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  1. Article ; Online: MSCs mediate long-term efficacy in a Crohn's disease model by sustained anti-inflammatory macrophage programming via efferocytosis.

    Dave, Maneesh / Dev, Atul / Somoza, Rodrigo A / Zhao, Nan / Viswanath, Satish / Mina, Pooja Rani / Chirra, Prathyush / Obmann, Verena Carola / Mahabeleshwar, Ganapati H / Menghini, Paola / Durbin-Johnson, Blythe / Nolta, Jan / Soto, Christopher / Osme, Abdullah / Khuat, Lam T / Murphy, William J / Caplan, Arnold I / Cominelli, Fabio

    NPJ Regenerative medicine

    2024  Volume 9, Issue 1, Page(s) 6

    Abstract: Mesenchymal stem cells (MSCs) are novel therapeutics for the treatment of Crohn's disease. However, their mechanism of action is unclear, especially in disease-relevant chronic models of inflammation. Thus, we used SAMP-1/YitFc (SAMP), a chronic and ... ...

    Abstract Mesenchymal stem cells (MSCs) are novel therapeutics for the treatment of Crohn's disease. However, their mechanism of action is unclear, especially in disease-relevant chronic models of inflammation. Thus, we used SAMP-1/YitFc (SAMP), a chronic and spontaneous murine model of small intestinal inflammation, to study the therapeutic effects and mechanism of action of human bone marrow-derived MSCs (hMSC). hMSC dose-dependently inhibited naïve T lymphocyte proliferation via prostaglandin E
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 2057-3995
    ISSN (online) 2057-3995
    DOI 10.1038/s41536-024-00347-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of liquiritigenin on chloroquine accumulation in digestive vacuole leading to apoptosis-like death of chloroquine-resistant P. falciparum.

    Kumar, Saurabh / Kapkoti, Deepak Singh / Mina, Pooja Rani / Gupta, Madhuri / Kumar, Ravi / Kumar, Parmanand / Pathak, Priyanka / Bhakuni, R S / Rout, Prasant / Pal, Anirban / Darokar, Mahendra P

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2023  Volume 114, Page(s) 154738

    Abstract: Background: Malaria remains one of the major health concerns, especially in tropical countries. Although drugs such as artemisinin-based combinations are efficient for treating Plasmodium falciparum, the growing threat from multi-drug resistance has ... ...

    Abstract Background: Malaria remains one of the major health concerns, especially in tropical countries. Although drugs such as artemisinin-based combinations are efficient for treating Plasmodium falciparum, the growing threat from multi-drug resistance has become a major challenge. Thus, there is a constant need to identify and validate new combinations to sustain current disease control strategies to overcome the challenge of drug resistance in the malaria parasites. To meet this demand, liquiritigenin (LTG) has been found to positively interact in combination with the existing clinically used drug chloroquine (CQ), which has become unfunctional due to acquired drug resistance.
    Purpose: To evaluate the best interaction between LTG and CQ against CQ- resistant strain of P. falciparum. Furthermore, the in vivo antimalarial efficacy and possible mechanism of action of the best combination was also assessed.
    Methods: The in vitro anti-plasmodial potential of LTG against CQ- resistant strain K1 of P. falciparum was tested using Giemsa staining method. The behaviour of the combinations was evaluated using the fix ratio method and evaluated the interaction of LTG and CQ by calculating the fractional inhibitory concentration index (FICI). Oral toxicity study was carried out in a mice model. In vivo antimalarial efficacy of LTG alone and in combination with CQ was evaluated using a four-day suppression test in a mouse model. The effect of LTG on CQ accumulation was measured using HPLC and the rate of alkalinization of the digestive vacuole. Cytosolic Ca
    Results: LTG possesses anti-plasmodial activity on its own and it showed to be an adjuvant of CQ. In in vitro studies, LTG showed synergy with CQ only in the ratio (CQ: LTG-1:4) against CQ-resistant strain (K1) of P. falciparum. Interestingly, in vivo studies, LTG in combination with CQ showed higher chemo-suppression and enhanced mean survival time at much lower concentrations compared to individual doses of LTG and CQ against CQ- resistant strain (N67) of Plasmodium yoelli nigeriensis. LTG was found to increase the CQ accumulation into digestive vacuole, reducing the rate of alkalinization, in turn increasing cytosolic Ca
    Conclusion: LTG showed synergy with CQ in the ratio LTG: CQ, 4:1) in vitro and was able to curtail the IC
    MeSH term(s) Animals ; Mice ; Chloroquine/pharmacology ; Antimalarials/pharmacology ; Chromatography, Liquid ; Vacuoles ; Tandem Mass Spectrometry ; Malaria/drug therapy ; Plasmodium falciparum ; Apoptosis ; Drug Resistance ; Disease Models, Animal
    Chemical Substances Chloroquine (886U3H6UFF) ; Antimalarials ; liquiritigenin (T194LKP9W6)
    Language English
    Publishing date 2023-03-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2023.154738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4115: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article: 4-Chlorothymol Exerts Antiplasmodial Activity Impeding Redox Defense System in

    Kumar, Saurabh / Mina, Pooja Rani / Kumar, Ravi / Pal, Anirban / Ahmad, Ateeque / Tandon, Sudeep / Darokar, Mahendra P

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 628970

    Abstract: Malaria remains one of the major health concerns due to the resistance ... ...

    Abstract Malaria remains one of the major health concerns due to the resistance of
    Language English
    Publishing date 2021-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.628970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: 4-chloro eugenol interacts synergistically with artesunate against drug resistant P. falciparum inducing oxidative stress.

    Mina, Pooja Rani / Kumar, Saurabh / Agarwal, Karishma / Kumar, Ravi / Pal, Anirban / Tandon, Sudeep / Yadav, Sanjeev Kumar / Yadav, Sanjay / Darokar, Mahendra P

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2021  Volume 137, Page(s) 111311

    Abstract: 4-chloro eugenol (4CE), a semisynthetic analog of phytomolecule eugenol exhibited potent antiplasmodial activity with ... ...

    Abstract 4-chloro eugenol (4CE), a semisynthetic analog of phytomolecule eugenol exhibited potent antiplasmodial activity with IC
    MeSH term(s) Animals ; Antimalarials/pharmacology ; Artesunate/pharmacology ; Calcium/metabolism ; DNA Damage ; Drug Resistance/drug effects ; Drug Synergism ; Eugenol/pharmacology ; Lipid Peroxidation/drug effects ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/parasitology ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Oxidative Stress/drug effects ; Plasmodium falciparum/drug effects ; Protein Carbonylation/drug effects ; Reactive Nitrogen Species/metabolism ; Reactive Oxygen Species/metabolism
    Chemical Substances Antimalarials ; Reactive Nitrogen Species ; Reactive Oxygen Species ; Eugenol (3T8H1794QW) ; Artesunate (60W3249T9M) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-01-30
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2021.111311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Silymarin, a polyphenolic flavonoid impede Plasmodium falciparum growth through interaction with heme

    Mina, Pooja Rani / Kumar, Yogesh / Verma, Ajeet Kumar / Khan, Feroz / Tandon, Sudeep / Pal, Anirban / Darokar, Mahendra Pandurang

    Natural product research. 2020 Sept. 16, v. 34, no. 18

    2020  

    Abstract: A polyphenolic flavonoid, Silymarin isolated from Silybum marianum is widely known for its hepatoprotective action. In the present study anti-plasmodial activity of Silymarin has been demonstrated for the first time having IC₅₀ of 14 ± 0.33 μM against ... ...

    Abstract A polyphenolic flavonoid, Silymarin isolated from Silybum marianum is widely known for its hepatoprotective action. In the present study anti-plasmodial activity of Silymarin has been demonstrated for the first time having IC₅₀ of 14 ± 0.33 μM against the NF-54 strain of P. falciparum with high selectivity index (>100). The parasitostatic action is exerted through inhibition of β-hematin/hemozoin formation which is due to the interaction (Kd = 3.63 ± 0.9µM) of silymarin with free heme in a Stoichiometry of 1:1 Silymarin: heme complex resulting into heme-induced membrane damage in the parasite. Silymarin could hinder the glutathione and hydrogen peroxide-induced heme detoxification. Silymarin also induces apoptosis in the parasite through the elevation of caspase-3 level in a dose-dependent manner. Results from the docking studies suggest that Silymarin interacts with heme.
    Keywords Plasmodium falciparum ; Silybum marianum ; antiplasmodial properties ; apoptosis ; caspase-3 ; dose response ; glutathione ; heme ; hepatoprotective effect ; hydrogen peroxide ; parasites ; research ; silymarin ; stoichiometry
    Language English
    Dates of publication 2020-0916
    Size p. 2647-2651.
    Publishing place Taylor & Francis
    Document type Article
    Note NAL-light
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2018.1548449
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Mesenchymal stem cells ameliorate inflammation in an experimental model of Crohn's disease via the mesentery.

    Dave, Maneesh / Dev, Atul / Somoza, Rodrigo A / Zhao, Nan / Viswanath, Satish / Mina, Pooja Rani / Chirra, Prathyush / Obmann, Verena Carola / Mahabeleshwar, Ganapati H / Menghini, Paola / Johnson, Blythe Durbin / Nolta, Jan / Soto, Christopher / Osme, Abdullah / Khuat, Lam T / Murphy, William / Caplan, Arnold I / Cominelli, Fabio

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Objective: Mesenchymal stem cells (MSCs) are novel therapeutics for treatment of Crohn's disease. However, their mechanism of action is unclear, especially in disease-relevant chronic models of inflammation. Thus, we used SAMP-1/YitFc, a chronic and ... ...

    Abstract Objective: Mesenchymal stem cells (MSCs) are novel therapeutics for treatment of Crohn's disease. However, their mechanism of action is unclear, especially in disease-relevant chronic models of inflammation. Thus, we used SAMP-1/YitFc, a chronic and spontaneous murine model of small intestinal inflammation, to study the therapeutic effect and mechanism of human bone marrow-derived MSCs (hMSC).
    Design: hMSC immunosuppressive potential was evaluated through in vitro mixed lymphocyte reaction, ELISA, macrophage co-culture, and RT-qPCR. Therapeutic efficacy and mechanism in SAMP were studied by stereomicroscopy, histopathology, MRI radiomics, flow cytometry, RT-qPCR, small animal imaging, and single-cell RNA sequencing (Sc-RNAseq).
    Results: hMSC dose-dependently inhibited naïve T lymphocyte proliferation in MLR via PGE
    Conclusion: hMSCs result in healing and tissue regeneration in a chronic model of small intestinal inflammation. Despite being short-lived, exert long-term effects via macrophage reprogramming to an anti-inflammatory phenotype.
    Data transparency statement: Single-cell RNA transcriptome datasets are deposited in an online open access repository 'Figshare' (DOI: https://doi.org/10.6084/m9.figshare.21453936.v1 ).
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.22.541829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Silymarin, a polyphenolic flavonoid impede

    Mina, Pooja Rani / Kumar, Yogesh / Verma, Ajeet Kumar / Khan, Feroz / Tandon, Sudeep / Pal, Anirban / Darokar, Mahendra Pandurang

    Natural product research

    2019  Volume 34, Issue 18, Page(s) 2647–2651

    Abstract: A polyphenolic flavonoid, Silymarin isolated ... ...

    Abstract A polyphenolic flavonoid, Silymarin isolated from
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Flavonoids/pharmacology ; Heme/metabolism ; Hemeproteins/antagonists & inhibitors ; Inhibitory Concentration 50 ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/growth & development ; Silymarin/chemistry ; Silymarin/metabolism ; Silymarin/pharmacology
    Chemical Substances Antioxidants ; Flavonoids ; Hemeproteins ; Silymarin ; hemozoin (39404-00-7) ; Heme (42VZT0U6YR)
    Language English
    Publishing date 2019-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2018.1548449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cliv-92-Loaded Glycyrrhetinic Acid-Modified Chitosan Nanoparticles for Enhanced Hepatoprotection-Preparation, Characterization, and In Vivo Evaluation.

    Yadav, Kuldeep Singh / Srivastava, Nidhi / Rai, Vineet Kumar / Ranjana / Tandon, Sudeep / Mina, Pooja Rani / Chanda, Debabrata / Kalleti, Navodayam / Rath, Srikanta Kumar / Darokar, Mahendra Pandurang / Ajayakumar, P V / Shanker, Karuna / Yadav, Narayan Prasad

    AAPS PharmSciTech

    2021  Volume 22, Issue 8, Page(s) 259

    Abstract: Cliv-92 is a mixture of three structurally similar coumarinolignoids and a proven hepatoprotective agent. Low aqueous solubility and poor bioavailability are notable hindrances for its further use. Therefore, glycyrrhetinic acid-linked chitosan ... ...

    Abstract Cliv-92 is a mixture of three structurally similar coumarinolignoids and a proven hepatoprotective agent. Low aqueous solubility and poor bioavailability are notable hindrances for its further use. Therefore, glycyrrhetinic acid-linked chitosan nanoparticles loaded with Cliv-92 were prepared for active targeting to the liver. The nanoparticles were prepared by the ionic gelation method to avoid the use of toxic solvents/rigorous agitation. The method of preparation was optimized using a central composite design with independent variables, namely polymer: drug ratio (3:1, w/w), crosslinker concentration (0.5%), and stirring speed (750 rpm). The optimized nanoparticles had a mean particle size of 185.17 nm, a polydispersity index of 0.41, a zeta potential of 30.93 mV, and a drug loading of 16.30%. The prepared formulation showed sustained release of approximately 63% of loaded Cliv-92 over 72 h. The nanoparticles were freeze-dried for long-term storage and further characterized. The formulation was found to be biocompatible for parenteral delivery. In vivo imaging study showed that optimized nanoparticles were preferentially accumulated in the liver and successfully targeting the liver. The present study successfully demonstrated the improved pharmacokinetic properties (≈12% relative bioavailability) and efficacy profile (evidenced by in vivo and histopathological studies) of fabricated Cliv-92 nanoparticles.
    MeSH term(s) Chitosan ; Drug Carriers ; Glycyrrhetinic Acid ; Nanoparticles ; Particle Size ; Solubility
    Chemical Substances Drug Carriers ; Chitosan (9012-76-4) ; Glycyrrhetinic Acid (P540XA09DR)
    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-021-02130-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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