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Article ; Online: Afro-descendant ethnicity does not negatively influence neuroblastoma survival in the French West Indies.

Felix, Arthur / Dichamp, Claire / Michaux, Katell / Minard-Colin, Véronique / Sarnacki, Sabine / Lacour, Brigitte / Valteau-Couanet, Dominique

Pediatric blood & cancer

2024 , Page(s) e31037

Language	English
Publishing date	2024-05-14
Publishing country	United States
Document type	Letter
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.31037
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Article ; Online: Neuroblastome de haut risque - Place actuelle et perspectives de l’utilisation des anticorps monoclonaux anti-GD2.

Valteau-Couanet, Dominique / Minard-Colin, Véronique / Pasqualini, Claudia

Medecine sciences : M/S

2020 Volume 35, Issue 12, Page(s) 997–1000

Abstract: Neuroblastoma is the most frequent extra-cranial pediatric solid tumor, occurring in young children, 90% being less than 5 years at diagnosis. It remains a therapeutic challenge since survival of high-risk neuroblastoma patients that represent around 50% ...

Title translation	Anti-GD2 antibodies in treatment of high-risk Neuroblastoma: present and perspectives.
Abstract	Neuroblastoma is the most frequent extra-cranial pediatric solid tumor, occurring in young children, 90% being less than 5 years at diagnosis. It remains a therapeutic challenge since survival of high-risk neuroblastoma patients that represent around 50% of the patients is around 50% in spite of extensive combined treatments. Immunotherapy based on the use of antibodies directed to GD2, a ganglioside strongly expressed by almost all neuroblastoma cells, has been developed during the last decade. In SIOPEN studies have shown that dinatuximab beta (Qarziba
MeSH term(s)	Animals ; Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents, Immunological/therapeutic use ; Brain Neoplasms/drug therapy ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Child ; Child, Preschool ; Gangliosides/immunology ; Humans ; Infant ; Medical Oncology/methods ; Medical Oncology/trends ; Neuroblastoma/drug therapy ; Neuroblastoma/mortality ; Neuroblastoma/pathology ; Risk Factors
Chemical Substances	Antibodies, Monoclonal ; Antineoplastic Agents, Immunological ; Gangliosides ; ganglioside, GD2 (65988-71-8)
Language	French
Publishing date	2020-01-06
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2019197
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Article ; Online: Novel targeted therapeutic agents for the treatment of childhood, adolescent and young adult non-Hodgkin lymphoma.

Barth, Matthew J / Minard-Colin, Veronique

British journal of haematology

2019 Volume 185, Issue 6, Page(s) 1111–1124

Abstract: Non-Hodgkin lymphomas (NHLs) are a heterogeneous group of malignancies. Most NHLs in children, adolescent and young adult patients are aggressive lymphomas that are generally treated with multi-agent chemotherapy or immunochemotherapy regimens. While ... ...

Abstract	Non-Hodgkin lymphomas (NHLs) are a heterogeneous group of malignancies. Most NHLs in children, adolescent and young adult patients are aggressive lymphomas that are generally treated with multi-agent chemotherapy or immunochemotherapy regimens. While overall survival is high, the treatment can lead to a high rate of acute and long-term toxicity. However, in the rarer instance of relapsed or refractory disease, outcomes are dismal. Novel therapeutic approaches to the treatment of both T-cell and B-cell NHLs are critical to improve outcomes while also minimising the associated toxicity of current treatment regimes. Potential therapeutic approaches in development include humoral and cellular immunotherapies, small molecule inhibitors of relevant signalling pathways and epigenetic modifying agents. In this review, we will highlight the current state of development of agents of interest with a focus on agents relevant to childhood, adolescent and young adult NHL.
MeSH term(s)	Adolescent ; Anaplastic Lymphoma Kinase/genetics ; Anaplastic Lymphoma Kinase/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/antagonists & inhibitors ; Child ; Diagnosis, Differential ; Humans ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/etiology ; Lymphoma, Non-Hodgkin/diagnosis ; Lymphoma, Non-Hodgkin/drug therapy ; Lymphoma, Non-Hodgkin/etiology ; Lymphoma, Non-Hodgkin/metabolism ; Molecular Targeted Therapy/methods ; Neoplasm Grading ; Signal Transduction/drug effects ; Young Adult
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor ; ALK protein, human (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1)
Language	English
Publishing date	2019-01-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.15783
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Article ; Online: Long-term urological complications after conservative local treatment (surgery and brachytherapy) in children with bladder-prostate rhabdomyosarcoma: A single-team experience.

Akkary, Rezkalla / Guérin, Florent / Chargari, Cyrus / Jochault, Loic / Audry, Georges / Pio, Luca / Minard-Colin, Veronique / Haie-Meder, Christine / Martelli, Hélène

Pediatric blood & cancer

2022 Volume 69, Issue 8, Page(s) e29532

Abstract: Background: Outcome of children with bladder-prostate rhabdomyosarcoma (RMS) has improved with multimodal therapies, including surgery and/or radiotherapy for local treatment. Our aim was to report long-term urological complications after a conservative ...

Abstract	Background: Outcome of children with bladder-prostate rhabdomyosarcoma (RMS) has improved with multimodal therapies, including surgery and/or radiotherapy for local treatment. Our aim was to report long-term urological complications after a conservative approach combining conservative surgery and brachytherapy. Patients and methods: Eighty-six patients, free of disease, were retrospectively reviewed. Symptoms related to urinary tract obstruction, incontinence, infection, and lithiasis were reported and graded according to the Common Terminology Criteria for Adverse Events (CTCAE) classification. Only symptomatic patients underwent urodynamic studies. Risk factors for complications were analyzed. Results: There were 76 males and 10 females. The median follow-up was 6.3 years (18 months to 24 years). Complications occurred after a median follow-up of 5 years (0-21). Twenty-two patients (26%) had long-term urological complications. Urinary tract obstruction was found in 15 patients (17%) and urinary incontinence in 14 patients (16%). Recurrent urinary tract infection occurred in four patients and urinary lithiasis in four (5%). The underlying physiopathology included bladder dysfunction in 15 patients (17%), urethral stenosis in six (7%), and ureterovesical junction stenosis in five (6%). On univariate analysis, posterior bladder wall dissection (p = .001), bladder neck trigone dissection (p = .010), and partial prostatectomy (p = .023) were significantly associated with an increased risk of bladder dysfunction; on multivariate analysis, only age ≤2 years (p = .028) at operation and posterior bladder wall dissection (p = .006) were found to be significant. Conclusion: The conservative surgical approach combined with brachytherapy for bladder-prostate RMS leads to long-term urological complications in 26% of survivors. Optimizing brachytherapy doses for young children and establishing a clear and long-term follow-up protocol could help to reduce these complications.
MeSH term(s)	Brachytherapy/adverse effects ; Brachytherapy/methods ; Child ; Child, Preschool ; Humans ; Male ; Pelvic Neoplasms ; Prostate/pathology ; Prostatic Neoplasms/drug therapy ; Retrospective Studies ; Rhabdomyosarcoma/radiotherapy ; Rhabdomyosarcoma/surgery ; Urinary Bladder/pathology ; Urinary Bladder Neoplasms/radiotherapy ; Urinary Bladder Neoplasms/surgery
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.29532
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Article ; Online: Prognostic value of hemogram parameters in osteosarcoma: The French OS2006 experience.

Bastard, Paul / Cozic, Nathalie / Brion, Régis / Gaspar, Nathalie / Piperno-Neumann, Sophie / Cordero, Camille / Leculée-Thébaud, Estelle / Gomez-Mascard, Anne / Rédini, Françoise / Marchais, Antonin / Ikonomova, Raina / Cleirec, Morgane / Laurence, Valérie / Rigaud, Charlotte / Abbas, Rachid / Verrecchia, Franck / Brugières, Laurence / Minard-Colin, Véronique

Pediatric blood & cancer

2024 , Page(s) e31029

Abstract: Background: Previous studies have shown that neutrophil-to-lymphocyte (NLR) ratio at diagnosis and early lymphocytes recovery on doxorubicin-based chemotherapy, may impact the outcome in patients with osteosarcoma (OST). This study aimed to evaluate the ...

Abstract	Background: Previous studies have shown that neutrophil-to-lymphocyte (NLR) ratio at diagnosis and early lymphocytes recovery on doxorubicin-based chemotherapy, may impact the outcome in patients with osteosarcoma (OST). This study aimed to evaluate the prognostic value of hemogram parameters in patients with OST treated with high-dose methotrexate and etoposide/ifosfamide (M-EI) chemotherapy. Materials and methods: We retrospectively analyzed the prognostic value of various hemogram parameters at diagnosis and during therapy in a large consecutive cohort of patients with OST included in the French OS2006 trial and treated with M-EI chemotherapy. Results: A total of 164 patients were analyzed. The median age was 14.7 years (interquartile range [IQR]: 11.7-17). Median follow-up was 5.6 years (IQR: 3.3-7.7 years). Three-year event-free survival (EFS) and overall survival (OS) were 71.5% (95% confidence interval [CI]: 64%-78%) and 86.4% (95% CI: 80%-91%), respectively. In univariate analysis, blood count parameters at diagnosis and early lymphocyte recovery at Day 14 were not found prognostic of survival outcomes. By contrast, an increase of NLR ratio at Day 1 of the first EI chemotherapy (NLR-W4) was associated with reduced OS in univariate (p = .0044) and multivariate analysis (hazards ratio [HR] = 1.3, 95% CI: 1.1-1.5; p = .002), although not with EFS. After adjustment on histological response and metastatic status, an increase of the ratio NLR-W4 of 1 was associated with an increased risk of death of 30%. Conclusions: We identified NLR-W4 as a potential early biomarker for survival in patients with OST treated with M-EI chemotherapy. Further studies are required to confirm the prognostic value of NLR and better identify immune mechanisms involved in disease surveillance.
Language	English
Publishing date	2024-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.31029
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Article: Biological Role and Clinical Implications of

Di Carlo, Daniela / Chisholm, Julia / Kelsey, Anna / Alaggio, Rita / Bisogno, Gianni / Minard-Colin, Veronique / Jenney, Meriel / Dávila Fajardo, Raquel / Merks, Johannes H M / Shipley, Janet M / Selfe, Joanna L

Cancers

2023 Volume 15, Issue 6

Abstract: Major progress in recent decades has furthered our clinical and biological understanding of rhabdomyosarcoma (RMS) with improved stratification for treatment based on risk factors. Clinical risk factors alone were used to stratify patients for treatment ... ...

Abstract	Major progress in recent decades has furthered our clinical and biological understanding of rhabdomyosarcoma (RMS) with improved stratification for treatment based on risk factors. Clinical risk factors alone were used to stratify patients for treatment in the European Pediatric Soft Tissue Sarcoma Study Group (EpSSG) RMS 2005 protocol. The current EpSSG overarching study for children and adults with frontline and relapsed rhabdomyosarcoma (FaR-RMS NCT04625907) includes
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15061644
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Article: Maintenance Chemotherapy for Patients with Rhabdomyosarcoma.

Bisogno, Gianni / Minard-Colin, Veronique / Jenney, Meriel / Ferrari, Andrea / Chisholm, Julia / Di Carlo, Daniela / Hjalgrim, Lisa Lyngsie / Orbach, Daniel / Merks, Johannes Hendrikus Maria / Casanova, Michela

Cancers

2023 Volume 15, Issue 15

Abstract: Maintenance chemotherapy (MC) defines the administration of prolonged relatively low-intensity chemotherapy with the aim of "maintaining" tumor complete remission. This paper aims to report an update of the RMS2005 trial, which demonstrated better ... ...

Abstract	Maintenance chemotherapy (MC) defines the administration of prolonged relatively low-intensity chemotherapy with the aim of "maintaining" tumor complete remission. This paper aims to report an update of the RMS2005 trial, which demonstrated better survival for patients with high-risk localized rhabdomyosarcoma (RMS) when MC with vinorelbine and low-dose cyclophosphamide was added to standard chemotherapy, and to discuss the published experience on MC in RMS. In the RMS2005 study, the outcome for patients receiving MC vs. those who stopped the treatment remains superior, with a 5-year disease-free survival of 78.1% vs. 70.1% (
Language	English
Publishing date	2023-08-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15154012
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Article ; Online: Seasonality of main childhood embryonal tumours and rhabdomyosarcoma, France, 2000-2015.

Awounou, Danielle / Lacour, Brigitte / Desandes, Emmanuel / Guissou, Sandra / Cassoux, Nathalie / Doz, François / Dufour, Christelle / Minard-Colin, Véronique / Schleiermacher, Gudrun / Taque, Sophie / Verschuur, Arnauld / Clavel, Jacqueline / Goujon, Stéphanie

Cancer medicine

2023 Volume 12, Issue 7, Page(s) 8789–8803

Abstract: Few studies have investigated the seasonal patterns of embryonal tumours. Based on data from the French National Registry of Childhood Cancers, the present study aimed to investigate seasonal variations in embryonal tumour incidence rates by month of ... ...

Abstract	Few studies have investigated the seasonal patterns of embryonal tumours. Based on data from the French National Registry of Childhood Cancers, the present study aimed to investigate seasonal variations in embryonal tumour incidence rates by month of birth and by month of diagnosis. The study included 6635 primary embryonal tumour cases diagnosed before the age of 15 years over the period 2000-2015 in mainland France. Assuming monthly variations in incidence rates were homogeneous over 2000-2015, we used a Poisson regression model to test for overall heterogeneity in standardised incidence ratios (SIRs) by month of birth or diagnosis. The seasonal scan statistic method was used to detect monthly excesses or deficits of embryonal tumour cases over the whole study period. The annual reproducibility of the observed monthly variations was formally tested. An overall heterogeneity in incidence rates by month of birth was observed for rhabdomyosarcoma in boys only. Based on the month of diagnosis, a seasonality was evidenced for unilateral retinoblastoma, with a lower incidence rate in the summer (SIR
MeSH term(s)	Male ; Humans ; Adolescent ; Retinoblastoma ; Reproducibility of Results ; Rhabdomyosarcoma ; Incidence ; France/epidemiology ; Retinal Neoplasms
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.5624
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Article ; Online: Residential proximity to vines and risk of childhood embryonal tumours in France - GEOCAP case-control study, 2006-2013.

Awounou, Danielle / Mancini, Matthieu / Lacour, Brigitte / de Crouy-Chanel, Perrine / Aerts, Isabelle / Minard-Colin, Véronique / Schleiermacher, Gudrun / Verschuur, Arnauld / Guissou, Sandra / Desandes, Emmanuel / Guldner, Laurence / Clavel, Jacqueline / Goujon, Stéphanie

Environmental research

2023 Volume 240, Issue Pt 2, Page(s) 117417

Abstract: Background: Exposure to pesticides has been suggested as a potential risk factor for childhood embryonal tumour. The existing literature has mainly focused on parental occupational exposure and domestic use of pesticides, and is very limited for ... ...

Abstract	Background: Exposure to pesticides has been suggested as a potential risk factor for childhood embryonal tumour. The existing literature has mainly focused on parental occupational exposure and domestic use of pesticides, and is very limited for residential exposures to agricultural pesticides. The study aimed to test the hypothesis of an increased risk of embryonal tumour in children living close to viticultural plots, likely to be subject to frequent pesticide applications. Methods: The study is part of the French national registry-based GEOCAP program. We included 2761 cases of neuroblastoma, retinoblastoma, Wilms tumour and rhabdomyosarcoma diagnosed before the age of 15 years in the 2006-2013 period, and 40,196 controls representative of the same age population during this period. Indicators of proximity to vines, the presence of vines and viticulture density within 1000 m of the geocoded addresses of residence, were evaluated combining three sources of data on agricultural land use in a geographic information system. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regressions and carried out several sensitivity analyses to test the stability of the results. Results: Approximately 10% of the controls lived within 1000 m of vines, with regional variations ranging from <1% to 38%. We observed a 5% increase in the risk of neuroblastoma for a 10% increase in viticulture density (OR = 1.05, 95% CI: 0.98-1.13), with a regional heterogeneity. The indicators of proximity to vines were not associated with the other non-CNS embryonal tumours. Conclusion: The study showed a slight increase in the risk of neuroblastoma in children living close to vines, suggesting that residential exposure to agricultural pesticides may be involved in the occurrence of these tumours.
MeSH term(s)	Humans ; Child ; Adolescent ; Case-Control Studies ; Neuroblastoma ; Pesticides/toxicity ; France/epidemiology ; Neoplasms, Germ Cell and Embryonal/chemically induced ; Neoplasms, Germ Cell and Embryonal/epidemiology
Chemical Substances	Pesticides
Language	English
Publishing date	2023-10-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.117417
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Article ; Online: Cost-effectiveness analysis alongside the inter-B-NHL ritux 2010 trial: rituximab in children and adolescents with B cell non-Hodgkin's lymphoma.

Lueza, Béranger / Aupérin, Anne / Rigaud, Charlotte / Gross, Thomas G / Pillon, Marta / Delgado, Rafael F / Uyttebroeck, Anne / Amos Burke, G A / Zsíros, József / Csóka, Monika / Simonin, Mathieu / Patte, Catherine / Minard-Colin, Véronique / Bonastre, Julia

The European journal of health economics : HEPAC : health economics in prevention and care

2023 Volume 25, Issue 2, Page(s) 307–317

Abstract: Objectives: The randomized controlled trial Inter-B-NHL ritux 2010 showed overall survival (OS) benefit and event-free survival (EFS) benefit with the addition of rituximab to standard Lymphomes Malins B (LMB) chemotherapy in children and adolescents ... ...

Abstract	Objectives: The randomized controlled trial Inter-B-NHL ritux 2010 showed overall survival (OS) benefit and event-free survival (EFS) benefit with the addition of rituximab to standard Lymphomes Malins B (LMB) chemotherapy in children and adolescents with high-risk, mature B cell non-Hodgkin's lymphoma. Our aim was to assess the cost-effectiveness of rituximab-chemotherapy versus chemotherapy alone in the French setting. Methods: We used a decision-analytic semi-Markov model with four health states and 1-month cycles. Resource use was prospectively collected in the Inter-B-NHL ritux 2010 trial (NCT01516580). Transition probabilities were assessed from patient-level data from the trial (n = 328). In the base case analysis, direct medical costs from the French National Insurance Scheme and life-years (LYs) were computed in both arms over a 3-year time horizon. Incremental net monetary benefit and cost-effectiveness acceptability curve were computed through a probabilistic sensitivity analysis. Deterministic sensitivity analysis and several sensitivity analyses on key assumptions were also conducted, including one exploratory analysis with quality-adjusted life years as the health outcome. Results: OS and EFS benefits shown in the Inter-B-NHL ritux 2010 trial translated into the model by rituximab-chemotherapy being the most effective and also the least expensive strategy over the chemotherapy strategy. The mean difference in LYs between arms was 0.13 [95% CI 0.02; 0.25], and the mean cost difference € - 3 710 [95% CI € - 17,877; € 10,525] in favor of rituximab-chemotherapy group. For a € 50,000 per LY willingness-to-pay threshold, the probability of the rituximab-chemotherapy strategy being cost-effective was 91.1%. All sensitivity analyses confirmed these findings. Conclusion: Adding rituximab to LMB chemotherapy in children and adolescents with high-risk mature B-cell non-Hodgkin's lymphoma is highly cost-effective in France. Trial registration: ClinicalTrials.gov identifier: NCT01516580.
MeSH term(s)	Child ; Humans ; Adolescent ; Rituximab/therapeutic use ; Cost-Effectiveness Analysis ; Cost-Benefit Analysis ; Progression-Free Survival ; Lymphoma, Non-Hodgkin/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Chemical Substances	Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2023-04-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2045253-6
ISSN	1618-7601 ; 1618-7598
ISSN (online)	1618-7601
ISSN	1618-7598
DOI	10.1007/s10198-023-01581-y
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