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  1. Article ; Online: A vagal reflex evoked by airway closure.

    Schappe, Michael S / Brinn, Philip A / Joshi, Narendra R / Greenberg, Rachel S / Min, Soohong / Alabi, AbdulRasheed A / Zhang, Chuchu / Liberles, Stephen D

    Nature

    2024  Volume 627, Issue 8005, Page(s) 830–838

    Abstract: Airway integrity must be continuously maintained throughout life. Sensory neurons guard against airway obstruction and, on a moment-by-moment basis, enact vital reflexes to maintain respiratory ... ...

    Abstract Airway integrity must be continuously maintained throughout life. Sensory neurons guard against airway obstruction and, on a moment-by-moment basis, enact vital reflexes to maintain respiratory function
    MeSH term(s) Animals ; Female ; Male ; Mice ; Epithelial Cells/metabolism ; Lung/cytology ; Lung/innervation ; Lung/physiology ; Mechanoreceptors/metabolism ; Parvalbumins/metabolism ; Reflex/physiology ; Respiration ; Sensory Receptor Cells/metabolism ; Vagus Nerve/physiology ; Lung Compliance/physiology ; Respiratory Mechanics/physiology
    Chemical Substances Parvalbumins ; Piezo2 protein, mouse
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07144-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  2. Article ; Online: The reasons why fractional flow reserve and instantaneous wave-free ratio are similar using wave separation analysis.

    Min, Soohong / Kang, Gwansuk / Paeng, Dong-Guk / Choi, Joon Hyouk

    BMC cardiovascular disorders

    2021  Volume 21, Issue 1, Page(s) 48

    Abstract: Background and objectives: Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are the two most commonly used coronary indices of physiological stenosis severity based on pressure. To minimize the effect of wedge pressure (P: Methods! ...

    Abstract Background and objectives: Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are the two most commonly used coronary indices of physiological stenosis severity based on pressure. To minimize the effect of wedge pressure (P
    Methods: An in vitro circulation system was constructed to calculate P
    Results: Based on the in vitro results, the correlation between P
    Conclusions: Reconstructed FFR and iFR were in good agreement with conventional FFR and iFR. FFR and iFR can be expressed as the variation of trans-stenotic forward pressure, indicating that the two values are inferred from the same formula under different conditions.
    MeSH term(s) Cardiac Catheterization ; Coronary Angiography ; Coronary Stenosis/diagnosis ; Coronary Stenosis/physiopathology ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/physiopathology ; Fractional Flow Reserve, Myocardial ; Humans ; Hyperemia/physiopathology ; Models, Anatomic ; Models, Cardiovascular ; Predictive Value of Tests ; Reproducibility of Results ; Severity of Illness Index ; Signal Processing, Computer-Assisted
    Language English
    Publishing date 2021-01-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-021-01855-4
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  3. Article ; Online: Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses.

    Yoon, Woongchang / Min, Soohong / Ryu, Ho-Sung / Chung, Sun Ju / Chung, Jongkyeong

    Communications biology

    2022  Volume 5, Issue 1, Page(s) 872

    Abstract: Although levodopa is the most effective medication for Parkinson's disease, long-term levodopa treatment is largely compromised due to late motor complications, including levodopa-induced dyskinesia (LID). However, the genetic basis of LID pathogenesis ... ...

    Abstract Although levodopa is the most effective medication for Parkinson's disease, long-term levodopa treatment is largely compromised due to late motor complications, including levodopa-induced dyskinesia (LID). However, the genetic basis of LID pathogenesis has not been fully understood. Here, we discover genes pathogenic for LID using Drosophila genetics and behavioral analyses combined with genome-wide association studies on 578 patients clinically diagnosed with LID. Similar to the therapeutic effect of levodopa in patients, acute levodopa treatments restore the motor defect of Parkinson's disease model flies, while prolonged treatments cause LID-related symptoms, such as increased yawing, freezing and abrupt acceleration of locomotion. These symptoms require dopamine 1-like receptor 1 and are induced by neuronal overexpression of the receptor. Among genes selected from our analyses in the patient genome, neuronal knockdown of adenylyl cyclase 2 suppresses the levodopa-induced phenotypes and the receptor overexpression-induced symptoms in Drosophila. Together, our study provides genetic insights for LID pathogenesis through the D1-like receptor-adenylyl cyclase 2 signaling axis.
    MeSH term(s) Animals ; Drosophila/genetics ; Dyskinesia, Drug-Induced/drug therapy ; Dyskinesia, Drug-Induced/genetics ; Genome-Wide Association Study ; Genomics ; Levodopa/adverse effects ; Parkinson Disease/drug therapy ; Parkinson Disease/genetics
    Chemical Substances Levodopa (46627O600J)
    Language English
    Publishing date 2022-08-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-022-03830-x
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  4. Article ; Online: Interoperable Nanoparticle Sensor Capable of Strain and Vibration Measurement for Rotor Blade Monitoring.

    Min, Soo-Hong / Quan, Ying-Jun / Park, Su-Young / Lee, Gil-Yong / Ahn, Sung-Hoon

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 11

    Abstract: Recent advances in nanomaterials technology create the new possibility to fabricate high performance sensors. However, there has been limitations in terms of multivariate measurable and interoperable sensors. In this study, we fabricated an interoperable ...

    Abstract Recent advances in nanomaterials technology create the new possibility to fabricate high performance sensors. However, there has been limitations in terms of multivariate measurable and interoperable sensors. In this study, we fabricated an interoperable silver nanoparticle sensor fabricated by an aerodynamically focused nanomaterial (AFN) printing system which is a direct printing technique for inorganic nanomaterials onto a flexible substrate. The printed sensor exhibited the maximum measurable frequency of 850 Hz, and a gauge factor of 290.62. Using a fabricated sensor, we evaluated the sensing performance and demonstrated the measurement independency of strain and vibration sensing. Furthermore, using the proposed signal separation algorithm based on the Kalman filter, strain and vibration were each measured in real time. Finally, we applied the printed sensor to quadrotor condition monitoring to predict the motion of a quadrotor.
    Language English
    Publishing date 2021-05-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21113648
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  5. Article ; Online: Identification of a neural pathway governing satiety in Drosophila.

    Min, Soohong / Chung, Jongkyeong

    BMB reports

    2015  Volume 49, Issue 3, Page(s) 137–138

    Abstract: Satiety cues a feeding animal to cease further ingestion of food, thus protecting it from excessive energy gain. Impaired control of satiety is often associated with feeding-related disorders such as obesity. In our recent study, we reported the ... ...

    Abstract Satiety cues a feeding animal to cease further ingestion of food, thus protecting it from excessive energy gain. Impaired control of satiety is often associated with feeding-related disorders such as obesity. In our recent study, we reported the identification of a neural pathway that expresses the myoinhibitory peptide (MIP), critical for satiety responses in Drosophila. Targeted silencing of MIP neuron activity strikingly increased the body weight (BW) through elevated food intake. Similarly, genetic disruption of the gene encoding MIP also elevated feeding and BW. Suppressing the MIP pathway behaviorally transformed the satiated flies to feed similar to the starved ones, with augmented sensitivity to food. Conversely, temporal activation of MIP neuron markedly reduced the food intake and BW, and blunted the sensitivity of the starved flies to food as if they have been satiated. Shortly after termination of MIP neuron activation, the reduced BW reverted to the normal level along with a strong feeding rebound. Together our results reveal the switch-like role of the MIP pathway in feeding regulation by controlling satiety. [BMB Reports 2016; 49(3): 137-138].
    MeSH term(s) Animals ; Body Weight ; Drosophila Proteins/metabolism ; Drosophila melanogaster/physiology ; Feeding Behavior ; Neural Pathways/physiology ; Neurons/metabolism ; Satiety Response/physiology
    Chemical Substances Drosophila Proteins ; myoinhibitory peptide, Drosophila
    Language English
    Publishing date 2015-12-02
    Publishing country Korea (South)
    Document type News
    ZDB-ID 2410389-5
    ISSN 1976-670X ; 1976-6696
    ISSN (online) 1976-670X
    ISSN 1976-6696
    DOI 10.5483/bmbrep.2016.49.3.046
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4202: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Stretchable Biaxial and Shear Strain Sensors Using Diffractive Structural Colors.

    Quan, Ying-Jun / Kim, Young-Gyun / Kim, Min-Soo / Min, Soo-Hong / Ahn, Sung-Hoon

    ACS nano

    2020  Volume 14, Issue 5, Page(s) 5392–5399

    Abstract: Structural colors that can be changed dynamically, using either plasmonic nanostructures or photonic crystals, are rapidly emerging research areas for stretchable sensors. Despite the wide applications of various techniques to achieve strain-responsive ... ...

    Abstract Structural colors that can be changed dynamically, using either plasmonic nanostructures or photonic crystals, are rapidly emerging research areas for stretchable sensors. Despite the wide applications of various techniques to achieve strain-responsive structural colors, important factors in the feasibility of strain sensors-such as their sensing mechanism, stability, and reproducibility-have not yet been explored. Here, we introduce a stretchable, diffractive, color-based wireless strain sensor that can measure strain using the entire visible spectrum, based on an array of cone-shaped nanostructures on the surface of an elastomeric substrate. By stretching or compressing the substrate, the diffractive color can be tuned according to the changing grating pitch. Using the proposed method, we designed three types of strain-sensing modes: large-deformation (maximum 100%) tensile strain, biaxial 2D strain, and shear strain (maximum 78%). The strain sensors were fabricated, and applicability to strain-sensing was evaluated.
    Language English
    Publishing date 2020-04-15
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.9b08953
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  7. Article: Directly Printed Low-Cost Nanoparticle Sensor for Vibration Measurement during Milling Process.

    Min, Soo-Hong / Lee, Tae Hun / Lee, Gil-Yong / Zontar, Daniel / Brecher, Christian / Ahn, Sung-Hoon

    Materials (Basel, Switzerland)

    2020  Volume 13, Issue 13

    Abstract: A real-time, accurate, and reliable process monitoring is a basic and crucial enabler of intelligent manufacturing operation and digital twin applications. In this study, we represent a novel vibration measurement method for workpiece during the milling ... ...

    Abstract A real-time, accurate, and reliable process monitoring is a basic and crucial enabler of intelligent manufacturing operation and digital twin applications. In this study, we represent a novel vibration measurement method for workpiece during the milling process using a low-cost nanoparticle vibration sensor. We directly printed the vibration sensor based on silver nanoparticles positioned onto a polyimide substrate using an aerodynamically-focused nanomaterials printing system, which is a direct printing technique for inorganic nanomaterials positioned onto a flexible substrate. Since it does not require any post-process such as chemical etching and heat treatment, a highly sensitive vibration sensor composed of a microscale porous structure was fabricated at a cost of several cents each. Furthermore, accurate and reliable vibration data was obtained by simple and direct attachment to a workpiece. In this study, we discussed the performance of vibration measurement of a fabricated sensor in comparison to a commercial vibration sensor. Using frequency and power spectrum analysis of obtained data, we directly measured the vibration of workpiece during the milling process, according to a process parameter. Lastly, we applied a fabricated sensor for the digital twins of turbine blade manufacturing in which vibration greatly affects the quality of the product to predict the process defects in real-time.
    Language English
    Publishing date 2020-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13132920
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  8. Article ; Online: Misato underlies visceral myopathy in Drosophila.

    Min, Soohong / Yoon, Woongchang / Cho, Hyunho / Chung, Jongkyeong

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 17700

    Abstract: Genetic mechanisms for the pathogenesis of visceral myopathy (VM) have been rarely demonstrated. Here we report the visceral role of misato (mst) in Drosophila and its implications for the pathogenesis of VM. Depletion of mst using three independent RNAi ...

    Abstract Genetic mechanisms for the pathogenesis of visceral myopathy (VM) have been rarely demonstrated. Here we report the visceral role of misato (mst) in Drosophila and its implications for the pathogenesis of VM. Depletion of mst using three independent RNAi lines expressed by a pan-muscular driver elicited characteristic symptoms of VM, such as abnormal dilation of intestinal tracts, reduced gut motility, feeding defects, and decreased life span. By contrast, exaggerated expression of mst reduced intestine diameters, but increased intestinal motilities along with thickened muscle fibers, demonstrating a critical role of mst in the visceral muscle. Mst expression was detected in the adult intestine with its prominent localization to actin filaments and was required for maintenance of intestinal tubulin and actomyosin structures. Consistent with the subcellular localization of Mst, the intestinal defects induced by mst depletion were dramatically rescued by exogenous expression of an actin member. Upon ageing the intestinal defects were deteriorative with marked increase of apoptotic responses in the visceral muscle. Taken together, we propose the impairment of actomyosin structures induced by mst depletion in the visceral muscle as a pathogenic mechanism for VM.
    MeSH term(s) Actins/metabolism ; Actomyosin/metabolism ; Animals ; Apoptosis/physiology ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/physiology ; Intestinal Pseudo-Obstruction/genetics ; Intestinal Pseudo-Obstruction/physiopathology ; Intestines/physiology ; Muscles/metabolism ; RNA Interference ; Tubulin/metabolism
    Chemical Substances Actins ; Cell Cycle Proteins ; Cytoskeletal Proteins ; Drosophila Proteins ; Tubulin ; mst protein, Drosophila ; Actomyosin (9013-26-7)
    Language English
    Publishing date 2017-12-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-17961-3
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  9. Article ; Online: Control of feeding by Piezo-mediated gut mechanosensation in

    Min, Soohong / Oh, Yangkyun / Verma, Pushpa / Whitehead, Samuel C / Yapici, Nilay / Van Vactor, David / Suh, Greg Sb / Liberles, Stephen

    eLife

    2021  Volume 10

    Abstract: Across animal species, meals are terminated after ingestion of large food volumes, yet underlying mechanosensory receptors have so far remained elusive. Here, we identify an essential role ... ...

    Abstract Across animal species, meals are terminated after ingestion of large food volumes, yet underlying mechanosensory receptors have so far remained elusive. Here, we identify an essential role for
    MeSH term(s) Animals ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/physiology ; Feeding Behavior/physiology ; Female ; Gastrointestinal Tract/physiology ; Ion Channels/genetics ; Ion Channels/metabolism ; Male ; Mechanotransduction, Cellular/genetics ; Sensory Receptor Cells/physiology
    Chemical Substances Drosophila Proteins ; Ion Channels ; Piezo protein, Drosophila
    Language English
    Publishing date 2021-02-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.63049
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  10. Article ; Online: Loss of UCHL1 rescues the defects related to Parkinson's disease by suppressing glycolysis.

    Ham, Su Jin / Lee, Daewon / Xu, Wen Jun / Cho, Eunjoo / Choi, Sekyu / Min, Soohong / Park, Sunghyouk / Chung, Jongkyeong

    Science advances

    2021  Volume 7, Issue 28

    Abstract: The role of ubiquitin carboxyl-terminal hydrolase L1 ( ...

    Abstract The role of ubiquitin carboxyl-terminal hydrolase L1 (
    Language English
    Publishing date 2021-07-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abg4574
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