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  1. Article ; Online: The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention.

    Miller, Frederick W

    Current opinion in immunology

    2022  Volume 80, Page(s) 102266

    Abstract: Autoimmunity is characterized by self-reactive immune components and autoimmune disease by autoimmunity plus pathology. Both autoimmunity and autoimmune diseases are dramatically increasing in many parts of the world, likely as a result of changes in our ...

    Abstract Autoimmunity is characterized by self-reactive immune components and autoimmune disease by autoimmunity plus pathology. Both autoimmunity and autoimmune diseases are dramatically increasing in many parts of the world, likely as a result of changes in our exposures to environmental factors. Current evidence implicates the momentous alterations in our foods, xenobiotics, air pollution, infections, personal lifestyles, stress, and climate change as causes for these increases. Autoimmune diseases have a major impact on the individuals and families they affect, as well as on our society and healthcare costs, and current projections suggest they may soon take their place among the predominant medical disorders. This necessitates that we increase the scope and scale of our efforts, and coordinate our resources and studies, to understand autoimmune disease risk factors and pathogeneses and improve our diagnostic, therapeutic, and preventive approaches, as the costs of inaction will be profound and far greater without such investments.
    MeSH term(s) Humans ; Autoimmunity ; Prevalence ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/epidemiology ; Autoimmune Diseases/therapy ; Air Pollution
    Language English
    Publishing date 2022-11-26
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Intramural
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2022.102266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Idiopathic inflammatory myopathies

    Miller, Frederick W.

    (Rheumatic disease clinics of North America ; 28,4)

    2002  

    Author's details Frederick W. Miller, guest ed
    Series title Rheumatic disease clinics of North America ; 28,4
    Collection
    Language English
    Size XIII S., S. 723 - 1030 : Ill.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013554680
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 363 -28,4- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Slicing and dicing myositis for cures and prevention.

    Miller, Frederick W

    Nature reviews. Rheumatology

    2020  Volume 17, Issue 5, Page(s) 255–256

    MeSH term(s) Humans ; Myositis/drug therapy ; Myositis/prevention & control
    Language English
    Publishing date 2020-12-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-021-00592-4
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  4. Article ; Online: Reply.

    Dellaripa, Paul F / Bush, Thomas / Miller, Frederick W / Feldman, Candace H

    Arthritis & rheumatology (Hoboken, N.J.)

    2023  Volume 75, Issue 8, Page(s) 1494

    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42488
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  5. Article ; Online: Development of a computed tomography calcium scoring technique for assessing calcinosis distribution, pattern and burden in dermatomyositis.

    Cervantes, Briana A / Gowda, Prateek / Rider, Lisa G / Miller, Frederick W / Chen, Marcus Y / Schiffenbauer, Adam

    Rheumatology (Oxford, England)

    2023  Volume 63, Issue 1, Page(s) 58–63

    Abstract: Objectives: To utilize whole-body CT imaging and calcium scoring techniques as tools for calcinosis assessment in a prospective cohort of patients with adult and juvenile dermatomyositis (DM and JDM, respectively).: Methods: Thirty-one patients (14 ... ...

    Abstract Objectives: To utilize whole-body CT imaging and calcium scoring techniques as tools for calcinosis assessment in a prospective cohort of patients with adult and juvenile dermatomyositis (DM and JDM, respectively).
    Methods: Thirty-one patients (14 DM and 17 JDM) who fulfilled Bohan and Peter Classification criteria as probable or definite DM, the EULAR-ACR criteria for definite DM, and with calcinosis identified by physical examination or prior imaging studies were included. Non-contrast whole-body CT scans were obtained using low-dose radiation procedures. Scans were read qualitatively and quantitated. We calculated the sensitivity and specificity of calcinosis detection of physician physical exam against CT. We quantified calcinosis burden using the Agatston scoring technique.
    Results: We identified five distinct calcinosis patterns: Clustered, Disjoint, Interfascial, Confluent and Fluid-filled. Novel locations of calcinosis were observed, including the cardiac tissue, pelvic and shoulder bursa, and the spermatic cord. Quantitative measures using Agatston scoring for calcinosis were used in regional distributions across the body. Physician physical exams had a sensitivity of 59% and a specificity of 90% compared with CT detection. A higher calcium score correlated with higher Physician Global Damage, Calcinosis Severity scores, and disease duration.
    Conclusion: Whole-body CT scans and the Agatston scoring metric define distinct calcinosis patterns and provide novel insights relating to calcinosis in DM and JDM patients. Physicians' physical examinations underrepresented the presence of calcium. Calcium scoring of CT scans correlated with clinical measures, which suggests that this method may be used to assess calcinosis and follow its progression.
    MeSH term(s) Male ; Adult ; Humans ; Dermatomyositis/diagnostic imaging ; Coronary Artery Disease ; Calcium ; Prospective Studies ; Tomography, X-Ray Computed/methods ; Calcinosis/diagnostic imaging
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead256
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  6. Article ; Online: The Climate Emergency and the Health of Our Patients: The Role of the Rheumatologist.

    Dellaripa, Paul F / Bush, Thomas / Miller, Frederick W / Feldman, Candace H

    Arthritis & rheumatology (Hoboken, N.J.)

    2022  Volume 75, Issue 1, Page(s) 1–3

    MeSH term(s) Humans ; Rheumatologists ; Arthritis, Rheumatoid ; Rheumatology ; Patients
    Language English
    Publishing date 2022-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42279
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  7. Article ; Online: The American College of Rheumatology White Paper: The Effects of Climate Change on Rheumatic Conditions - An Evolving Landscape and a Path Forward.

    Dellaripa, Paul F / Sung, Lily H / Bain, Paul A / Lanata, Cristina / Blazar, Ashira / Miller, Frederick W / Feldman, Candace H

    Arthritis & rheumatology (Hoboken, N.J.)

    2024  

    Abstract: Background: Increases in global temperatures and extreme weather events associated with climate change have complex yet poorly understood detrimental impacts on human health. We reviewed the current published literature on climate change-related effects ...

    Abstract Background: Increases in global temperatures and extreme weather events associated with climate change have complex yet poorly understood detrimental impacts on human health. We reviewed the current published literature on climate change-related effects and rheumatic conditions.
    Methods: To summarize our current understanding of the likely effects of climate change, including increased air pollution, on rheumatic disease, we searched the published, peer-reviewed English-language literature from January 2000-December 2022. Articles were reviewed by a team of rheumatologists and clinical and translational science researchers. Systematic review articles were not included but informed additional literature searches.
    Results: After extensive examination and adjudication, 88 articles met inclusion criteria and were selected for review. Much of the epidemiologic investigations assessed associations between air pollution and increased risk of development of rheumatoid arthritis, anti-citrullinated protein antibodies, flares of gout and hospitalizations for systemic lupus erythematosus. Increased heat vulnerability was associated with higher odds of recurrent hospitalizations across rheumatic conditions. Mechanisms for observed associations are poorly understood but could include the effects of epigenetic changes, oxidative stress, and inflammatory cytokines. Studies had limitations including restricted geography and populations studied without focus on historically marginalized communities at highest risk for adverse effects from pollution and climate change, the relative lack of mechanistic evaluations, and most with only indirect links to climate change.
    Conclusions: To date, the published literature lacks studies that directly examine effects of climate change on rheumatic diseases. Collaborative translational and epidemiologic research is needed to enhance our understanding and awareness in this area.
    Language English
    Publishing date 2024-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42919
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  8. Article ; Online: Population-based estimates of humoral autoimmunity from the U.S. National Health and Nutrition Examination Surveys, 1960-2014.

    Dillon, Charles F / Weisman, Michael H / Miller, Frederick W

    PloS one

    2020  Volume 15, Issue 1, Page(s) e0226516

    Abstract: Objective: Based on US National Health and Nutrition Examination Survey (NHANES) data, we attempted to provide an unbiased, population-based estimate of autoantibody prevalence overall and by age and sex.: Methods: US autoantibody prevalence ... ...

    Abstract Objective: Based on US National Health and Nutrition Examination Survey (NHANES) data, we attempted to provide an unbiased, population-based estimate of autoantibody prevalence overall and by age and sex.
    Methods: US autoantibody prevalence estimates for detectable rheumatoid factor, anti-thyroglobulin, anti-thyroperoxidase, anti-transglutaminase, anti-endomysial, anti-GAD65, antinuclear autoantibodies, and autoantibodies to extractable nuclear antigens were estimated from the 1960-1962 National Health Examination Survey, NHANES III (1988-1994), and the NHANES 1999-2014 cross-sectional surveys. Survey design variables and sample weights were used to account for differential probabilities of selection within the complex survey design. Data analysis used SASTM and SUDAAN™ software. US Census Bureau data were used to estimate the absolute numbers of persons with autoantibodies.
    Results: NHANES III data show that the overall US prevalence of having a detectable serum autoantibody is substantial in adults, in both women and men. Thyroid autoantibodies were present in 18% of US adults (31 million persons) including 10% of younger adults and 25% of older persons. Overall autoantibody prevalences increased significantly with age: 32% of US adults 60+ years of age (12.8 million persons) had at least one of the four autoantibodies rheumatoid factor, anti-thyroglobulin, anti-thyroperoxidase, or anti-tissue transglutaminase. Older women had higher levels of autoantibodies, but this was a relative difference. Autoantibody prevalence in both sexes was substantial (women 39%; men 22%). Fourteen percent of adults 60+ years of age have multiple autoantibodies.
    Conclusions: Autoantibodies are present in a significant fraction of the general population, especially in older adults and women relative to men. Although all known clinically significant autoantibodies were not analyzed, these data provide an important population perspective on the scope and magnitude of humoral autoimmunity in the US. This is vital for prevention efforts to reduce autoimmune disease and helps clarify the potential impact of autoimmunity on the general population.
    MeSH term(s) Adolescent ; Adult ; Aged ; Autoantibodies/blood ; Autoimmunity ; Cross-Sectional Studies ; Databases, Factual ; Female ; Health Surveys ; Humans ; Immunity, Humoral ; Male ; Middle Aged ; Nutrition Surveys ; United States ; Young Adult
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2020-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0226516
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  9. Article: The origins, evolution and future of the International Myositis Assessment and Clinical Studies Group (IMACS).

    Isenberg, David A / Chinoy, Hector / Dimachkie, Mazen M / Miller, Frederick W / Rider, Lisa G

    Clinical and experimental rheumatology

    2022  Volume 40, Issue 2, Page(s) 214–218

    MeSH term(s) Humans ; Myositis/diagnosis
    Language English
    Publishing date 2022-01-20
    Publishing country Italy
    Document type Editorial
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/yg743i
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  10. Article ; Online: Anti-dense fine speckled 70 (DFS70) autoantibodies: correlates and increasing prevalence in the United States.

    Dinse, Gregg E / Zheng, Bing / Co, Caroll A / Parks, Christine G / Weinberg, Clarice R / Miller, Frederick W / Chan, Edward K L

    Frontiers in immunology

    2023  Volume 14, Page(s) 1186439

    Abstract: Objective: Recent studies report high-titer anti-dense fine speckled 70 (DFS70) autoantibodies in persons with inflammatory conditions, but the clinical significance remains unclear. Our goals were to estimate anti-DFS70 autoantibody prevalence, ... ...

    Abstract Objective: Recent studies report high-titer anti-dense fine speckled 70 (DFS70) autoantibodies in persons with inflammatory conditions, but the clinical significance remains unclear. Our goals were to estimate anti-DFS70 autoantibody prevalence, identify correlates, and assess time trends.
    Methods: Serum antinuclear antibodies (ANA) were measured by indirect immunofluorescence assay on HEp-2 cells in 13,519 participants ≥12 years old from three time periods (1988-1991, 1999-2004, 2011-2012) of the National Health and Nutrition Examination Survey. ANA-positive participants with dense fine speckled staining were evaluated for anti-DFS70 antibodies by enzyme-linked immunosorbent assay. We used logistic models adjusted for survey-design variables to estimate period-specific anti-DFS70 antibody prevalence in the US, and we further adjusted for sex, age, and race/ethnicity to identify correlates and assess time trends.
    Results: Women were more likely than men (odds ratio (OR)=2.97), black persons were less likely than white persons (OR=0.60), and active smokers were less likely than nonsmokers (OR=0.28) to have anti-DFS70 antibodies. The prevalence of anti-DFS70 antibodies increased from 1.6% in 1988-1991 to 2.5% in 1999-2004 to 4.0% in 2011-2012, which corresponds to 3.2 million, 5.8 million, and 10.4 million seropositive individuals, respectively. This increasing time trend in the US population (P<0.0001) was modified in some subgroups and was not explained by concurrent changes in tobacco smoke exposure. Some, but not all, anti-DFS70 antibody correlates and time trends resembled those reported for total ANA.
    Conclusion: More research is needed to elucidate anti-DFS70 antibody triggers, their pathologic or potentially protective influences on disease, and their possible clinical implications.
    MeSH term(s) Female ; Humans ; Male ; Adaptor Proteins, Signal Transducing ; Antibodies, Antinuclear ; Autoantibodies ; Nutrition Surveys ; Prevalence ; United States/epidemiology
    Chemical Substances Adaptor Proteins, Signal Transducing ; Antibodies, Antinuclear ; Autoantibodies
    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1186439
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