Result 1 - 10 of total 40
An update from the Office for Students: 2 April 2020
2020
| Keywords | covid19 |
|---|---|
| Language | English |
| Publisher | Office for Students |
| Publishing country | uk |
| Document type | Book ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
The Cochrane database of systematic reviews
2019 Volume 4, Page(s) CD003498
Abstract: Background: It has been suggested that peptides from gluten and casein may have a role in the origins of autism and that the physiology and psychology of autism might be explained by excessive opioid activity linked to these peptides. Research has ... ...
| Abstract | Background: It has been suggested that peptides from gluten and casein may have a role in the origins of autism and that the physiology and psychology of autism might be explained by excessive opioid activity linked to these peptides. Research has reported abnormal levels of peptides in the urine and cerebrospinal fluid of people with autism. Objectives: To determine the efficacy of gluten and/or casein free diets as an intervention to improve behaviour, cognitive and social functioning in individuals with autism. Search methods: The following electronic databases were searched: CENTRAL(The Cochrane Library Issue 2, 2007), MEDLINE (1966 to April 2007), PsycINFO (1971 to April 2007), EMBASE (1974 to April 2007), CINAHL (1982 to April 2007), ERIC (1965 to 2007), LILACS (1982 to April 2007), and the National Research register 2007 (Issue1). Review bibliographies were also examined to identify potential trials. Selection criteria: All randomised controlled trials (RCT) involving programmes which eliminated gluten, casein or both gluten and casein from the diets of individuals diagnosed with an autistic spectrum disorder. Data collection and analysis: Abstracts of studies identified in searches of electronic databases were assessed to determine inclusion by two independent authors The included trials did not share common outcome measures and therefore no meta-analysis was possible. Data are presented in narrative form. Main results: Two small RCTs were identified (n = 35). No meta-analysis was possible. There were only three significant treatment effects in favour of the diet intervention: overall autistic traits, mean difference (MD) = -5.60 (95% CI -9.02 to -2.18), z = 3.21, p=0.001 (Knivsberg 2002) social isolation, MD = -3.20 (95% CI -5.20 to 1.20), z = 3.14, p = 0.002) and overall ability to communicate and interact, MD = 1.70 (95% CI 0.50 to 2.90), z = 2.77, p = 0.006) (Knivsberg 2003). In addition three outcomes showed no significant difference between the treatment and control group and we were unable to calculate mean differences for ten outcomes because the data were skewed. No outcomes were reported for disbenefits including harms. Authors' conclusions: Research has shown of high rates of use of complementary and alternative therapies (CAM) for children with autism including gluten and/or casein exclusion diets. Current evidence for efficacy of these diets is poor. Large scale, good quality randomised controlled trials are needed. |
|---|---|
| Language | English |
| Publishing date | 2019-04-02 |
| Publishing country | England |
| Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
| ISSN | 1469-493X |
| ISSN (online) | 1469-493X |
| DOI | 10.1002/14651858.CD003498.pub4 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 165, Issue 5, Page(s) 1355–1363
Abstract: Background: Intracranial meningioma with bone involvement and primary intraosseous meningioma is uncommon. There is currently no consensus for optimal management. This study aimed to describe the management strategy and outcomes for a 10-year ... ...
| Abstract | Background: Intracranial meningioma with bone involvement and primary intraosseous meningioma is uncommon. There is currently no consensus for optimal management. This study aimed to describe the management strategy and outcomes for a 10-year illustrative cohort, and propose an algorithm to aid clinicians in selecting cranioplasty material in such patients. Methods: A single-centre, retrospective cohort study (January 2010-August 2021). All adult patients requiring cranial reconstruction due to meningioma with bone involvement or primary intraosseous meningioma were included. Baseline patient and meningioma characteristics, surgical strategy, and surgical morbidity were examined. Descriptive statistics were performed using SPSS v24.0. Data visualisation was performed using R v4.1.0. Results: Thirty-three patients were identified (mean age 56 years; SD 15) There were 19 females. Twenty-nine patients had secondary bone involvement (88%). Four had primary intraosseous meningioma (12%). Nineteen had gross total resection (GTR; 58%). Thirty had primary 'on-table' cranioplasty (91%). Cranioplasty materials included pre-fabricated polymethyl methacrylate (pPMMA) (n = 12; 36%), titanium mesh (n = 10; 30%), hand-moulded polymethyl methacrylate cement (hPMMA) (n = 4; 12%), pre-fabricated titanium plate (n = 4; 12%), hydroxyapatite (n = 2; 6%), and a single case combining titanium mesh with hPMMA cement (n = 1; 3%). Five patients required reoperation for a postoperative complication (15%). Conclusion: Meningioma with bone involvement and primary intraosseous meningioma often requires cranial reconstruction, but this may not be evident prior to surgical resection. Our experience demonstrates that a wide variety of materials have been used successfully, but that pre-fabricated materials may be associated with fewer postoperative complications. Further research within this population is warranted to identify the most appropriate operative strategy. |
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| MeSH term(s) | Adult ; Female ; Humans ; Middle Aged ; Meningioma/diagnostic imaging ; Meningioma/surgery ; Meningioma/complications ; Polymethyl Methacrylate/therapeutic use ; Retrospective Studies ; Titanium ; Skull/diagnostic imaging ; Skull/surgery ; Postoperative Complications/epidemiology ; Decompressive Craniectomy/adverse effects ; Meningeal Neoplasms/diagnostic imaging ; Meningeal Neoplasms/surgery ; Meningeal Neoplasms/complications |
| Chemical Substances | Polymethyl Methacrylate (9011-14-7) ; Titanium (D1JT611TNE) |
| Language | English |
| Publishing date | 2023-03-06 |
| Publishing country | Austria |
| Document type | Journal Article |
| ZDB-ID | 80010-7 |
| ISSN | 0942-0940 ; 0001-6268 |
| ISSN (online) | 0942-0940 |
| ISSN | 0001-6268 |
| DOI | 10.1007/s00701-023-05535-4 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Uk I Zs.180: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Journal of bodywork and movement therapies
2017 Volume 21, Issue 2, Page(s) 362–374
Abstract: In clinical practice, Osteopaths and Manual Therapists commonly direct treatment towards the diaphragm by the use of a 'Diaphragm Release'. Currently, there is paucity within the literature to support the use of this technique, specifically in pain ... ...
| Abstract | In clinical practice, Osteopaths and Manual Therapists commonly direct treatment towards the diaphragm by the use of a 'Diaphragm Release'. Currently, there is paucity within the literature to support the use of this technique, specifically in pain outcomes. This research aims to support a neurophysiological mechanism based upon the osteopathic principle "The body is a unit". Demonstrating that directing treatment to distal tissue which is neurologically related can reduce pain in the originating spinal segments. This study investigated the immediate hypoalgesic effects of a 'Diaphragm Release' on pain pressure thresholds in the cervical spine. A single-blind, randomised, sham-controlled, repeated measures within subject, crossover design was conducted on 17 asymptomatic subjects. Pain pressure thresholds were measured bilaterally in the C4 paraspinal musculature, lateral end of the clavicle and upper third of the tibialis anterior before and after a 'Diaphragm Release'. Results demonstrated a statistically significant hypoalgesic effect was only found in the spinal segment C4 in both the right (p = 0.016) and left (p = 0.004) sides. Averaging the hypoalgesic effect from both sides equates to a 17.17% change which is considered clinically significant, the effect magnitude was calculated to be small but educationally significant for the right (d = 0.26) and left (d = 0.40) sides. This study supports a novel neurophysiological mechanism, Regional Interdependent Inhibition, to induce a hypoalgesic state at segmentally related spinal segments, specifically C4. Suggesting that directing treatment towards the diaphragm, using a 'Diaphragm Release', could induce an immediate clinically and statistically significant hypoalgesic effect local to the fourth cervical segment due to its relationship with the phrenic nerve. |
|---|---|
| Language | English |
| Publishing date | 2017-04 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2029441-4 |
| ISSN | 1532-9283 ; 1360-8592 |
| ISSN (online) | 1532-9283 |
| ISSN | 1360-8592 |
| DOI | 10.1016/j.jbmt.2016.08.015 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5620: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Journal of bodywork and movement therapies
2017 Volume 22, Issue 2, Page(s) 252–260
Abstract: Background: Neurodynamics is a clinical medium for testing the mechanical sensitivity of peripheral nerves which innervate the tissues of both the upper and lower limb. Currently, there is paucity in the literature of neurodynamic testing in osteopathic ...
| Abstract | Background: Neurodynamics is a clinical medium for testing the mechanical sensitivity of peripheral nerves which innervate the tissues of both the upper and lower limb. Currently, there is paucity in the literature of neurodynamic testing in osteopathic research, and where there is research, these are often methodologically flawed, without the appropriate comparators, blinding and reliability testing. Aims: This study aimed to assess the physiological effects (measured through Range of Motion; ROM), of a commonly utilized cervical mobilization treatment during a neurodynamic test, with the appropriate methodology, i.e., compared against a control and sham. Specifically, this was to test whether cervical mobilization could reduce upper limb neural mechanical sensitivity. Methodology: Thirty asymptomatic participants were assessed and randomly allocated to either a control, sham or mobilization group, where they were all given a neurodynamic test and ROM was assessed. Results: The results showed that the mobilization group had the greatest and most significant increase in ROM with Change-Left p < 0.05 and Change-Right p < 0.05 compared against the control group, and Change-Left p < 0.01 and Change-Right p < 0.05 compared against the sham group. Conclusions: This study has highlighted that, as expected, cervical mobilization has an effect at reducing upper limb neural mechanical sensitivity. However, there may be other factors interacting with neural mechanosensitivity outside of somatic influences such as psychological expectation bias. Further research could utilize the methodology employed here, but with other treatment areas to help develop neural tissue research. In addition to this, further exploration of psychological factors should be made such as utilizing complex top-down cognitive processing theories such as the neuromatrix or categorization theories to help further understand cognitive biases such as the placebo effect, which is commonly ignored in osteopathic research, as well as other areas of science, and which would further complete a holistic perspective. |
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| MeSH term(s) | Adolescent ; Adult ; Cervical Vertebrae/physiology ; Female ; Humans ; Male ; Manipulation, Osteopathic/methods ; Median Nerve/physiology ; Range of Motion, Articular ; Upper Extremity/physiology ; Young Adult |
| Language | English |
| Publishing date | 2017-05-18 |
| Publishing country | United States |
| Document type | Journal Article ; Randomized Controlled Trial |
| ZDB-ID | 2029441-4 |
| ISSN | 1532-9283 ; 1360-8592 |
| ISSN (online) | 1532-9283 |
| ISSN | 1360-8592 |
| DOI | 10.1016/j.jbmt.2017.05.009 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5620: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Journal of Neurological Surgery Part B: Skull Base
2019 Volume 80, Issue S 01
| Event/congress | 29th Annual Meeting North American Skull Base Society, Hilton Orlando Bonnet Creek Orlando, Florida, 2019-02-15 |
|---|---|
| Language | English |
| Publishing date | 2019-02-01 |
| Publisher | Georg Thieme Verlag KG |
| Publishing place | Stuttgart ; New York |
| Document type | Article ; Conference proceedings |
| ZDB-ID | 2654269-9 |
| ISSN | 2193-634X ; 2193-6331 |
| ISSN (online) | 2193-634X |
| ISSN | 2193-6331 |
| DOI | 10.1055/s-0039-1679816 |
| Database | Thieme publisher's database |
| Zs.A 3425: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2014 Volume 4, Issue 12, Page(s) e006421
Abstract: Objectives: To explore access to primary healthcare and drug therapy by refugee children in the East Midlands region of England.: Design: Interviews with refugees with children and a control group of British parents with children.: Setting: East ... ...
| Abstract | Objectives: To explore access to primary healthcare and drug therapy by refugee children in the East Midlands region of England. Design: Interviews with refugees with children and a control group of British parents with children. Setting: East Midlands region of England. Participants: 50 refugees with children and a control group of 50 parents with children. Main outcome measures: Number of medicines used by children in the last month and the past 6 months. Health of parents and children. Registration with a general practitioner (GP). Results: All families in both groups were registered with a GP. There was no difference in the number of children in the two groups experiencing illnesses .In the last month, 30 refugee children received 60 medicines and 31 control children 63 medicines. In the past 6 months, 48 refugee children received 108 medicines and 43 control children 96 medicines. There was no difference between the two groups of children in relation to the likelihood of receiving any medicines in either the last month (P=0.839) or the past 6 months (p=0.81). Children in the refugee group were more likely to receive prescribed medicines for the last month (p=0.008) and the past 6 months (p<0.001). They were also less likely to receive over the counter (OTC) medicines in the past 6 months (p=0.009). Conclusions: The refugee children in this study in the East Midlands had access to primary healthcare, medicines and a family doctor. They were more likely to receive prescribed medicines and less likely to receive OTC medicines, especially paracetamol. |
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| MeSH term(s) | Acetaminophen ; Adult ; Child ; Child, Preschool ; Cross-Sectional Studies ; England ; Ethnic Groups ; Female ; Health Services Accessibility ; Humans ; Male ; Nonprescription Drugs ; Parents ; Physicians, Family ; Prescription Drugs ; Primary Health Care ; Refugees |
| Chemical Substances | Nonprescription Drugs ; Prescription Drugs ; Acetaminophen (362O9ITL9D) |
| Language | English |
| Publishing date | 2014-12-18 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2747269-3 |
| ISSN | 2044-6055 ; 2044-6055 ; 2053-3624 |
| ISSN (online) | 2044-6055 |
| ISSN | 2044-6055 ; 2053-3624 |
| DOI | 10.1136/bmjopen-2014-006421 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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The Cochrane database of systematic reviews
2008 , Issue 2, Page(s) CD003498
Abstract: Background: It has been suggested that peptides from gluten and casein may have a role in the origins of autism and that the physiology and psychology of autism might be explained by excessive opioid activity linked to these peptides. Research has ... ...
| Abstract | Background: It has been suggested that peptides from gluten and casein may have a role in the origins of autism and that the physiology and psychology of autism might be explained by excessive opioid activity linked to these peptides. Research has reported abnormal levels of peptides in the urine and cerebrospinal fluid of people with autism. Objectives: To determine the efficacy of gluten and/or casein free diets as an intervention to improve behaviour, cognitive and social functioning in individuals with autism. Search strategy: The following electronic databases were searched: CENTRAL(The Cochrane Library Issue 2, 2007), MEDLINE (1966 to April 2007), PsycINFO (1971 to April 2007), EMBASE (1974 to April 2007), CINAHL (1982 to April 2007), ERIC (1965 to 2007), LILACS (1982 to April 2007), and the National Research register 2007 (Issue1). Review bibliographies were also examined to identify potential trials. Selection criteria: All randomised controlled trials (RCT) involving programmes which eliminated gluten, casein or both gluten and casein from the diets of individuals diagnosed with an autistic spectrum disorder. Data collection and analysis: Abstracts of studies identified in searches of electronic databases were assessed to determine inclusion by two independent authors The included trials did not share common outcome measures and therefore no meta-analysis was possible. Data are presented in narrative form. Main results: Two small RCTs were identified (n = 35). No meta-analysis was possible. There were only three significant treatment effects in favour of the diet intervention: overall autistic traits, mean difference (MD) = -5.60 (95% CI -9.02 to -2.18), z = 3.21, p=0.001 (Knivsberg 2002) social isolation, MD = -3.20 (95% CI -5.20 to 1.20), z = 3.14, p = 0.002) and overall ability to communicate and interact, MD = 1.70 (95% CI 0.50 to 2.90), z = 2.77, p = 0.006) (Knivsberg 2003). In addition three outcomes showed no significant difference between the treatment and control group and we were unable to calculate mean differences for ten outcomes because the data were skewed. No outcomes were reported for disbenefits including harms. Authors' conclusions: Research has shown of high rates of use of complementary and alternative therapies (CAM) for children with autism including gluten and/or casein exclusion diets. Current evidence for efficacy of these diets is poor. Large scale, good quality randomised controlled trials are needed. |
|---|---|
| MeSH term(s) | Autistic Disorder/diet therapy ; Autistic Disorder/etiology ; Autistic Disorder/psychology ; Caseins/administration & dosage ; Caseins/adverse effects ; Child ; Glutens/administration & dosage ; Glutens/adverse effects ; Humans ; Randomized Controlled Trials as Topic |
| Chemical Substances | Caseins ; Glutens (8002-80-0) |
| Language | English |
| Publishing date | 2008-04-16 |
| Publishing country | England |
| Document type | Journal Article ; Review ; Systematic Review |
| ISSN | 1469-493X |
| ISSN (online) | 1469-493X |
| DOI | 10.1002/14651858.CD003498.pub3 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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BJR case reports
2015 Volume 1, Issue 3, Page(s) 20150022
Abstract: Identification of the cause of recurrent meningitis may pose a diagnostic challenge. Evaluation of a patient with recurrent meningitis calls for meticulous review of skull base structures by cross sectional imaging to exclude any underlying anatomical ... ...
| Abstract | Identification of the cause of recurrent meningitis may pose a diagnostic challenge. Evaluation of a patient with recurrent meningitis calls for meticulous review of skull base structures by cross sectional imaging to exclude any underlying anatomical abnormality. Our case highlights the importance of excluding persistent craniopharyngeal duct, a rare but treatable cause of recurrent meningitis. The isolation of |
|---|---|
| Language | English |
| Publishing date | 2015-07-17 |
| Publishing country | England |
| Document type | Case Reports |
| ISSN | 2055-7159 |
| ISSN | 2055-7159 |
| DOI | 10.1259/bjrcr.20150022 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2015 Volume 5, Issue 6, Page(s) e008298
Abstract: Objectives: To prospectively determine the nature and rate of adverse drug reactions (ADRs) in children on antiepileptic drugs (AEDs) and to prospectively evaluate the effect of AEDs on behaviour.: Setting: A single centre prospective observational ... ...
| Abstract | Objectives: To prospectively determine the nature and rate of adverse drug reactions (ADRs) in children on antiepileptic drugs (AEDs) and to prospectively evaluate the effect of AEDs on behaviour. Setting: A single centre prospective observational study. Participants: Children (<18 years old) receiving one or more AEDs for epilepsy, at each clinically determined follow-up visit. Primary and secondary outcomes: Primary outcome was adverse reactions of AEDs. Behavioural and cognitive functions were secondary outcomes. Results: 180 children were recruited. Sodium valproate and carbamazepine were the most frequently used AEDs. A total of 114 ADRs were recorded in 56 of these children (31%). 135 children (75%) were on monotherapy. 27 of the 45 children (60%) on polytherapy had ADRs; while 29 (21%) of those on monotherapy had ADRs. The risk of ADRs was significantly lower in patients receiving monotherapy than polytherapy (RR: 0.61, 95% CI 0.47 to 0.79, p<0.0001). Behavioural problems and somnolence were the most common ADRs. 23 children had to discontinue their AED due to an ADR. Conclusions: Behavioural problems and somnolence were the most common ADRs. Polytherapy significantly increases the likelihood of ADRs in children. Trail registration number: EudraCT (2007-000565-37). |
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| MeSH term(s) | Adolescent ; Anticonvulsants/administration & dosage ; Anticonvulsants/adverse effects ; Carbamazepine/administration & dosage ; Carbamazepine/adverse effects ; Child ; Child, Preschool ; Cognition Disorders/chemically induced ; Drug Therapy, Combination/adverse effects ; Epilepsy/drug therapy ; Female ; Follow-Up Studies ; Humans ; Lamotrigine ; Male ; Prospective Studies ; Severity of Illness Index ; Sleep Disorders, Intrinsic/etiology ; Triazines/administration & dosage ; Triazines/adverse effects ; United Kingdom/epidemiology ; Valproic Acid/administration & dosage ; Valproic Acid/adverse effects |
| Chemical Substances | Anticonvulsants ; Triazines ; Carbamazepine (33CM23913M) ; Valproic Acid (614OI1Z5WI) ; Lamotrigine (U3H27498KS) |
| Language | English |
| Publishing date | 2015-06-01 |
| Publishing country | England |
| Document type | Journal Article ; Observational Study |
| ZDB-ID | 2599832-8 |
| ISSN | 2044-6055 ; 2044-6055 |
| ISSN (online) | 2044-6055 |
| ISSN | 2044-6055 |
| DOI | 10.1136/bmjopen-2015-008298 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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