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  1. Article ; Online: Regulation of Copper Metabolism by Nitrogen Utilization in Saccharomyces cerevisiae

    Suzie Kang / Hyewon Seo / Min-Gyu Lee / Cheol-Won Yun

    Journal of Fungi, Vol 7, Iss 756, p

    2021  Volume 756

    Abstract: To understand the relationship between carbon or nitrogen utilization and iron homeostasis, we performed an iron uptake assay with several deletion mutants with partial defects in carbon or nitrogen metabolism. Among them, some deletion mutants defective ...

    Abstract To understand the relationship between carbon or nitrogen utilization and iron homeostasis, we performed an iron uptake assay with several deletion mutants with partial defects in carbon or nitrogen metabolism. Among them, some deletion mutants defective in carbon metabolism partially and the MEP2 deletion mutant showed lower iron uptake activity than the wild type. Mep2 is known as a high-affinity ammonia transporter in Saccharomyces cerevisiae . Interestingly, we found that nitrogen starvation resulted in lower iron uptake activity than that of wild-type cells without downregulation of the genes involved in the high-affinity iron uptake system FET3/FTR1 . However, the gene expression of FRE1 and CTR1 was downregulated by nitrogen starvation. The protein level of Ctr1 was also decreased by nitrogen starvation, and addition of copper to the nitrogen starvation medium partially restored iron uptake activity. However, the expression of MAC1, which is a copper-responsive transcriptional activator, was not downregulated by nitrogen starvation at the transcriptional level but was highly downregulated at the translational level. Mac1 was downregulated dramatically under nitrogen starvation, and treatment with MG132, which is an inhibitor of proteasome-dependent protein degradation, partially attenuated the downregulation of Mac1. Taken together, these results suggest that nitrogen starvation downregulates the high-affinity iron uptake system by degrading Mac1 in a proteasome-dependent manner and eventually downregulates copper metabolism.
    Keywords S. cerevisiae ; copper ; iron ; nitrogen ; Mac1 ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Effect of the Fluorination of Graphene Nanoflake on the Dispersion and Mechanical Properties of Polypropylene Nanocomposites

    Min Gyu Lee / Sangwoon Lee / Jaehyun Cho / Seokyoung Bae / Jae Young Jho

    Nanomaterials, Vol 10, Iss 1171, p

    2020  Volume 1171

    Abstract: In order to investigate the effect of fluorination of graphene nanoflake on the dispersibility in polypropylene (PP) composites, fluorinated graphene oxide (FGO) was prepared by solvo-thermal reaction and applied as a filler of the PP nanocomposite. Due ... ...

    Abstract In order to investigate the effect of fluorination of graphene nanoflake on the dispersibility in polypropylene (PP) composites, fluorinated graphene oxide (FGO) was prepared by solvo-thermal reaction and applied as a filler of the PP nanocomposite. Due to the weakened inter-particle attraction among the graphene nanoflake and reduced surface energy difference between PP and the filler, PP/FGO composites showed better exfoliation and dispersion state of the filler compared with that of PP/graphene oxide (GO) or PP/reduced graphene oxide (RGO) composites. The improved exfoliation and dispersion of graphene nanoflake resulted in a significant reinforcement on the composites. The Young’s modulus and tensile strength of PP composites filled with 2 wt% of FGO increased by 31% and 15%, respectively, compared with those of PP.
    Keywords polypropylene ; fluorinated graphene oxide ; surface energy ; dispersion ; mechanical property ; Chemistry ; QD1-999
    Subject code 620
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Association of adenotonsillar disease and adenotonsillectomy with the development of vitiligo

    Jong Seung Kim / Min Gyu Lee / Sang-Kyung Lee / Sang-Woo Yeom / Min-Gu Kang / Jong Hwan Lee / Il-Jae Lee / Jin Park / Seok-kweon Yun / Kyung-Hwa Nam

    Frontiers in Medicine, Vol

    A nationwide population-based cohort study

    2022  Volume 9

    Abstract: BackgroundVitiligo is a common acquired skin depigmentation disorder and is associated with various other autoimmune diseases which include thyroid disease and rheumatoid arthritis. Similarly, adenotonsillar disease (ATD) may induce inflammatory or ... ...

    Abstract BackgroundVitiligo is a common acquired skin depigmentation disorder and is associated with various other autoimmune diseases which include thyroid disease and rheumatoid arthritis. Similarly, adenotonsillar disease (ATD) may induce inflammatory or autoimmune diseases in other organs which include the skin. However, the influence of ATD on the development of vitiligo has not been studied.ObjectivesTo determine the association between ATD and adenotonsillectomy, and the development of vitiligo.Design and methodsUsing data from the National Health Insurance Service database, patients diagnosed with ATD between 2008 and 2010 were included in the study. We performed two rounds of 1:1 propensity score matching in the ATD and adenotonsillectomy groups. The ATD and non-ATD groups both included 206,514 individuals. Among the ATD group, the adenotonsillectomy and non-adenotonsillectomy groups both included 23,354 individuals. Each individual was monitored until 2019. The primary end point was the risk of vitiligo. Using the Cox Proportional Hazards model, the incidence of vitiligo and the hazard ratio (HR) were calculated.ResultsThe incidence of vitiligo was 1.16-fold higher in the ATD group than in the non-ATD group [adjusted HR (aHR), 1.16; 95% confidence interval (CI), 1.09–1.24] and 0.82-fold lower in the adenotonsillectomy group than in the non-adenotonsillectomy group (aHR, 0.82; 95% CI, 0.68–0.99). Additionally, the other risk factors for developing vitiligo included thyroid disease (aHR, 1.48; 95% CI, 1.11–1.98), age younger than 30 years (aHR, 1.18; 95% CI, 1.09–1.27), and age over 60 years (aHR, 1.22; 95% CI, 1.06–1.41), whereas factors including rural residency (aHR, 0.91; 95% CI, 0.85–0.98) and low economic status (aHR 0.87; 95% CI, 0.82–0.93) were associated with decreased incidence of vitiligo.ConclusionIn this study, ATD increases the risk of vitiligo and adenotonsillectomy attenuates its development. Clinicians should consider ATD as a pathogenic factor for vitiligo and the potential effect of ...
    Keywords adenoids ; tonsil ; adenoidectomy ; tonsillectomy ; vitiligo ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Author Correction

    Marco Napoli / Sarah J. Wu / Bethanie L. Gore / Hussein A. Abbas / Kyubum Lee / Rahul Checker / Shilpa Dhar / Kimal Rajapakshe / Aik Choon Tan / Min Gyu Lee / Cristian Coarfa / Elsa R. Flores

    Nature Communications, Vol 13, Iss 1, Pp 1-

    ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer

    2022  Volume 1

    Keywords Science ; Q
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer

    Marco Napoli / Sarah J. Wu / Bethanie L. Gore / Hussein Abbas / Kyubum Lee / Rahul Checker / Shilpa Dhar / Kimal Rajapakshe / Aik Choon Tan / Min Gyu Lee / Cristian Coarfa / Elsa R. Flores

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 16

    Abstract: The mechanistic role regulated by the oncogene ∆Np63 in lung cancer development is currently unclear. Here, the authors show that ΔNp63 is pro-tumorigenic in lung adenocarcinoma as well as squamous cell carcinoma, and maintains lung cancer progenitor ... ...

    Abstract The mechanistic role regulated by the oncogene ∆Np63 in lung cancer development is currently unclear. Here, the authors show that ΔNp63 is pro-tumorigenic in lung adenocarcinoma as well as squamous cell carcinoma, and maintains lung cancer progenitor cells via regulation of super-enhancer-associated genes, including BCL9L
    Keywords Science ; Q
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: HARVESTED ENERGY-ADAPTIVE MAC PROTOCOL FOR ENERGY HARVESTING IOT NETWORKS

    Hyeong-Kyu Lee / MinGyu Lee / Tae-Jin Lee

    Computer Science & Information Technology, Vol 5, Iss 16, Pp 51-

    2015  Volume 58

    Abstract: In energy harvesting IoT networks, an energy queue state of an IoT device will change dynamically and the number of IoT devices that transmit data to the IoT AP will vary in a frame. So we need a MAC protocol to adjust the frame length taking the amount ... ...

    Abstract In energy harvesting IoT networks, an energy queue state of an IoT device will change dynamically and the number of IoT devices that transmit data to the IoT AP will vary in a frame. So we need a MAC protocol to adjust the frame length taking the amount of energy of IoT devices into consideration. Since the existing Framed slotted ALOHA (F-ALOHA) Medium Access Control (MAC) protocol utilizes the fixed frame size, the resource efficiency can be reduced. In this paper, we propose a Harvested Energy-adaptive Medium Access Control (HEMAC) protocol where an IoT Access Point (AP) allocates slots in accordance with the number of IoT devices that try to transmit data in a frame. The proposed HE-MAC protocol improves the resource efficiency of the F-ALOHA MAC protocol. We show that the resource efficiency of the HE-MAC protocol is superior to those of the F-ALOHA MAC protocol through simulations.
    Keywords Internet of Things ; Energy Harvesting ; Framed Slotted ALOHA ; Medium Access Control ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
    Subject code 600
    Language English
    Publishing date 2015-12-01T00:00:00Z
    Publisher Academy & Industry Research Collaboration Center (AIRCC)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Transcriptomics-Based Repositioning of Natural Compound, Eudesmin, as a PRC2 Modulator

    Sang Ah Yi / Ki Hong Nam / Min Gyu Lee / Hwamok Oh / Jae Sung Noh / Jae Kyun Jeong / Sangwoo Kwak / Ye Ji Jeon / So Hee Kwon / Jaecheol Lee / Jeung-Whan Han

    Molecules, Vol 26, Iss 5665, p

    2021  Volume 5665

    Abstract: Extensive epigenetic remodeling occurs during the cell fate determination of stem cells. Previously, we discovered that eudesmin regulates lineage commitment of mesenchymal stem cells through the inhibition of signaling molecules. However, the epigenetic ...

    Abstract Extensive epigenetic remodeling occurs during the cell fate determination of stem cells. Previously, we discovered that eudesmin regulates lineage commitment of mesenchymal stem cells through the inhibition of signaling molecules. However, the epigenetic modulations upon eudesmin treatment in genomewide level have not been analyzed. Here, we present a transcriptome profiling data showing the enrichment in PRC2 target genes by eudesmin treatment. Furthermore, gene ontology analysis showed that PRC2 target genes downregulated by eudesmin are closely related to Wnt signaling and pluripotency. We selected DKK1 as an eudesmin-dependent potential top hub gene in the Wnt signaling and pluripotency. Through the ChIP-qPCR and RT-qPCR, we found that eudesmin treatment increased the occupancy of PRC2 components, EZH2 and SUZ12, and H3K27me3 level on the promoter region of DKK1 , downregulating its transcription level. According to the analysis of GEO profiles, DEGs by depletion of Oct4 showed an opposite pattern to DEGs by eudesmin treatment. Indeed, the expression of pluripotency markers, Oct4, Sox2, and Nanog, was upregulated upon eudesmin treatment. This finding demonstrates that pharmacological modulation of PRC2 dynamics by eudesmin might control Wnt signaling and maintain pluripotency of stem cells.
    Keywords eudesmin ; transcriptome ; polycomb repressive complex 2 ; wnt ; pluripotency ; Organic chemistry ; QD241-441
    Subject code 570
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4

    Yanli Liu / Su Qin / Tsai-Yu Chen / Ming Lei / Shilpa S. Dhar / Jolene Caifeng Ho / Aiping Dong / Peter Loppnau / Yanjun Li / Min Gyu Lee / Jinrong Min

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 11

    Abstract: MLL3 and MLL4 are members of the SET1/MLL family of histone H3K4 methyltransferases, which are responsible for monomethylating histone H3K4 on enhancers. Here the authors show that an extended PHD domain (ePHD6) in MLL3 and MLL4 specifically recognizes ... ...

    Abstract MLL3 and MLL4 are members of the SET1/MLL family of histone H3K4 methyltransferases, which are responsible for monomethylating histone H3K4 on enhancers. Here the authors show that an extended PHD domain (ePHD6) in MLL3 and MLL4 specifically recognizes an H4H18-containing fragment of histone H4, and that modifications of residues surrounding H4H18 modulate H4 binding to MLL3/4.
    Keywords Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Nature Publishing Group
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    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4

    Yanli Liu / Su Qin / Tsai-Yu Chen / Ming Lei / Shilpa S. Dhar / Jolene Caifeng Ho / Aiping Dong / Peter Loppnau / Yanjun Li / Min Gyu Lee / Jinrong Min

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 11

    Abstract: MLL3 and MLL4 are members of the SET1/MLL family of histone H3K4 methyltransferases, which are responsible for monomethylating histone H3K4 on enhancers. Here the authors show that an extended PHD domain (ePHD6) in MLL3 and MLL4 specifically recognizes ... ...

    Abstract MLL3 and MLL4 are members of the SET1/MLL family of histone H3K4 methyltransferases, which are responsible for monomethylating histone H3K4 on enhancers. Here the authors show that an extended PHD domain (ePHD6) in MLL3 and MLL4 specifically recognizes an H4H18-containing fragment of histone H4, and that modifications of residues surrounding H4H18 modulate H4 binding to MLL3/4.
    Keywords Science ; Q
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Broad genic repression domains signify enhanced silencing of oncogenes

    Dongyu Zhao / Lili Zhang / Min Zhang / Bo Xia / Jie Lv / Xinlei Gao / Guangyu Wang / Qingshu Meng / Yang Yi / Sen Zhu / Alin S. Tomoiaga / Min Gyu Lee / John P. Cooke / Qi Cao / Kaifu Chen

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 14

    Abstract: Epigenetically altered genes can have a key role in cancer pathobiology but epigenetic signatures that distinguish oncogenes are not yet known. Here, the authors identify broad genic repression domains, defined by widespread H3K27me3 modification, as an ... ...

    Abstract Epigenetically altered genes can have a key role in cancer pathobiology but epigenetic signatures that distinguish oncogenes are not yet known. Here, the authors identify broad genic repression domains, defined by widespread H3K27me3 modification, as an epigenetic signature to provide mutation-independent information for discovery of potential oncogenes.
    Keywords Science ; Q
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Nature Publishing Group
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