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  1. Article ; Online: Use of Topical Anesthetics in the Management of Patients With Simple Corneal Abrasions: Consensus Guidelines From the American College of Emergency Physicians.

    Green, Steven M / Tomaszewski, Christian / Valente, Jonathan H / Lo, Bruce / Milne, Ken

    Annals of emergency medicine

    2024  Volume 83, Issue 5, Page(s) 477–489

    Abstract: The management of corneal abrasions has largely excluded dispensing topical local anesthetics for home use due to concern for corneal toxicity. We have reviewed and critically appraised the available literature evidence regarding the use of topical ... ...

    Abstract The management of corneal abrasions has largely excluded dispensing topical local anesthetics for home use due to concern for corneal toxicity. We have reviewed and critically appraised the available literature evidence regarding the use of topical anesthetics in patients with simple corneal abrasions. Using sequential Delphi review, we have developed these clinical guidelines. Herein are evidentiary summaries and consensus recommendations for 8 specific relevant questions. Our key observation is that for only simple corneal abrasions, as diagnosed and treated in accordance with the full protocol described herein, it appears safe to prescribe or otherwise provide a commercial topical anesthetic (ie, proparacaine, tetracaine, oxybuprocaine) for use up to every 30 minutes as needed during the first 24 hours after presentation, as long as no more than 1.5 to 2 mL total (an expected 24-hour supply) is dispensed and any remainder is discarded after 24 hours. Importantly, although published findings suggest absent harm for short courses, more rigorous studies with a greater cumulative sample size and ophthalmologic follow-up are needed.
    MeSH term(s) Humans ; Anesthetics, Local ; Corneal Injuries/drug therapy ; Tetracaine ; Cornea ; Physicians
    Chemical Substances Anesthetics, Local ; Tetracaine (0619F35CGV)
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2024.01.004
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    Zs.A 1344: Show issues Location:
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  2. Article ; Online: Valproate pregnancy prevention scheme: what are the barriers to enrolling patients and how do we meet them?

    Watila, Musa Mamman / James, Alistair / Milne, Karen / Mackay, Graham

    BMJ neurology open

    2023  Volume 5, Issue 2, Page(s) e000433

    Abstract: Background: The UK Medicines Health products Regulation Agency instructs that valproate prescriptions should be restricted in women of childbearing age to those consenting to the Pregnancy Prevention Programme (PPP). We assessed the compliance and ... ...

    Abstract Background: The UK Medicines Health products Regulation Agency instructs that valproate prescriptions should be restricted in women of childbearing age to those consenting to the Pregnancy Prevention Programme (PPP). We assessed the compliance and barriers to the valproate PPP.
    Methods: We retrospectively audited NHS Grampian's compliance with PPP guidelines among women of childbearing potential prescribed valproate between October 2017 and March 2018. Additionally, we prospectively reviewed new valproate prescriptions from February 2019 to March 2022 and compared this with our retrospective data to assess the effectiveness of our identification process using descriptive statistics.
    Results: We identified 351 women retrospectively and 80 women prospectively. Epilepsy, migraine and psychiatry were the main indications. There was a decline in valproate use over the years, particularly for epilepsy. Initially, only 132 (37.6%) met the PPP requirement, and eventually, 81 (23%) stopped the medication. Despite efforts, 38 (10.8%) had contact with secondary care but still did not meet PPP and 100 (28.5%) had no documentation or referral to secondary care. Patients not meeting PPP lacked capacity, most commonly with severe learning difficulties. Women treated for psychiatric purposes were less likely to meet PPP than other indications.
    Conclusions: A significant proportion of women continue valproate treatment without meeting the PPP requirement. This is linked to their indication for prescription and their comorbidities. Collaborative input from relevant specialities and primary care is required to fully achieve PPP if a national valproate database is to be established.
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article
    ISSN 2632-6140
    ISSN (online) 2632-6140
    DOI 10.1136/bmjno-2023-000433
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  3. Article ; Online: News Stories of Intimate Partner Violence: An Experimental Examination of Media Framing and Perpetrator Sex in LGBTQ Versus Heterosexual Relationships.

    Savage, Matthew W / Scarduzio, Jennifer / Milne, Katie

    Journal of interpersonal violence

    2022  Volume 37, Issue 23-24, Page(s) NP22226–NP22249

    Abstract: This study experimentally examines the effects of perpetrator sex (male or female), relationship context (heterosexual or homosexual), and the type of media framing (episodic or thematic) on endorsement for public health perspectives about intimate ... ...

    Abstract This study experimentally examines the effects of perpetrator sex (male or female), relationship context (heterosexual or homosexual), and the type of media framing (episodic or thematic) on endorsement for public health perspectives about intimate partner violence (IPV) and punishment preferences for IPV perpetrators. Participants (
    MeSH term(s) Female ; Humans ; Male ; Heterosexuality ; Homosexuality ; Homosexuality, Female ; Intimate Partner Violence/legislation & jurisprudence ; Mass Media ; Sexual and Gender Minorities ; Violence ; Punishment ; Social Control, Formal
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2028900-5
    ISSN 1552-6518 ; 0886-2605
    ISSN (online) 1552-6518
    ISSN 0886-2605
    DOI 10.1177/08862605211071143
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  4. Article: Nurse can't ignore her conscience.

    Milne, Kaye

    Nursing New Zealand (Wellington, N.Z. : 1995)

    2013  Volume 19, Issue 9, Page(s) 3

    MeSH term(s) Abortion, Induced/ethics ; Contraception/ethics ; Family Planning Services/ethics ; Female ; Health Services Accessibility/ethics ; Humans ; Nursing Staff/ethics
    Language English
    Publishing date 2013-10
    Publishing country New Zealand
    Document type Comment ; Letter
    ZDB-ID 1155405-8
    ISSN 1173-2032 ; 1172-1979
    ISSN 1173-2032 ; 1172-1979
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    Zs.A 3724: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Chronic Lymphocytic Leukaemia in 2020: the Future Has Arrived.

    Milne, Kate / Sturrock, Beattie / Chevassut, Timothy

    Current oncology reports

    2020  Volume 22, Issue 4, Page(s) 36

    Abstract: Purpose of review: Chronic lymphocytic leukaemia is now recognised as a heterogenous disease with a variety of clinical outcomes. Here we summarise the way it is currently stratified according to genetic risk and patient characteristics and the ... ...

    Abstract Purpose of review: Chronic lymphocytic leukaemia is now recognised as a heterogenous disease with a variety of clinical outcomes. Here we summarise the way it is currently stratified according to genetic risk and patient characteristics and the treatment approaches used for these different subgroups.
    Recent findings: Certain patients appear to sustain MRD negativity after combination chemoimmunotherapy, leading to the suggestion that their CLL may be cured. However, 17p-deleted, p53-mutated or IGHV-UM subgroups are generally resistant to FCR, and much better responses are seen with ibrutinib and venetoclax, frequently inducing MRD negativity that hopefully will be translated into durable remissions. Small molecule inhibitors have already revolutionised CLL treatment. Going forward, we anticipate their use in the majority of patients, early after diagnosis and with curative intent.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chromosome Deletion ; Chromosomes, Human, Pair 17/genetics ; Cyclophosphamide/administration & dosage ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Mutation ; Rituximab/administration & dosage ; Tumor Suppressor Protein p53/genetics ; Vidarabine/administration & dosage ; Vidarabine/analogs & derivatives
    Chemical Substances Tumor Suppressor Protein p53 ; Rituximab (4F4X42SYQ6) ; Cyclophosphamide (8N3DW7272P) ; Vidarabine (FA2DM6879K) ; fludarabine (P2K93U8740)
    Language English
    Publishing date 2020-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-020-0893-0
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    Zs.A 5521: Show issues Location:
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  6. Article ; Online: Acute Exacerbations of Chronic Lung Disease: Cardiac Considerations

    Milne, Kate / Sin, Don D.

    Cardiac Considerations in Chronic Lung Disease

    Abstract: The importance of appropriately recognizing and managing patients with cardiovascular and pulmonary comorbidities is underscored by the poor outcomes described in complex comorbid patients. Patients with chronic obstructive pulmonary disease (COPD) have ... ...

    Abstract The importance of appropriately recognizing and managing patients with cardiovascular and pulmonary comorbidities is underscored by the poor outcomes described in complex comorbid patients. Patients with chronic obstructive pulmonary disease (COPD) have an increased risk, up to one-third greater than the general population, of cardiovascular comorbidities including hypertension and diabetes [1].
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1007/978-3-030-43435-9_12
    Database COVID19

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  7. Article ; Online: Response time and eye tracking datasets for activities demanding varying cognitive load.

    Pillai, Prarthana / Ayare, Prathamesh / Balasingam, Balakumar / Milne, Kevin / Biondi, Francesco

    Data in brief

    2020  Volume 33, Page(s) 106389

    Abstract: The dataset contains the following three measures that are widely used to determine cognitive load in humans: Detection Response Task - response time, pupil diameter, and eye gaze. These measures were recorded from 28 participants while they underwent ... ...

    Abstract The dataset contains the following three measures that are widely used to determine cognitive load in humans: Detection Response Task - response time, pupil diameter, and eye gaze. These measures were recorded from 28 participants while they underwent tasks that are designed to permeate three different cognitive difficulty levels. The dataset will be useful to those researchers who seek to employ low cost, non-invasive sensors to detect cognitive load in humans and to develop algorithms for human-system automation. One such application is found in Advanced Driver Assistance Systems where eye-trackers are employed to monitor the alertness of the drivers. The dataset would also be helpful to researchers who are interested in employing machine learning algorithms to develop predictive models of humans for applications in human-machine system automation. The data is collected by the authors at the Department of Electrical & Computer Engineering in collaboration with the Faculty of Human Kinetics at the University of Windsor under the guidance of their Research Ethics Board.
    Language English
    Publishing date 2020-10-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2020.106389
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  8. Article ; Online: Molecular mechanisms for thrombosis risk in Black people: a role in excess mortality from COVID-19.

    Ramasamy, Roshan / Milne, Kate / Bell, Deanne / Stoneham, Simon / Chevassut, Timothy

    British journal of haematology

    2020  Volume 190, Issue 2, Page(s) e78–e80

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Thrombosis
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16869
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    Uh III Zs.182: Show issues Location:
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  9. Article ; Online: Interpretation bias and social anxiety: does interpretation bias mediate the relationship between trait social anxiety and state anxiety responses?

    Chen, Junwen / Milne, Kirby / Dayman, Janet / Kemps, Eva

    Cognition & emotion

    2018  Volume 33, Issue 4, Page(s) 630–645

    Abstract: Two studies aimed to examine whether high socially anxious individuals are more likely to negatively interpret ambiguous social scenarios and facial expressions compared to low socially anxious individuals. We also examined whether interpretation bias ... ...

    Abstract Two studies aimed to examine whether high socially anxious individuals are more likely to negatively interpret ambiguous social scenarios and facial expressions compared to low socially anxious individuals. We also examined whether interpretation bias serves as a mediator of the relationship between trait social anxiety and state anxiety responses, in particular current state anxiety, bodily sensations, and perceived probability and cost of negative evaluation pertaining to a speech task. Study 1 used ambiguous social scenarios and Study 2 used ambiguous facial expressions as stimuli to objectively assess interpretation bias. Undergraduate students with high and low social anxiety completed measures of state anxiety responses at three time points: baseline, after the interpretation bias task, and after the preparation for an impromptu speech. Results showed that high socially anxious individuals were more likely to endorse threat interpretations for ambiguous social scenarios and to interpret ambiguous faces as negative than low socially anxious individuals. Furthermore, negative interpretations mediated the relationship between trait social anxiety and perceived probability of negative evaluation pertaining to the speech task in Study 1 but not Study 2. The present studies provide new insight into the role of interpretation bias in social anxiety.
    MeSH term(s) Adolescent ; Adult ; Anxiety/psychology ; Facial Expression ; Female ; Humans ; Male ; Middle Aged ; Social Perception ; Young Adult
    Language English
    Publishing date 2018-05-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639123-0
    ISSN 1464-0600 ; 0269-9931
    ISSN (online) 1464-0600
    ISSN 0269-9931
    DOI 10.1080/02699931.2018.1476323
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    Zs.B 3087: Show issues Location:
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  10. Article ; Online: Immune Activation following Irbesartan Treatment in a Colorectal Cancer Patient: A Case Study.

    Titmuss, E / Milne, K / Jones, M R / Ng, T / Topham, J T / Brown, S D / Schaeffer, D F / Kalloger, S / Wilson, D / Corbett, R D / Williamson, L M / Mungall, K / Mungall, A J / Holt, R A / Nelson, B H / Jones, S J M / Laskin, J / Lim, H J / Marra, M A

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Colorectal cancers are one of the most prevalent tumour types worldwide and, despite the emergence of targeted and biologic therapies, have among the highest mortality rates. The Personalized OncoGenomics (POG) program at BC Cancer performs whole genome ... ...

    Abstract Colorectal cancers are one of the most prevalent tumour types worldwide and, despite the emergence of targeted and biologic therapies, have among the highest mortality rates. The Personalized OncoGenomics (POG) program at BC Cancer performs whole genome and transcriptome analysis (WGTA) to identify specific alterations in an individual's cancer that may be most effectively targeted. Informed using WGTA, a patient with advanced mismatch repair-deficient colorectal cancer was treated with the antihypertensive drug irbesartan and experienced a profound and durable response. We describe the subsequent relapse of this patient and potential mechanisms of response using WGTA and multiplex immunohistochemistry (m-IHC) profiling of biopsies before and after treatment from the same metastatic site of the L3 spine. We did not observe marked differences in the genomic landscape before and after treatment. Analyses revealed an increase in immune signalling and infiltrating immune cells, particularly CD8+ T cells, in the relapsed tumour. These results indicate that the observed anti-tumour response to irbesartan may have been due to an activated immune response. Determining whether there may be other cancer contexts in which irbesartan may be similarly valuable will require additional studies.
    MeSH term(s) Humans ; Irbesartan/therapeutic use ; Antihypertensive Agents/therapeutic use ; CD8-Positive T-Lymphocytes/pathology ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology
    Chemical Substances Irbesartan (J0E2756Z7N) ; Antihypertensive Agents
    Language English
    Publishing date 2023-03-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065869
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