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  1. Book: A nuclear-weapon-free-world

    Blackaby, Frank Thomas / Milne, Tom

    steps along the way

    2000  

    Author's details ed. by Frank Blackaby and Tom Milne. Forew. by Michael Atiyah
    Language English
    Size X, 283 S, graph. Darst, 23 cm
    Publisher Macmillan Press u.a.
    Publishing place Basingstoke, Hampshire u.a.
    Document type Book
    Note Includes bibliographical references and index
    ISBN 0333791894 ; 0333791908 ; 9780333791899 ; 9780333791905
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book: Nicholas Ray

    Eisenschitz, Bernard / Milne, Tom / Ray, Nicholas

    an American journey

    1993  

    Title translation Roman Américain <engl.>
    Author's details Bernard Eisenschitz. Translated by Tom Milne
    Language English
    Size XX, 599 S., Ill., graph. Darst., 25 cm
    Publisher Faber and Faber
    Publishing place London
    Document type Book
    Note Translation of: Roman Américain ; Includes bibliographical references (p. 493-549), filmography (p. 550-571) and index ; Includes index
    ISBN 0571140866 ; 9780571140862
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book: The cinema of Carl Dreyer

    Milne, Tom

    (The international film guide series)

    1971  

    Author's details by Tom Milne
    Series title The international film guide series
    Language English
    Size 191 S, Ill
    Publisher Barnes u.a.
    Publishing place New York u.a.
    Document type Book
    ISBN 0302020578 ; 049807711X ; 9780302020579 ; 9780498077111
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article ; Online: Three wound-dressing strategies to reduce surgical site infection after abdominal surgery: the Bluebelle feasibility study and pilot RCT.

    Reeves, Barnaby C / Rooshenas, Leila / Macefield, Rhiannon C / Woodward, Mark / Welton, Nicky J / Waterhouse, Benjamin R / Torrance, Andrew D / Strong, Sean / Siassakos, Dimitrios / Seligman, William / Rogers, Chris A / Rickard, Lloyd / Pullyblank, Anne / Pope, Caroline / Pinkney, Thomas D / Pathak, Samir / Owais, Anwar / O'Callaghan, Jamie / O'Brien, Stephen /
    Nepogodiev, Dmitri / Nadi, Khaldoun / Murkin, Charlotte E / Munder, Tonia / Milne, Tom / Messenger, David / McMullan, Christel M / Mathers, Jonathan M / Mason, Matthew / Marshall, Morwena / Lovegrove, Richard / Longman, Robert J / Lloyd, Jessica / Lim, Jeffrey / Lee, Kathryn / Korwar, Vijay / Hughes, Daniel / Hill, George / Harris, Rosie / Hamdan, Mohammed / Brown, Hannah Gould / Gooberman-Hill, Rachael / Glasbey, James / Fryer, Caroline / Ellis, Lucy / Elliott, Daisy / Dumville, Jo C / Draycott, Tim / Donovan, Jenny L / Cotton, David / Coast, Joanna / Clout, Madeleine / Calvert, Melanie J / Byrne, Benjamin E / Brown, Oliver D / Blencowe, Natalie S / Bera, Katarzyna D / Bennett, Joanne / Bamford, Richard / Bakhbakhi, Danya / Atif, Muhammad / Ashton, Kate / Armstrong, Elizabeth / Andronis, Lazaros / Ananthavarathan, Piriyankan / Blazeby, Jane M

    Health technology assessment (Winchester, England)

    2019  Volume 23, Issue 39, Page(s) 1–166

    Abstract: Background: Surgical site infection (SSI) affects up to 20% of people with a primary closed wound after surgery. Wound dressings may reduce SSI.: Objective: To assess the feasibility of a multicentre randomised controlled trial (RCT) to evaluate the ... ...

    Abstract Background: Surgical site infection (SSI) affects up to 20% of people with a primary closed wound after surgery. Wound dressings may reduce SSI.
    Objective: To assess the feasibility of a multicentre randomised controlled trial (RCT) to evaluate the effectiveness and cost-effectiveness of dressing types or no dressing to reduce SSI in primary surgical wounds.
    Design: Phase A - semistructured interviews, outcome measure development, practice survey, literature reviews and value-of-information analysis. Phase B - pilot RCT with qualitative research and questionnaire validation. Patients and the public were involved.
    Setting: Usual NHS care.
    Participants: Patients undergoing elective/non-elective abdominal surgery, including caesarean section.
    Interventions: Phase A - none. Phase B - simple dressing, glue-as-a-dressing (tissue adhesive) or 'no dressing'.
    Main outcome measures: Phase A - pilot RCT design; SSI, patient experience and wound management questionnaires; dressing practices; and value-of-information of a RCT. Phase B - participants screened, proportions consented/randomised; acceptability of interventions; adherence; retention; validity and reliability of SSI measure; and cost drivers.
    Data sources: Phase A - interviews with patients and health-care professionals (HCPs), narrative data from published RCTs and data about dressing practices. Phase B - participants and HCPs in five hospitals.
    Results: Phase A - we interviewed 102 participants. HCPs interpreted 'dressing' variably and reported using available products. HCPs suggested practical/clinical reasons for dressing use, acknowledged the weak evidence base and felt that a RCT including a 'no dressing' group was acceptable. A survey showed that 68% of 1769 wounds (727 participants) had simple dressings and 27% had glue-as-a-dressing. Dressings were used similarly in elective and non-elective surgery. The SSI questionnaire was developed from a content analysis of existing SSI tools and interviews, yielding 19 domains and 16 items. A main RCT would be valuable to the NHS at a willingness to pay of £20,000 per quality-adjusted life-year. Phase B - from 4 March 2016 to 30 November 2016, we approached 862 patients for the pilot RCT; 81.1% were eligible, 59.4% consented and 394 were randomised (simple,
    Limitations: Multiple activities, often in parallel, were challenging to co-ordinate. An amendment took 4 months, restricting recruitment to the pilot RCT. Only 67% of participants completed the SSI questionnaire. We could not implement photography in theatres.
    Conclusions: A main RCT of dressing strategies is feasible and would be valuable to the NHS. The SSI questionnaire is sufficiently accurate to be used as the primary outcome. A main trial with three groups (as in the pilot) would be valuable to the NHS, using a primary outcome of SSI at discharge and patient-reported SSI symptoms at 4-8 weeks.
    Trial registration: Phase A - Current Controlled Trials ISRCTN06792113; Phase B - Current Controlled Trials ISRCTN49328913.
    Funding: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in
    MeSH term(s) Abdomen/surgery ; Adult ; Aged ; Bandages/classification ; Bandages/microbiology ; Cesarean Section/adverse effects ; Cost-Benefit Analysis ; Feasibility Studies ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Quality-Adjusted Life Years ; Reproducibility of Results ; Surgical Procedures, Operative/adverse effects ; Surgical Wound Infection/microbiology ; Surgical Wound Infection/prevention & control ; Surveys and Questionnaires
    Language English
    Publishing date 2019-09-04
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2006765-3
    ISSN 2046-4924 ; 1366-5278
    ISSN (online) 2046-4924
    ISSN 1366-5278
    DOI 10.3310/hta23390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5162: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book: Rouben Mamoulian

    Milne, Tom / Mamoulian, Rouben

    (Cinema one ; 13)

    1969  

    Author's details Tom Milne
    Series title Cinema one ; 13
    Language English
    Size 176 S, zahlr. Ill, 19 cm
    Publisher Thames & Hudson
    Publishing place London
    Document type Book
    Note Filmogr. R. Mamoulian S. 161 - 176
    ISBN 050047012X ; 0500480125 ; 9780500470121 ; 9780500480120
    Database Former special subject collection: coastal and deep sea fishing

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  6. Book: Losey on Losey

    Losey, Joseph / Milne, Tom

    (Cinema one ; 2)

    1967  

    Author's details ed. and introd. by Tom Milne
    Series title Cinema one ; 2
    Language English
    Size 192 S., Ill., 19 cm
    Publisher Secker & Warburg
    Publishing place London
    Document type Book
    Note Filmogr. J. Losey S. 173 - 192
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article: Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.

    Zeisig, Bernd B / Milne, Tom / García-Cuéllar, María-Paz / Schreiner, Silke / Martin, Mary-Ellen / Fuchs, Uta / Borkhardt, Arndt / Chanda, Sumit K / Walker, John / Soden, Richard / Hess, Jay L / Slany, Robert K

    Molecular and cellular biology

    2003  Volume 24, Issue 2, Page(s) 617–628

    Abstract: MLL fusion proteins are oncogenic transcription factors that are associated with aggressive lymphoid and myeloid leukemias. We constructed an inducible MLL fusion, MLL-ENL-ERtm, that rendered the transcriptional and transforming properties of MLL-ENL ... ...

    Abstract MLL fusion proteins are oncogenic transcription factors that are associated with aggressive lymphoid and myeloid leukemias. We constructed an inducible MLL fusion, MLL-ENL-ERtm, that rendered the transcriptional and transforming properties of MLL-ENL strictly dependent on the presence of 4-hydroxy-tamoxifen. MLL-ENL-ERtm-immortalized hematopoietic cells required 4-hydroxy-tamoxifen for continuous growth and differentiated terminally upon tamoxifen withdrawal. Microarray analysis performed on these conditionally transformed cells revealed Hoxa9 and Hoxa7 as well as the Hox coregulators Meis1 and Pbx3 among the targets upregulated by MLL-ENL-ERtm. Overexpression of the Hox repressor Bmi-1 inhibited the growth-transforming activity of MLL-ENL. Moreover, the enforced expression of Hoxa9 in combination with Meis1 was sufficient to substitute for MLL-ENL-ERtm function and to maintain a state of continuous proliferation and differentiation arrest. These results suggest that MLL fusion proteins impose a reversible block on myeloid differentiation through aberrant activation of a limited set of homeobox genes and Hox coregulators that are consistently expressed in MLL-associated leukemias.
    MeSH term(s) Animals ; Cell Line ; Cell Transformation, Neoplastic/drug effects ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Down-Regulation ; Genes, Homeobox ; Homeodomain Proteins/genetics ; Humans ; Leukemia/genetics ; Leukemia/metabolism ; Mice ; Myeloid Ecotropic Viral Integration Site 1 Protein ; Myeloid-Lymphoid Leukemia Protein ; Neoplasm Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism ; Tamoxifen/analogs & derivatives ; Tamoxifen/pharmacology ; Up-Regulation
    Chemical Substances Homeodomain Proteins ; MEIS1 protein, human ; MLL-ENL oncoprotein, human ; Meis1 protein, mouse ; Myeloid Ecotropic Viral Integration Site 1 Protein ; Neoplasm Proteins ; Oncogene Proteins, Fusion ; Receptors, Estrogen ; homeobox protein HOXA9 ; Tamoxifen (094ZI81Y45) ; Myeloid-Lymphoid Leukemia Protein (149025-06-9) ; afimoxifene (17197F0KYM)
    Language English
    Publishing date 2003-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.24.2.617-628.2004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1666: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book: The Encore reader

    Findlater, Richard / Hale, Owen / Marowitz, Charles / Milne, Tom

    a chronicle of the new drama

    (University paperbacks : Drama ; 323)

    1970  

    Author's details [ed. by Charles Marowitz; Tom Milne; Hale Owen. With a foreword by Richard Findlater]
    Series title University paperbacks : Drama ; 323
    Keywords Drama ; Aufführung
    Language English
    Size 308 S., Ill.
    Publisher Methuen
    Publishing place London
    Document type Book
    ISBN 0416181309 ; 9780416181302
    Database Former special subject collection: coastal and deep sea fishing

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