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Article ; Online: The use of seismically isolated buildings by urban wildlife in Japan.

Seki, Yoshikazu / Hara, Keita / Minami, Yoshinori

The Journal of veterinary medical science

2024 Volume 86, Issue 3, Page(s) 290–294

Abstract: Some wildlife species that have expanded their range into urban areas use various anthropogenic structures for breeding and resting. We investigated the use of seismically isolated buildings, with gaps between the structures and ground surface, by urban ... ...

Abstract	Some wildlife species that have expanded their range into urban areas use various anthropogenic structures for breeding and resting. We investigated the use of seismically isolated buildings, with gaps between the structures and ground surface, by urban wildlife in Japan. Camera traps set in a building revealed that masked palm civets (Paguma larvata) continued to use the building for approximately 3 years. Civet feces and footprints were found in two buildings during field sign surveys. To ensure public health, civets should be prevented from invading seismically isolated buildings by covering gaps with elastic materials and avoiding placing pipes that could be used by the animals near these gaps.
MeSH term(s)	Animals ; Animals, Wild ; Viverridae ; Japan ; Public Health ; Phylogeny
Language	English
Publishing date	2024-01-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.23-0378
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Article ; Online: Exceptional Response to PD-1 Blockade as First-Line Therapy in Head and Neck Squamous Cell Carcinoma.

Kumai, Takumi / Komatsuda, Hiroki / Minami, Yoshinori / Harabuchi, Yasuaki

ORL; journal for oto-rhino-laryngology and its related specialties

2020 Volume 82, Issue 6, Page(s) 343–350

Abstract: The effect of PD-1 blockade as a first-line therapy in nonmetastatic head and neck squamous cell carcinoma (HNSCC) remains unknown. We report a case of an exceptional response to PD-1 blockade as a first-line therapy in a patient with HNSCC and lung ... ...

Abstract	The effect of PD-1 blockade as a first-line therapy in nonmetastatic head and neck squamous cell carcinoma (HNSCC) remains unknown. We report a case of an exceptional response to PD-1 blockade as a first-line therapy in a patient with HNSCC and lung cancer. A 59-year-old man presented with cheek swelling and chest pain. He was diagnosed with maxillary sinus carcinoma (squamous cell carcinoma) and lung cancer (non-small-cell lung cancer, not otherwise specified). The maxillary sinus carcinoma was completely resolved after 8 cycles of pembrolizumab. Immune checkpoint blockade warrants further evaluation in previously untreated patients with HNSCC.
MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Antigens, Neoplasm ; Antineoplastic Agents, Immunological/therapeutic use ; Biomarkers, Tumor ; Carcinoma, Non-Small-Cell Lung ; Head and Neck Neoplasms/drug therapy ; Humans ; Male ; Maxillary Sinus/diagnostic imaging ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/pathology ; Tomography Scanners, X-Ray Computed ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antigens, Neoplasm ; Antineoplastic Agents, Immunological ; Biomarkers, Tumor ; Programmed Cell Death 1 Receptor ; pembrolizumab (DPT0O3T46P)
Language	English
Publishing date	2020-09-03
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	121482-2
ISSN	1423-0275 ; 0301-1569
ISSN (online)	1423-0275
ISSN	0301-1569
DOI	10.1159/000509485
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Article: Monitoring SARS-CoV-2 Viral Load and CD4+ T-cell Count After ART in a Patient Diagnosed With AIDS Following SARS-CoV-2 Infection: A Case Report.

Umekage, Yasuhiro / Hatayama, Mayumi / Yagita, Akari / Nitanai, Kiichi / Yanada, Hiraku / Shigaki, Ryota / Minami, Yoshinori / Sasaki, Takaaki

Cureus

2023 Volume 15, Issue 12, Page(s) e51189

Abstract: We describe the case of a 36-year-old man diagnosed with human immunodeficiency virus (HIV) following prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. The patient had a complication of pneumocystis pneumonia. Upon ... ...

Abstract	We describe the case of a 36-year-old man diagnosed with human immunodeficiency virus (HIV) following prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. The patient had a complication of pneumocystis pneumonia. Upon initiating highly active antiretroviral therapy, we monitored HIV RNA levels, CD4+ T-cell count, SARS-CoV-2 viral load, and IgG antibodies against SARS-CoV-2. At 167 days post SARS-CoV-2 diagnosis, the patient's CD4+ T-cell count increased to 180 cells/μL. IgG antibodies against SARS-CoV-2 were undetectable despite a decreased SARS-CoV-2 viral load. HIV screening is necessary in cases of prolonged SARS-CoV-2 pneumonia or persistent SARS-CoV-2 shedding. When diagnosed with HIV infection, it is advisable to consider the possibility of pneumocystis pneumonia.
Language	English
Publishing date	2023-12-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.51189
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Article: Monomerization of ALK Fusion Proteins as a Therapeutic Strategy in

Hirai, Noriko / Sasaki, Takaaki / Okumura, Shunsuke / Minami, Yoshinori / Chiba, Shinichi / Ohsaki, Yoshinobu

Frontiers in oncology

2020 Volume 10, Page(s) 419

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2020-04-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2020.00419
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Article: Detection of resistance mutations in patients with anaplastic lymphoma kinase-rearranged lung cancer through liquid biopsy.

Sasaki, Takaaki / Yoshida, Ryohei / Nitanai, Kiichi / Watanabe, Takashi / Tenma, Toshiyuki / Kida, Ryotaro / Mori, Chie / Umekage, Yasuhiro / Hirai, Noriko / Minami, Yoshinori / Okumura, Shunsuke

Translational lung cancer research

2023 Volume 12, Issue 7, Page(s) 1445–1453

Abstract: Background: Tyrosine kinase inhibitors (TKIs) significantly improve clinical outcomes in patients with non-small cell lung cancer due to anaplastic lymphoma kinase (: Methods: In this mixed prospective and retrospective observational cohort study, we ...

Abstract	Background: Tyrosine kinase inhibitors (TKIs) significantly improve clinical outcomes in patients with non-small cell lung cancer due to anaplastic lymphoma kinase ( Methods: In this mixed prospective and retrospective observational cohort study, we investigated the clinical feasibility of continuous quantitative monitoring of Results: The numbers of samples showing the G1202R, C1156Y, G1269A, F1174L, T1151ins, and I1171T mutations were 32, 16, 5, 4, 1, and 1, respectively. The L1196M, L1152R, V1180L, and S1206Y mutations were not detected. Correlation analyses between progression-free survival and the time from treatment initiation (or treatment modification) to the detection of resistance mutations revealed that although resistance mutations may occur before a drug change becomes necessary, there is a duration during which the disease does not progress. Conclusions: Our findings suggest that real-time quantitative monitoring of
Language	English
Publishing date	2023-07-20
Publishing country	China
Document type	Journal Article
ZDB-ID	2754335-3
ISSN	2226-4477 ; 2218-6751
ISSN (online)	2226-4477
ISSN	2218-6751
DOI	10.21037/tlcr-22-671
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Article: Case Report: Case series: association between blood concentration and side effects of sotorasib.

Shigaki, Ryota / Yoshida, Ryohei / Yagita, Akari / Nagasue, Kazunori / Naraoka, Taeka / Nitanai, Kiichi / Yanada, Hiraku / Tenma, Toshiyuki / Kida, Ryotaro / Umekage, Yasuhiro / Mori, Chie / Minami, Yoshinori / Sato, Hideki / Iwayama, Kuninori / Hashino, Yasuhisa / Fukudo, Masahide / Sasaki, Takaaki

Frontiers in oncology

2023 Volume 13, Page(s) 1269991

Abstract: Introduction: Sotorasib is a crucial therapeutic agent for patients with non-small cell lung cancer (NSCLC) harboring the KRAS p.G12C mutation. Despite its efficacy, the relationship between blood sotorasib concentrations and side effects remains ... ...

Abstract	Introduction: Sotorasib is a crucial therapeutic agent for patients with non-small cell lung cancer (NSCLC) harboring the KRAS p.G12C mutation. Despite its efficacy, the relationship between blood sotorasib concentrations and side effects remains largely unexplored. Methods: This study enrolled five patients with KRAS p.G12C-positive NSCLC treated with sotorasib (LUMAKRAS Results: Variable blood sotorasib levels were observed among the participants. Notably, one patient developed interstitial pneumonitis, although a definitive attribution to sotorasib was uncertain due to prior pembrolizumab treatment. The study revealed no consistent association between blood sotorasib levels and adverse events or therapeutic outcomes, with some patients experiencing severe side effects at higher concentrations, while others did not. Conclusion: Preliminary findings suggested that monitoring blood sotorasib levels may aid in anticipating adverse events in this small cohort. However, future studies with larger sample sizes and extended follow-up periods are required to validate these initial observations. Such studies could potentially offer insights into personalized dosing strategies, thereby mitigating adverse effects and enhance patient care for individuals with KRAS p.G12C-positive NSCLC.
Language	English
Publishing date	2023-11-16
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1269991
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Article: Acute eosinophilic pneumonia following inhalation of turpentine oil: A case report.

Umekage, Yasuhiro / Okumura, Shunsuke / Tenma, Toshiyuki / Kazebayashi, Yoshihiro / Hirai, Noriko / Minami, Yoshinori / Doshita, Kazushi / Sasaki, Takaaki / Yamamoto, Yasushi / Ohsaki, Yoshinobu

Respiratory medicine case reports

2020 Volume 31, Page(s) 101143

Abstract: Acute eosinophilic pneumonia (AEP) is an eosinophilic lung disease associated with environmental substances including smoking. Although the etiology of AEP has not been fully elucidated, it has been hypothesized that IL-33 plays a central role in the ... ...

Abstract	Acute eosinophilic pneumonia (AEP) is an eosinophilic lung disease associated with environmental substances including smoking. Although the etiology of AEP has not been fully elucidated, it has been hypothesized that IL-33 plays a central role in the pathogenesis of AEP. Turpentine oil, from resins of pine trees, is not only used in paints, but also utilized in experimental animal models of inflammation because it leads to the production of inflammatory cytokines including IL-33. Here, we report the first case of AEP following turpentine oil inhalation. A 67-year-old woman reported using urushiol with turpentine oil to repair home goods. She had fever and persistent cough after turpentine inhalation over a very short period of time. The chest X-ray image showed consolidation in the upper right lung field. Laboratory findings indicated that there was no evidence of infection, collagen vascular diseases, and other allergic diseases that cause pneumonia, but analysis of the bronchoalveolar lavage fluid revealed 29% eosinophils with a small number of lipid-laden macrophages. With these findings, the diagnostic criteria of AEP was met. We rendered a diagnosis of AEP by inhalation of turpentine because no other cause for AEP was identified even with a structured questionnaire survey. The manifestations resolved immediately after steroid therapy. This is the first report of a case of AEP caused by the inhalation of turpentine oil.
Language	English
Publishing date	2020-07-02
Publishing country	England
Document type	Case Reports
ZDB-ID	2666110-X
ISSN	2213-0071
ISSN	2213-0071
DOI	10.1016/j.rmcr.2020.101143
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Article: Cyclin-dependent kinase 4 upregulation mediates acquired resistance of dabrafenib plus trametinib in

Hirai, Noriko / Hatanaka, Yutaka / Hatanaka, Kanako C / Uno, Yuji / Chiba, Shin-Ichi / Umekage, Yasuhiro / Minami, Yoshinori / Okumura, Shunsuke / Ohsaki, Yoshinobu / Sasaki, Takaaki

Translational lung cancer research

2021 Volume 10, Issue 9, Page(s) 3737–3744

Abstract: Background: Combination therapy with the B-Raf inhibitor, dabrafenib, and the MEK inhibitor, trametinib (DT) is commonly used to treat patients with B-Raf proto-oncogene, serine/threonine kinase V600E (: Methods: We compared genomic signatures before ...

Abstract	Background: Combination therapy with the B-Raf inhibitor, dabrafenib, and the MEK inhibitor, trametinib (DT) is commonly used to treat patients with B-Raf proto-oncogene, serine/threonine kinase V600E ( Methods: We compared genomic signatures before and after DT treatment in patients with NSCLC. Results: Two of four patients treated with DT developed carcinomatous pleuritis within 3 months. Target DNA sequencing and quantitative polymerase chain reaction (PCR) analyses revealed the increased expression level of cyclin-dependent kinase 4 ( Conclusions: Our findings suggest a possible relationship between
Language	English
Publishing date	2021-10-29
Publishing country	China
Document type	Journal Article
ZDB-ID	2754335-3
ISSN	2226-4477 ; 2218-6751
ISSN (online)	2226-4477
ISSN	2218-6751
DOI	10.21037/tlcr-21-415
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Article ; Online: Nicotinamide phosphoribosyltransferase: a potent therapeutic target in non-small cell lung cancer with epidermal growth factor receptor-gene mutation.

Okumura, Shunsuke / Sasaki, Takaaki / Minami, Yoshinori / Ohsaki, Yoshinobu

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

2012 Volume 7, Issue 1, Page(s) 49–56

Abstract: Background: Non-small cell lung cancer (NSCLC) often has an epidermal growth factor receptor (EGFR) gene mutation. Growth of EGFR-gene-mutated NSCLC depends predominantly on EGFR signaling and requires a large amount of intracellular ATP to activate ... ...

Abstract	Background: Non-small cell lung cancer (NSCLC) often has an epidermal growth factor receptor (EGFR) gene mutation. Growth of EGFR-gene-mutated NSCLC depends predominantly on EGFR signaling and requires a large amount of intracellular ATP to activate EGFR signal transduction. Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in nicotinamide adenine dinucleotide biosynthesis, and it regulates intracellular ATP levels in mammalian cells. The effect of NAMPT inhibition on NSCLC has not been completely understood. Methods: We aimed to clarify the hypothesis that NAMPT inhibition suppresses growth of EGFR-gene-mutated NSCLC through reduction of intracellular ATP levels, using NAMPT-siRNA transfection and NAMPT inhibitor FK866. We used four lung adenocarcinoma cell lines, including H358 (Wild type EGFR), LC2 (EGFR), PC9 (EGFR), and H1975 (EGFR), and evaluated the effect of FK866 on these cells and its mechanisms, using cell proliferation, Western blot, ATP, and apoptosis assay. Results: We found that (1) H358, LC2, and H1975 cell lines highly expressed NAMPT-mRNA; (2) NAMPT-specific siRNA and FK866 suppressed proliferation of these NSCLCs; (3) FK866 reduced intracellular ATP levels in H1975 cells; (4) FK866 dephosphorylated EGFR signal proteins, including EGFR, Akt, Map kinase kinase 1/2, and extracellular signal-regulated kinase 1/2 (ERK 1/2); (5) FK866 induced apoptosis of H1975 cells; and (6) FK866 suppressed growth of H1975 xenograft tumors and attenuated expression of phospho-ERK 1/2 in the tumors in a tumor-bearing mouse model. Conclusion: These findings indicate that NAMPT is a potent therapeutic target in the treatment of EGFR-gene-mutated NSCLC.
MeSH term(s)	Acrylamides/pharmacology ; Acrylamides/therapeutic use ; Adenocarcinoma/drug therapy ; Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Adenosine Triphosphate/metabolism ; Animals ; Apoptosis/drug effects ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase 2/metabolism ; Mice ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors ; Nicotinamide Phosphoribosyltransferase/genetics ; Piperidines/pharmacology ; Piperidines/therapeutic use ; RNA, Messenger/metabolism ; RNA, Small Interfering/pharmacology ; RNA, Small Interfering/therapeutic use ; Receptor, Epidermal Growth Factor/genetics ; Receptor, Epidermal Growth Factor/metabolism ; Signal Transduction
Chemical Substances	Acrylamides ; N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide ; Piperidines ; RNA, Messenger ; RNA, Small Interfering ; Adenosine Triphosphate (8L70Q75FXE) ; Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12) ; Receptor, Epidermal Growth Factor (EC 2.7.10.1) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24) ; MAP Kinase Kinase 1 (EC 2.7.12.2) ; MAP Kinase Kinase 2 (EC 2.7.12.2)
Language	English
Publishing date	2012-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2432037-7
ISSN	1556-1380 ; 1556-0864
ISSN (online)	1556-1380
ISSN	1556-0864
DOI	10.1097/JTO.0b013e318233d686
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Zs.A 6664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: The feasibility of circulating tumor DNA analysis as a marker of recurrence in triple-negative breast cancer.

Okazaki, Satoshi / Sasaki, Takaaki / Yasuda, Shunsuke / Abe, Masahiro / Yoshida, Nana / Yoshida, Ryohei / Ishibashi, Kei / Minami, Yoshinori / Okumura, Shunsuke / Chiba, Shinichi / Takei, Hidehiro / Hayashi, Ryusuke / Nagato, Toshihiro / Kobayashi, Hiroya / Sugitani, Ayumu / Ono, Yusuke / Mizukami, Yusuke / Kitada, Masahiro / Ohsaki, Yoshinobu

Oncology letters

2021 Volume 21, Issue 5, Page(s) 420

Abstract: Triple-negative breast cancer (TNBC) has a poorer prognosis than other breast cancer subtypes; therefore, identifying markers of early recurrence is important. The present study aimed to establish a liquid biopsy protocol for droplet digital PCR-based ... ...

Abstract	Triple-negative breast cancer (TNBC) has a poorer prognosis than other breast cancer subtypes; therefore, identifying markers of early recurrence is important. The present study aimed to establish a liquid biopsy protocol for droplet digital PCR-based detection of frequently mutated genes in patients with TNBC. Tumor DNA from 36 patients with TNBC who relapsed within 2 years after surgical resection was retrospectively analyzed. Somatic mutational profiles were evaluated using targeted sequencing to identify frequently mutated genes and genes associated with molecularly targeted therapies. The association between genetic alterations and associated protein phosphorylation was investigated using immunohistochemical analysis. Recurrent hot spot mutations in the plasma were monitored over time. Mutation-specific probes were used to successfully detect mutations in the blood samples of patients who were positive for
Language	English
Publishing date	2021-03-28
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2021.12681
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