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Article ; Online: Biofilm-producing Bacteria and Quality of Life after Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis with Nasal Polyposis.

Milovanović, Jovica / Božić, Dragana D / Pavlović, Bojan / Jotić, Ana / Brkić, Snežana / Ćirković, Ivana

2024 Volume 38, Issue 3, Page(s) 159–168

Abstract: Background: Chronic rhinosinusitis (CRS) is one of the most common health disorders in humans and has a major impact on health-related quality of life (HRQoL). Of the many factors contributing to the etiology of CRS, less is known about the correlation ... ...

Abstract	Background: Chronic rhinosinusitis (CRS) is one of the most common health disorders in humans and has a major impact on health-related quality of life (HRQoL). Of the many factors contributing to the etiology of CRS, less is known about the correlation between CRS and bacterial biofilms and their impact on HRQoL. Objective: The aim of this prospective study was to investigate the relationship between biofilm-producing bacteria and patients' objective findings and HRQoL. Methods: Forty-eight patients with CRSwNP were enrolled in a 12-month prospective study. The Lund-Mackay (LM) CT and endoscopic Lund-Kennedy (LK) scores were obtained before endoscopic sinus surgery (ESS), and patients completed the HRQoL instruments: the 22-item Sinonasal Outcome Test (SNOT-22), the 36-item Short Questionnaire (SF-36), and the visual analog scale (VAS). A sinus culture was obtained at ESS, bacteria were isolated, and Results: The most common bacterial isolates in patients with CRSwNP were Conclusions: Patients with strong biofilm producers had higher LK and LM scores preoperatively, and greater improvement in LK and HRQoL scores postoperatively. Microbiologic surveillance of all CRS patients is recommended.
MeSH term(s)	Humans ; Prospective Studies ; Quality of Life ; Staphylococcus aureus ; Rhinosinusitis ; Rhinitis/surgery ; Rhinitis/epidemiology ; Sinusitis/surgery ; Sinusitis/epidemiology ; Nasal Polyps/surgery ; Nasal Polyps/epidemiology ; Chronic Disease ; Endoscopy ; Biofilms ; Bacteria ; Treatment Outcome
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2482804-X
ISSN	1945-8932 ; 1945-8924
ISSN (online)	1945-8932
ISSN	1945-8924
DOI	10.1177/19458924241236233
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Article: Senior engineering students in the USA carry misconceptions about climate change: Implications for engineering education

Milovanovic, Julie / Shealy, Tripp / Godwin, Allison

Journal of cleaner production. 2022 Apr. 15, v. 345

2022

Abstract: Engineers are an essential part of solving the effects of climate change. They must be aware of the issues related to this phenomenon and empowered to make change to reduce and shift the impact of humans on the planet. Engineering students in their ... ...

Abstract	Engineers are an essential part of solving the effects of climate change. They must be aware of the issues related to this phenomenon and empowered to make change to reduce and shift the impact of humans on the planet. Engineering students in their fourth-year of undergraduate studies in the United States (n = 4364) were asked 24 questions about climate change. We also explored how covering climate science-related topics in their college courses related to their understanding of climate change science. Our results indicate that climate change science was not well understood by engineering students in this sample. Only 30 percent of students in our sample understood the specific causes and methods to address it. For example, students incorrectly believed the hole in the earth ozone layer causes global climate change. This misconception is consistent with the literature on middle and high school students' understanding of climate change causes and consequences. We found that college courses and scientific publications have a positive effect on students' science knowledge related to climate change. Mainstream media, friends and family members have a reverse effect. While covering climate change and sustainable development in college courses favored students' knowledge of climate change, it was not sufficient to correct some climate change misconceptions. Our results suggest that engineering education in the U.S. does not provide an adequate impact on students’ knowledge of this important topic. Understanding the science of climate change is a first step toward taking action to address it. Engineering students in the U.S. about to enter the workforce carry misconceptions about climate science, which is an educational issue that should be addressed. They need an understanding of climate change science for them to take relevant action to address it. The study provides directions to better prepare engineers to address climate change in their future practices.
Keywords	climate ; climate change ; education ; labor force ; ozonosphere ; sustainable development
Language	English
Dates of publication	2022-0415
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2022.131129
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Article ; Online: The prognostic significance of serum interferon-gamma (IFN-γ) in hormonally dependent breast cancer.

Todorović-Raković, Nataša / Milovanović, Jelena / Greenman, John / Radulovic, Marko

Cytokine

2022 Volume 152, Page(s) 155836

Abstract: Background: Interferon-γ (IFN-γ) is a pleiotropic immunomodulatory cytokine. Because of its contradictory and even dualistic roles in malignancies, its potential as a biomarker remains to be unraveled.: Aim: To evaluate the prognostic significance of ...

Abstract	Background: Interferon-γ (IFN-γ) is a pleiotropic immunomodulatory cytokine. Because of its contradictory and even dualistic roles in malignancies, its potential as a biomarker remains to be unraveled. Aim: To evaluate the prognostic significance of serum IFN-γ in hormonally treated breast cancer patients. Material and methods: The study included 72 premenopausal breast cancer patients with known clinicopathological characteristics. All patients received adjuvant hormonal therapy based on hormone receptor-positivity. The median follow-up period was 93 months. IFN-γ serum protein levels were determined by quantitative ELISA. Prognostic performance was evaluated by the receiver operating characteristic (ROC), Cox proportional hazards regression and Kaplan-Meier analyses. Classification of patients into IFN-γ Results: The best prognostic performance was achieved by IFN-γ (AUC = 0.24 and p = 0.01 for distant events, AUC = 0.29 and p = 0.01 for local and distant events combined). Age and IFN-γ were prognostically significant in instances of all types of outcomes and IFN-γ was the independent prognostic parameter (Cox regression). There was a significant difference between IFN-γ values of patients without any events and those with distant metastases (Mann-Whitney test, p = 0.007). IFN-γ levels correlated significantly with nodal status and tumor stage (Spearman's rank order, r = -0.283 and r = -0.238, respectively). Distant recurrence incidence was 4% for the IFN-γ Conclusions: Raised serum IFN-γ levels associate independently with favorable disease outcome in hormonally dependent breast cancer.
MeSH term(s)	Biomarkers, Tumor ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Female ; Humans ; Interferon-gamma ; Kaplan-Meier Estimate ; Prognosis
Chemical Substances	Biomarkers, Tumor ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2022.155836
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Article ; Online: Brackish Groundwaters Contain Plastic- and Cellulose-Degrading Bacteria.

Šaraba, Vladimir / Milovanovic, Jelena / Nikodinovic-Runic, Jasmina / Budin, Clémence / de Boer, Tjalf / Ciric, Milica

Microbial ecology

2023 Volume 86, Issue 4, Page(s) 2747–2755

Abstract: The selected brackish groundwater occurrences in the geotectonic regions of Inner Dinarides of western Serbia (Obrenovačka Banja) and Serbian crystalline core (Lomnički Kiseljak and Velika Vrbnica) were sampled for isolation and identification of plastic- ...

Abstract	The selected brackish groundwater occurrences in the geotectonic regions of Inner Dinarides of western Serbia (Obrenovačka Banja) and Serbian crystalline core (Lomnički Kiseljak and Velika Vrbnica) were sampled for isolation and identification of plastic- and lignocellulose-degrading bacteria, as well as for the assessment of their enzymatic potential. The examined occurrences belong to the cold and warm (subthermal), weakly alkaline, neutral, and weakly acidic groundwater, and their genetic types are HCO
MeSH term(s)	Cellulose/metabolism ; Ecosystem ; Plastics ; Bacteria ; Groundwater
Chemical Substances	Cellulose (9004-34-6) ; Plastics
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1462065-0
ISSN	1432-184X ; 0095-3628
ISSN (online)	1432-184X
ISSN	0095-3628
DOI	10.1007/s00248-023-02278-8
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Article ; Online: Enzymatic functionalization of liquid phase exfoliated graphene using horseradish peroxidase and laccase.

Mitrović, Aleksandra / Milovanović, Jelena / Gurgul, Jacek / Žekić, Andrijana / Nikodinović-Runić, Jasmina / Maslak, Veselin

Enzyme and microbial technology

2023 Volume 170, Page(s) 110293

Abstract: We present a novel approach for the enzymatic functionalization of graphene, utilizing horseradish peroxidase (HPO) and laccase (LC) from Trametes versicolor. This study demonstrates, for the first time, the covalent modification of non-homogeneous ... ...

Abstract	We present a novel approach for the enzymatic functionalization of graphene, utilizing horseradish peroxidase (HPO) and laccase (LC) from Trametes versicolor. This study demonstrates, for the first time, the covalent modification of non-homogeneous graphene with a low surface-to-volume ratio, both in solution and on solid support. Through thermogravimetry analysis, we estimate the degree of functionalization to be 11% with HPO and 4% with LC, attributed to the varying redox potentials of the enzymes. This work highlights the potential of enzymatic reactions for tailored functionalization of graphene under mild conditions.
MeSH term(s)	Horseradish Peroxidase ; Laccase ; Graphite ; Trametes
Chemical Substances	Horseradish Peroxidase (EC 1.11.1.-) ; Laccase (EC 1.10.3.2) ; Graphite (7782-42-5)
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	423729-8
ISSN	1879-0909 ; 0141-0229
ISSN (online)	1879-0909
ISSN	0141-0229
DOI	10.1016/j.enzmictec.2023.110293
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Article ; Online: Vascular endothelial growth factor (VEGF) -A, -C and VE-cadherin as potential biomarkers in early breast cancer patients.

Milovanović, Jelena / Vujasinović, Tijana / Todorović-Raković, Nataša / Greenman, John / Hranisavljević, Jelena / Radulovic, Marko

Pathology, research and practice

2023 Volume 252, Page(s) 154923

Abstract: Background: Vascular endothelial growth factor (VEGF) -A and -C act as multifunctional molecules and growth factors, while VE-cadherin (cadherin 5, CDH5) is the endothelial junction protein.: Aim: To assess the relationship between intratumoral VEGF - ...

Abstract	Background: Vascular endothelial growth factor (VEGF) -A and -C act as multifunctional molecules and growth factors, while VE-cadherin (cadherin 5, CDH5) is the endothelial junction protein. Aim: To assess the relationship between intratumoral VEGF -A, -C and CDH5 levels and clinical outcome, in primary, early-stage, breast cancer patients. Patients and methods: The study included 69 node-negative (N0) breast cancer patients, all of whom had not received any prior hormonal or chemotherapeutic systemic therapy that would affect the course of disease. The median follow-up period was 144 months. Intratumoral mRNA levels of VEGF -A, -C and CDH5 were determined by RT-qPCR. Prognostic performance was evaluated by Cox proportional hazards regression, Kaplan-Meier analysis, as well as by the multivariable approach based on the least absolute shrinkage and selection operator (LASSO) logit regression. Classification of patients into the low and high subgroups was performed using the outcome-oriented cut-off point categorization approach. Results: Of the measured mRNAs, only CDH5 mRNA (t = -2.17; p = 0.04) and VEGF-C mRNA (t = -2.41; p = 0.03) showed significant differences between values in patient subgroups with distant metastasis and those without recurrences, respectively. These t-test results were in agreement with the Cox regression by which CDH5 mRNA reached the most pronounced hazard ratio (HR=2.07; p = 0.05), followed by VEGF-C mRNA (HR=1.59; p = 0.005). HR values above 1.0 indicate that high levels of either CDH5 or VEGF-C mRNAs associated with a higher risk of poor clinical outcome. Distant recurrence incidence was 26% for the CDH5 Conclusion: Intratumoral VEGF-A levels did not associate with disease outcome in primary, early-stage, breast cancer patients, whilst raised levels of either CDH5 or VEGF-C prognosticated a high risk of distant metastasis.
MeSH term(s)	Humans ; Female ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Vascular Endothelial Growth Factor C/genetics ; Vascular Endothelial Growth Factor C/metabolism ; Antigens, CD/metabolism ; Vascular Endothelial Growth Factors ; Prognosis ; RNA, Messenger/genetics ; Biomarkers, Tumor/analysis
Chemical Substances	Vascular Endothelial Growth Factor A ; cadherin 5 ; Vascular Endothelial Growth Factor C ; Antigens, CD ; Vascular Endothelial Growth Factors ; RNA, Messenger ; Biomarkers, Tumor
Language	English
Publishing date	2023-11-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.154923
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Article ; Online: The significance of HOXB7 and IL17RB serum levels in prognosis of hormonally dependent breast cancer: A pilot study.

Todorović-Raković, Nataša / Milovanović, Jelena / Greenman, John / Radulovic, Marko

Advances in medical sciences

2021 Volume 66, Issue 2, Page(s) 359–365

Abstract: Purpose: Improved prognostication of a patient's outcome could allow for personalized treatment decisions in breast cancer. Homeobox B7 (HOXB7) and interleukin 17 receptor B (IL17RB) are proteins reportedly involved in the development of hormonal ... ...

Abstract	Purpose: Improved prognostication of a patient's outcome could allow for personalized treatment decisions in breast cancer. Homeobox B7 (HOXB7) and interleukin 17 receptor B (IL17RB) are proteins reportedly involved in the development of hormonal therapy resistance. Their prognostic value was previously investigated in tumor tissue but recent mass spectrometric detection of HOXB7 and IL17RB proteins in serum has prompted us to perform the first prognostic evaluation of their serum levels. Patients and methods: The study included 81 premenopausal breast cancer patients that received adjuvant hormonal therapy. The median follow-up period was 61 months. HOXB7 and IL17RB serum protein levels were measured by quantitative sandwich ELISA and prognostically evaluated by Cox proportional hazards regression analysis. Results: HOXB7 protein was detected in 96.3% and IL17RB in 33.3% of serum samples. Higher levels of serum HOXB7 significantly associated with favorable disease outcome by prognosticating distant (by HR = 0.04; P = 0.001) and local recurrence (by HR = 0.03, P = 0.001). The recurrence rates in the HOXB7 Conclusions: Our findings validate the previous mass-spectrometry data by showing that HOXB7 and IL17RB cellular proteins are detectable in serum by a standard ELISA assay. Furthermore, we show that HOXB7 serum levels are the relevant prognosticator of response to hormonal therapy.
MeSH term(s)	Biomarkers, Tumor ; Breast Neoplasms/drug therapy ; Female ; Homeodomain Proteins ; Humans ; Pilot Projects ; Prognosis ; Receptors, Estrogen ; Receptors, Interleukin-17
Chemical Substances	Biomarkers, Tumor ; HOXB7 protein, human ; Homeodomain Proteins ; IL17RB protein, human ; Receptors, Estrogen ; Receptors, Interleukin-17
Language	English
Publishing date	2021-07-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273668-2
ISSN	1898-4002 ; 1896-1126
ISSN (online)	1898-4002
ISSN	1896-1126
DOI	10.1016/j.advms.2021.07.007
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Article ; Online: The prognostic value of cyclin D1 in breast cancer patients treated with hormonal therapy: A pilot study.

Todorović-Raković, Nataša / Milovanović, Jelena / Durosaro, Samuel Olutunde / Radulovic, Marko

Pathology, research and practice

2021 Volume 222, Page(s) 153430

Abstract: The aim: of the study was to determine the clinical relevance of cyclin D1 (cD1) and its association with clinicopathological parameters in breast cancer patients treated with hormonal therapy.: Material and methods: The study included 96 primary ... ...

Abstract	The aim: of the study was to determine the clinical relevance of cyclin D1 (cD1) and its association with clinicopathological parameters in breast cancer patients treated with hormonal therapy. Material and methods: The study included 96 primary breast cancer patients with known clinicopathological parameters. In adjuvant setting, 44 patients were tamoxifen-treated and 52 were treated with ovarian irradiation/ablation. The cD1 status (gene amplified/nonamplified) was determined on formalin-fixed paraffin-embedded tumor tissue sections by chromogenic in situ hybridization. Associations between parameters were analyzed by Chi-square and Spearman's rank order correlation tests. Cox proportional hazards regression test was performed. Survival curves for relapse-free survival were constructed according to the Kaplan-Meier method. Results: There were no significant associations between cyclin D1 and clinicopathological parameters in either patient group. Amplified cyclin D1 associated significantly with the actual relapse incidence in the ovarian ablation patient group (p = 0.01, HR = 3.1), but not in the tamoxifen-treated patient group. Estrogen receptor and cyclin D1 have proven to be independent parameters of poor outcome in the ovarian ablation patient group (p = 0.03, HR = 2.9; and p = 0.009, HR = 2.5; respectively). Conclusions: Cyclin D1 might be a candidate biomarker of poor outcome in breast cancer patients treated with ovarian ablation, suggesting its possible involvement in acquirement of hormonal resistance. The role of cyclin D1 as potential parameter of response to tamoxifen was not as pronounced.
MeSH term(s)	Adult ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cyclin D1/drug effects ; Cyclin D1/metabolism ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/drug therapy ; Prognosis ; Receptors, Estrogen/drug effects ; Tamoxifen/pharmacology ; Tamoxifen/therapeutic use
Chemical Substances	CCND1 protein, human ; Receptors, Estrogen ; Tamoxifen (094ZI81Y45) ; Cyclin D1 (136601-57-5)
Language	English
Publishing date	2021-04-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2021.153430
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Article ; Online: Comparison Of Sorafenib Cost-Effectiveness And Budget Impact When Used For Advanced Hepatocellular Carcinoma In Two Neighbouring Balkan Countries.

Jankovic, S M / Kostic, M / Milovanovic, J

Clinical therapeutics

2016 Volume 38, Issue 10S, Page(s) e16–e17

Language	English
Publishing date	2016-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	603113-4
ISSN	1879-114X ; 0149-2918
ISSN (online)	1879-114X
ISSN	0149-2918
DOI	10.1016/j.clinthera.2016.07.125
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Article ; Online: Can granulysin provide prognostic value in primary breast cancer?

Milovanović, Jelena / Todorović-Raković, Nataša / Vujasinović, Tijana / Greenman, John / Mandušić, Vesna / Radulovic, Marko

Pathology, research and practice

2022 Volume 237, Page(s) 154039

Abstract: Background: Granulysin (GNLY) is a cytolytic and proinflammatory molecule which also acts as an immune alarmin. The multifunctional nature of this molecule has made it challenging to define its full potential as a biomarker in breast cancer.: Aim: To ...

Abstract	Background: Granulysin (GNLY) is a cytolytic and proinflammatory molecule which also acts as an immune alarmin. The multifunctional nature of this molecule has made it challenging to define its full potential as a biomarker in breast cancer. Aim: To evaluate the prognostic value of intratumoral GNLY in primary breast cancer patients and its association with established clinicopathological parameters. Patients and methods: The study included 69 node-negative breast cancer patients with known clinicopathological parameters, all of whom had not received any prior hormonal or chemotherapeutic systemic therapy that would interfere with the course of disease. The median follow-up period was 144 months. Steroid hormone receptor status was determined by ligand-binding assay and HER2 status by chromogenic in situ hybridisation (CISH). Intratumoral GNLY mRNA levels were determined by RT-qPCR. Prognostic performance was evaluated by the receiver operating characteristic (ROC), Cox proportional hazards regression and Kaplan-Meier analysis. Classification of patients into GNLY Results: There was a significant difference between GNLY values of patients without any recurrences and those with local or distant recurrences (Mann-Whitney test, p = 0.05 and p = 0.02, respectively). None of the tested parameters showed prognostic significance for local and distant recurrences when combined. When distant metastases and local recurrences were separated as events, the best prognostic performance was observed for GNLY as compared with any clinicopathological parameter (AUC=0.24 and p = 0.04 for local events; AUC=0.71 and p = 0.03 for distant events). Local recurrence incidence was 0% for the GNLY Conclusion: High levels of granulysin prognosticate low risk of local recurrence but a high risk of distant metastasis in primary, untreated, breast cancer patients.
MeSH term(s)	Humans ; Female ; Prognosis ; Breast Neoplasms/pathology ; Alarmins/therapeutic use ; Ligands ; Neoplasm Recurrence, Local/pathology ; RNA, Messenger ; Steroids/therapeutic use ; Hormones/therapeutic use
Chemical Substances	Alarmins ; Ligands ; RNA, Messenger ; Steroids ; Hormones
Language	English
Publishing date	2022-07-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2022.154039
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