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  1. Article ; Online: LepRb+ cell–specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice

    Min-Hyun Kim / Yuan Li / Qiantao Zheng / Lin Jiang / Martin G. Myers Jr. / Wen-Shu Wu / Liangyou Rui

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 4

    Abstract: Leptin exerts its biological actions by activating the long-form leptin receptor (LepRb). LepRb signaling impairment and leptin resistance are believed to cause obesity. The transcription factor Slug — also known as Snai2 — recruits epigenetic modifiers ... ...

    Abstract Leptin exerts its biological actions by activating the long-form leptin receptor (LepRb). LepRb signaling impairment and leptin resistance are believed to cause obesity. The transcription factor Slug — also known as Snai2 — recruits epigenetic modifiers and regulates gene expression by an epigenetic mechanism; however, its epigenetic action has not been explored in leptin resistance. Here, we uncover a proobesity function of neuronal Slug. Hypothalamic Slug was upregulated in obese mice. LepRb+ cell–specific Slug-knockout (SlugΔLepRb) mice were resistant to diet-induced obesity, type 2 diabetes, and liver steatosis and experienced decreased food intake and increased fat thermogenesis. Leptin stimulated hypothalamic Stat3 phosphorylation and weight loss to a markedly higher level in SlugΔLepRb than in Slugfl/fl mice, even before their body weight divergence. Conversely, hypothalamic LepRb+ neuron–specific overexpression of Slug, mediated by AAV-hSyn-DIO-Slug transduction, induced leptin resistance, obesity, and metabolic disorders in mice on a chow diet. At the genomic level, Slug bound to and repressed the LepRb promoter, thereby inhibiting LepRb transcription. Consistently, Slug deficiency decreased methylation of LepRb promoter H3K27, a repressive epigenetic mark, and increased LepRb mRNA levels in the hypothalamus. Collectively, these results unravel what we believe to be a previously unrecognized hypothalamic neuronal Slug/epigenetic reprogramming/leptin resistance axis that promotes energy imbalance, obesity, and metabolic disease.
    Keywords Cell biology ; Metabolism ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Hybrid Approach for Facial Expression Recognition Using Convolutional Neural Networks and SVM

    Jin-Chul Kim / Min-Hyun Kim / Han-Enul Suh / Muhammad Tahir Naseem / Chan-Su Lee

    Applied Sciences, Vol 12, Iss 5493, p

    2022  Volume 5493

    Abstract: Facial expression recognition is very useful for effective human–computer interaction, robot interfaces, and emotion-aware smart agent systems. This paper presents a new framework for facial expression recognition by using a hybrid model: a combination ... ...

    Abstract Facial expression recognition is very useful for effective human–computer interaction, robot interfaces, and emotion-aware smart agent systems. This paper presents a new framework for facial expression recognition by using a hybrid model: a combination of convolutional neural networks (CNNs) and a support vector machine (SVM) classifier using dynamic facial expression data. In order to extract facial motion characteristics, dense facial motion flows and geometry landmark flows of facial expression sequences were used as inputs to the CNN and SVM classifier, respectively. CNN architectures for facial expression recognition from dense facial motion flows were proposed. The optimal weighting combination of the hybrid classifiers provides better facial expression recognition results than individual classifiers. The system has successfully classified seven facial expressions signalling anger, contempt, disgust, fear, happiness, sadness and surprise classes for the CK+ database, and facial expressions of anger, disgust, fear, happiness, sadness and surprise for the BU4D database. The recognition performance of the proposed system is 99.69% for the CK+ database and 94.69% for the BU4D database. The proposed method shows state-of-the-art results for the CK+ database and is proven to be effective for the BU4D database when compared with the previous schemes.
    Keywords facial expression recognition ; convolutional neural networks ; support vector machine ; mixture of classifiers ; hybrid model ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 629
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Deletion of metal transporter Zip14 (Slc39a14) produces skeletal muscle wasting, endotoxemia, Mef2c activation and induction of miR-675 and Hspb7

    Jinhee Kim / Tolunay Beker Aydemir / Felix R. Jimenez-Rondan / Courtney H. Ruggiero / Min-Hyun Kim / Robert J. Cousins

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 15

    Abstract: Abstract Skeletal muscle represents the largest pool of body zinc, however, little is known about muscle zinc homeostasis or muscle-specific zinc functions. Zip14 (Slc39a14) was the most highly expressed zinc transporter in skeletal muscle of mice in ... ...

    Abstract Abstract Skeletal muscle represents the largest pool of body zinc, however, little is known about muscle zinc homeostasis or muscle-specific zinc functions. Zip14 (Slc39a14) was the most highly expressed zinc transporter in skeletal muscle of mice in response to LPS-induced inflammation. We compared metabolic parameters of skeletal muscle from global Zip14 knockout (KO) and wild-type mice (WT). At basal steady state Zip14 KO mice exhibited a phenotype that included muscle wasting and metabolic endotoxemia. Microarray and qPCR analysis of gastrocnemius muscle RNA revealed that ablation of Zip14 produced increased muscle p-Mef2c, Hspb7 and miR-675-5p expression and increased p38 activation. ChIP assays showed enhanced binding of NF-$$\kappa \beta $$ κβ to the Mef2c promoter. In contrast, LPS-induced systemic inflammation enhanced Zip14-dependent zinc uptake by muscle, increased expression of Atrogin1 and MuRF1 and markedly reduced MyoD. These signatures of muscle atrophy and cachexia were not influenced by Zip14 ablation, however. LPS-induced miR-675-3p and -5p expression was Zip14-dependent. Collectively, these results with an integrative model are consistent with a Zip14 function in skeletal muscle at steady state that supports myogenesis through suppression of metabolic endotoxemia and that Zip14 ablation coincides with sustained activity of phosphorylated components of signaling pathways including p-Mef2c, which causes Hspb7-dependent muscle wasting.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease

    Lin Jiang / Haoran Su / Xiaoyin Wu / Hong Shen / Min-Hyun Kim / Yuan Li / Martin G. Myers / Chung Owyang / Liangyou Rui

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 13

    Abstract: Leptin regulates the sympathetic nervous system, energy expenditure and body weight through incompletely understood mechanisms. Here the authors report that Sh2b1 in leptin receptor positive neurons mediates the ability of leptin to stimulate sympathetic ...

    Abstract Leptin regulates the sympathetic nervous system, energy expenditure and body weight through incompletely understood mechanisms. Here the authors report that Sh2b1 in leptin receptor positive neurons mediates the ability of leptin to stimulate sympathetic nerve activity in brown adipose tissue, body temperature and cold tolerance.
    Keywords Science ; Q
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease

    Lin Jiang / Haoran Su / Xiaoyin Wu / Hong Shen / Min-Hyun Kim / Yuan Li / Martin G. Myers / Chung Owyang / Liangyou Rui

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 13

    Abstract: Leptin regulates the sympathetic nervous system, energy expenditure and body weight through incompletely understood mechanisms. Here the authors report that Sh2b1 in leptin receptor positive neurons mediates the ability of leptin to stimulate sympathetic ...

    Abstract Leptin regulates the sympathetic nervous system, energy expenditure and body weight through incompletely understood mechanisms. Here the authors report that Sh2b1 in leptin receptor positive neurons mediates the ability of leptin to stimulate sympathetic nerve activity in brown adipose tissue, body temperature and cold tolerance.
    Keywords Science ; Q
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Author Correction

    Lin Jiang / Haoran Su / Xiaoyin Wu / Hong Shen / Min-Hyun Kim / Yuan Li / Martin G. Myers / Chung Owyang / Liangyou Rui

    Nature Communications, Vol 11, Iss 1, Pp 1-

    Leptin receptor-expressing neuron Sh2b1 supports sympathetic nervous system and protects against obesity and metabolic disease

    2020  Volume 1

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords Science ; Q
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Discrepancies in general surgery medical terminology between South and North Korea

    Keunyoung Hur / Do-Eon Park / Heung-Kwon Oh / Hyun Hui Yang / Dayoung Ko / Min-Hyun Kim / Myung Jo Kim / Sung Il Kang / Duck-Woo Kim / Sung-Bum Kang

    Korean Journal of Medical Education, Vol 30, Iss 1, Pp 51-

    2018  Volume 56

    Abstract: Purpose The purpose of this study was to categorize surgery-related medical terminologies used in South and North Korea and to compare and analyze discrepancies observed in the terms. Methods This study collected medical terminology used in the North ... ...

    Abstract Purpose The purpose of this study was to categorize surgery-related medical terminologies used in South and North Korea and to compare and analyze discrepancies observed in the terms. Methods This study collected medical terminology used in the North Korean medical book “Surgery” and compared it to medical terminology found in the medical glossary of South Korea. The order of the subtitle was described according to the Instruction to Authors. Results In total, there were 2,168 individual medical terms, of which only 1,004 words (46.3%) were identical to South Korean medical terms. There were 581 similar terms (26.8%), 265 different terms (12.2%), and 318 terms that are nonexistent in South Korea (14.7%). Conclusion Less than half of the medical terms used in North Korea match those used in South Korea. It is expected that the prolongation of the current division of South and North Korea will only worsen this discrepancy. Further efforts to bridge the gap through academic exchange between South Korea and North Korea are required in preparation for an era of reunification.
    Keywords Republic of Korea ; Democratic People’s Republic of Korea ; Medical terminology ; Discrepancy ; Education (General) ; L7-991 ; Medicine (General) ; R5-920
    Subject code 200
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher Korean Society of Medical Education
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Quality of life after sphincter preservation surgery or abdominoperineal resection for low rectal cancer (ASPIRE)

    Sung-Bum Kang / Jung Rae Cho / Seung-Yong Jeong / Jae Hwan Oh / Soyeon Ahn / Sunkyu Choi / Duck-Woo Kim / Bong Hwa Lee / Eui Gon Youk / Sung Chan Park / Seung Chul Heo / Doo-Seok Lee / Seung-Bum Ryoo / Ji Won Park / Hyoung-Chul Park / Sung-Min Lee / Sung Il Kang / Min Hyun Kim / Heung-Kwon Oh /
    Rumi Shin / Min Jung Kim / Kyoung Ho Lee / Young-Hoon Kim / Jae-Sung Kim / Keun-Wook Lee / Hye Seung Lee / Hyun Jung Kim / Young Soo Park / Dae Kyung Sohn / Kyu Joo Park

    The Lancet Regional Health. Western Pacific, Vol 6, Iss , Pp 100087- (2021)

    A long-term prospective, multicentre, cohort study

    2021  

    Abstract: Summary: Background: The long-term effects of radical resection on quality of life may influence the treatment selection. The objective of this study was to determine whether abdominoperineal resection has a better effect on the quality of life than ... ...

    Abstract Summary: Background: The long-term effects of radical resection on quality of life may influence the treatment selection. The objective of this study was to determine whether abdominoperineal resection has a better effect on the quality of life than sphincter preservation surgery at 3 years after surgery Methods: This prospective, cohort study included patients who underwent radical resection for low rectal cancer. The primary outcomes were European Organisation for Research and Treatment of Cancer QLQ-C30 and CR38 quality of life scores 3 years after surgery, which were compared with linear generalised estimating equations, after adjustment for baseline values, a time effect, and an interaction effect between time and treatment. The secondary outcomes included sexual-urinary functions and oncological outcomes. The study was registered with ClinicalTrials.gov (NCT01461525). Findings: Between December 2011 and August 2016, 342 patients were enrolled: 268 (78•4%) underwent sphincter preservation surgery and 74 (21•6%) underwent abdominoperineal resection. The global quality of life scores did not differ between sphincter preservation surgery and abdominoperineal resection groups (adjusted mean difference, 4•2 points on a 100-point scale; 95% confidence interval [CI], −1•3 to 9•7, p = 0•1316). Abdominoperineal resection was associated with a worse body image (9•8 points; 95% CI, 2•9 to 16•6, p = 0•0052), micturition symptoms (−8•0 points; 95% CI, -14•1 to −1•8, p = 0•0108), male sexual problems (−19•9 points; 95% CI, -33•1 to -6•7, p = 0•0032), less confidence in getting and maintaining an erection in males (0•5 points on a 5-point scale; 95% CI, 0•1 to 0•8, p = 0•0155), and worse urinary symptoms (−5•4 points on a 35-point scale; 95% CI, −8•0 to −2•7, p < 0•0001). The 5-year overall survival was worse with abdominoperineal resection in unadjusted (92•2% vs 80•9%; difference 11•3%, hazard ratio 2•38; 95% CI, 1•27 to 4•46, p = 0•0052), but did not differ after adjustment. Interpretation: In this long-term ...
    Keywords Quality of life ; Rectal cancer ; Abdominoperineal resection ; Sphincter preservation surgery ; Sexual function ; Urinary function ; Public aspects of medicine ; RA1-1270
    Subject code 616
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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