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  1. Article: Editorial: Micronutrients and critically ill patients.

    Lazzarin, Taline / Azevedo, Paula Schmidt / Cardoso, Barbara Rita / Suen, Vivian Marques Miguel / Minicucci, Marcos Ferreira

    Frontiers in medicine

    2024  Volume 10, Page(s) 1352808

    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1352808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The supplementation of L-carnitine in septic shock patients: Systematic review and meta-analysis.

    Guedes, Gabriel Voltani / Minicucci, Marcos Ferreira / Tanni, Suzana Erico

    Clinics (Sao Paulo, Brazil)

    2022  Volume 77, Page(s) 100124

    Abstract: Background: Sepsis and septic shock are severe and difficult-to-treat conditions with high lethality. There is interest in identifying new adjunct therapies that are effective in reducing mortality. In this context, L-carnitine has been investigated in ... ...

    Abstract Background: Sepsis and septic shock are severe and difficult-to-treat conditions with high lethality. There is interest in identifying new adjunct therapies that are effective in reducing mortality. In this context, L-carnitine has been investigated in trials as a potentially beneficial drug. Therefore, the aim of this systematic review was to assess the clinical evidence to support the use of L-carnitine in septic shock patients to reduce the risk of mortality. The objective of this review was to evaluate the effect of L-carnitine compared to placebo or Usual Care (UC) on the mortality rate in hospitalized adult septic shock patients.
    Methods: The authors exclusively included randomized clinical trials that compared the use of L-carnitine versus placebo in adult (> 18 years old) septic shock patients. The outcome was a mortality rate of 28 days. This systematic review and meta-analysis were performed following the PRISMA guidelines and registered in PROSPERO with the ID CRD42020180499.
    Results: Following the initial search, 4007 citations were identified, with 2701 remaining after duplicate removal. Eight citations were selected for body text reading, and two were selected for inclusion. The studies enrolled 275 patients, with 186 in the carnitine arm and 89 in the placebo arm. The effect of L-carnitine uses in septic shock patients showed a difference risk of -0.03 (95% Confidence Interval: -0.15-0.10, I
    Conclusions: There is low-quality evidence that the use of L-carnitine has no significant effect on reducing 28-day mortality in septic shock patients.
    MeSH term(s) Adult ; Humans ; Adolescent ; Shock, Septic/drug therapy ; Carnitine/therapeutic use ; Sepsis ; Dietary Supplements
    Chemical Substances Carnitine (S7UI8SM58A)
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.1016/j.clinsp.2022.100124
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  3. Article: Editorial: Outcome of sepsis and prediction of mortality risk.

    Munari, Elena / Minicucci, Marcos Ferreira / Ming, Zhong / Girardis, Massimo / Busani, Stefano

    Frontiers in medicine

    2023  Volume 10, Page(s) 1338938

    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1338938
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  4. Article ; Online: Is There a Role For Whole Body Vibration in Protecting Cardiovascular Disease?

    Zornoff, Leonardo / Minicucci, Marcos Ferreira

    Arquivos brasileiros de cardiologia

    2019  Volume 112, Issue 1, Page(s) 38–39

    MeSH term(s) Animals ; Cardiovascular Diseases ; Ischemia ; Male ; Myocardium ; Rats ; Vibration
    Language Portuguese
    Publishing date 2019-01-18
    Publishing country Brazil
    Document type Editorial ; Comment
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.5935/abc.20180257
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  5. Article: Methylene blue in sepsis and septic shock: a systematic review and meta-analysis.

    Ballarin, Raquel Simões / Lazzarin, Taline / Zornoff, Leonardo / Azevedo, Paula Schmidt / Pereira, Filipe Welson Leal / Tanni, Suzana Erico / Minicucci, Marcos Ferreira

    Frontiers in medicine

    2024  Volume 11, Page(s) 1366062

    Abstract: Background: Methylene blue is an interesting approach in reducing fluid overload and vasoactive drug administration in vasodilatory shock. The inhibition of guanylate cyclase induced by methylene blue infusion reduces nitric oxide production and ... ...

    Abstract Background: Methylene blue is an interesting approach in reducing fluid overload and vasoactive drug administration in vasodilatory shock. The inhibition of guanylate cyclase induced by methylene blue infusion reduces nitric oxide production and improves vasoconstriction. This systematic review and meta-analysis aimed to assess the effects of methylene blue administration compared to placebo on the hemodynamic status and clinical outcomes in patients with sepsis and septic shock.
    Methods: The authors specifically included randomized controlled trials that compared the use of methylene blue with placebo in adult patients with sepsis and septic shock. The outcomes were length of intensive care unit stay, hemodynamic parameters [vasopressor use], and days on mechanical ventilation. We also evaluated the abnormal levels of methemoglobinemia. This systematic review and meta-analysis were recorded in PROSPERO with the ID CRD42023423470.
    Results: During the initial search, a total of 1,014 records were identified, out of which 393 were duplicates. Fourteen citations were selected for detailed reading, and three were selected for inclusion. The studies enrolled 141 patients, with 70 of them in the methylene blue group and 71 of them in the control group. Methylene blue treatment was associated with a lower length of intensive care unit stay (MD -1.58; 95%CI -2.97, -0.20;
    Conclusion: Administering methylene blue to patients with sepsis and septic shock leads to reduced time to vasopressor discontinuation, length of intensive care unit stay, and days on mechanical ventilation.
    Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023423470, CRD42023423470.
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1366062
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  6. Article ; Online: Role of sulfonylurea administration in sepsis and septic shock patients: A systematic review.

    Lazzarin, Taline / Ballarin, Raquel Simões / Pereira, Filipe Welson Leal / Azevedo, Paula Schmidt / Tanni, Suzana Erico / Minicucci, Marcos Ferreira

    Clinics (Sao Paulo, Brazil)

    2023  Volume 78, Page(s) 100197

    MeSH term(s) Humans ; Shock, Septic ; Sepsis ; Hospital Mortality
    Language English
    Publishing date 2023-04-24
    Publishing country United States
    Document type Systematic Review ; Letter
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.1016/j.clinsp.2023.100197
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  7. Article ; Online: FRAIL scale as a screening tool and a predictor of mortality in non-dialysis dependent patients.

    Rodrigues, Hellen Christina Neves / Sousa, Amanda Goulart de Oliveira / Preto, Vitória Rodrigues Morais / Ferro, Camila Moura Batista / Sugizaki, Clara Sandra de Araújo / Freitas, Ana Tereza Vaz de Souza / Minicucci, Marcos Ferreira / Azevedo, Paula Schmidt / Peixoto, Maria do Rosário Gondim / Costa, Nara Aline

    Journal of nephrology

    2024  

    Abstract: Background: This study aimed to compare the diagnostic yield of the FRAIL scale with respect to the physical frailty phenotype measure and their association with mortality in non-dialysis-dependent patients.: Methods: In this prospective cohort study, ...

    Abstract Background: This study aimed to compare the diagnostic yield of the FRAIL scale with respect to the physical frailty phenotype measure and their association with mortality in non-dialysis-dependent patients.
    Methods: In this prospective cohort study, non-dialysis dependent patients with chronic kidney disease (CKD) stages 3b-5 seen in the nephrology outpatient clinics of two university hospitals were included. The presence of frailty was evaluated by physical frailty phenotype measure and the FRAIL scale. Patients were evaluated for six months, and mortality was recorded. The Kappa test was used to evaluate the diagnostic properties between the methods, and logistic regression to test the association between frailty and mortality.
    Results: One hundred fifty-three patients were evaluated; average age was 65 (56-70) years, 50.9% were women, and the all-cause mortality rate was 2.6%. Forty-six patients were classified as living with frailty according to the physical frailty phenotype while 36 patients were rated frail by the FRAIL scale. In adults < 60 years of age, the FRAIL scale showed good accuracy (84.9%) and specificity (93.2%) but had low sensitivity (41.3%) and moderate agreement (Kappa = 0.41; p < 0.001) compared to the definition of the physical frailty phenotype. The adjusted logistic regression model showed that the patients with frailty assessed by the FRAIL scale had a greater chance of mortality than the non-frail patients (OR: 6.8; CI95%:1.477-31.513; p = 0.014).
    Conclusion: Physical frailty phenotype identifies more patients as having pre-frailty and frailty in non-dialysis dependent patients as compared to the FRAIL scale. However, the FRAIL scale is a simple bedside tool that can be useful for screening for frailty and whose results were associated with mortality.
    Language English
    Publishing date 2024-03-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-024-01900-3
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    Zs.A 3369: Show issues Location:
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  8. Article ; Online: Serum urea increase during hospital stay is associated with worse outcomes after in-hospital cardiac arrest.

    Barros, João Carlos Clarck / Ferreira, Gustavo Martins / Souza, Isabelle de Almeida / Shalova, Asiya / Azevedo, Paula Schmidt / Polegato, Bertha Furlan / Zornoff, Leonardo / de Paiva, Sergio Alberto Rupp / Favero, Edson Luiz / Lazzarin, Taline / Minicucci, Marcos Ferreira

    The American journal of the medical sciences

    2024  

    Abstract: Background: Evaluate the association between serum urea at admission and during hospital stay with return of spontaneous circulation (ROSC) and in-hospital mortality in patients with in-hospital cardiac arrest (IHCA).: Methods: This retrospective ... ...

    Abstract Background: Evaluate the association between serum urea at admission and during hospital stay with return of spontaneous circulation (ROSC) and in-hospital mortality in patients with in-hospital cardiac arrest (IHCA).
    Methods: This retrospective study included patients over 18 years with IHCA attended from May 2018 to December 2022. The exclusion criteria were the absence of exams to calculate delta urea and the express order of "do-not-resuscitate". Data were collected from the electronic medical records. Serum admission urea and urea 24 hours before IHCA were also collected and used to calculate delta urea.
    Results: A total of 504 patients were evaluated; 125 patients were excluded due to the absence of variables to calculate delta urea and 5 due to "do-not-resuscitate" order. Thus, we included 374 patients in the analysis. The mean age was 65.0 ± 14.5 years, 48.9% were male, 45.5% had ROSC, and in-hospital mortality was 91.7%. In logistic regression models, ROSC was associated with lower urea levels 24 hours before IHCA (OR: 0.996; CI95%: 0.992-1.000; p: 0.032). In addition, increased levels of urea 24 hours before IHCA (OR: 1.020; CI95%: 1.008-1.033; p: 0.002) and of delta urea (OR: 1.001; CI95%: 1.001-1.019; p: 0.023) were associated with in-hospital mortality. ROC curve analysis showed that the area under the ROC curve for mortality prediction was higher for urea 24 hours before IHCA (Cutoff > 120.1 mg/dL) than for delta urea (Cutoff > 34.83 mg/dL).
    Conclusions: In conclusion, increased serum urea levels during hospital stay were associated with worse prognosis in IHCA.
    Language English
    Publishing date 2024-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2024.04.016
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  9. Article ; Online: Should we introduce a feeding tube before assessing the risk of variceal bleeding?

    Romeiro, Fernando Gomes / Minicucci, Marcos Ferreira / de Paiva, Sergio Alberto Rupp

    Clinical nutrition (Edinburgh, Scotland)

    2020  Volume 39, Issue 4, Page(s) 1304

    MeSH term(s) Enteral Nutrition ; Esophageal and Gastric Varices/epidemiology ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/epidemiology ; Gastrointestinal Hemorrhage/etiology ; Humans ; Liver Cirrhosis ; Liver Diseases
    Language English
    Publishing date 2020-02-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2020.02.005
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  10. Article ; Online: VEGFR-2: One of Pioglitazone's Signaling Pathways in the Heart.

    Minicucci, Marcos Ferreira / Zornoff, Leonardo Antonio Mamede

    Arquivos brasileiros de cardiologia

    2018  Volume 111, Issue 2, Page(s) 170–171

    MeSH term(s) Pioglitazone ; Signal Transduction ; Thiazolidinediones ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-2
    Chemical Substances Thiazolidinediones ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1) ; Pioglitazone (X4OV71U42S)
    Language Portuguese
    Publishing date 2018-09-05
    Publishing country Brazil
    Document type Editorial ; Comment
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.5935/abc.20180147
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