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Book ; Online: Neuronal Mechanics and Transport

Miller, Kyle E. / Suter, Daniel M.

2016

Abstract: Understanding the underlying mechanisms of how axons and dendrites develop is a fundamental problem in neuroscience and a main goal of research on nervous system development and regeneration. Previous studies have provided a tremendous amount of ... ...

Abstract	Understanding the underlying mechanisms of how axons and dendrites develop is a fundamental problem in neuroscience and a main goal of research on nervous system development and regeneration. Previous studies have provided a tremendous amount of information on signaling and cytoskeletal proteins regulating axonal and dendritic growth and guidance. However, relatively little is known about the relative contribution and role of cytoskeletal dynamics, transport of organelles and cytoskeletal components, and force generation to axonal elongation. Advancing the knowledge of these biomechanical processes is critical to better understand the development of the nervous system, the pathological progression of neurodegenerative diseases, acute traumatic injury, and for designing novel approaches to promote neuronal regeneration following disease, stroke, or trauma. Mechanical properties and forces shape the development of the nervous system from the cellular up to the organ level. Recent advances in quantitative live cell imaging, biophysical, and nanotechnological methods such as traction force microscopy, optical tweezers, and atomic force microscopy have enabled researchers to gain better insights into how cytoskeletal dynamics and motor-driven transport, membrane-dynamics, adhesion, and substrate rigidity influence axonal elongation. Given the complexity and mechanical nature of this problem, mathematical modeling contributes significantly to our understanding of neuronal mechanics. Nonetheless, there has been limited direct interaction and discussions between experimentalists and theoreticians in this research area. The purpose of this Frontiers Research Topic is to highlight exciting and important work that is currently developing in the fields of neuronal cell biology, neuronal mechanics, intracellular transport, and mathematical modeling in the form of primary research articles, reviews, perspectives, and commentaries
Keywords	Neurosciences. Biological psychiatry. Neuropsychiatry ; Science (General)
Size	1 electronic resource (212 p.)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020090546
ISBN	9782889198238 ; 2889198235
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: ORIGAMI MODEL FOR TEACHING BINOCULAR INDIRECT OPHTHALMOSCOPY.

Miller, Kyle E

Retina (Philadelphia, Pa.)

2015 Volume 35, Issue 8, Page(s) 1711–1712

MeSH term(s)	Education, Medical, Graduate/methods ; Humans ; Models, Anatomic ; Ophthalmology/education ; Ophthalmoscopy ; Retina/anatomy & histology ; Teaching Materials ; Vision, Binocular
Language	English
Publishing date	2015-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	603192-4
ISSN	1539-2864 ; 0275-004X
ISSN (online)	1539-2864
ISSN	0275-004X
DOI	10.1097/IAE.0000000000000710
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Article ; Online: Live Imaging and Quantitative Analysis of Organelle Transport in Sensory Neurons of Aplysia Californica.

Badal, Kerriann / Zhao, Yibo / Miller, Kyle E / Puthanveettil, Sathyanarayanan V

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2431, Page(s) 23–48

Abstract: Axonal transport moves proteins, RNAs, and organelles between the soma and synapses to support synaptic function and activity-dependent changes in synaptic strength. This transport is impaired in several neurodegenerative disorders such as Alzheimer's ... ...

Abstract	Axonal transport moves proteins, RNAs, and organelles between the soma and synapses to support synaptic function and activity-dependent changes in synaptic strength. This transport is impaired in several neurodegenerative disorders such as Alzheimer's disease. Thus, it is critical to understand the regulation and underlying mechanisms of the transport process. Aplysia californica provides a powerful experimental system for studying the interplay between synaptic activity and transport because its defined synaptic circuits can be built in-vitro. Advantages include precise pre- and postsynaptic manipulation, and high-resolution imaging of axonal transport. Here, we describe methodologies for the quantitative analysis of axonal transport in Aplysia sensory neurons.
MeSH term(s)	Animals ; Aplysia/physiology ; Axonal Transport/physiology ; Organelles/metabolism ; Sensory Receptor Cells ; Synapses/metabolism
Language	English
Publishing date	2022-05-23
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1990-2_2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An Integrated Cytoskeletal Model of Neurite Outgrowth.

Miller, Kyle E / Suter, Daniel M

Frontiers in cellular neuroscience

2018 Volume 12, Page(s) 447

Abstract: Neurite outgrowth underlies the wiring of the nervous system during development and regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics of growth and guidance are not fully understood, and the relative ... ...

Abstract	Neurite outgrowth underlies the wiring of the nervous system during development and regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics of growth and guidance are not fully understood, and the relative contributions of individual cytoskeletal processes to neurite growth are controversial. Here, we review the structural organization and biophysical properties of neurons to make a semi-quantitative comparison of the relative contributions of different processes to neurite growth. From this, we develop the idea that neurons are active fluids, which generate strong contractile forces in the growth cone and weaker contractile forces along the axon. As a result of subcellular gradients in forces and material properties, actin flows rapidly rearward in the growth cone periphery, and microtubules flow forward in bulk along the axon. With this framework, an integrated model of neurite outgrowth is proposed that hopefully will guide new approaches to stimulate neuronal growth.
Language	English
Publishing date	2018-11-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2018.00447
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effectiveness of the Ophthalmological Training Component of the STOMP (Simulation Training for Operational Medical Providers) Curriculum.

Spooner, Michael T / Delorey, Donald / Miller, Kyle E / Greer, Joy A

Cureus

2021 Volume 13, Issue 2, Page(s) e13269

Abstract: Introduction: Simulation has been used in medicine to train clinicians to manage a variety of clinical scenarios. A key adaptation of the use of simulation in military healthcare occurred in 2015 with the development of the STOMP (Simulation Training ... ...

Abstract	Introduction: Simulation has been used in medicine to train clinicians to manage a variety of clinical scenarios. A key adaptation of the use of simulation in military healthcare occurred in 2015 with the development of the STOMP (Simulation Training for Operational Medical Providers) curriculum, a specific curriculum designed for the intern (PGY-1) trained physicians being sent into the military to practice primary care. Despite showing the curriculum's influence on self-perceived comfort scores, no study has determined whether simulation is an effective means of improving general medical officer (GMO) physicians' skills compared to other traditional styles of education. Specifically, this study sought to determine whether simulation-based education (SBE) of ophthalmologic skills improves GMO physicians' clinical performance, as compared to traditional didactic-based instruction. Methods: The study, conducted at Naval Medical Center Portsmouth, included GMO physicians who were enrolled in the 2019 STOMP class. Following a brief overview of the study, GMO physicians who elected to participate in the study were randomized to either SBE or lecture-based training for three commonly used ophthalmological procedures: slit lamp exam, tonometry, and corneal foreign body removal. After completing the simulation and lecture-based education training sessions, participants' procedural performance was evaluated utilizing a locally developed performance checklist, and completion time for each of the three procedures was recorded. Data were analyzed using the t-test and Mann-Whitney test. A significance level of 0.05 was considered to be statistically significant. Results: Of the 50 consented participants, 46 completed the study. The mean overall completion scores for the performance checklists were significantly higher for the SBE group (n=26) compared to the lecture group (n=20) [80% (95% CI 78-82%) vs 41% (95% CI 35-47%), respectively]. Time to completion of the individual tasks was also significantly shorter for the SBE group compared to the lecture group (with mean differences ranging from 27 to 126 seconds, all p<.05). Conclusions: Simulation-based training appeared to be more effective at teaching three ophthalmological procedures (slit lamp exam, tonometry, and corneal foreign body removal) to GMO physicians compared to didactic-based instruction alone.
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.13269
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Needle decompression of the eye! Emergent management of a vision threatening surgical complication.

Norling, Karen / Lange, Kristopher / Bloom, Adam / Miller, Kyle E

The American journal of emergency medicine

2021 Volume 51, Page(s) 428.e1–428.e3

Abstract: Acute angle-closure glaucoma (AACG) is a medical emergency that can cause permanent visual deficits without prompt recognition. From 2006 to 2011, nearly 12 million visits to emergency departments (ED) in the United States were ophthalmologic in nature, ... ...

Abstract	Acute angle-closure glaucoma (AACG) is a medical emergency that can cause permanent visual deficits without prompt recognition. From 2006 to 2011, nearly 12 million visits to emergency departments (ED) in the United States were ophthalmologic in nature, making it crucial for emergency physicians to be familiar with the diagnosis and treatment of ophthalmologic emergencies. AACG can be precipitated by several mechanisms including pupillary block, anticholinergic medications, and sympathomimetic medications. We present a rare case of angle-closure glaucoma status post pneumatic retinopexy with cryotherapy due to migration of an intravitreal gas bubble into the anterior chamber with emphasis on understanding how retinal surgery types lead to significant differences in management.
MeSH term(s)	Acute Disease ; Anterior Chamber/pathology ; Cryotherapy/adverse effects ; Decompression/methods ; Glaucoma, Angle-Closure/etiology ; Glaucoma, Angle-Closure/surgery ; Humans ; Male ; Middle Aged ; Needles ; Retina/surgery
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2021.06.078
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Article ; Online: Diplopia and Strabismus After Corneal Refractive Surgery.

Mehta, Aditya / Reed, Donovan / Miller, Kyle E

Military medicine

2019 Volume 185, Issue 5-6, Page(s) e755–e758

Abstract: Introduction: Diplopia and strabismus are known complications after corneal refractive surgery (CRS). Within the U.S. Armed Forces, refractive surgery is used to improve the operational readiness of the service member, and these complications could ... ...

Abstract	Introduction: Diplopia and strabismus are known complications after corneal refractive surgery (CRS). Within the U.S. Armed Forces, refractive surgery is used to improve the operational readiness of the service member, and these complications could cause significant degradation to their capability. This study was performed in order to identify the incidence of strabismus and diplopia following CRS within the U.S. Military Health System. Methods: A retrospective review of all patients who underwent photorefractive keratectomy (PRK) or laser-assisted in situ keratomileusis (LASIK) in the Department of Defense from January 2006 through September 2013 was designed and approved by the Naval Medical Center Portsmouth Institutional Review Board. The military health system data mart was queried for all patients who underwent one of these procedures and subsequently had an International Classification of Disease-9 code for any strabismus or diplopia through 2014 allowing at least 1 year of follow-up. We then calculated the incidence of both diplopia and strabismus for these procedures as the primary measure and the overall prevalence as a secondary measure. Results: A total of 108,157 patients underwent PRK or LASIK during our study period with 41 of these patients subsequently having a diagnosis of diplopia or strabismus. After chart review, 16 of these patients were excluded resulting in 25 patients for inclusion in either the strabismus (23 patients, 0.02%) or diplopia (3 patients, 0.003%) cohorts with one patient having both. Of the 23 patients with postoperative strabismus, 4 were new cases giving an incidence of 0.004% and 2 new cases of diplopia for an incidence of 0.002%. Conclusion: Diplopia and strabismus are rare complications after CRS in the U.S. military population. These procedures continue to increase the operational readiness of our service members with minimal risk of these potentially debilitating complications. Overall, this study provides support for the continued use of PRK and LASIK despite study limitations related to the use of large databases for retrospective review. Future prospective studies using delineated preoperative and postoperative examinations with sensorimotor testing included may be able to resolve the limitations of this study.
MeSH term(s)	Cornea/surgery ; Diplopia/epidemiology ; Diplopia/etiology ; Humans ; Keratomileusis, Laser In Situ/adverse effects ; Lasers, Excimer/adverse effects ; Photorefractive Keratectomy/adverse effects ; Prospective Studies ; Retrospective Studies ; Strabismus/epidemiology ; Strabismus/surgery
Language	English
Publishing date	2019-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usz395
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Article: Editorial: Neuronal Mechanics and Transport.

Miller, Kyle E / Suter, Daniel M

Frontiers in cellular neuroscience

2016 Volume 10, Page(s) 1

Language	English
Publishing date	2016-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2016.00001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Penetrating Orbital Injury From a Needlefish.

Miller, Kyle E / Coan, Erin B

Military medicine

2016 Volume 181, Issue 8, Page(s) e962–4

Abstract: Orbital penetrating injuries are an unfortunately common occurrence; however, those from marine animals are rare. Injuries from marine animals can be quite profound and there are no known reports of complete visual recovery after an orbital penetrating ... ...

Abstract	Orbital penetrating injuries are an unfortunately common occurrence; however, those from marine animals are rare. Injuries from marine animals can be quite profound and there are no known reports of complete visual recovery after an orbital penetrating injury. Complications range from secondary infection to a carotid-cavernous fistula, which can complicate the management of these patients. We report a case of penetrating orbital injury from a needlefish with complete return of visual function after surgical removal of foreign debris and an extended course of antibiotics.
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.7205/MILMED-D-15-00449
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Article ; Online: Modeling the Axon as an Active Partner with the Growth Cone in Axonal Elongation.

de Rooij, Rijk / Kuhl, Ellen / Miller, Kyle E

Biophysical journal

2018 Volume 115, Issue 9, Page(s) 1783–1795

Abstract: Forces generated by the growth cone are vital for the proper development of the axon and thus brain function. Although recent experiments show that forces are generated along the axon, it is unknown whether the axon plays a direct role in controlling ... ...

Abstract	Forces generated by the growth cone are vital for the proper development of the axon and thus brain function. Although recent experiments show that forces are generated along the axon, it is unknown whether the axon plays a direct role in controlling growth cone advance. Here, we use analytic and finite element modeling of microtubule dynamics and the activity of the molecular motors myosin and dynein to investigate mechanical force balance along the length of the axon and its effects on axonal outgrowth. Our modeling indicates that the paradoxical effects of stabilizing microtubules and the consequences of microtubule disassembly on axonal outgrowth can be explained by changes in the passive and active mechanical properties of axons. Our findings suggest that a full understanding of growth cone motility requires a consideration of the mechanical contributions of the axon. Our study not only has potential applications during neurodevelopment but might also help identify strategies to manipulate and promote axonal regrowth to treat neurodegeneration.
MeSH term(s)	Actins/metabolism ; Axons/metabolism ; Biomechanical Phenomena ; Cytoskeleton/metabolism ; Dyneins/metabolism ; Growth Cones/metabolism ; Mechanical Phenomena ; Microtubules/metabolism ; Models, Neurological ; Myosins/metabolism ; Viscosity ; tau Proteins/metabolism
Chemical Substances	Actins ; tau Proteins ; Myosins (EC 3.6.4.1) ; Dyneins (EC 3.6.4.2)
Language	English
Publishing date	2018-10-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	218078-9
ISSN	1542-0086 ; 0006-3495
ISSN (online)	1542-0086
ISSN	0006-3495
DOI	10.1016/j.bpj.2018.08.047
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