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  1. AU="Miller, Geoff"
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  1. Artikel ; Online: Application of micro capillary blood sampling in an anti-doping setting.

    Lewis, Laura / Goodrum, Jenna / Cai, Calvin / Muir, Tessa / Boutard, Kristin / Capdevielle, Thomas / Longo, Stefano / Fedoruk, Matthew / Miller, Geoff

    Drug testing and analysis

    2023  

    Abstract: Blood collection is an important facet of anti-doping testing, forming the basis of the Athlete Biological Passport (ABP). Traditional blood collection via venipuncture can be uncomfortable for athletes, especially those who are tested frequently or ... ...

    Abstract Blood collection is an important facet of anti-doping testing, forming the basis of the Athlete Biological Passport (ABP). Traditional blood collection via venipuncture can be uncomfortable for athletes, especially those who are tested frequently or close to competition. Athletes may also have negative perceptions of venipuncture due to past experiences or the risks of adverse health events such as bruising, hematomas, syncope, and general discomfort that has the potential to affect performance. Advances in capillary whole blood collection technology now affords the ability to collect micro-volumetric capillary whole blood from the upper arm (or other suitable vascular location such as the abdomen) that is "needle-free" and virtually painless using devices such as the Tasso+. The present study extends previous work, by collecting microliter capillary whole blood samples via the Tasso+ EDTA device in an official anti-doping setting prior to competition, as well as requiring temperature-monitored cold chain shipping by air to the laboratory before analysis. Fifty-eight matched capillary and venous blood samples were collected under official doping control conditions by certified Doping Control Officers. No impact of sample shipment by air under cool conditions was observed on sample integrity. Provided that no visible clots were identified prior to analysis, capillary and venous blood samples showed excellent laboratory agreement for all CBC parameters, with the exception of platelets. Micro capillary blood collection provides a valid alternative to venous blood collection for ABP purposes, with the advantage of providing a more athlete-friendly experience, particularly close to competition.
    Sprache Englisch
    Erscheinungsdatum 2023-11-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.3603
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Cow bells and cold chains: the spread of smallpox vaccine and vaccination before refrigeration.

    Miller, Geoff

    Pharmaceutical historian

    2008  Band 38, Heft 1, Seite(n) 3–5

    Mesh-Begriff(e) Cold Temperature ; Drug Storage/methods ; History, 18th Century ; History, 19th Century ; Humans ; Smallpox/history ; Smallpox/prevention & control ; Smallpox Vaccine/history ; Vaccination/history
    Chemische Substanzen Smallpox Vaccine
    Sprache Englisch
    Erscheinungsdatum 2008-03
    Erscheinungsland England
    Dokumenttyp Historical Article ; Journal Article
    ZDB-ID 2915813-8
    ISSN 0079-1393
    ISSN 0079-1393
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Detection of erythropoiesis stimulating agent Luspatercept after administration to healthy volunteers for antidoping purposes.

    Marchand, Alexandre / Miller, Geoff / Martin, Laurent / Gobbo, Coralie / Crouch, Andre K / Eichner, Daniel / Ericsson, Magnus

    Drug testing and analysis

    2022  Band 14, Heft 11-12, Seite(n) 1952–1961

    Abstract: Luspatercept (Reblozyl®) is a newly approved anti-anemic drug prohibited by the World Anti-Doping Agency. It promotes erythropoiesis by limiting apoptosis of immature erythroblasts and the risk of misuse by athletes for doping is high. Proposed detection ...

    Abstract Luspatercept (Reblozyl®) is a newly approved anti-anemic drug prohibited by the World Anti-Doping Agency. It promotes erythropoiesis by limiting apoptosis of immature erythroblasts and the risk of misuse by athletes for doping is high. Proposed detection methods have been published recently but only evaluated in vitro. The objective of this study was to perform the first administration of luspatercept in healthy volunteers for antidoping purpose and to evaluate the detectability in serum, dried capillary blood spots (DBS, collected using TASSO M20 device), and urine. Indirect detection was also evaluated by analyzing hematological parameters for the Athlete Biological Passport. Four volunteers (two males, two females) received one subtherapeutic dose of luspatercept (0.25 mg/kg) followed 3 weeks after by a second dose. Samples were collected from before administration until 7 weeks after the second dose. After immunopurification, electrophoretic separation SDS-/SAR-/IEF- polyacrylamide gel electrophoresis (PAGE), and immunodetection, luspatercept was detected at high levels in serum until the end of the collection, sign of a very slow elimination and similarly detected unchanged at lower levels in urine from 2 days after the first administration until 7 weeks postadministration. DBS showed also the same long window of detection. Luspatercept effects were however of limited amplitude on hematological markers, and only two subjects presented atypical points outside the physiological limits during the study. The direct detection method was very efficient, and change of electrophoretic method and detection antibody can be used for confirmation of suspicious samples.
    Mesh-Begriff(e) Male ; Female ; Humans ; Hematinics ; Healthy Volunteers ; Activin Receptors, Type II ; Immunoglobulin Fc Fragments ; Doping in Sports ; Substance Abuse Detection/methods
    Chemische Substanzen Hematinics ; luspatercept (AQK7UBA1LS) ; Activin Receptors, Type II (EC 2.7.11.30) ; Immunoglobulin Fc Fragments
    Sprache Englisch
    Erscheinungsdatum 2022-07-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.3341
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss.

    Chaudhury, Anwesha / Miller, Geoff D / Eichner, Daniel / Higgins, John M

    eLife

    2019  Band 8

    Abstract: Low blood count is a fundamental disease state and is often an early sign of illnesses including infection, cancer, and malnutrition, but our understanding of the homeostatic response to blood loss is limited, in part by coarse interpretation of blood ... ...

    Abstract Low blood count is a fundamental disease state and is often an early sign of illnesses including infection, cancer, and malnutrition, but our understanding of the homeostatic response to blood loss is limited, in part by coarse interpretation of blood measurements. Many common clinical blood tests actually include thousands of single-cell measurements. We present an approach for modeling the unsteady-state population dynamics of the human response to controlled blood loss using these clinical measurements of single-red blood cell (RBC) volume and hemoglobin. We find that the response entails (1) increased production of new RBCs earlier than is currently detectable clinically and (2) a previously unrecognized decreased RBC turnover. Both component responses offset the loss of blood. The model provides a personalized dimensionless ratio that quantifies the balance between increased production and delayed clearance for each individual and may enable earlier detection of both blood loss and the response it elicits.
    Mesh-Begriff(e) Adolescent ; Adult ; Blood Cell Count/statistics & numerical data ; Erythrocyte Indices/physiology ; Erythrocytes/cytology ; Erythrocytes/physiology ; Female ; Hemoglobins/metabolism ; Hemorrhage/blood ; Homeostasis/physiology ; Humans ; Kinetics ; Male ; Models, Statistical ; Single-Cell Analysis/methods
    Chemische Substanzen Hemoglobins
    Sprache Englisch
    Erscheinungsdatum 2019-12-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.48590
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Use of a catch-up programme to improve routine immunization in 13 provinces of Papua New Guinea, 2020-2022.

    Mekonnen, Dessie Ayalew / Bauri, Mathias / Pogo, Martha / Shang, Mei / Bettels, Deborah / Kabir, Shaikh Humayun / Edward, Waramin / Sibauk, Bieb / Dalton, Milena / Miller, Geoff / Amarasinghe, Ananda / Takashima, Yoshihiro / Luo, Dapeng / Huseynova, Sevil

    Western Pacific surveillance and response journal : WPSAR

    2023  Band 14, Heft 4, Seite(n) 1–6

    Abstract: Objective: Routine immunization coverage in Papua New Guinea has decreased in the past 5 years. This persistently low routine immunization coverage has resulted in low population immunity and frequent outbreaks of vaccine-preventable disease across the ... ...

    Abstract Objective: Routine immunization coverage in Papua New Guinea has decreased in the past 5 years. This persistently low routine immunization coverage has resulted in low population immunity and frequent outbreaks of vaccine-preventable disease across the country. We describe the use of a catch-up programme to improve routine immunization during the coronavirus disease pandemic in Papua New Guinea during 2020-2022.
    Methods: In June 2020, 13 provinces of Papua New Guinea were selected to undergo a vaccination catch-up programme, with technical support from the World Health Organization (WHO) and the United Nations Children's Fund. Twelve provinces received financial and logistic support through the Accelerated Immunization and Health Systems Strengthening programme, and one received support from WHO. All stakeholders were involved in planning and implementing the catch-up programme.
    Results: Between July 2020 and June 2022, about 340 health facilities conducted catch-up activities. The highest number of children aged under 1 year were vaccinated in 2022 (
    Discussion: The catch-up programme was an instrumental tool to improve routine immunization coverage between 2020 and 2022 and during the pandemic in Papua New Guinea. With appropriate technical and logistic support, including financial and human resources, catch-up programmes can strengthen routine immunization coverage across the country.
    Mesh-Begriff(e) Child ; Humans ; Papua New Guinea/epidemiology ; Vaccination ; Immunization ; Vaccination Coverage ; Measles Vaccine ; Vaccines, Combined ; Immunization Programs
    Chemische Substanzen Measles Vaccine ; Vaccines, Combined
    Sprache Englisch
    Erscheinungsdatum 2023-12-19
    Erscheinungsland Philippines
    Dokumenttyp Case Reports
    ZDB-ID 2592503-9
    ISSN 2094-7313 ; 2094-7313
    ISSN (online) 2094-7313
    ISSN 2094-7313
    DOI 10.5365/wpsar.2023.14.4.1055
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Detection and in vitro metabolism of the confiscated peptides BPC 157 and MGF R23H.

    Cox, Holly D / Miller, Geoff D / Eichner, Daniel

    Drug testing and analysis

    2017  Band 9, Heft 10, Seite(n) 1490–1498

    Abstract: A new peptide, body protecting compound (BPC), BPC 157, and a variant of mechano-growth factor (MGF), MGF R23H, were identified in confiscated vials. BPC 157 has the amino acid sequence, GEPPPGKPADDAGLV, and is currently under investigation for the ... ...

    Abstract A new peptide, body protecting compound (BPC), BPC 157, and a variant of mechano-growth factor (MGF), MGF R23H, were identified in confiscated vials. BPC 157 has the amino acid sequence, GEPPPGKPADDAGLV, and is currently under investigation for the promotion of healing and recovery in a variety of tissues. In vitro metabolism experiments in plasma demonstrate that MGF R23H has good stability and should be detectable in urine, while BPC 157 forms a stable metabolite that should be detectable in urine. A weak cation exchange solid phase extraction method was validated for detection of BPC 157 in urine. The method has a limit of detection of 0.1 ng/mL, precision of less than 20%, and good linearity, r
    Mesh-Begriff(e) Amino Acid Sequence ; Doping in Sports ; Female ; Humans ; Insulin-Like Growth Factor I/analysis ; Insulin-Like Growth Factor I/metabolism ; Insulin-Like Growth Factor I/urine ; Limit of Detection ; Male ; Peptide Fragments/analysis ; Peptide Fragments/metabolism ; Peptide Fragments/urine ; Proteins/analysis ; Proteins/metabolism ; Solid Phase Extraction/methods ; Substance Abuse Detection/methods
    Chemische Substanzen Peptide Fragments ; Proteins ; Insulin-Like Growth Factor I (67763-96-6) ; BPC 157 (8ED8NXK95P)
    Sprache Englisch
    Erscheinungsdatum 2017-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Validation Studies
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.2152
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: A tale of forgery, pharmacy and a famous murder.

    Miller, Geoff

    Pharmacy history Australia : the newsletter of the Australian Academy of the History of Pharmacy

    2003  , Heft 19, Seite(n) 3–7

    Mesh-Begriff(e) Australia ; Crime/history ; History, 19th Century ; Pharmacy/history
    Sprache Englisch
    Erscheinungsdatum 2003-03
    Erscheinungsland Australia
    Dokumenttyp Historical Article ; Journal Article
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Tasmania: green pastures for the Browne family of pharmacists.

    Miller, Geoff

    Pharmacy history Australia : the newsletter of the Australian Academy of the History of Pharmacy

    2002  , Heft 16, Seite(n) 4–6

    Abstract: This is the story of another Pharmacy dynasty, the Brownes of Tasmania, who can trace three generations of pharmacists from the one family, going back to 1882. ...

    Abstract This is the story of another Pharmacy dynasty, the Brownes of Tasmania, who can trace three generations of pharmacists from the one family, going back to 1882.
    Mesh-Begriff(e) Australia ; History, 19th Century ; History, 20th Century ; Pharmacists/history ; Pharmacopoeias, Homeopathic/history
    Sprache Englisch
    Erscheinungsdatum 2002-05-07
    Erscheinungsland Australia
    Dokumenttyp Biography ; Historical Article ; Journal Article ; Portrait
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Door to door collectibles. Salves, lotions, pills and potions from W.T. Rawleigh.

    Miller, Geoff

    Pharmacy history Australia : the newsletter of the Australian Academy of the History of Pharmacy

    2002  , Heft 17, Seite(n) 7–10

    Mesh-Begriff(e) Commerce/history ; Equipment and Supplies/history ; History, 19th Century ; History, 20th Century ; Pharmacy/history ; United States
    Sprache Englisch
    Erscheinungsdatum 2002-07
    Erscheinungsland Australia
    Dokumenttyp Biography ; Historical Article ; Journal Article
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Konferenzbeitrag ; Online: Australian Agricultural & Trade Policy

    Miller, Geoff

    Adventures of a (former) Policy Activist

    2006  

    Schlagwörter Agricultural and Food Policy
    Sprache Englisch
    Verlag AgEcon Search
    Erscheinungsland us
    Dokumenttyp Konferenzbeitrag ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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