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Article ; Online: METTL3/LINC00662/miR-186-5p feedback loop regulates docetaxel resistance in triple negative breast cancer.

Jing, Lei / Lan, Liu / Mingxin, Zhang / Zhaofeng, Zhang

2022 Volume 12, Issue 1, Page(s) 16715

Abstract: Insight into the mechanism of docetaxel resistance in breast cancer may help to improve prognosis. We aimed to investigate the role of N6-methyladenosine (m6A) and the METTL3/LINC00662/miR-186-5p pathway in regulating docetaxel resistance in triple ... ...

Abstract	Insight into the mechanism of docetaxel resistance in breast cancer may help to improve prognosis. We aimed to investigate the role of N6-methyladenosine (m6A) and the METTL3/LINC00662/miR-186-5p pathway in regulating docetaxel resistance in triple negative breast cancer (TNBC). We have recruited 193 pathologically diagnosed TNBC patients from 2016 to 2017 in our hospital. Quantitative real-time PCR was used to evaluate the expression of LINC00662 and miR-186-5p both in vivo and in vitro. CCK8 tests were used to assess cell viability. ELISA was used for protein expression evaluation. Dual luciferase reporter gene assay and RNA pull-down were used to evaluate the interaction between LINC00662 and miR-186-5p. m6A levels were enhanced in breast cancer tissues and cells. LINC00662, miR-186-5p and METTL3 were differentially expressed in vivo, and METTL3 expression was associated with LINC00662 and miR-186-5p expression. LINC00662 and miR-186-5p were differentially expressed in vitro; LINC00662 promoted cell viability and decreased the apoptosis rate, whereas miR-186-5p inhibited cell viability and increased the apoptosis rate. Furthermore, we found that METTL3 regulated m6A levels in docetaxel-resistant breast cancer cells by regulating the expression of LINC00662. Moreover, LINC00662 and miR-186-5p regulated the cell viability rate of docetaxel-resistant breast cancer cells. Further experiments showed that LINC00662 directly interacted with miR-186-5p to exert biological functions; besides miR-186-5p could regulate the expression of METTL3. METTL3 promotes m6A levels and docetaxel resistance in breast cancer by regulating the expression of LINC00662 and miR-186-5p; more experiments are needed to clarify the role of m6A regulation in drug resistance.
MeSH term(s)	Cell Line, Tumor ; Cell Proliferation/genetics ; Docetaxel/pharmacology ; Feedback ; Gene Expression Regulation, Neoplastic ; Humans ; Methyltransferases/genetics ; MicroRNAs/genetics ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics
Chemical Substances	MIRN186 microRNA, human ; MicroRNAs ; Docetaxel (15H5577CQD) ; Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62)
Language	English
Publishing date	2022-10-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-20477-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Editorial

Mingxin Zhang / Ning Lu / Qian Li / Manli Cui / Mingzhen Zhang

Frontiers in Molecular Biosciences, Vol

Drug Delivery System Based on Nanoparticles for Inflammation and Cancer Therapy

2022 Volume 9

Keywords	drug delivery system ; nanoparticles ; vaccine ; inflammation ; cancer ; therapy ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Convolution-GRU Based on Independent Component Analysis for fMRI Analysis with Small and Imbalanced Samples

Shan Wang / Feng Duan / Mingxin Zhang

Applied Sciences, Vol 10, Iss 7465, p

2020 Volume 7465

Abstract: Functional magnetic resonance imaging (fMRI) is a commonly used method of brain research. However, due to the complexity and particularity of the fMRI task, it is difficult to find enough subjects, resulting in a small and, often, imbalanced dataset. A ... ...

Abstract	Functional magnetic resonance imaging (fMRI) is a commonly used method of brain research. However, due to the complexity and particularity of the fMRI task, it is difficult to find enough subjects, resulting in a small and, often, imbalanced dataset. A dataset with small samples causes overfitting of the learning model, and the imbalance will make the model insensitive to the minority class, which has been a problem in classification. It is of great significance to classify fMRI data with small and imbalanced samples. In the present study, we propose a 3-step method on a small and imbalanced fMRI dataset from a word-scene memory task. The steps of the method are as follows: (1) An independent component analysis is performed to reduce the dimension of data; (2) The synthetic minority oversampling technique is used to generate new samples of the minority class to balance data; (3) A convolution-Gated Recurrent Unit (GRU) network is used to classify the independent component signals, indicating whether the subjects are performing episodic memory tasks. The accuracy of the proposed method is 72.2%, which improves the classification performance compared with traditional classifiers such as support vector machines (SVM), logistic regression (LGR), linear discriminant analysis (LDA) and k-nearest neighbor (KNN), and this study gives a biomarker for evaluating the reactivation of episodic memory.
Keywords	functional magnetic resonance imaging ; independent component analysis ; deep learning ; recurrent neural network ; functional connectivity ; episodic memory ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	006
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Associated Urogenital Disease

Guangdi Chu / Wei Jiao / Fei Xie / Mingxin Zhang / Haitao Niu

The World Journal of Men's Health, Vol 39, Iss 3, Pp 444-

A Current Update

2021 Volume 453

Abstract: Severe Acute Respiratory Syndrome Coronavirus 2, which is quickly spreading around the world and causes coronavirus disease 2019, may attack the urogenital system. We thought that a summary of the current literature about urogenital disease associated ... ...

Abstract	Severe Acute Respiratory Syndrome Coronavirus 2, which is quickly spreading around the world and causes coronavirus disease 2019, may attack the urogenital system. We thought that a summary of the current literature about urogenital disease associated with the virus would be useful for physicians treating patients with coronavirus disease 2019. PubMed was com-prehensively screened for studies published from 2019 to 2020. Studies of coronavirus disease 2019 patients with kidney dis-ease, reproductive system diseases, or urological cancer were included. Through reviewing current literature, we summarized that acute kidney injury is a risk factor for patients with coronavirus disease 2019 and is related to their survival. A diagnosis of chronic kidney disease increases the risk of infection. The therapy for kidney transplant patients should be cautious and implemented on a case-by-case basis. When the public health burden is too heavy to bear, a rational selection of treatment for patients with urological cancer is vital. The male reproductive system is at high risk of being attacked by the virus, which may cause damage to reproductive function, and the long-term effects require further study. So, the complications associated with the urogenital system should not be ignored during the course of infection treatment and more robust evidence of long-term effects on the urogenital system will be proposed as more studies are published.
Keywords	humans ; infections ; reproductive health ; severe acute respiratory syndrome coronavirus 2 ; urogenital system ; Medicine ; R ; Diseases of the genitourinary system. Urology ; RC870-923
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Korean Society for Sexual Medicine and Andrology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Electrospun Nanofiber Membranes for Air Filtration

Yangjian Zhou / Yanan Liu / Mingxin Zhang / Zhangbin Feng / Deng-Guang Yu / Ke Wang

Nanomaterials, Vol 12, Iss 1077, p

A Review

2022 Volume 1077

Abstract: Nanomaterials for air filtration have been studied by researchers for decades. Owing to the advantages of high porosity, small pore size, and good connectivity, nanofiber membranes prepared by electrospinning technology have been considered as an ... ...

Abstract	Nanomaterials for air filtration have been studied by researchers for decades. Owing to the advantages of high porosity, small pore size, and good connectivity, nanofiber membranes prepared by electrospinning technology have been considered as an outstanding air-filter candidate. To satisfy the requirements of material functionalization, electrospinning can provide a simple and efficient one-step process to fabricate the complex structures of functional nanofibers such as core–sheath structures, Janus structures, and other multilayered structures. Additionally, as a nanoparticle carrier, electrospun nanofibers can easily achieve antibacterial properties, flame-retardant properties, and the adsorption properties of volatile gases, etc. These simple and effective approaches have benefited from the significate development of electrospun nanofibers for air-filtration applications. In this review, the research progress on electrospun nanofibers as air filters in recent years is summarized. The fabrication methods, filtration performances, advantages, and disadvantages of single-polymer nanofibers, multipolymer composite nanofibers, and nanoparticle-doped hybrid nanofibers are investigated. Finally, the basic principles of air filtration are concluded upon and prospects for the application of complex-structured nanofibers in the field of air filtration are proposed.
Keywords	electrospinning ; nanofiber ; particulate matter ; polymer ; nanostructure ; Chemistry ; QD1-999
Subject code	690
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Polymer-Based Nanofiber–Nanoparticle Hybrids and Their Medical Applications

Mingxin Zhang / Wenliang Song / Yunxin Tang / Xizi Xu / Yingning Huang / Dengguang Yu

Polymers, Vol 14, Iss 351, p

2022 Volume 351

Abstract: The search for higher-quality nanomaterials for medicinal applications continues. There are similarities between electrospun fibers and natural tissues. This property has enabled electrospun fibers to make significant progress in medical applications. ... ...

Abstract	The search for higher-quality nanomaterials for medicinal applications continues. There are similarities between electrospun fibers and natural tissues. This property has enabled electrospun fibers to make significant progress in medical applications. However, electrospun fibers are limited to tissue scaffolding applications. When nanoparticles and nanofibers are combined, the composite material can perform more functions, such as photothermal, magnetic response, biosensing, antibacterial, drug delivery and biosensing. To prepare nanofiber and nanoparticle hybrids (NNHs), there are two primary ways. The electrospinning technology was used to produce NNHs in a single step. An alternate way is to use a self-assembly technique to create nanoparticles in fibers. This paper describes the creation of NNHs from routinely used biocompatible polymer composites. Single-step procedures and self-assembly methodologies are used to discuss the preparation of NNHs. It combines recent research discoveries to focus on the application of NNHs in drug release, antibacterial, and tissue engineering in the last two years.
Keywords	polymer composites ; nanoparticle ; polymer blends ; medical applications ; electrospinning ; Organic chemistry ; QD241-441
Subject code	620
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

Xinkuan Liu / Mingxin Zhang / Wenliang Song / Yu Zhang / Deng-Guang Yu / Yanbo Liu

Gels, Vol 8, Iss 357, p

2022 Volume 357

Abstract: The gels of cellulose and its derivatives have a broad and deep application in pharmaceutics; however, limited attention has been paid to the influences of other additives on the gelation processes and their functional performances. In this study, a new ... ...

Abstract	The gels of cellulose and its derivatives have a broad and deep application in pharmaceutics; however, limited attention has been paid to the influences of other additives on the gelation processes and their functional performances. In this study, a new type of electrospun core–shell nanohybrid was fabricated using modified, coaxial electrospinning which contained composites of hydroxypropyl methyl cellulose (HPMC) and acetaminophen (AAP) in the core sections and composites of PVP and sucralose in the shell sections. A series of characterizations demonstrated that the core–shell hybrids had linear morphology with clear core–shell nanostructures, and AAP and sucralose distributed in the core and shell section in an amorphous state separately due to favorable secondary interactions such as hydrogen bonding. Compared with the electrospun HPMC–AAP nanocomposites from single-fluid electrospinning of the core fluid, the core–shell nanohybrids were able to promote the water absorbance and HMPC gelation formation processes, which, in turn, ensured a faster release of AAP for potential orodispersible drug delivery applications. The mechanisms of the drug released from these nanofibers were demonstrated to be a combination of erosion and diffusion mechanisms. The presented protocols pave a way to adjust the properties of electrospun, cellulose-based, fibrous gels for better functional applications.
Keywords	HPMC ; coaxial electrospinning ; core–shell nanohybrids ; orodispersible drug delivery ; fast dissolution ; poorly water-soluble drug ; Science ; Q ; Chemistry ; QD1-999 ; Inorganic chemistry ; QD146-197 ; General. Including alchemy ; QD1-65
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Highly Strain‐Stable Intrinsically Stretchable Olfactory Sensors for Imperceptible Health Monitoring

Guodong Zhao / Jing Sun / Mingxin Zhang / Shanlei Guo / Xue Wang / Juntong Li / Yanhong Tong / Xiaoli Zhao / Qingxin Tang / Yichun Liu

Advanced Science, Vol 10, Iss 29, Pp n/a-n/a (2023)

2023

Abstract: Abstract Intrinsically stretchable gas sensors possess outstanding advantages in seamless conformability and high‐comfort wearability for real‐time detection toward skin/respiration gases, making them promising candidates for health monitoring and non‐ ... ...

Abstract	Abstract Intrinsically stretchable gas sensors possess outstanding advantages in seamless conformability and high‐comfort wearability for real‐time detection toward skin/respiration gases, making them promising candidates for health monitoring and non‐invasive disease diagnosis and therapy. However, the strain‐induced deformation of the sensitive semiconductor layers possibly causes the sensing signal drift, resulting in failure in achievement of the reliable gas detection. Herein, a surprising result that the stretchable organic polymers present a universal strain‐insensitive gas sensing property is shown. All the stretchable polymers with different degrees of crystallinity, including indacenodithiophene‐benzothiadiazole (PIDTBT), diketo‐pyrrolo‐pyrrole bithiophene thienothiophene (DPPT‐TT) and poly[4‐(4,4‐dihexadecyl‐4H‐cyclopenta[1,2‐b:5,4‐b′]dithiophen‐2‐yl)‐alt‐[1,2,5]thiad‐iazolo [3,4‐c] pyridine] (PCDTPT), show almost unchanged gas response signals in the different stretching states. This outstanding advantage enables the intrinsically stretchable devices to imperceptibly adhere on human skin and well conform to the versatile deformations such as bending, twisting, and stretching, with the highly strain‐stable gas sensing property. The intrinsically stretchable PIDTBT sensor also demonstrates the excellent selectivity toward the skin‐emitted trimethylamine (TMA) gas, with a theoretical limit of detection as low as 0.3 ppb. The work provides new insights into the preparation of the reliable skin‐like gas sensors and highlights the potential applications in the real‐time detection of skin gas and respiration gas for non‐invasive medical treatment and disease diagnosis.
Keywords	gas sensor ; intrinsically stretchable ; strain‐insensitive ; Science ; Q
Subject code	621
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of a Novel Protein-Based Signature to Improve Prognosis Prediction in Renal Clear Cell Carcinoma

Guangdi Chu / Ting Xu / Guanqun Zhu / Shuaihong Liu / Haitao Niu / Mingxin Zhang

Frontiers in Molecular Biosciences, Vol

2021 Volume 8

Abstract: BackgroundClear cell renal cell carcinoma (ccRCC) is one of the most common types of malignant adult kidney cancer, and its incidence and mortality are not optimistic. It is well known that tumor-related protein markers play an important role in cancer ... ...

Abstract	BackgroundClear cell renal cell carcinoma (ccRCC) is one of the most common types of malignant adult kidney cancer, and its incidence and mortality are not optimistic. It is well known that tumor-related protein markers play an important role in cancer detection, prognosis prediction, or treatment selection, such as carcinoembryonic antigen (CEA), programmed cell death 1 (PD-1), programmed cell death 1 ligand 1 (PD-L1), and cytotoxic T lymphocyte antigen 4 (CTLA-4), so a comprehensive analysis was performed in this study to explore the prognostic value of protein expression in patients with ccRCC.Materials and MethodsProtein expression data were obtained from The Cancer Proteome Atlas (TCPA), and clinical information were downloaded from The Cancer Genome Atlas (TCGA). We selected 445 patients with complete information and then separated them into a training set and testing set. We performed univariate, least absolute shrinkage and selection operator (LASSO) Cox analyses to find prognosis-related proteins (PRPs) and constructed a protein signature. Then, we used stratified analysis to fully verify the prognostic significance of the prognostic-related protein signature score (PRPscore). Besides, we also explored the differences in immunotherapy response and immune cell infiltration level in high and low score groups. The consensus clustering analysis was also performed to identify potential cancer subgroups.ResultsFrom the training set, a total of 233 PRPs were selected, and a seven-protein signature was constructed, including ACC1, AR, MAPK, PDK1, PEA15, SYK, and BRAF. Based on the PRPscore, patients could be divided into two groups with significantly different overall survival rates. Univariate and multivariate Cox regression analyses proved that this signature was an independent prognostic factor for patients (P < 0.001). Moreover, the signature showed a high ability to distinguish prognostic outcomes among subgroups, and the low score group had a better prognosis (P < 0.001) and better immunotherapy ...
Keywords	clear cell renal cell carcinoma ; proteomics ; immunotherapy ; TCGA ; TCPA ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Study of the Brain Network Connectivity in Visual-Word Pairing Associative Learning and Episodic Memory Reactivating Task

Mingxin Zhang / Feng Duan / Shan Wang / Kai Zhang / Xuyi Chen / Zhe Sun

Computational Intelligence and Neuroscience, Vol

2021 Volume 2021

Abstract: Episodic memory allows a person to recall and mentally reexperience specific episodes from one’s personal past. Studies of episodic memory are of great significance for the diagnosis and the exploration of the mechanism of memory generation. Most of the ... ...

Abstract	Episodic memory allows a person to recall and mentally reexperience specific episodes from one’s personal past. Studies of episodic memory are of great significance for the diagnosis and the exploration of the mechanism of memory generation. Most of the current studies focus on certain brain regions and pay less attention to the interrelationship between multiple brain regions. To explore the interrelationship in the brain network, we use an open fMRI dataset to construct the brain functional connectivity and effective connectivity network. We establish a binary directed network of the memory when it is reactivated. The binary directed network shows that the occipital lobe and parietal lobe have the most causal connections. The number of edges starting from the superior parietal lobule is the highest, with 49 edges, and 31 of which are connected to the occipital cortex. This means that the interaction between the superior parietal lobule and the occipital lobe plays the most important role in episodic memory, and the superior parietal lobule plays a more causal role in causality. In addition, memory regions such as the precuneus and fusiform also have some edges. The results show that the posterior parietal cortex plays an important role of hub node in the episodic memory network. From the brain network model, more information can be obtained, which is conducive to exploring the brain’s changing pattern in the whole memory process.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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