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Article ; Online: Correction: Min, J.-Y.; Min, K.-B. Comparisons of Two Bioelectrical Impedance Devices and Manual versus Sensor-Based Short Physical Performance Batteries for Assessment of Muscle Mass and Physical Performance.

Min, Jin-Young / Min, Kyoung-Bok

2024 Volume 24, Issue 6

Abstract: There were five errors in the original article [ ... ]. ...

Abstract	There were five errors in the original article [...].
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24062003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Stearoyl-CoA Desaturase 1 as a Therapeutic Biomarker: Focusing on Cancer Stem Cells.

Min, Jin-Young / Kim, Do-Hee

International journal of molecular sciences

2023 Volume 24, Issue 10

Abstract: The dysregulation of lipid metabolism and alterations in the ratio of monounsaturated fatty acids (MUFAs) to saturated fatty acids (SFAs) have been implicated in cancer progression and stemness. Stearoyl-CoA desaturase 1 (SCD1), an enzyme involved in ... ...

Abstract	The dysregulation of lipid metabolism and alterations in the ratio of monounsaturated fatty acids (MUFAs) to saturated fatty acids (SFAs) have been implicated in cancer progression and stemness. Stearoyl-CoA desaturase 1 (SCD1), an enzyme involved in lipid desaturation, is crucial in regulating this ratio and has been identified as an important regulator of cancer cell survival and progression. SCD1 converts SFAs into MUFAs and is important for maintaining membrane fluidity, cellular signaling, and gene expression. Many malignancies, including cancer stem cells, have been reported to exhibit high expression of SCD1. Therefore, targeting SCD1 may provide a novel therapeutic strategy for cancer treatment. In addition, the involvement of SCD1 in cancer stem cells has been observed in various types of cancer. Some natural products have the potential to inhibit SCD1 expression/activity, thereby suppressing cancer cell survival and self-renewal activity.
MeSH term(s)	Stearoyl-CoA Desaturase/metabolism ; Fatty Acids/metabolism ; Fatty Acids, Monounsaturated/metabolism ; Cell Survival ; Neoplastic Stem Cells/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism
Chemical Substances	Stearoyl-CoA Desaturase (EC 1.14.19.1) ; Fatty Acids ; Fatty Acids, Monounsaturated
Language	English
Publishing date	2023-05-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24108951
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparisons of Two Bioelectrical Impedance Devices and Manual versus Sensor-Based Short Physical Performance Batteries for Assessment of Muscle Mass and Physical Performance.

Min, Jin-Young / Min, Kyoung-Bok

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 13

Abstract: The assessment of muscle mass and physical performance is essential for the diagnosis of sarcopenia. This study examined the validity of bioimpedance analysis (BIA) and a sensor-based short physical performance battery (SPPB) device for analyzing ... ...

Abstract	The assessment of muscle mass and physical performance is essential for the diagnosis of sarcopenia. This study examined the validity of bioimpedance analysis (BIA) and a sensor-based short physical performance battery (SPPB) device for analyzing appendicular skeletal muscle mass (ASM) and physical performance. Forty-one older adults were measured for ASM and physical performance with two BIA devices (InBody770 vs. T-SCAN PLUS III) and two SPPB devices (manual mSPPB vs. sensor-based sSPPB). Validity statistics included the intraclass correlation coefficient (ICC) and Bland-Altman plots to examine the agreement of data from the BIA (InBody770 vs. T-SCAN PLUS III) and the SPPBs (mSPPB vs. sSPPB). There was a significant ICC for skeletal muscle mass between the T-SCAN PLUS III and InBody770 devices (ICC = 0.8822;
MeSH term(s)	Humans ; Aged ; Muscle, Skeletal/physiology ; Body Mass Index ; Electric Impedance ; Sarcopenia/diagnosis ; Physical Functional Performance ; Body Composition/physiology ; Absorptiometry, Photon/methods
Language	English
Publishing date	2023-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23136026
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Workplace Violence Experienced by Personal Care Workers in a District in Seoul, Republic of Korea: A Comparison Study with Office and Service Workers.

Cho, Mi-Suk / Min, Kyoung-Bok / Min, Jin-Young

Healthcare (Basel, Switzerland)

2024 Volume 12, Issue 3

Abstract: This study compared the level of workplace violence experienced by personal healthcare workers in a district in Seoul, Republic of Korea, with those experienced by workers in office or service jobs. We matched 150 personal care workers with 150 office ... ...

Abstract	This study compared the level of workplace violence experienced by personal healthcare workers in a district in Seoul, Republic of Korea, with those experienced by workers in office or service jobs. We matched 150 personal care workers with 150 office workers and 150 service workers using a propensity score. Workplace violence was categorized into psychological violence and physical violence. Of the surveyed personal care workers, 53.3% reported experiencing psychological violence, and 42.0% reported experiencing physical violence. After adjusting for self-reported work-related symptoms, personal care workers had significantly higher odds of experiencing psychological violence than office workers (OR = 5.01; 95% CI: 2.80-8.97) or service workers (OR = 7.54; 95% CI: 3.93-14.47). The adjusted odds for physical violence were also significantly higher for personal care workers compared with those for office workers (OR = 5.83; 95% CI: 2.96-11.50) and service workers (OR = 6.00; 95% CI: 2.88-12.49). In terms of specific types of workplace violence, personal care workers were 7-10 times more likely to experience unwanted sexual attention, sexual harassment, and physical violence than office or service workers. We found that personal care workers were more prone to workplace violence than office or service workers, with gender-based or physical violence being the most common types. Considering the negative impact of workplace violence on workers' well-being and health services, policy updates and interventions focusing on personal care workers are needed to reduce workplace violence, safeguard workers' rights, and establish a secure working environment.
Language	English
Publishing date	2024-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12030320
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Article: The versatile utility of cysteine as a target for cancer treatment.

Min, Jin-Young / Chun, Kyung-Soo / Kim, Do-Hee

Frontiers in oncology

2023 Volume 12, Page(s) 997919

Abstract: Owing to its unique nucleophilicity, cysteine is an attractive sulfhydryl-containing proteinogenic amino acid. It is also utilized in various metabolic pathways and redox homeostasis, as it is used for the component of major endogenous antioxidant ... ...

Abstract	Owing to its unique nucleophilicity, cysteine is an attractive sulfhydryl-containing proteinogenic amino acid. It is also utilized in various metabolic pathways and redox homeostasis, as it is used for the component of major endogenous antioxidant glutathione and the generation of sulfur-containing biomolecules. In addition, cysteine is the most nucleophilic amino acid of proteins and can react with endogenous or exogenous electrophiles which can result in the formation of covalent bonds, which can alter the cellular states and functions. Moreover, post-translational modifications of cysteines trigger redox signaling and affect the three-dimensional protein structure. Protein phosphorylation mediated by kinases and phosphatases play a key role in cellular signaling that regulates many physiological and pathological processes, and consequently, the modification of cysteine regulates its activities. The modification of cysteine residues in proteins is critically important for the design of novel types of pharmacological agents. Therefore, in cancer metabolism and cancer cell survival, cysteine plays an essential role in redox regulation of cellular status and protein function. This review summarizes the diverse regulatory mechanisms of cysteine bound to or free from proteins in cancer. Furthermore, it can enhance the comprehension of the role of cysteine in tumor biology which can help in the development of novel effective cancer therapies.
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.997919
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Associations between Cognitive Function, Depressive Symptoms, and Contact with Adult Children in Older Couples.

Min, Jin-Young / Kim, Beom / Min, Kyoung-Bok

Journal of clinical medicine

2023 Volume 12, Issue 16

Abstract: The aim of this study was to investigate the association between cognitive function and depressive symptoms in older couples while also examining the relationship between cognitive performance and the frequency of contact with adult children. A total of ... ...

Abstract	The aim of this study was to investigate the association between cognitive function and depressive symptoms in older couples while also examining the relationship between cognitive performance and the frequency of contact with adult children. A total of 96 couples volunteered for this study and provided their informed consent at enrollment. Participants completed a neuropsychological test battery consisting of five cognitive domains: attention, language and related functions, visuospatial functions, memory, and frontal/executive functions. Symptoms of depression were assessed using the short version of the Geriatric Depression Scale. The number of contacts with children was categorized into ≥1 per month and <1 per month. We found that the cognitive functions of husbands with depressed wives were significantly lower in the frontal/executive functions. In contrast, the wives' cognitive performance was not associated with the husbands' depressive symptoms. For couples who had contact with their adult children less than once a month, the odds of the husbands with lower cognitive performance were significantly higher, which was reflected in their scores in visuospatial and executive functions. Among older married couples, the cognitive functions of husbands may be influenced more by their wives' mental health and degree of contact with their adult children. This infers that wives and offspring may act as a buffer against the cognitive impairment of older married men.
Language	English
Publishing date	2023-08-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12165431
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Article ; Online: Association between pseudoexfoliation and Alzheimer's disease-related brain atrophy.

Jeong, Won Cheol / Min, Jin-Young / Kang, Tae Gu / Bae, Heewon

PloS one

2023 Volume 18, Issue 6, Page(s) e0286727

Abstract: Background/aims: Pseudoexfoliation (PEX) syndrome is an age-related disorder characterized by the accumulation of extracellular material in the anterior eye segment. PEX pathogenesis is not fully understood, but amyloid which accumulates in the brain of ...

Abstract	Background/aims: Pseudoexfoliation (PEX) syndrome is an age-related disorder characterized by the accumulation of extracellular material in the anterior eye segment. PEX pathogenesis is not fully understood, but amyloid which accumulates in the brain of patients with Alzheimer's disease (AD) is a PEX component. PEX deposition shares features with amyloid aggregation in AD, and brain atrophy is a common AD feature, with β-amyloid accumulation among contributing factors. This study investigated whether PEX syndrome is associated with AD-related brain atrophy. Methods: We reviewed the medical records of patients diagnosed with PEX at the Veterans Health Service Medical Center between January 2015 and August 2021. This retrospective cohort study included 48 patients with PEX and 48 healthy age- and sex-matched controls. Patients with PEX were divided into two groups: with and without glaucoma. The main outcome measure was brain atrophy, using a visual rating scale, and AD incidence. Brain atrophy was measured using the Scheltens scale for medial temporal atrophy, the posterior cortical atrophy scale for parietal atrophy, and the Pasquier scale for global cortical atrophy. Results: The percentage of participants with medial temporal atrophy was 56.3% in the PEX group and 35.4% in the control group. The global cortical atrophy and parietal atrophy scores were significantly higher in the PEX group (P<0.05), whereas the PEX and PEX glaucoma groups showed no difference. Among the 96 participants, 16 and 5 participants in the PEX and control groups, respectively, were diagnosed with dementia. Patients with PEX glaucoma tended to have lower Mini-Mental State Examination scores, indicating impaired cognitive function, than those without glaucoma. Conclusion: PEX is associated with brain atrophy, reflecting the risk of developing AD. Patients with PEX glaucoma may present with advanced AD stages. Our results suggest that PEX may be a predictor of AD.
MeSH term(s)	Humans ; Alzheimer Disease/pathology ; Retrospective Studies ; Glaucoma/pathology ; Exfoliation Syndrome/complications ; Brain/pathology ; Atrophy/pathology
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0286727
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Corrigendum: Use of electroencephalogram, gait, and their combined signals for classifying cognitive impairment and normal cognition.

Min, Jin-Young / Ha, Sang-Won / Lee, Kiwon / Min, Kyoung-Bok

Frontiers in aging neuroscience

2023 Volume 15, Page(s) 1349594

Abstract: This corrects the article DOI: 10.3389/fnagi.2022.927295.]. ...

Abstract	[This corrects the article DOI: 10.3389/fnagi.2022.927295.].
Language	English
Publishing date	2023-12-20
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1349594
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Article ; Online: Anti-aging protein klotho was associated with vitamin B12 concentration in adults.

Choi, Ju-Young / Min, Jin-Young / Min, Kyoung-Bok

Medicine

2022 Volume 101, Issue 40, Page(s) e30710

Abstract: Previous studies have reported that serum klotho and vitamin B12 levels are valuable aging-related markers. However, studies supporting the association between serum klotho and vitamin B12 levels are lacking. We investigated the association between serum ...

Abstract	Previous studies have reported that serum klotho and vitamin B12 levels are valuable aging-related markers. However, studies supporting the association between serum klotho and vitamin B12 levels are lacking. We investigated the association between serum klotho and vitamin B12 concentrations in adults in the United States. The analytic study sample was 2065 aged 40 to 79 who participated in the 2011 to 2014 National Health and Nutrition Examination Survey (NHANES). Serum klotho and vitamin B12 collected from adults who consented to the use of their samples in the future. The participants were divided into 2 groups based on estimated glomerular filtration rate (eGFR) levels (high: ≥90 mL/min/1.73 m2 or low: <90 mL/min/1.73 m2). Of the 2065 participants, the log-transformed klotho concentration was significantly correlated with log-transformed vitamin B12 in the high eGFR group, but not in the low eGFR group. After adjusting for all potential covariates, there was a significant association between klotho and vitamin B12 concentrations in the high eGFR groups (beta = 0.100, SE = 0.040). In contrast, there was no significant relationship between klotho and vitamin B12 concentrations in the low eGFR group (beta = 0.012, SE = 0.019). Serum klotho concentration was significantly associated with vitamin B12 increases in US adults with high kidney function. Vitamin B12 concentration may be an important marker of klotho concentration in older adults.
MeSH term(s)	Aged ; Aging ; Biomarkers ; Glomerular Filtration Rate ; Glucuronidase ; Humans ; Hydrolases ; Nutrition Surveys ; United States ; Vitamin B 12
Chemical Substances	Biomarkers ; Hydrolases (EC 3.-) ; Glucuronidase (EC 3.2.1.31) ; Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	2022-10-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000030710
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Article: Association between pyrethroids and prostate endpoints; stratified according to renal function

Hong, Dongui / Min, Jin-Young / Min, Kyoung-bok

Environment international. 2021 Aug., v. 153

2021

Abstract: Pyrethroids, one of the most commonly used pesticide classes, are considered to be selectively toxic toward insects rather than toward humans. However, there are accumulating data about pyrethroids toxicity in humans, especially sex organs. Thus, we ... ...

Abstract	Pyrethroids, one of the most commonly used pesticide classes, are considered to be selectively toxic toward insects rather than toward humans. However, there are accumulating data about pyrethroids toxicity in humans, especially sex organs. Thus, we investigated whether pyrethroids affected reproductive organs, especially the prostate gland.With 1305 subjects who participated in the National Health and Nutrition Examination Survey, several measurements were performed: 3-phenoxybenzoic acid (3-PBA), a common metabolite of pyrethroids; prostate-specific antigen (PSA); and other covariates. Both logistic and linear regression analyses were performed after stratifying according to kidney function, which was evaluated based on the estimated glomerular filtration rate (eGFR).By logistic regression, the ORs (95% CIs) of the highest quantile to the reference group for higher total PSA were 2.039 (1.018 – 4.084) in the total study population and 2.219 (1.083–4.548) in the high eGFR group. The ORs (95% CIs) of the highest quantile to the reference group for a lower PSA ratio were 1.979 (1.057 – 3.707) in the total study population and 2.101 (1.086 – 4.064) in the high eGFR group. By linear regression, a marginally significant positive correlation between urinary 3-PBA and total PSA (β ± Standard Error = 0.049 ± 0.026, p = 0.0712) and a significant positive correlation between urinary 3-PBA and PSA ratio (β ± Standard Error = 0.018 ± 0.007, p = 0.0191) among the low eGFR group were observed.This study showed that exposure to pyrethroids was associated with either increased levels of total PSA or alterations in the PSA ratio.
Keywords	National Health and Nutrition Examination Survey ; environment ; glomerular filtration rate ; metabolites ; pesticides ; prostate-specific antigen ; pyrethrins ; regression analysis ; toxicity
Language	English
Dates of publication	2021-08
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2021.106489
Database	NAL-Catalogue (AGRICOLA)

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