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Article ; Online: Control Technology of Roof-Cutting and Pressure Relief for Roadway Excavation with Strong Mining Small Coal Pillar

Mingzhong Wang / Hanghang Zheng / Zhenqian Ma / Hang Mu / Xiaolei Feng

Sustainability, Vol 15, Iss 2046, p

2023 Volume 2046

Abstract: In order to solve the problem of serious deformation and failure of surrounding rock and difficult maintenance of gob-side entries with strong mining-induced small coal pillars, taking the A110607 return airway of the Shanwenjiaba Coal Mine as the ... ...

Abstract	In order to solve the problem of serious deformation and failure of surrounding rock and difficult maintenance of gob-side entries with strong mining-induced small coal pillars, taking the A110607 return airway of the Shanwenjiaba Coal Mine as the engineering background, the key parameters of roof-cutting and pressure relief control technology for roadway excavation with strong mining-induced small coal pillars were studied by using two-way concentrated blasting roof-cutting and pressure relief technology, combined with theoretical analysis, numerical simulation and a field industrial test. A collaborative control scheme of “roof-cutting pressure relief + anchor cable combined support” is proposed. The test results show that when the height of roof-cutting is 8 m, the angle of roof-cutting is 15°, and when the width of the coal pillar is 3 m, the effect of roof-cutting and pressure relief is the best. Through the field blasting test, it was determined that the blast hole spacing was 800 mm, 321 charge structure was used in the intact roof, and 221 or 211 charge structures were used in the broken roof and geological structure zones. During the driving and strong mining period, the roof and floor movement of the roof-cutting section of the roadway excavation was reduced by about 38% compared with the uncut section, and the deformation of the two sides of the roadway was reduced by about 44% compared with the uncut section. It shows that the collaborative control scheme of “roof-cutting pressure relief + anchor cable combined support” has a good effect on the roadway excavation driving of small coal pillars in strong mining.
Keywords	strong mining ; numerical simulation ; roadway excavation ; roof-cutting and pressure releasing ; blasthole spacing ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	670
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Relationship between the T C of Smart Meta-Superconductor Bi(Pb)SrCaCuO and Inhomogeneous Phase Content

Honggang Chen / Mingzhong Wang / Yao Qi / Yongbo Li / Xiaopeng Zhao

Nanomaterials, Vol 11, Iss 1061, p

2021 Volume 1061

Abstract: A smart meta-superconductor Bi(Pb)SrCaCuO (B(P)SCCO) may increase the critical transition temperature ( T C ) of B(P)SCCO by electroluminescence (EL) energy injection of inhomogeneous phases. However, the increase amplitude Δ T C (

Abstract	A smart meta-superconductor Bi(Pb)SrCaCuO (B(P)SCCO) may increase the critical transition temperature ( T C ) of B(P)SCCO by electroluminescence (EL) energy injection of inhomogeneous phases. However, the increase amplitude Δ T C ( <math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi mathvariant="sans-serif">Δ</mi><msub><mi>T</mi><mi>C</mi></msub><mo>=</mo><msub><mi>T</mi><mi>C</mi></msub><mo>−</mo><msub><mi>T</mi><mrow><mi>C</mi><mo>,</mo><mi>p</mi><mi>u</mi><mi>r</mi><mi>e</mi></mrow></msub></mrow></semantics></math> ) of T C is relatively small. In this study, a smart meta-superconductor B(P)SCCO with different matrix sizes was designed. Three kinds of raw materials with different particle sizes were used, and different series of Y 2 O 3 :Sm 3+ , Y 2 O 3 , Y 2 O 3 :Eu 3+ , and Y 2 O 3 :Eu 3+ +Ag-doped samples and pure B(P)SCCO were prepared. Results indicated that the T C of the Y 2 O 3 or Y 2 O 3 :Sm 3+ non-luminescent dopant doping sample is lower than that of pure B(P)SCCO. However, the T C of the Y 2 O 3 :Eu 3+ +Ag or Y 2 O 3 :Eu 3+ luminescent inhomogeneous phase doping sample is higher than that of pure B(P)SCCO. With the decrease of the raw material particle size from 30 to 5 μm, the particle size of the B(P)SCCO superconducting matrix in the prepared samples decreases, and the doping content of the Y 2 O 3 :Eu 3+ +Ag or Y 2 O 3 :Eu 3+ increases from 0.2% to 0.4%. Meanwhile, the increase of the inhomogeneous phase content enhances the Δ T C . When the particle size of raw material is 5 μm, the doping concentration of the luminescent inhomogeneous phase can be increased to 0.4%. At this time, the zero-resistance temperature and onset transition temperature of the Y 2 O 3 :Eu 3+ +Ag doped sample are 4 and 6.3 K higher than ...
Keywords	smart meta-superconductor B(P)SCCO ; inhomogeneous phase content ; critical transition temperature ; EL energy injection ; increase amplitude Δ T C ; Chemistry ; QD1-999
Subject code	290 ; 333
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Smart meta-superconductor MgB2 constructed by the dopant phase of luminescent nanocomposite

Yongbo Li / Honggang Chen / Mingzhong Wang / Longxuan Xu / Xiaopeng Zhao

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 7

Abstract: Abstract On the basis of the idea that the injecting energy will improve the conditions for the formation of Cooper pairs, a smart meta-superconductor (SMSC) was prepared by doping luminescent nanocomposite Y2O3:Eu3+/Ag in MgB2. To improve the ... ...

Abstract	Abstract On the basis of the idea that the injecting energy will improve the conditions for the formation of Cooper pairs, a smart meta-superconductor (SMSC) was prepared by doping luminescent nanocomposite Y2O3:Eu3+/Ag in MgB2. To improve the superconducting transition temperature (T C ) of the MgB2-based superconductor, two types of Y2O3:Eu3+/Ag, which has the strong luminescence characteristic, with different sizes were prepared and marked as m-Y2O3:Eu3+/Ag and n-Y2O3:Eu3+/Ag. MgB2 SMSC was prepared through an ex situ process. Results show that when the dopant content was fixed at 2.0 wt.%, the T C of MgB2 SMSC increased initially then decreased with the increase in the Ag content in the dopant. When the Ag content is 5%, the T C of MgB2 SMSC was 37.2–38.0 K, which was similar to that of pure MgB2. Meanwhile, the T C of MgB2 SMSC doped with n-Y2O3:Eu3+/Ag increased initially then decreased basically with the increase in the content of n-Y2O3:Eu3+/Ag, in which the Ag content is fixed at 5%. The T C of MgB2 SMSC doped with 0.5 wt.% n-Y2O3:Eu3+/Ag was 37.6–38.4 K, which was 0.4 K higher than that of pure MgB2. It is thought that the doping luminescent nanocomposite into the superconductor is a new means to improve the T C of SMSC.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chelerythrine inhibits HSV-1 infection by suppressing virus binding to the cells

Ziwei Hu / Chaowei Zhang / Jianfeng Zhong / Hao Hu / Chenyang Li / Yunshi Zhao / Lu Wang / Liang Ye / Cong Yan / Mingzhong Wang / Qinchang Zhu / Bo Wen / Longxia He / Muhammad Shahid Riaz Rajoka / Xun Song / Zhendan He

Pharmacological Research - Modern Chinese Medicine, Vol 6, Iss , Pp 100223- (2023)

2023

Abstract: Objective: Herpes simplex virus type 1 (HSV-1) is a worldwide pathogen and mainly puts immunocompromised patients at higher risk of various complications. This research aims to demonstrate the antiviral activity of chelerythrine (CHE), an alkaloid ... ...

Abstract	Objective: Herpes simplex virus type 1 (HSV-1) is a worldwide pathogen and mainly puts immunocompromised patients at higher risk of various complications. This research aims to demonstrate the antiviral activity of chelerythrine (CHE), an alkaloid compound derived from the traditional Chinese medicine Mcleaya cordata, towards the HSV-1 F strain. Methods: Bioassay-guided fractionation was carried out in order to isolate the antiviral compound CHE. The plaque reduction assay was used to evaluate the antiviral activity of CHE. The combination of quantitative PCR (qPCR) and western blot was used to elucidate whether CHE interferes with viral DNA synthesis, followed by time-of-addition assay to examine which steps of HSV-1 infection CHE affected. The immunofluorescent assay and transmission electron microscopy assay were performed to further analyze the intracellular localization and the ultrastructural features of HSV-1 virions with the treatment of CHE. The binding affinity in CHE to targeted viral glycoprotein was investigated by surface plasmon resonance (SPR) assay and docking simulation. Results: CHE displayed a significant antiviral effect against HSV-1 at 0.312 to 2.5 µM with a viral titer reduction of 29.38% to 61.02%. CHE had an EC50 value of 1.78 µM against HSV-1, and the selectivity index (SI) for CHE was 4.07. Additionally, CHE inhibits ICP0 expression in the immediate early stage of infection, which further affected the early stage of infection, and subsequent viral replication. Results of the SPR assay showed that CHE had strong-binding affinity to gB with a KD value of 7.80 × 107 M, while gD with a value of 1.18 × 106 M. TEM revealed that CHE can clearly inhibit the virion release. In silico experiments further confirmed that CHE had low binding free energy in the activity sites of gB and gD. Conclusion: This study revealed that CHE directly targeted viral gB or gD as a potent glycoprotein inhibitor, which suggested that CHE could be a virus entry inhibitor for HSV-1 treatment.
Keywords	Herpes simplex virus type 1 ; Chelerythrine ; Antiviral ; Glycoprotein B ; Glycoprotein D ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
Subject code	570
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Antiviral Effects of Jasminin via Endogenous TNF-α and the Underlying TNF-α-Inducing Action

Xiaohong Zhu / Ziwei Hu / Tian Yu / Hao Hu / Yunshi Zhao / Chenyang Li / Qinchang Zhu / Mingzhong Wang / Peng Zhai / Longxia He / Muhammad Shahid Riaz Rajoka / Xun Song / Zhendan He

Molecules, Vol 27, Iss 1598, p

2022 Volume 1598

Abstract: Previous studies have reported that recombinant tumor necrosis factor (TNF)-α has powerful antiviral activity but severe systematic side effects. Jasminin is a common bioactive component found in Chinese herbal medicine beverage “Jasmine Tea”. Here, we ... ...

Abstract	Previous studies have reported that recombinant tumor necrosis factor (TNF)-α has powerful antiviral activity but severe systematic side effects. Jasminin is a common bioactive component found in Chinese herbal medicine beverage “Jasmine Tea”. Here, we report that jasminin-induced endogenous TNF-α showed antiviral activity in vitro. The underlying TNF-α-inducing action of jasminin was also investigated in RAW264.7 cells. The level of endogenous TNF-α stimulated by jasminin was first analyzed by an enzyme-linked immunosorbent assay (ELISA) from the cell culture supernatant of RAW264.7 cells. The supernatants were then collected to investigate the potential antiviral effect against herpes simplex virus 1 (HSV-1). The antiviral effects of jasminin alone or its supernatants were evaluated by a plaque reduction assay. The potential activation of the PI3K–Akt pathway, three main mitogen-activated protein kinases (MAPKs), and nuclear factor (NF)–κB signaling pathways that induce TNF-α production were also investigated. Jasminin induces TNF-α protein expression in RAW264.7 cells without additional stimuli 10-fold more than the control. No significant up-expression of type I, II, and III interferons; interleukins 2 and 10; nor TNF-β were observed by the jasminin stimuli. The supernatants, containing jasminin-induced-TNF-α, showed antiviral activity against HSV-1. The jasminin-stimulated cells caused the simultaneous activation of the Akt, MAPKs, and NF–κB signal pathways. Furthermore, the pretreatment of the cells with the Akt, MAPKs, and NF–κB inhibitors effectively suppressed jasminin-induced TNF-α production. Our research provides evidence that endogenous TNF-α can be used as a strategy to encounter viral infections. Additionally, the Akt, MAPKs, and NF–κB signaling pathways are involved in the TNF-α synthesis that induced by jasminin.
Keywords	jasminin ; TNF-α ; RAW264.7 cells ; MAPKs ; antiviral ; HSV-1 ; Organic chemistry ; QD241-441
Subject code	570
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: ID List Forwarding Free Confidentiality Preserving Data Aggregation for Wireless Sensor Networks

Liehuang Zhu / Zhen Yang / Mingzhong Wang / Meng Li

International Journal of Distributed Sensor Networks, Vol

2013 Volume 9

Abstract: Wireless sensor networks (WSNs) are composed of sensor nodes with limited energy which is difficult to replenish. Data aggregation is considered to help reduce communication overhead with in-network processing, thus minimizing energy consumption and ... ...

Abstract	Wireless sensor networks (WSNs) are composed of sensor nodes with limited energy which is difficult to replenish. Data aggregation is considered to help reduce communication overhead with in-network processing, thus minimizing energy consumption and maximizing network lifetime. Meanwhile, it comes with challenges for data confidentiality protection. Many existing confidentiality preserving aggregation protocols have to transfer list of sensors' ID for base station to explicitly tell which sensor nodes have actually provided measurement. However, forwarding a large number of node IDs brings overwhelming extra communication overhead. In this paper, we propose provably secure aggregation scheme perturbation-based efficient confidentiality preserving protocol (PEC2P) that allows efficient aggregation of perturbed data without transferring any ID information. In general, environmental data is confined to a certain range; hence, we utilize this feature and design an algorithm to help powerful base station retrieve the ID of reporting nodes. We analyze the accuracy of PEC2P and conclude that base station can retrieve the sum of environmental data with an overwhelming probability. We also prove that PEC2P is CPA secure by security reduction. Experiment results demonstrate that PEC2P significantly reduces node congestion (especially for the root node) during aggregation process in comparison with the existing protocols.
Keywords	Electronic computers. Computer science ; QA75.5-76.95
Subject code	003
Language	English
Publishing date	2013-05-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Discovery of 2-(1-(3-(4-Chloroxyphenyl)-3-oxo- propyl)pyrrolidine-3-yl)-1 H -benzo[d]imidazole-4-carboxamide

Rui Min / Weibin Wu / Mingzhong Wang / Lin Tang / Dawei Chen / Huan Zhao / Cunlong Zhang / Yuyang Jiang

Molecules, Vol 24, Iss 10, p

A Potent Poly(ADP-ribose) Polymerase (PARP) Inhibitor for Treatment of Cancer

2019 Volume 1901

Abstract: A series of benzimidazole carboxamide derivatives have been synthesized and characterized by 1 H-NMR, 13 C-NMR and HRMS. PARP inhibition assays and cellular proliferation assays have also been carried out. Compounds 5cj and 5cp exhibited potential ... ...

Abstract	A series of benzimidazole carboxamide derivatives have been synthesized and characterized by 1 H-NMR, 13 C-NMR and HRMS. PARP inhibition assays and cellular proliferation assays have also been carried out. Compounds 5cj and 5cp exhibited potential anticancer activities with IC 50 values of about 4 nM against both PARP-1 and PARP-2, similar to the reference drug veliparib. The two compounds also displayed slightly better in vitro cytotoxicities against MDA-MB-436 and CAPAN-1 cell lines than veliparib and olaparib, with values of 17.4 µM and 11.4 µM, 19.8 µM and 15.5 µM, respectively. The structure-activity relationship based on molecular docking was discussed as well.
Keywords	poly(ADP-ribose) polymerase ; PARP enzyme inhibition ; benzimidazole carboxamide ; Organic chemistry ; QD241-441
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phytochemical and Biological Characteristics of Mexican Chia Seed Oil

Yingbin Shen / Liyou Zheng / Jun Jin / Xiaojing Li / Junning Fu / Mingzhong Wang / Yifu Guan / Xun Song

Molecules, Vol 23, Iss 12, p

2018 Volume 3219

Abstract: The purpose of this research was to investigate the chemical profile, nutritional quality, antioxidant and hypolipidemic effects of Mexican chia seed oil (CSO) in vitro. Chemical characterization of CSO indicated the content of α-linolenic acid (63.64% ... ...

Abstract	The purpose of this research was to investigate the chemical profile, nutritional quality, antioxidant and hypolipidemic effects of Mexican chia seed oil (CSO) in vitro. Chemical characterization of CSO indicated the content of α-linolenic acid (63.64% of total fatty acids) to be the highest, followed by linoleic acid (19.84%), and saturated fatty acid (less than 11%). Trilinolenin content (53.44% of total triacylglycerols (TAGs)) was found to be the highest among seven TAGs in CSO. The antioxidant capacity of CSO, evaluated with ABTS •+ and DPPH • methods, showed mild antioxidant capacity when compared with Tocopherol and Catechin. In addition, CSO was found to lower triglyceride (TG) and low-density lipoprotein-cholesterol (LDL-C) levels by 25.8% and 72.9%respectively in a HepG2 lipid accumulation model. As CSO exhibits these chemical and biological characteristics, it is a potential resource of essential fatty acids for human use.
Keywords	Chia seed oil ; polyunsaturated fatty acid ; antioxidant ; lipid-lowering effect ; Organic chemistry ; QD241-441
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Observed particle sizes and fluxes of Aeolian sediment in the near surface layer during sand-dust storms in the Taklamakan Desert

Huo, Wen / Qing He / Fan Yang / Xinghua Yang / Qing Yang / Fuyin Zhang / Ali Mamtimin / Xinchun Liu / Mingzhong Wang / Yong Zhao / Xiefei Zhi

Theoretical and applied climatology. 2017 Nov., v. 130, no. 3-4

2017

Abstract: Monitoring, modeling and predicting the formation and movement of dust storms across the global deserts has drawn great attention in recent decades. Nevertheless, the scarcity of real-time observations of the wind-driven emission, transport and ... ...

Abstract	Monitoring, modeling and predicting the formation and movement of dust storms across the global deserts has drawn great attention in recent decades. Nevertheless, the scarcity of real-time observations of the wind-driven emission, transport and deposition of dusts has severely impeded progress in this area. In this study, we report an observational analysis of sand-dust storm samples collected at seven vertical levels from an 80-m-high flux tower located in the hinterland of the great Taklamakan Desert for ten sand-dust storm events that occurred during 2008â2010. We analyzed the vertical distribution of sandstorm particle grain sizes and horizontal sand-dust sediment fluxes from the near surface up to 80Â m high in this extremely harsh but highly representative environment. The results showed that the average sandstorm grain size was in the range of 70 to 85Â Î¼m. With the natural presence of sand dunes and valleys, the horizontal dust flux appeared to increase with height within the lower surface layer, but was almost invariant above 32Â m. The average flux values varied within the range of 8 to 14Â kgÂ mâ»Â² and the vertical distribution was dominated by the wind speed in the boundary layer. The dominant dust particle size was PMâââ and below, which on average accounted for 60â80Â % of the samples collected, with 0.9â2.5Â % for PMâââ.â, 3.5â7.0Â % for PMââââ, 5.0â14.0Â % for PMââââ and 20.0â40.0Â % for PMââââ. The observations suggested that on average the sand-dust vertical flux potential is about 0.29Â kgÂ mâ»Â² from the top of the 80Â m tower to the upper planetary boundary layer and free atmosphere through the transport of particles smaller than PMââ. Some of our results differed from previous measurements from other desert surfaces and laboratory wind-dust experiments, and therefore provide valuable observations to support further improvement of modeling of sandstorms across different natural environmental conditions.
Keywords	deserts ; dunes ; dust ; dust storms ; environmental factors ; hinterland ; models ; monitoring ; observational studies ; particle size ; prediction ; sediments ; spatial distribution ; troposphere ; valleys ; wind speed
Language	English
Dates of publication	2017-11
Size	p. 735-746.
Publishing place	Springer Vienna
Document type	Article
ZDB-ID	1463177-5
ISSN	1434-4483 ; 0177-798X
ISSN (online)	1434-4483
ISSN	0177-798X
DOI	10.1007/s00704-016-1917-4
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Hexanucleotide Repeat Expansion in C9ORF72 Is Not Detected in the Treatment-Resistant Schizophrenia Patients of Chinese Han.

Xijia Xu / Shiping Xie / Xiaomeng Shi / Jie Lv / Xiaowei Tang / Xiaolan Wang / Shuiping Lu / Mingzhong Wang / Xiaobing Zhang / Jing Sun / Hui Yao

PLoS ONE, Vol 10, Iss 12, p e

2015 Volume 0145347

Abstract: Hexanucleotide (GGGGCC) repeat expansion in C9ORF72 (HRE) causes frontotemporal lobar degeneration, frontotemporal dementia-amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis. HRE was also seen in the genomes of patients suffering from ... ...

Abstract	Hexanucleotide (GGGGCC) repeat expansion in C9ORF72 (HRE) causes frontotemporal lobar degeneration, frontotemporal dementia-amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis. HRE was also seen in the genomes of patients suffering from several other degenerative diseases. However, whether it is present in the treatment-resistant schizophrenia patients remains unknown. Genotyping 386 patients suffering from treatment-resistant schizophrenia using the method of Repeat-Primed PCR, we reported here that no HRE was detected in the patients of Chinese Han.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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