert, Christopher A / Miller, Cameron A / Clarke, Shaun D / Kearfott, Kimberlee J / Matuszak, Martha M / Pozzi, Sara A

    IEEE access : practical innovations, open solutions

    2020  Volume 8, Page(s) 111347–111354

    Abstract: The outbreak of the novel coronavirus disease, COVID-19 turned into a global pandemic in March 2020. During these unprecedented times, there is an increased demand in medical and personal protective equipment (PPE). Since the supplies may take a long ... ...

    Abstract The outbreak of the novel coronavirus disease, COVID-19 turned into a global pandemic in March 2020. During these unprecedented times, there is an increased demand in medical and personal protective equipment (PPE). Since the supplies may take a long time to meet the global demand, reusing PPEs will help health care workers in their response to the COVID-19 pandemic. To ensure the safety and well-being of the medical first responders, PPE needs to be sterilized before reuse. In this review, we examine various sterilization techniques that can be used to sterilize PPEs and point out its limitations. The objective is to provide a foundation of knowledge incorporating different sterilization techniques that allow hospitals and clinics to pick the most suitable technique for sterilization of a particular PPE.
    Language English
    Publishing date 2020-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2687964-5
    ISSN 2169-3536
    ISSN 2169-3536
    DOI 10.1109/ACCESS.2020.3002886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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