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Article ; Online: Iron deficiency anemia: a common and curable disease.

Miller, Jeffery L

Cold Spring Harbor perspectives in medicine

2013 Volume 3, Issue 7

Abstract: Iron deficiency anemia arises when the balance of iron intake, iron stores, and the body's loss of iron are insufficient to fully support production of erythrocytes. Iron deficiency anemia rarely causes death, but the impact on human health is ... ...

Abstract	Iron deficiency anemia arises when the balance of iron intake, iron stores, and the body's loss of iron are insufficient to fully support production of erythrocytes. Iron deficiency anemia rarely causes death, but the impact on human health is significant. In the developed world, this disease is easily identified and treated, but frequently overlooked by physicians. In contrast, it is a health problem that affects major portions of the population in underdeveloped countries. Overall, the prevention and successful treatment for iron deficiency anemia remains woefully insufficient worldwide, especially among underprivileged women and children. Here, clinical and laboratory features of the disease are discussed, and then focus is placed on relevant economic, environmental, infectious, and genetic factors that converge among global populations.
MeSH term(s)	Adult ; Anemia, Iron-Deficiency/epidemiology ; Anemia, Iron-Deficiency/etiology ; Anemia, Iron-Deficiency/prevention & control ; Animals ; Child ; Constriction ; Dietary Supplements ; Early Diagnosis ; Female ; Ferritins/physiology ; Global Health ; Hemorrhage/complications ; Hepcidins/physiology ; Hookworm Infections/complications ; Humans ; Iron/therapeutic use ; Malabsorption Syndromes/complications ; Malaria/complications ; Male ; Perinatal Care/methods ; Pregnancy ; Pregnancy Complications, Hematologic/epidemiology ; Pregnancy Complications, Hematologic/prevention & control ; Transferrin/physiology ; Umbilical Cord
Chemical Substances	Hepcidins ; Transferrin ; Ferritins (9007-73-2) ; Iron (E1UOL152H7)
Language	English
Publishing date	2013-07-01
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2157-1422
ISSN (online)	2157-1422
DOI	10.1101/cshperspect.a011866
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sickle cell disease in children.

Meier, Emily Riehm / Miller, Jeffery L

Drugs

2012 Volume 72, Issue 7, Page(s) 895–906

Abstract: Early identification of infants with sickle cell disease (SCD) by newborn screening, now universal in all 50 states in the US, has improved survival, mainly by preventing overwhelming sepsis with the early use of prophylactic penicillin. Routine ... ...

Abstract	Early identification of infants with sickle cell disease (SCD) by newborn screening, now universal in all 50 states in the US, has improved survival, mainly by preventing overwhelming sepsis with the early use of prophylactic penicillin. Routine transcranial Doppler screening with the institution of chronic transfusion decreases the risk of stroke from 10% to 1% in paediatric SCD patients. Hydroxyurea decreases the number and frequency of painful crises, acute chest syndromes and number of blood transfusions in children with SCD. Genetic research continues to be driven toward the prevention and ultimate cure of SCD before adulthood. This review focuses on clinical manifestations and therapeutic strategies for paediatric SCD as well as the evolving topic of gene-focused prevention and therapy.
MeSH term(s)	Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/diagnosis ; Anemia, Sickle Cell/drug therapy ; Blood Transfusion ; Child ; Child, Preschool ; Genetic Predisposition to Disease ; Humans ; Hydroxyurea/therapeutic use ; Infant ; Infant, Newborn ; Mass Screening/methods ; Neonatal Screening/methods ; Stroke/prevention & control ; Ultrasonography, Doppler, Transcranial/methods
Chemical Substances	Hydroxyurea (X6Q56QN5QC)
Language	English
Publishing date	2012-05-08
Publishing country	New Zealand
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	120316-2
ISSN	1179-1950 ; 0012-6667
ISSN (online)	1179-1950
ISSN	0012-6667
DOI	10.2165/11632890-000000000-00000
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Zs.A 762: Show issues

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Article: Signaled expression of fetal hemoglobin during development.

Miller, Jeffery L

Transfusion

2005 Volume 45, Issue 7, Page(s) 1229–1232

MeSH term(s)	Animals ; Cells, Cultured ; Erythroblasts/cytology ; Erythroblasts/metabolism ; Erythropoiesis ; Erythropoietin/pharmacology ; Fetal Hemoglobin/biosynthesis ; Fetal Hemoglobin/chemistry ; Fetal Hemoglobin/genetics ; Fetal Hemoglobin/metabolism ; Gene Expression Regulation/drug effects ; Growth and Development ; Humans ; Models, Biological ; Signal Transduction
Chemical Substances	Erythropoietin (11096-26-7) ; Fetal Hemoglobin (9034-63-3)
Language	English
Publishing date	2005-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/j.1537-2995.2005.00182.x
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Zs.A 284: Show issues

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Article ; Online: Ask about ice, then consider iron.

Rabel, Antoinette / Leitman, Susan F / Miller, Jeffery L

Journal of the American Association of Nurse Practitioners

2015 Volume 28, Issue 2, Page(s) 116–120

Abstract: Background and purpose: The study aims to review a condition defined by the desire to consume ice in order to satisfy an addictive-like compulsion, rather than for purposes of hydration or pain relief. This condition is called ice pica, or pagophagia. ... ...

Abstract	Background and purpose: The study aims to review a condition defined by the desire to consume ice in order to satisfy an addictive-like compulsion, rather than for purposes of hydration or pain relief. This condition is called ice pica, or pagophagia. Associations between ice pica and iron deficiency, suggestions for clinical screening of at risk populations, and recommendations for treatment and follow-up care are provided. Data sources: An extensive literature review of original research articles, reviews, clinical practice manuscripts, and scientific publications on pica and pagophagia. Conclusions: A compulsion or craving for the consumption of ice is often overlooked in clinical practice. It is therefore important for clinicians to include ice pica as part of the review of systems for certain patient populations. Ice pica is frequently associated with iron deficiency, and iron supplementation is an effective therapy in most cases. Implications for practice: Knowledge gained from screening for ice pica can generate valuable patient information and lead to the diagnosis and treatment of iron deficiency. The populations at risk include young women and blood donors of either sex.
MeSH term(s)	Anemia, Iron-Deficiency/diagnosis ; Female ; Humans ; Ice ; Iron/analysis ; Iron/therapeutic use ; Male ; Pica/diagnosis ; Pica/psychology
Chemical Substances	Ice ; Iron (E1UOL152H7)
Language	English
Publishing date	2015-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2716317-9
ISSN	2327-6924 ; 1745-7599 ; 2327-6886 ; 1041-2972
ISSN (online)	2327-6924 ; 1745-7599
ISSN	2327-6886 ; 1041-2972
DOI	10.1002/2327-6924.12268
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Zs.A 2909: Show issues

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Article: A genome-based approach for the study of erythroid biology and disease.

Miller, Jeffery L

Blood cells, molecules & diseases

2004 Volume 32, Issue 3, Page(s) 341–343

Abstract: The human genome contains all elements of the erythroid transcriptome with the exception of those genes encoded in mitochondrial DNA. The concept of a "genome-based" approach for the study of erythroid biology and disease was envisioned in the mid-1990s ... ...

Abstract	The human genome contains all elements of the erythroid transcriptome with the exception of those genes encoded in mitochondrial DNA. The concept of a "genome-based" approach for the study of erythroid biology and disease was envisioned in the mid-1990s as a logical offshoot of efforts to map the human genome. Although a completed human genome map was not expected until 2005 [Science 279 (1998) 23], the idea of creating a robust and retrievable description of erythroid gene activity was both encouraged and supported on the NIDDK Bethesda campus of the National Institutes of Health. The 5-10-year goals were organized into three parts. The initial project goal involved the collection of sequence data derived from mRNA expressed in developmentally staged erythroblasts. Those cells were isolated prospectively by flow cytometry monitoring of CD71 and glycophorin A expression patterns. Next, the sequence data was organized into a database and integrated with related information available in the public domain. The paramount goal of the project continues to be clinical application. As discussed in this paper, progress already made in each of these areas suggests that genome-based approaches will greatly facilitate future studies of erythroid biology and disease.
MeSH term(s)	Animals ; Databases, Factual ; Erythrocytes ; Genomics/methods ; Hematologic Diseases/genetics ; Humans ; RNA, Messenger/analysis ; RNA, Messenger/genetics ; Research Design
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2004-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1237083-6
ISSN	1096-0961 ; 1079-9796
ISSN (online)	1096-0961
ISSN	1079-9796
DOI	10.1016/j.bcmd.2004.01.003
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Zs.A 1138: Show issues

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Article: [GDF15 expression and iron overload in ineffective erythropoiesis].

Tanno, Toshihiko / Miller, Jeffery L

Rinsho ketsueki] The Japanese journal of clinical hematology

2011 Volume 52, Issue 6, Page(s) 387–398

MeSH term(s)	Antimicrobial Cationic Peptides/metabolism ; Erythroblasts/secretion ; Erythropoiesis/physiology ; Gene Expression ; Growth Differentiation Factor 15/metabolism ; Growth Differentiation Factor 15/physiology ; Hematologic Diseases/blood ; Hematologic Diseases/genetics ; Hepcidins ; Humans ; Iron/metabolism ; Iron Overload/blood ; Iron Overload/genetics ; Liver/metabolism ; Proteins/physiology ; Proteins/secretion
Chemical Substances	Antimicrobial Cationic Peptides ; GDF15 protein, human ; Growth Differentiation Factor 15 ; Hepcidins ; Proteins ; twisted gastrulation protein, mouse ; Iron (E1UOL152H7)
Language	English
Publishing date	2011-06
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	390900-1
ISSN	0485-1439
ISSN	0485-1439
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Zs.A 1175: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 535: Show issues

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Article ; Online: Reticulocytosis and anemia are associated with an increased risk of death and stroke in the newborn cohort of the Cooperative Study of Sickle Cell Disease.

Meier, Emily Riehm / Wright, Elizabeth C / Miller, Jeffery L

American journal of hematology

2014 Volume 89, Issue 9, Page(s) 904–906

Abstract: Prior analyses of the Cooperative Study of Sickle Cell Disease (CSSCD) newborn cohort identified elevated white blood cell (WBC) count, low baseline hemoglobin and dactylitis between the ages of 1 and 2 years as markers of severe disease. Reticulocytosis ...

Abstract	Prior analyses of the Cooperative Study of Sickle Cell Disease (CSSCD) newborn cohort identified elevated white blood cell (WBC) count, low baseline hemoglobin and dactylitis between the ages of 1 and 2 years as markers of severe disease. Reticulocytosis was also associated with severe disease. Here, we further analyzed data collected on enrolled CSSCD infants for the predictive value of those markers for stroke and death later in life. Three hundred fifty-four CSSCD subjects were identified who had absolute reticulocyte counts (ARC) measured during infancy (2 to 6 months of age). Infants with higher ARC had significantly increased risk of stroke or death during childhood; lower hemoglobin levels also increased the risk but to a lesser degree than ARC. WBC levels and dactylitis were not predictive of death or stroke. These data suggest that reticulocytosis among asymptomatic infants with sickle cell anemia is associated with an increased risk of death or stroke during childhood.
MeSH term(s)	Anemia, Sickle Cell/blood ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/mortality ; Child, Preschool ; Female ; Hemoglobins/analysis ; Humans ; Infant ; Infant, Newborn ; Kaplan-Meier Estimate ; Leukocyte Count ; Male ; Predictive Value of Tests ; Reticulocyte Count ; Reticulocytes/cytology ; Reticulocytosis ; Risk ; Stroke/blood ; Stroke/etiology ; Stroke/mortality
Chemical Substances	Hemoglobins
Language	English
Publishing date	2014-06-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.23777
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Zs.A 1251: Show issues

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Article ; Online: Iron Loading and Overloading due to Ineffective Erythropoiesis.

Tanno, Toshihiko / Miller, Jeffery L

Advances in hematology

2010 Volume 2010, Page(s) 358283

Abstract: Erythropoiesis describes the hematopoietic process of cell proliferation and differentiation that results in the production of mature circulating erythrocytes. Adult humans produce 200 billion erythrocytes daily, and approximately 1 billion iron ... ...

Abstract	Erythropoiesis describes the hematopoietic process of cell proliferation and differentiation that results in the production of mature circulating erythrocytes. Adult humans produce 200 billion erythrocytes daily, and approximately 1 billion iron molecules are incorporated into the hemoglobin contained within each erythrocyte. Thus, iron usage for the hemoglobin production is a primary regulator of plasma iron supply and demand. In many anemias, additional sources of iron from diet and tissue stores are needed to meet the erythroid demand. Among a subset of anemias that arise from ineffective erythropoiesis, iron absorption and accumulation in the tissues increases to levels that are in excess of erythropoiesis demand even in the absence of transfusion. The mechanisms responsible for iron overloading due to ineffective erythropoiesis are not fully understood. Based upon data that is currently available, it is proposed in this review that loading and overloading of iron can be regulated by distinct or combined mechanisms associated with erythropoiesis. The concept of erythroid regulation of iron is broadened to include both physiological and pathological hepcidin suppression in cases of ineffective erythropoiesis.
Language	English
Publishing date	2010-05-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2494501-8
ISSN	1687-9112 ; 1687-9104
ISSN (online)	1687-9112
ISSN	1687-9104
DOI	10.1155/2010/358283
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Book ; Audio / Video: Erythroid cell genomics

Miller, Jeffery L

(NIH director's seminar series)

2005

Title variant	A genome-based approach for the study of erythroid biology & disease
Institution	National Institutes of Health (U.S.). / Medical Arts and Photography Branch
Author's details	Office of Research Services, Medical Arts and Photography Branch
Series title	NIH director's seminar series
MeSH term(s)	Erythroid Cells ; Genomics ; Hemoglobins ; Blood Group Antigens ; Hemoglobinopathies/genetics
Language	English
Size	1 videocassette of 1 (Betacam SP) (55 min.) :, sd., col. ;, 1/2 in. ; 1 videocassette of 1 (VHS) (55 min.) :, sd., col. ;, 1/2 in.
Publisher	National Institutes of Health
Publishing place	Bethesda, Md
Document type	Book ; Audio / Video
Note	Closed-captioned.
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Hemoglobin switching and modulation: genes, cells, and signals.

Miller, Jeffery L

Current opinion in hematology

2002 Volume 9, Issue 2, Page(s) 87–92

Abstract: A detailed understanding of hemoglobin production in erythroid cells is of fundamental clinical importance for the treatment of hemoglobinopathies. Several hundred scientific reports and dozens of reviews describe this intriguing topic of research. Early ...

Abstract	A detailed understanding of hemoglobin production in erythroid cells is of fundamental clinical importance for the treatment of hemoglobinopathies. Several hundred scientific reports and dozens of reviews describe this intriguing topic of research. Early studies demonstrated the temporal nature of a hemoglobin-switching phenomenon during development in the circulating erythrocytes of humans. The focus then shifted from descriptive to experimental analyses and model systems in an effort to define the switching mechanisms. The application of molecular biology in those experimental models has been a primary focus for the last two decades. Today, advances in the fields of stem cell biology and signal transduction are being integrated with those genetic studies. Genomic and proteomic approaches are also being developed to provide a more robust description of the biologic variables involved. This review highlights recent advances in erythroid genetics and cellular biology with an emphasis upon the modulation of fetal hemoglobin expression during the maturation of adult human erythrocytes.
MeSH term(s)	Erythropoiesis/genetics ; Fetal Hemoglobin/genetics ; Gene Expression Regulation, Developmental ; Genes, Switch ; Hemoglobins/genetics ; Humans ; Signal Transduction/physiology
Chemical Substances	Hemoglobins ; Fetal Hemoglobin (9034-63-3)
Language	English
Publishing date	2002-01-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1153887-9
ISSN	1531-7048 ; 1065-6251
ISSN (online)	1531-7048
ISSN	1065-6251
DOI	10.1097/00062752-200203000-00001
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Zs.A 3703: Show issues

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