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Article: Laparoscopic transabdominal preperitoneal repair for inguinal hernia in a patient with an adult Still's disease receiving anti-interleukin-6 receptor monoclonal antibody therapy.

Mimatsu, Kenji / Kamitaki, Yusuke / Fukino, Nobutada

2022 Volume 2022, Issue 3, Page(s) rjac071

Abstract: Tocilizumab, a monoclonal antibody drug against interleukin-6 receptor, has been reported to cause wound infection and delayed wound healing. Therefore, surgeries using artificial materials in patients receiving tocilizumab require careful observation. A ...

Abstract	Tocilizumab, a monoclonal antibody drug against interleukin-6 receptor, has been reported to cause wound infection and delayed wound healing. Therefore, surgeries using artificial materials in patients receiving tocilizumab require careful observation. A 75-year-old man who had been receiving tocilizumab and steroids for the treatment of adult Still's disease was diagnosed with an inguinal hernia and underwent laparoscopic transabdominal preperitoneal repair. Tocilizumab administration was discontinued for 3 weeks before surgery and was restarted 2 weeks after the surgery. Postoperatively, there was no fever, and the C-reactive protein level was marginally elevated. The patient was discharged from the hospital on the fourth day without any postoperative complications, and no delayed infection or delayed wound healing 1 year after the surgery. A few weeks withdrawal of tocilizumab administration before and after surgery permitted safe laparoscopic hernia surgery using a surgical mesh without infection or delayed wound healing.
Language	English
Publishing date	2022-03-09
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjac071
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Surgical Laparotomy for Repeated Delayed Arterial Hemorrhage after Pancreaticoduodenectomy.

Mimatsu, Kenji / Fukino, Nobutada / Kano, Hisao / Kawasaki, Atsushi / Oida, Takatsugu

Case reports in gastroenterology

2019 Volume 13, Issue 1, Page(s) 50–57

Abstract: Postpancreatectomy hemorrhage is one of the major life-threatening complications of pancreatic surgery. Radiological intervention is used as a first-line approach for the initial treatment of late arterial hemorrhage. However, rehemorrhage has a high ... ...

Abstract	Postpancreatectomy hemorrhage is one of the major life-threatening complications of pancreatic surgery. Radiological intervention is used as a first-line approach for the initial treatment of late arterial hemorrhage. However, rehemorrhage has a high risk for mortality, and it is undecided which urgent intervention provides optimal management for rehemorrhage. We experienced a successful surgical laparotomy for the repeated delayed arterial hemorrhage caused by a pancreaticoduodenectomy (PD) for chronic pancreatitis. A 57-year-old man had undergone PD with pancreaticogastrostomy for tumor-forming pancreatitis with possible pancreatic cancer. A delayed massive hemorrhage from the drain developed 11 days after surgery. Although angiography was done, the bleeding site was not clearly detected. Therefore, urgent surgical laparotomy was performed. Arterial bleeding was detected from the stump of the gastroduodenal artery. Surgical ligation, using the suture technique, was performed for hemostasis, and a closed drain was placed in the area due to drainage of pancreatic juice and an abscess. However, rehemorrhage from the drain developed 7 days after the initial hemorrhage. Relaparotomy was performed immediately. The surgical ligation and compression hemostasis with absorbable hemostatic cotton was done. After relaparotomy for rehemorrhage, there was no hemorrhage or fatal hepatic failure. He left our hospital 64 days after initial surgery. Surgical laparotomy is one of the feasible procedures for hemostasis of a massive arterial hemorrhage. Proper blood vessel ligation is necessary for reliable hemostasis and proper drainage of pancreatic juice and abscesses to prevent hemorrhage.
Language	English
Publishing date	2019-02-13
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2440540-1
ISSN	1662-0631
ISSN	1662-0631
DOI	10.1159/000496918
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Article: [Primary Tumor Resection in Incurable Stage IV Colorectal Cancer].

Mimatsu, Kenji / Kida, Kazutoshi / Fukino, Nobutada

Gan to kagaku ryoho. Cancer & chemotherapy

2016 Volume 43, Issue 12, Page(s) 1476–1478

Abstract: The influence of primary tumor resection on the prognosis of patients with incurable Stage IV colorectal cancer is unclear. We retrospectively analyzed 30 patients with incurable Stage IV colorectal cancer who underwent primary tumor resection. ... ...

Abstract	The influence of primary tumor resection on the prognosis of patients with incurable Stage IV colorectal cancer is unclear. We retrospectively analyzed 30 patients with incurable Stage IV colorectal cancer who underwent primary tumor resection. Postoperative complications occurred in 13 patients(43.3%)classified as grades greater than Clavien-Dindo classification II . There was no mortality. Median duration of hospital stay after surgery was 23 days. Fourteen patients(46.7%)underwent chemotherapy after surgery, of which 12 were administered molecular targeted therapy. The median number of chemotherapy regimens was 2(range, 1 to 3). The median time between start and end of chemotherapy was 11.8 months. The median survival time(MST)of all patients was 16.9 months. The MST of patients treated with chemotherapy combined with molecular targeted therapy(60.6 months)was significantly longer than those who did not undergo chemotherapy(10.9 months). Chemotherapy combined with molecular targeted therapy contributes to survival after primary tumor resection in patients with incurable Stage IV colorectal cancer.
MeSH term(s)	Aged ; Chemotherapy, Adjuvant ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Female ; Humans ; Male ; Neoplasm Metastasis ; Neoplasm Staging ; Postoperative Complications ; Retrospective Studies
Language	Japanese
Publishing date	2016-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Utility of Inflammatory Marker- and Nutritional Status-based Prognostic Factors for Predicting the Prognosis of Stage IV Gastric Cancer Patients Undergoing Non-curative Surgery.

Mimatsu, Kenji / Fukino, Nobutada / Ogasawara, Yasuo / Saino, Yoko / Oida, Takatsugu

Anticancer research

2017 Volume 37, Issue 8, Page(s) 4215–4222

Abstract: Background/aim: The present study aimed to compare the utility of various inflammatory marker- and nutritional status-based prognostic factors, including many previous established prognostic factors, for predicting the prognosis of stage IV gastric ... ...

Abstract	Background/aim: The present study aimed to compare the utility of various inflammatory marker- and nutritional status-based prognostic factors, including many previous established prognostic factors, for predicting the prognosis of stage IV gastric cancer patients undergoing non-curative surgery. Patients and methods: A total of 33 patients with stage IV gastric cancer who had undergone palliative gastrectomy and gastrojejunostomy were included in the study. Univariate and multivariate analyses were performed to evaluate the relationships between the mGPS, PNI, NLR, PLR, the CONUT, various clinicopathological factors and cancer-specific survival (CS). Results: Among patients who received non-curative surgery, univariate analysis of CS identified the following significant risk factors: chemotherapy, mGPS and NLR, and multivariate analysis revealed that the mGPS was independently associated with CS. Conclusion: The mGPS was a more useful prognostic factor than the PNI, NLR, PLR and CONUT in patients undergoing non-curative surgery for stage IV gastric cancer.
MeSH term(s)	Aged ; Biomarkers, Tumor/blood ; Female ; Gastrectomy ; Humans ; Inflammation/blood ; Inflammation/pathology ; Inflammation/surgery ; Kaplan-Meier Estimate ; Lymphocyte Count ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Neutrophils/pathology ; Nutritional Status ; Palliative Care ; Platelet Count ; Prognosis ; Serum Albumin/isolation & purification ; Stomach Neoplasms/blood ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery
Chemical Substances	Biomarkers, Tumor ; Serum Albumin
Language	English
Publishing date	2017
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.11812
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Article: Effects of Enteral Immunonutrition in Esophageal Cancer.

Mimatsu, Kenji / Fukino, Nobutada / Ogasawara, Yasuo / Saino, Yoko / Oida, Takatsugu

Gastrointestinal tumors

2017 Volume 4, Issue 3-4, Page(s) 61–71

Abstract: Background: Immunonutrition (IN) significantly reduces the incidence of postoperative infectious complications and the length of hospitalization in patients undergoing major elective surgery for gastrointestinal malignances. However, the clinical ... ...

Abstract	Background: Immunonutrition (IN) significantly reduces the incidence of postoperative infectious complications and the length of hospitalization in patients undergoing major elective surgery for gastrointestinal malignances. However, the clinical benefit of IN in patients who have undergone esophagectomy for esophageal cancer is unclear. Moreover, the effect of enteral IN in patients during preoperative adjuvant chemoradiotherapy and in patients treated with concurrent chemoradiotherapy for advanced esophageal cancer is unknown. Summary: This review analyzes the evidence supporting the enteral administration of IN in patients who have undergone esophagectomy and/or chemoradiotherapy for esophageal cancer. Twelve trials that evaluated IN exclusively in patients who underwent esophagectomy were published between January 1980 and August 2017. Two trials concerning IN during chemoradiotherapy for esophageal cancer were identified in the same period. However, the evidence is insufficient to recommend enteral IN in patients who have undergone esophagectomy and/or chemoradiotherapy for esophageal cancer. Key message: Further evidence from well-designed randomized controlled trials is required to verify the clinical benefits of enteral IN in patients undergoing esophagectomy and/or chemoradiotherapy for esophageal cancer. Practical implications: Resolvins, which are generated from EPA, are novel anti-inflammatory lipid mediators and may play a key role in the resolution of acute inflammation when IN is supplemented with EPA in patients undergoing severely stressful operations.
Language	English
Publishing date	2017-11-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2735769-7
ISSN	2296-3766 ; 2296-3774
ISSN (online)	2296-3766
ISSN	2296-3774
DOI	10.1159/000481797
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Article: Surgical Laparotomy for Repeated Delayed Arterial Hemorrhage after Pancreaticoduodenectomy

Mimatsu, Kenji / Fukino, Nobutada / Kano, Hisao / Kawasaki, Atsushi / Oida, Takatsugu

Case Reports in Gastroenterology

2019 Volume 13, Issue 1, Page(s) 50–57

Institution	Department of Surgery, Japan Community Healthcare Organization, Yokohama Chuo Hospital, Yokohama, Japan Department of Gastroenterological Surgery, Nihon University School of Medicine, Tokyo, Japan Department of Surgery, Tokyo Hernia Center, Tokyo, Japan Department of Surgery, Kiba Hospital, Tokyo, Japan
Abstract	Postpancreatectomy hemorrhage is one of the major life-threatening complications of pancreatic surgery. Radiological intervention is used as a first-line approach for the initial treatment of late arterial hemorrhage. However, rehemorrhage has a high risk for mortality, and it is undecided which urgent intervention provides optimal management for rehemorrhage. We experienced a successful surgical laparotomy for the repeated delayed arterial hemorrhage caused by a pancreaticoduodenectomy (PD) for chronic pancreatitis. A 57-year-old man had undergone PD with pancreaticogastrostomy for tumor-forming pancreatitis with possible pancreatic cancer. A delayed massive hemorrhage from the drain developed 11 days after surgery. Although angiography was done, the bleeding site was not clearly detected. Therefore, urgent surgical laparotomy was performed. Arterial bleeding was detected from the stump of the gastroduodenal artery. Surgical ligation, using the suture technique, was performed for hemostasis, and a closed drain was placed in the area due to drainage of pancreatic juice and an abscess. However, rehemorrhage from the drain developed 7 days after the initial hemorrhage. Relaparotomy was performed immediately. The surgical ligation and compression hemostasis with absorbable hemostatic cotton was done. After relaparotomy for rehemorrhage, there was no hemorrhage or fatal hepatic failure. He left our hospital 64 days after initial surgery. Surgical laparotomy is one of the feasible procedures for hemostasis of a massive arterial hemorrhage. Proper blood vessel ligation is necessary for reliable hemostasis and proper drainage of pancreatic juice and abscesses to prevent hemorrhage.
Keywords	Laparotomy ; Delayed arterial hemorrhage ; Pancreaticoduodenectomy
Language	English
Publishing date	2019-02-13
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Case and Review ; This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC).
ZDB-ID	2440540-1
ISSN	1662-0631 ; 1662-0631
ISSN (online)	1662-0631
ISSN	1662-0631
DOI	10.1159/000496918
Database	Karger publisher's database

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Article: Rehabilitation nutrition in pressure ulcer management with type 2 diabetes: a case report.

Saino, Yoko / Wakabayashi, Hidetaka / Maeda, Keisuke / Nishioka, Shinta / Hao, Takako / Mimatsu, Kenji

Asia Pacific journal of clinical nutrition

2018 Volume 27, Issue 3, Page(s) 728–734

Abstract: Background and objectives: Severe infection, inadequate food intake, and pressure ulcers in patients with type 2 diabetes can result in malnutrition. We describe a case in which rehabilitation nutrition was effective for treat-ing a pressure ulcer in a ... ...

Abstract	Background and objectives: Severe infection, inadequate food intake, and pressure ulcers in patients with type 2 diabetes can result in malnutrition. We describe a case in which rehabilitation nutrition was effective for treat-ing a pressure ulcer in a malnourished patient with type 2 diabetes. Methods and results: A 58-year-old man with type 2 diabetes was diagnosed with hidradenitis suppurativa on the left buttock and thigh and a severe pres-sure ulcer on his left kneecap. Malnutrition was related to hypermetabolism caused by chronic hidradenitis suppu-rativa and inadequate protein-energy intake before admission. We initiated a rehabilitation nutrition intervention to improve physical function and to treat a pressure ulcer by prescribing 2,000 kcal/day of food, including 80 g of protein, and physical rehabilitation for 40 minutes/day. The patient showed good progress in terms of his physical function and healing of the pressure ulcer. After prescribing 2,250 kcal/day of food, including 85 g of protein, and physical rehabilitation for 60 minutes/day, HbA1c levels increased to 7.4%. The energy prescription was de-creased to 2,000 kcal/day to improve glycemic levels. Then, the patient's weight decreased and his hand grip strength became weaker. On day 134 and discharge the patient could walk independently with a t-cane and ankle supporter. By day 14 after discharge, the pressure ulcer had epithelialized. Conclusion: Rehabilitation nutrition management improved physical function and facilitated pressure ulcer healing in a malnourished patient with type 2 diabetes. Close conjoint management of hyperglycemia was also necessary.
MeSH term(s)	Body Weight ; Diabetes Mellitus, Type 2/complications ; Energy Intake ; Humans ; Male ; Malnutrition/complications ; Malnutrition/diet therapy ; Malnutrition/rehabilitation ; Middle Aged ; Nutrition Therapy ; Nutritional Status ; Pressure Ulcer/diet therapy ; Pressure Ulcer/rehabilitation ; Wound Healing
Language	English
Publishing date	2018-05-07
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1460012-2
ISSN	0964-7058
ISSN	0964-7058
DOI	10.6133/apjcn.062017.05
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Article: [Report of a Successful Case of Combined Modality Therapy for a Patient with Local Recurrence of Rectal Cancer].

Fukino, Nobutada / Kida, Kazutoshi / Kuboi, Youichi / Mimatsu, Kenji / Amano, Sadao

Gan to kagaku ryoho. Cancer & chemotherapy

2016 Volume 43, Issue 12, Page(s) 2157–2159

Abstract: A 67-year-old man underwent abdominoperinealresection for rectalcancer (Rb, tub2>muc, A, N1, H0, P0, M0, Cy1, Stage III a). We administered mFOLFOX6 as adjuvant chemotherapy for 6 months. Twenty-seven months after surgery, his serum tumor marker level ... ...

Abstract	A 67-year-old man underwent abdominoperinealresection for rectalcancer (Rb, tub2>muc, A, N1, H0, P0, M0, Cy1, Stage III a). We administered mFOLFOX6 as adjuvant chemotherapy for 6 months. Twenty-seven months after surgery, his serum tumor marker level was increased, and local recurrence in the left rear of the prostate was detected by pelvic CT. The patient selected radiation(50 Gy/25 Fr), after rejecting resection for the local recurrence. After radiation, we performed chemotherapy combined with bevacizumab. Seventeen months from the start of chemotherapy, 47 months after surgery, chemotherapy was stopped because his tumor maker levels normalized and pelvic CT revealed a partial response. At present, his progression-free survival is 7 months after completion of chemotherapy. We conclude that combined modality therapy is an option for a patient with locally recurrent rectal cancer.
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Combined Modality Therapy ; Humans ; Male ; Rectal Neoplasms/therapy ; Recurrence ; Treatment Outcome
Language	Japanese
Publishing date	2016-11
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Adenocarcinoma arising from heterotopic pancreas at the third portion of the duodenum.

Fukino, Nobutada / Oida, Takatsugu / Mimatsu, Kenji / Kuboi, Youichi / Kida, Kazutoshi

World journal of gastroenterology

2015 Volume 21, Issue 13, Page(s) 4082–4088

Abstract: A 62-year-old Japanese man presented to our hospital with a history of weight loss of 6 kg in 4 mo. Imaging examinations revealed a tumor located on the third portion of the duodenum with stenosis. We suspected duodenal carcinoma and performed pancreas- ... ...

Abstract	A 62-year-old Japanese man presented to our hospital with a history of weight loss of 6 kg in 4 mo. Imaging examinations revealed a tumor located on the third portion of the duodenum with stenosis. We suspected duodenal carcinoma and performed pancreas-preserving segmental duodenectomy. Adenocarcinoma arising from a heterotopic pancreas at the third portion of the duodenum was finally diagnosed by immunohistochemical staining. Malignant transformation in the duodenum arising from a heterotopic pancreas is extremely rare; to our knowledge, only 13 cases have been reported worldwide, including the present case. The most common location of malignancy is the proximal duodenum at the first and descending portion. Herein, we describe the first case of adenocarcinoma arising from a heterotopic pancreas, which was located in the third portion of the duodenum, with a review of the literature.
MeSH term(s)	Adenocarcinoma/chemistry ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Biomarkers, Tumor/analysis ; Biopsy ; Choristoma/pathology ; Choristoma/surgery ; Duodenal Neoplasms/chemistry ; Duodenal Neoplasms/pathology ; Duodenal Neoplasms/surgery ; Duodenoscopy ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Pancreas ; Pancreatic Neoplasms ; Tomography, X-Ray Computed ; Treatment Outcome
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2015-04-07
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v21.i13.4082
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Article: Effects of Enteral Immunonutrition in Esophageal Cancer

Mimatsu, Kenji / Fukino, Nobutada / Ogasawara, Yasuo / Saino, Yoko / Oida, Takatsugu

Gastrointestinal Tumors

2017 Volume 4, Issue 3-4, Page(s) 61–71

Institution	Departments of Surgery and Nutrition, Japan Community Health Care Organization Yokohama Central Hospital, Yokohama, and Department of Surgery, Kiba Hospital, Tokyo, Japan
Abstract	Background: Immunonutrition (IN) significantly reduces the incidence of postoperative infectious complications and the length of hospitalization in patients undergoing major elective surgery for gastrointestinal malignances. However, the clinical benefit of IN in patients who have undergone esophagectomy for esophageal cancer is unclear. Moreover, the effect of enteral IN in patients during preoperative adjuvant chemoradiotherapy and in patients treated with concurrent chemoradiotherapy for advanced esophageal cancer is unknown. Summary: This review analyzes the evidence supporting the enteral administration of IN in patients who have undergone esophagectomy and/or chemoradiotherapy for esophageal cancer. Twelve trials that evaluated IN exclusively in patients who underwent esophagectomy were published between January 1980 and August 2017. Two trials concerning IN during chemoradiotherapy for esophageal cancer were identified in the same period. However, the evidence is insufficient to recommend enteral IN in patients who have undergone esophagectomy and/or chemoradiotherapy for esophageal cancer. Key Message: Further evidence from well-designed randomized controlled trials is required to verify the clinical benefits of enteral IN in patients undergoing esophagectomy and/or chemoradiotherapy for esophageal cancer. Practical Implications: Resolvins, which are generated from EPA, are novel anti-inflammatory lipid mediators and may play a key role in the resolution of acute inflammation when IN is supplemented with EPA in patients undergoing severely stressful operations.
Keywords	Chemoradiotherapy ; Esophageal cancer ; Immunonutrition ; Surgery
Language	English
Publishing date	2017-11-23
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Mini-Review
ZDB-ID	2735769-7
ISSN	2296-3766 ; 2296-3774
ISSN (online)	2296-3766
ISSN	2296-3774
DOI	10.1159/000481797
Database	Karger publisher's database

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