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  1. Article ; Online: A Rosetta Stone for Understanding Infectious Drops and Aerosols.

    Milton, Donald K

    Journal of the Pediatric Infectious Diseases Society

    2020  Volume 9, Issue 4, Page(s) 413–415

    MeSH term(s) Aerosols ; COVID-19 ; Communicable Diseases ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Humans ; Masks ; Pandemics ; Particle Size ; Pneumonia, Viral/transmission ; Terminology as Topic
    Chemical Substances Aerosols
    Language English
    Publishing date 2020-07-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piaa079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Applying the Hierarchy of Controls: What Occupational Safety Can Teach us About Safely Navigating the Next Phase of the Global COVID-19 Pandemic.

    Sehgal, Neil J / Milton, Donald K

    Frontiers in public health

    2021  Volume 9, Page(s) 747894

    Abstract: Eighteen months into the COVID-19 pandemic, and as the world struggles with global vaccine equity, emerging variants, and the reality that eradication is years away at soonest, we add to notion of "layered defenses" proposing a conceptual model for ... ...

    Abstract Eighteen months into the COVID-19 pandemic, and as the world struggles with global vaccine equity, emerging variants, and the reality that eradication is years away at soonest, we add to notion of "layered defenses" proposing a conceptual model for better understanding the differential applicability and effectiveness of precautions against SARS-CoV-2 transmission. The prevailing adaptation of Reason's Swiss cheese model conceives of all defensive layers as equally protective, when in reality some are more effective than others. Adapting the hierarchy of controls framework from occupational safety provides a better framework for understanding the relative benefit of different hazard control strategies to minimize the spread of SARS-CoV-2.
    MeSH term(s) COVID-19 ; Humans ; Occupational Health ; Pandemics/prevention & control ; SARS-CoV-2 ; Safety Management
    Language English
    Publishing date 2021-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2021.747894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: It Is Time to Address Airborne Transmission of Coronavirus Disease 2019 (COVID-19).

    Morawska, Lidia / Milton, Donald K

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 71, Issue 9, Page(s) 2311–2313

    MeSH term(s) Air Microbiology ; Air Pollutants/analysis ; COVID-19/prevention & control ; COVID-19/transmission ; Disease Transmission, Infectious/prevention & control ; Humans ; Inhalation Exposure/analysis ; SARS-CoV-2
    Chemical Substances Air Pollutants
    Keywords covid19
    Language English
    Publishing date 2020-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply to Chagla et al and Thomas.

    Morawska, Lidia / Milton, Donald K

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 73, Issue 11, Page(s) e3983–e3984

    Language English
    Publishing date 2020-08-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Remote Blood Oxygen Estimation From Videos Using Neural Networks.

    Mathew, Joshua / Tian, Xin / Wong, Chau-Wai / Ho, Simon / Milton, Donald K / Wu, Min

    IEEE journal of biomedical and health informatics

    2023  Volume 27, Issue 8, Page(s) 3710–3720

    Abstract: Peripheral blood oxygen saturation ( ... ...

    Abstract Peripheral blood oxygen saturation (SpO
    MeSH term(s) Humans ; COVID-19/blood ; Neural Networks, Computer ; Oximetry/instrumentation ; Oximetry/methods ; Oxygen/blood ; Smartphone ; Remote Sensing Technology/instrumentation ; Remote Sensing Technology/methods ; Video Recording ; Hand ; Proof of Concept Study ; Skin Pigmentation ; Deep Learning ; Datasets as Topic ; Sensitivity and Specificity ; Bayes Theorem
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2695320-1
    ISSN 2168-2208 ; 2168-2194
    ISSN (online) 2168-2208
    ISSN 2168-2194
    DOI 10.1109/JBHI.2023.3236631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: It is time to address airborne transmission of Coronavirus disease 2019 (COVID-19)

    Morawska, Lidia / Milton, Donald K

    Clinical Infectious Diseases

    2020  

    Abstract: We appeal to the medical community and to the relevant national and international bodies to recognize the potential for airborne spread of coronavirus disease 2019 (COVID-19). There is significant potential for inhalation exposure to viruses in ... ...

    Abstract We appeal to the medical community and to the relevant national and international bodies to recognize the potential for airborne spread of coronavirus disease 2019 (COVID-19). There is significant potential for inhalation exposure to viruses in microscopic respiratory droplets (microdroplets) at short to medium distances (up to several meters, or room scale), and we are advocating for the use of preventive measures to mitigate this route of airborne transmission.
    Keywords covid19
    Publishing date 2020-07-06
    Publisher Oxford University Press
    Publishing country au
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: It Is Time to Address Airborne Transmission of Coronavirus Disease 2019 (COVID-19)

    Morawska, Lidia / Milton, Donald K

    Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

    2020  

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/cid/ciaa939
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Influenza A and B Viruses in Fine Aerosols of Exhaled Breath Samples from Patients in Tropical Singapore.

    Chow, Vincent T K / Tay, Douglas Jie Wen / Chen, Mark I C / Tang, Julian W / Milton, Donald K / Tham, Kwok Wai

    Viruses

    2023  Volume 15, Issue 10

    Abstract: Influenza is a highly contagious respiratory illness that commonly causes outbreaks among human communities. Details about the exact nature of the droplets produced by human respiratory activities such as breathing, and their potential to carry and ... ...

    Abstract Influenza is a highly contagious respiratory illness that commonly causes outbreaks among human communities. Details about the exact nature of the droplets produced by human respiratory activities such as breathing, and their potential to carry and transmit influenza A and B viruses is still not fully understood. The objective of our study was to characterize and quantify influenza viral shedding in exhaled aerosols from natural patient breath, and to determine their viral infectivity among participants in a university cohort in tropical Singapore. Using the Gesundheit-II exhaled breath sampling apparatus, samples of exhaled breath of two aerosol size fractions ("coarse" > 5 µm and "fine" ≤ 5 µm) were collected and analyzed from 31 study participants, i.e., 24 with influenza A (including H1N1 and H3N2 subtypes) and 7 with influenza B (including Victoria and Yamagata lineages). Influenza viral copy number was quantified using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Infectivity of influenza virus in the fine particle fraction was determined by culturing in Madin-Darby canine kidney cells. Exhaled influenza virus RNA generation rates ranged from 9 to 1.67 × 10
    MeSH term(s) Humans ; Animals ; Dogs ; Influenza, Human ; Herpesvirus 1, Cercopithecine ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H3N2 Subtype/genetics ; Singapore ; Respiratory Aerosols and Droplets ; RNA, Viral/genetics
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2023-09-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15102033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: What was the primary mode of smallpox transmission? Implications for biodefense.

    Milton, Donald K

    Frontiers in cellular and infection microbiology

    2012  Volume 2, Page(s) 150

    Abstract: The mode of infection transmission has profound implications for effective containment by public health interventions. The mode of smallpox transmission was never conclusively established. Although, "respiratory droplet" transmission was generally ... ...

    Abstract The mode of infection transmission has profound implications for effective containment by public health interventions. The mode of smallpox transmission was never conclusively established. Although, "respiratory droplet" transmission was generally regarded as the primary mode of transmission, the relative importance of large ballistic droplets and fine particle aerosols that remain suspended in air for more than a few seconds was never resolved. This review examines evidence from the history of variolation, data on mucosal infection collected in the last decades of smallpox transmission, aerosol measurements, animal models, reports of smallpox lung among healthcare workers, and the epidemiology of smallpox regarding the potential importance of fine particle aerosol mediated transmission. I introduce briefly the term anisotropic infection to describe the behavior of Variola major in which route of infection appears to have altered the severity of disease.
    MeSH term(s) Aerosols ; Air Microbiology ; Animals ; Disease Models, Animal ; Disease Transmission, Infectious ; Humans ; Inhalation Exposure ; Smallpox/epidemiology ; Smallpox/transmission
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2012-11-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2012.00150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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