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  1. Article ; Online: Explore the effect of apparent temperature and air pollutants on the admission rate of acute myocardial infarction in Chongqing, China: a time-series study.

    Bai, Xiuyuan / Ming, Xin / Zhao, Mingming / Zhou, Li

    BMJ open

    2024  Volume 14, Issue 4, Page(s) e084376

    Abstract: Objective: Limited research has been conducted on the correlation between apparent temperature and acute myocardial infarction (AMI), as well as the potential impact of air pollutants in modifying this relationship. The objective of this study is to ... ...

    Abstract Objective: Limited research has been conducted on the correlation between apparent temperature and acute myocardial infarction (AMI), as well as the potential impact of air pollutants in modifying this relationship. The objective of this study is to investigate the lagged effect of apparent temperature on AMI and assess the effect modification of environmental pollutants on this association.
    Design: A time-series study.
    Setting and participants: The data for this study were obtained from the Academy of Medical Data Science at Chongqing Medical University, covering daily hospitalisations for AMI between 1 January 2015 and 31 December 2016. Meteorological and air pollutant data were provided by China's National Meteorological Information Centre.
    Outcome measures: We used a combined approach of quasi-Poisson generalised linear model and distributed lag non-linear model to thoroughly analyse the relationships. Additionally, we employed a generalised additive model to investigate the interaction between air pollutants and apparent temperature on the effect of AMI.
    Result: A total of 872 patients admitted to hospital with AMI were studied based on the median apparent temperature (20.43°C) in Chongqing. Low apparent temperature (10th, 7.19℃) has obvious lagged effect on acute myocardial infarction, first appearing on the 8th day (risk ratio (RR) 1.081, 95% CI 1.010 to 1.158) and the greatest risk on the 11th day (RR 1.094, 95% CI 1.037 to 1.153). No lagged effect was observed at high apparent temperature. In subgroup analysis, women and individuals aged 75 and above were at high risk. The interaction analysis indicates that there exist significant interactions between PM2.5 and high apparent temperature, as well as nitrogen dioxide (NO
    Conclusion: The occurrence of decreased apparent temperature levels was discovered to be linked with a heightened relative risk of hospitalisations for AMI. PM
    MeSH term(s) Humans ; Myocardial Infarction/epidemiology ; China/epidemiology ; Female ; Male ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Middle Aged ; Aged ; Temperature ; Hospitalization/statistics & numerical data ; Particulate Matter/adverse effects ; Air Pollution/adverse effects ; Risk Factors ; Environmental Exposure/adverse effects
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2024-084376
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  2. Article ; Online: Genome-Wide Identification and Functional Analysis of the Roles of SAUR Gene Family Members in the Promotion of Cucumber Root Expansion

    Jie Luan / Ming Xin / Zhiwei Qin

    International Journal of Molecular Sciences, Vol 24, Iss 5940, p

    2023  Volume 5940

    Abstract: Auxin serves as an essential regulator of the expression of many different genes in plants, thereby regulating growth and development. The specific functional roles of members of the SAUR (small auxin-up RNA) auxin early response gene family in the ... ...

    Abstract Auxin serves as an essential regulator of the expression of many different genes in plants, thereby regulating growth and development. The specific functional roles of members of the SAUR (small auxin-up RNA) auxin early response gene family in the development of cucumber plants, however, remain to be fully clarified. Here, 62 SAUR family genes were identified, followed by their classification into 7 groups that included several functionally associated cis-regulatory elements. Phylogenetic tree and chromosomal location-based analyses revealed a high degree of homology between two cucumber gene clusters and other plants in the Cucurbitaceae family. These findings, together with the results of an RNA-seq analysis, revealed high levels of CsSAUR31 expression within the root and male flower tissues. Plants overexpressing CsSAUR31 exhibited longer roots and hypocotyls. Together, these results provide a basis for further efforts to explore the roles that SAUR genes play in cucumber plants, while also expanding the pool of available genetic resources to guide research focused on plant growth and development.
    Keywords cucumber ; auxin ; small auxin-up RNA ; CsSAUR31 ; development ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 580
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Research Progress on the Structural Modification of Magnolol and Honokiol and the Biological Activities of Their Derivatives.

    Ming-Xin Guo, M M / Wu, Xia / Feng, Yi-Fan / Hu, Zhi-Qiang

    Chemistry & biodiversity

    2023  Volume 20, Issue 8, Page(s) e202300754

    Abstract: Magnolol and Honokiol are the primary active components that have been identified and extracted from Magnolia officinalis, and several investigations have demonstrated that they have significant pharmacological effects. Despite their therapeutic benefits ...

    Abstract Magnolol and Honokiol are the primary active components that have been identified and extracted from Magnolia officinalis, and several investigations have demonstrated that they have significant pharmacological effects. Despite their therapeutic benefits for a wide range of illnesses, research on and the implementation of these compounds have been hindered by their poor water solubility and low bioavailability. Researchers are continually using chemical methods to alter their structures to make them more effective in treating and preventing diseases. Researchers are also continuously developing derivative drugs with high efficacy and few adverse effects. This article summarizes and analyzes derivatives with significant biological activities reported in recent research obtained by structural modification. The modification sites have mainly focused on the phenolic hydroxy groups, benzene rings, and diene bonds. Changes to the allyl bisphenol structure will result in unexpected benefits, including high activity, low toxicity, and good bioavailability. Furthermore, alongside earlier experimental research in our laboratory, the structure-activity relationships of magnolol and honokiol were preliminarily summarized, providing experimental evidence for improving their development and utilization.
    MeSH term(s) Lignans/pharmacology ; Lignans/chemistry ; Biphenyl Compounds/chemistry ; Structure-Activity Relationship ; Magnolia/chemistry
    Chemical Substances magnolol (001E35HGVF) ; honokiol (11513CCO0N) ; Lignans ; Biphenyl Compounds
    Language English
    Publishing date 2023-07-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202300754
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  4. Article ; Online: Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways.

    Yang, Kai / Qi, Zhi-Xiang / Sun, Ming-Xin / Xie, Li-Ping

    International journal of medical sciences

    2024  Volume 21, Issue 4, Page(s) 690–702

    Abstract: Hyperoside is a natural flavonol glycoside widely found in plants and has been reported to have a variety of pharmacological effects, including anticancer abilities. In this study, we demonstrated for the first time that hyperoside inhibited the ... ...

    Abstract Hyperoside is a natural flavonol glycoside widely found in plants and has been reported to have a variety of pharmacological effects, including anticancer abilities. In this study, we demonstrated for the first time that hyperoside inhibited the proliferation of bladder cancer cells in vitro and in vivo. Moreover, hyperoside could not only induce cell cycle arrest, but also induce apoptosis of a few bladder cancer cells. Quantitative proteomics, bioinformatics analysis and Western blotting confirmed that hyperoside induced the overexpression of EGFR, Ras and Fas proteins, which affects a variety of synergistic and antagonistic downstream signaling pathways, including MAPKs and Akt, ultimately contributing to its anticancer effects in bladder cancer cells. This study reveals that hyperoside could be a promising therapeutic strategy for the prevention of bladder cancer.
    MeSH term(s) Humans ; Signal Transduction ; Cell Cycle Checkpoints ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/genetics ; Apoptosis ; Carcinogenesis/genetics ; ErbB Receptors/genetics ; Cell Proliferation ; Cell Line, Tumor ; Quercetin/analogs & derivatives
    Chemical Substances hyperoside (8O1CR18L82) ; ErbB Receptors (EC 2.7.10.1) ; EGFR protein, human (EC 2.7.10.1) ; Quercetin (9IKM0I5T1E)
    Language English
    Publishing date 2024-02-12
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.90261
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  5. Article ; Online: Effect of Yanshen No.1 Recipe on the microinflammatory state in patients with chronic kidney disease.

    Yuan, Guo-Dong / Wang, Ze-Ze / Guo, Ming-Xin / Tan, Jin-Chuan

    Asian journal of surgery

    2024  Volume 47, Issue 5, Page(s) 2366–2367

    MeSH term(s) Humans ; Renal Insufficiency, Chronic/complications ; Drugs, Chinese Herbal/therapeutic use ; Drugs, Chinese Herbal/administration & dosage ; Inflammation ; Male ; Female ; Middle Aged ; Treatment Outcome ; Aged
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.01.068
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Liquid Crystalline Nanoparticles via Polymerization-Induced Self-Assembly: Morphology Evolution and Function Regulation.

    Xu, Chang / Zheng, Ming-Xin / Wei, Yen / Yuan, Jin-Ying

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 15, Page(s) e202303586

    Abstract: Liquid crystalline nanoparticles (LC NPs) are a kind of polymer NPs with LC mesogens, which can form special anisotropic morphologies due to the influence of LC ordering. Owing to the stimuli-responsiveness of the LC blocks, LC NPs show abundant ... ...

    Abstract Liquid crystalline nanoparticles (LC NPs) are a kind of polymer NPs with LC mesogens, which can form special anisotropic morphologies due to the influence of LC ordering. Owing to the stimuli-responsiveness of the LC blocks, LC NPs show abundant morphology evolution behaviors in response to external regulation. LC NPs have great application potential in nano-devices, drug delivery, special fibers and other fields. Polymerization-induced self-assembly (PISA) method can synthesize LC NPs at high solid content, reducing the harsh demand for reaction solvent of the LC polymers, being a better choice for large-scale production. In this review, we introduced recent research progress of PISA-LC NPs by dividing them into several parts according to the LC mesogen, and discussed the improvement of experimental conditions and the potential application of these polymers.
    Language English
    Publishing date 2024-01-15
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202303586
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  7. Article ; Online: Airway clearance technique in the modern era of bronchiectasis management

    Cui-Xia Pan / Ming-Xin Shi / Wei-Jie Guan

    ERJ Open Research, Vol 9, Iss

    2023  Volume 2

    Keywords Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Airway clearance technique in the modern era of bronchiectasis management.

    Pan, Cui-Xia / Shi, Ming-Xin / Guan, Wei-Jie

    ERJ open research

    2023  Volume 9, Issue 2

    Abstract: There is a need and further room to strengthen airway clearance among patients with bronchiectasis in the modern era of clinical ... ...

    Abstract There is a need and further room to strengthen airway clearance among patients with bronchiectasis in the modern era of clinical management
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Editorial
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00674-2022
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  9. Article: 奥马珠单抗治疗血清总IgE>1 500 IU/mL的中重度过敏性哮喘儿童的前瞻性研究.

    Luo, Ming-Xin / Hua, Shan / Wei, Wen

    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

    2023  Volume 25, Issue 9, Page(s) 959–965

    Abstract: Objectives: To evaluate the clinical efficacy of omalizumab in the treatment of moderate or severe allergic asthma in children with serum total immunoglobulin E (IgE) levels >1 500 IU/mL.: Methods: A total of 95 children with moderate or severe ... ...

    Title translation Clinical efficacy of omalizumab for treatment of moderate or severe allergic asthma in children with serum immunoglobulin E levels >1 500 IU/mL: a prospective study.
    Abstract Objectives: To evaluate the clinical efficacy of omalizumab in the treatment of moderate or severe allergic asthma in children with serum total immunoglobulin E (IgE) levels >1 500 IU/mL.
    Methods: A total of 95 children with moderate or severe allergic asthma, who were treated at the Department of Respiratory Medicine in Anhui Provincial Children's Hospital from December 2020 to May 2022, were enrolled. Based on their serum total IgE levels and whether they received omalizumab treatment, they were divided into a control group (IgE >1 500 IU/mL, no omalizumab treatment), a normal treatment group (IgE levels between 30 and 1 500 IU/mL, omalizumab treatment), and an ultra-high IgE treatment group (IgE >1 500 IU/mL, omalizumab treatment). The differences in clinical characteristics, Childhood Asthma Control Test (C-ACT) scores before and after treatment, the proportion of acute attacks, IgE levels, pulmonary function indicators, and fractional exhaled nitric oxide (FeNO) concentrations were analyzed among the three groups.
    Results: At the 8th week of treatment, the normal treatment group and the ultra-high IgE treatment group had higher C-ACT scores, forced expiratory volume in first second (FEV
    Conclusions: Omalizumab therapy has a certain clinical efficacy in children with moderate or severe allergic asthma and serum total IgE levels >1 500 IU/mL, with no significant difference in efficacy compared to children with serum total IgE levels between 30 and 1 500 IU/mL.
    Language Chinese
    Publishing date 2023-09-17
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1008-8830
    ISSN 1008-8830
    DOI 10.7499/j.issn.1008-8830.2303102
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  10. Article ; Online: The role of the P2X4 receptor in trigeminal neuralgia, a common neurological disorder.

    Lu, Ming-Xin / Liu, Zeng-Xu

    Neuroreport

    2021  Volume 32, Issue 5, Page(s) 407–413

    Abstract: Neurological disorders, which include various types of diseases with complex pathological mechanisms, are more common in the elderly and have shown increased prevalence, morbidity and mortality worldwide. Unfortunately, current therapies for these ... ...

    Abstract Neurological disorders, which include various types of diseases with complex pathological mechanisms, are more common in the elderly and have shown increased prevalence, morbidity and mortality worldwide. Unfortunately, current therapies for these diseases are usually suboptimal or have undesirable side effects. This necessitates the development of new potential targets for disease-modifying therapies. P2X4R, a type of purinergic receptor, has multiple roles in neurological disorders. In this review, we briefly introduce a neurological disorder, trigeminal neuralgia and its' symptoms, etiology and pathology. Moreover, we focused on the role of P2X4R in neurological disorders and their related pathophysiologic mechanisms. Further studies of P2X4R are required to determine potential therapeutic effects for these pathophysiologies.
    MeSH term(s) Animals ; Humans ; Receptors, Purinergic P2X4 ; Trigeminal Neuralgia
    Chemical Substances Receptors, Purinergic P2X4
    Language English
    Publishing date 2021-03-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1049746-8
    ISSN 1473-558X ; 0959-4965
    ISSN (online) 1473-558X
    ISSN 0959-4965
    DOI 10.1097/WNR.0000000000001612
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3118: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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