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  1. Article ; Online: Access to Our Journals.

    Miller, Kenneth G

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

    2019  Volume 77, Issue 10, Page(s) 1965–1966

    MeSH term(s) Access to Information ; Periodicals as Topic ; Publishing
    Language English
    Publishing date 2019-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392404-x
    ISSN 1531-5053 ; 0278-2391
    ISSN (online) 1531-5053
    ISSN 0278-2391
    DOI 10.1016/j.joms.2019.04.034
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  2. Article: End Binding protein 1 promotes specific motor-cargo association in the cell body prior to axonal delivery of Dense Core Vesicles.

    Park, Junhyun / Miller, Kenneth G / De Camilli, Pietro / Yogev, Shaul

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Axonal transport is key to neuronal function. Efficient transport requires specific motor-cargo association in the soma, yet the mechanisms regulating this early step remain poorly understood. We found that EBP-1, ... ...

    Abstract Axonal transport is key to neuronal function. Efficient transport requires specific motor-cargo association in the soma, yet the mechanisms regulating this early step remain poorly understood. We found that EBP-1, the
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.12.523768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Keeping Neuronal Cargoes on the Right Track: New Insights into Regulators of Axonal Transport.

    Miller, Kenneth G

    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

    2016  Volume 23, Issue 3, Page(s) 232–250

    Abstract: In neurons, a single motor (dynein) transports large organelles as well as synaptic and dense core vesicles toward microtubule minus ends; however, it is unclear why dynein appears more active on organelles, which are generally excluded from mature axons, ...

    Abstract In neurons, a single motor (dynein) transports large organelles as well as synaptic and dense core vesicles toward microtubule minus ends; however, it is unclear why dynein appears more active on organelles, which are generally excluded from mature axons, than on synaptic and dense core vesicles, which are maintained at high levels. Recent studies in Zebrafish and Caenorhabditis elegans have shown that JIP3 promotes dynein-mediated retrograde transport to clear some organelles (lysosomes, early endosomes, and Golgi) from axons and prevent their potentially harmful accumulation in presynaptic regions. A JIP3 mutant suppressor screen in C. elegans revealed that JIP3 promotes the clearance of organelles from axons by blocking the action of the CSS system (Cdk5, SAD Kinase, SYD-2/Liprin). A synthesis of results in vertebrates with the new findings suggests that JIP3 blocks the CSS system from disrupting the connection between dynein and organelles. Most components of the CSS system are enriched at presynaptic active zones where they normally contribute to maintaining optimal levels of captured synaptic and dense core vesicles, in part by inhibiting dynein transport. The JIP3-CSS system model explains how neurons selectively regulate a single minus-end motor to exclude specific classes of organelles from axons, while at the same time ensuring optimal levels of synaptic and dense core vesicles.
    MeSH term(s) Animals ; Axonal Transport/physiology ; Humans ; Neurons/metabolism
    Language English
    Publishing date 2016-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1233753-5
    ISSN 1089-4098 ; 1073-8584
    ISSN (online) 1089-4098
    ISSN 1073-8584
    DOI 10.1177/1073858416648307
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  4. Article ; Online: End-binding protein 1 promotes specific motor-cargo association in the cell body prior to axonal delivery of dense core vesicles.

    Park, Junhyun / Xie, Yi / Miller, Kenneth G / De Camilli, Pietro / Yogev, Shaul

    Current biology : CB

    2023  Volume 33, Issue 18, Page(s) 3851–3864.e7

    Abstract: Axonal transport is key to neuronal function. Efficient transport requires specific motor-cargo association in the soma, yet the mechanisms regulating this early step remain poorly understood. We found that EBP-1, the C. elegans ortholog of the canonical- ...

    Abstract Axonal transport is key to neuronal function. Efficient transport requires specific motor-cargo association in the soma, yet the mechanisms regulating this early step remain poorly understood. We found that EBP-1, the C. elegans ortholog of the canonical-microtubule-end-binding protein EB1, promotes the specific association between kinesin-3/KIF1A/UNC-104 and dense core vesicles (DCVs) prior to their axonal delivery. Using single-neuron, in vivo labeling of endogenous cargo and EBs, we observed reduced axonal abundance and reduced secretion of DCV cargo, but not other KIF1A/UNC-104 cargoes, in ebp-1 mutants. This reduction could be traced back to fewer exit events from the cell body, where EBP-1 colocalized with the DCV sorting machinery at the trans Golgi, suggesting that this is the site of EBP-1 function. EBP-1 calponin homology (CH) domain was required for directing microtubule growth on the Golgi, and mammalian EB1 interacted with KIF1A in an EBH-domain-dependent manner. Loss- and gain-of-function experiments suggest a model in which both kinesin-3 binding and guidance of microtubule growth at the trans Golgi by EBP-1 promote motor-cargo association at sites of DCV biogenesis. In support of this model, tethering either EBP-1 or a kinesin-3/KIF1A/UNC-104-interacting domain from an unrelated protein to the Golgi restored the axonal abundance of DCV proteins in ebp-1 mutants. These results uncover an unexpected role for a microtubule-associated protein and provide insights into how specific kinesin-3 cargo is delivered to the axon.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/metabolism ; Kinesins/metabolism ; Cell Body/metabolism ; Dense Core Vesicles ; Neurons/metabolism ; Axons/metabolism ; Mammals
    Chemical Substances Kinesins (EC 3.6.4.4)
    Language English
    Publishing date 2023-08-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.07.052
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  5. Article ; Online: Swallowed prostheses.

    Miller, Kenneth G

    Journal of the American Dental Association (1939)

    2014  Volume 145, Issue 9, Page(s) 916, 919

    MeSH term(s) Deglutition ; Dental Prosthesis/adverse effects ; Female ; Foreign Bodies/etiology ; Humans ; Male ; Respiratory Aspiration/etiology
    Language English
    Publishing date 2014-07-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 220622-5
    ISSN 1943-4723 ; 0002-8177 ; 1048-6364
    ISSN (online) 1943-4723
    ISSN 0002-8177 ; 1048-6364
    DOI 10.1016/s0002-8177(14)60139-2
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  6. Article: Total cost of carbon capture and storage implemented at a regional scale: northeastern and midwestern United States.

    Schmelz, William J / Hochman, Gal / Miller, Kenneth G

    Interface focus

    2020  Volume 10, Issue 5, Page(s) 20190065

    Abstract: We model the costs of carbon capture and storage (CCS) in subsurface geological formations for emissions from 138 northeastern and midwestern electricity-generating power plants. The analysis suggests coal-sourced ... ...

    Abstract We model the costs of carbon capture and storage (CCS) in subsurface geological formations for emissions from 138 northeastern and midwestern electricity-generating power plants. The analysis suggests coal-sourced CO
    Language English
    Publishing date 2020-08-14
    Publishing country England
    Document type Journal Article
    ISSN 2042-8898
    ISSN 2042-8898
    DOI 10.1098/rsfs.2019.0065
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  7. Article ; Online: Localized uplift, widespread subsidence, and implications for sea level rise in the New York City metropolitan area.

    Buzzanga, Brett / Bekaert, David P S / Hamlington, Benjamin D / Kopp, Robert E / Govorcin, Marin / Miller, Kenneth G

    Science advances

    2023  Volume 9, Issue 39, Page(s) eadi8259

    Abstract: Regional relative sea level rise is exacerbating flooding hazards in the coastal zone. In addition to changes in the ocean, vertical land motion (VLM) is a driver of spatial variation in sea level change that can either diminish or enhance flood risk. ... ...

    Abstract Regional relative sea level rise is exacerbating flooding hazards in the coastal zone. In addition to changes in the ocean, vertical land motion (VLM) is a driver of spatial variation in sea level change that can either diminish or enhance flood risk. Here, we apply state-of-the-art interferometric synthetic aperture radar and global navigation satellite system time series analysis to estimate velocities and corresponding uncertainties at 30-m resolution in the New York City metropolitan area, revealing VLM with unprecedented detail. We find broad subsidence of 1.6 mm/year, consistent with glacial isostatic adjustment to the melting of the former ice sheets, and previously undocumented hot spots of both subsidence and uplift that can be physically explained in some locations. Our results inform ongoing efforts to adapt to sea level rise and reveal points of VLM that motivate both future scientific investigations into surface geology and assessments of engineering projects.
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adi8259
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  8. Article ; Online: A well-oxygenated eastern tropical Pacific during the warm Miocene.

    Hess, Anya V / Auderset, Alexandra / Rosenthal, Yair / Miller, Kenneth G / Zhou, Xiaoli / Sigman, Daniel M / Martínez-García, Alfredo

    Nature

    2023  Volume 619, Issue 7970, Page(s) 521–525

    Abstract: The oxygen content of the oceans is susceptible to climate change and has declined in recent ... ...

    Abstract The oxygen content of the oceans is susceptible to climate change and has declined in recent decades
    MeSH term(s) Climate Change/history ; Climate Change/statistics & numerical data ; Oxygen/analysis ; Oxygen/history ; Pacific Ocean ; Seawater/chemistry ; History, Ancient ; History, 21st Century ; Climate Models ; Foraminifera/isolation & purification ; Tropical Climate ; Geographic Mapping ; Uncertainty
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06104-6
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    Zs.MO 244: Show issues

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  9. Article: In my view: CT scanning in the dental office, cone beam computed tomography.

    Miller, Kenneth G

    Pennsylvania dental journal

    2011  Volume 78, Issue 2, Page(s) 27–28

    MeSH term(s) Adolescent ; Adult ; Child ; Cone-Beam Computed Tomography/economics ; Cone-Beam Computed Tomography/utilization ; Cost Savings ; Dental Offices/economics ; Head/radiation effects ; Humans ; Insurance, Dental/economics ; Insurance, Health, Reimbursement ; Practice Management, Dental/economics ; Radiation Dosage ; Safety ; Technology, Dental ; Tomography, X-Ray Computed/utilization ; Young Adult
    Language English
    Publishing date 2011-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603875-x
    ISSN 0031-4439
    ISSN 0031-4439
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  10. Article: Why CT scans are already standard of care?

    Miller, Kenneth G

    Pennsylvania dental journal

    2008  Volume 75, Issue 4, Page(s) 9

    MeSH term(s) Humans ; Radiography, Dental/standards ; Technology, Dental ; Tomography, X-Ray Computed/standards
    Language English
    Publishing date 2008-07
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 603875-x
    ISSN 0031-4439
    ISSN 0031-4439
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