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Article ; Online: [Bioinorganic Chemistry of Iron].

Mino, Yoshiki

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2018 Volume 138, Issue 3, Page(s) 373–387

Abstract: The X-ray crystallographic analysis of the single-crystal mugineic acid-Cu(II) complex showed that mugineic acid acts as a hexadentate ligand. Mugineic acid, a typical phytosiderophore, shows a marked stimulating effect ... ...

Abstract	The X-ray crystallographic analysis of the single-crystal mugineic acid-Cu(II) complex showed that mugineic acid acts as a hexadentate ligand. Mugineic acid, a typical phytosiderophore, shows a marked stimulating effect on
MeSH term(s)	Amino Acid Sequence ; Animals ; Azetidinecarboxylic Acid/analogs & derivatives ; Azetidinecarboxylic Acid/chemistry ; Azetidinecarboxylic Acid/metabolism ; Chlorophyll/biosynthesis ; Coordination Complexes/chemistry ; Coordination Complexes/metabolism ; Crystallography, X-Ray ; Female ; Ferredoxins/chemistry ; Humans ; Iron/chemistry ; Iron/metabolism ; Iron/toxicity ; Male ; Peroxidases ; Plants/metabolism ; Siderophores ; Spectrum Analysis, Raman
Chemical Substances	Coordination Complexes ; Ferredoxins ; Siderophores ; Chlorophyll (1406-65-1) ; Azetidinecarboxylic Acid (2517-04-6) ; Iron (E1UOL152H7) ; Peroxidases (EC 1.11.1.-) ; manganese peroxidase (EC 1.11.1.13) ; mugineic acid (KR256JY76I)
Language	Japanese
Publishing date	2018
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.17-00154
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Article ; Online: Enhanced oxygen consumption results in summertime hypoxia in Mikawa Bay, Japan

Mino, Yoshihisa / Sukigara, Chiho / Ishizaka, Joji

Environ Sci Pollut Res. 2023 Feb., v. 30, no. 10 p.26120-26136

2023

Abstract: In Mikawa Bay, where hypoxia occurs in the bottom layer during summer, six shipboard observations were conducted from the mouth to the head of the bay from May to August 2014 to investigate the spatiotemporal variation in the bottom layer oxygen ... ...

Abstract	In Mikawa Bay, where hypoxia occurs in the bottom layer during summer, six shipboard observations were conducted from the mouth to the head of the bay from May to August 2014 to investigate the spatiotemporal variation in the bottom layer oxygen consumption rate (OCR). The OCR was determined from the dark incubation of sample waters using an optical oxygen sensor, which showed a range of 5.7–38.3 mmol m⁻³ days⁻¹. A high OCR was observed at the inner-most station, where higher concentrations of nutrients and chlorophyll a (Chl a) than at the other stations were found, and bottom hypoxic water appeared during the observation period after late June. These OCRs can deplete the oxygen dissolved in water within a week. The OCR showed a highly significant positive correlation with particulate organic carbon concentrations in the bottom water. Considering the relatively low carbon-to-nitrogen mole ratio (~ 6.4–7.6) and high carbon isotope ratio (between approximately − 20.2 and − 18.8‰) of particulate organic matter at the stations, the supply of fresh organic matter produced in the bay as opposed to the land may have affected the OCR by acting as a substrate for microbial aerobic respiration. High temporal resolution data from two automated observation buoys near the bay mouth and the inner area captured increases in Chl a at both sites in response to typhoon events, along with the subsequent appearance of bottom hypoxic water at the inner site and its expansion at the mouth. This supports our hypothesis that enhanced organic matter production due to nutrient input to the surface layer through vertical mixing would increase the bottom OCR, resulting in hypoxia. The apparent oxygen decline in the bottom layer from the buoy data was consistent with incubation-based OCRs during the observation period. Therefore, it is essential to model the OCR in numerical simulations of hypoxia, to which the variability characteristics that we revealed made significant contributions.
Keywords	Japan ; aerobiosis ; automation ; chlorophyll ; decline ; hypoxia ; isotopes ; oxygen ; oxygen consumption ; particulate organic carbon ; summer ; typhoons
Language	English
Dates of publication	2023-02
Size	p. 26120-26136.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-23850-8
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Article ; Online: Enhanced oxygen consumption results in summertime hypoxia in Mikawa Bay, Japan.

Mino, Yoshihisa / Sukigara, Chiho / Ishizaka, Joji

Environmental science and pollution research international

2022 Volume 30, Issue 10, Page(s) 26120–26136

Abstract	In Mikawa Bay, where hypoxia occurs in the bottom layer during summer, six shipboard observations were conducted from the mouth to the head of the bay from May to August 2014 to investigate the spatiotemporal variation in the bottom layer oxygen consumption rate (OCR). The OCR was determined from the dark incubation of sample waters using an optical oxygen sensor, which showed a range of 5.7-38.3 mmol m
MeSH term(s)	Humans ; Chlorophyll A ; Japan ; Bays ; Water ; Seasons ; Oxygen/analysis ; Carbon ; Hypoxia ; Oxygen Consumption ; Eutrophication
Chemical Substances	Chlorophyll A (YF5Q9EJC8Y) ; Water (059QF0KO0R) ; Oxygen (S88TT14065) ; Carbon (7440-44-0)
Language	English
Publishing date	2022-11-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-23850-8
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Article ; Online: [Optimization of Immunosuppression and the Prevention of Fungal Infection in Autoimmune Diseases].

Mino, Yasuaki

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2015 Volume 135, Issue 10, Page(s) 1123–1127

Abstract: Mycophenolate mofetil (MMF) has recently been reported to be effective in the treatment of systemic lupus erythematosus (SLE). The therapeutic range of mycophenolic acid (MPA) and its 7-O-glucuronide (MPAG), and factors affecting their pharmacokinetics, ... ...

Abstract	Mycophenolate mofetil (MMF) has recently been reported to be effective in the treatment of systemic lupus erythematosus (SLE). The therapeutic range of mycophenolic acid (MPA) and its 7-O-glucuronide (MPAG), and factors affecting their pharmacokinetics, remain to be clarified. The influence of the pharmacokinetics of MPA and MPAG on the activity of inosine 5'-monophosphate dehydrogenase (IMPDH), a target of the MPA, also remains to be revealed. The pharmacokinetic variability of hydroxy-itraconazole (OH-ITZ), an active metabolite of itraconazole frequently co-administered with immunosuppressants in immunocompromised patients, is not fully known. The aim of this study was to establish the optimal dosage and administration of immunosuppressants and antifungal agents. MMF improved clinical laboratory markers and reduced prednisolone dosage in 31 SLE patients, with a pre-dose plasma concentration of MPA and MPAG in the interquartile ranges of 0.94-2.96 and 18.6-53.7 μg/mL, respectively. Renal function and co-administered metal influenced the pharmacokinetics of MPA and MPAG in 31 SLE patients in the remission maintenance phase. IMPDH activity was induced in 29 SLE patients receiving the MMF therapy. This induction was dependent on the plasma concentration of MPAG, but not MPA. In addition, IMPDH activity was negatively correlated with complement fraction C3. MPA exposure and disease activity in SLE patients may determine IMPDH activity. The pharmacokinetic variability of OH-ITZ was associated with saturated metabolism to keto-itraconazole, serum concentration of albumin, and renal function in 46 immunocompromised patients. Prevention of fungal infections and drug-drug interactions in immunocompromised patients can be obtained by considering these identified confounding factors.
MeSH term(s)	Complement C3/metabolism ; Drug Interactions ; Drug Monitoring ; Drug Therapy, Combination ; Glucuronides/administration & dosage ; Glucuronides/adverse effects ; Glucuronides/pharmacokinetics ; Humans ; IMP Dehydrogenase/metabolism ; Immunocompromised Host ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/pharmacokinetics ; Individuality ; Itraconazole/administration & dosage ; Itraconazole/pharmacokinetics ; Lupus Erythematosus, Systemic/drug therapy ; Mycophenolic Acid/administration & dosage ; Mycophenolic Acid/adverse effects ; Mycophenolic Acid/analogs & derivatives ; Mycophenolic Acid/pharmacokinetics ; Mycoses/etiology ; Mycoses/prevention & control ; Prednisolone/administration & dosage
Chemical Substances	Complement C3 ; Glucuronides ; Immunosuppressive Agents ; Itraconazole (304NUG5GF4) ; mycophenolic acid glucuronide (54TS5J9T0K) ; Prednisolone (9PHQ9Y1OLM) ; IMP Dehydrogenase (EC 1.1.1.205) ; Mycophenolic Acid (HU9DX48N0T)
Language	Japanese
Publishing date	2015
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.15-00193
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Article ; Online: Lattice Boltzmann method for simulation of wettable particles at a fluid-fluid interface under gravity.

Mino, Yasushi / Shinto, Hiroyuki

Physical review. E

2020 Volume 101, Issue 3-1, Page(s) 33304

Abstract: A computational technique was developed to simulate wettable particles trapped at a fluid-fluid interface under gravity. The proposed technique combines the improved smoothed profile-lattice Boltzmann method (iSP-LBM) for the treatment of moving solid- ... ...

Abstract	A computational technique was developed to simulate wettable particles trapped at a fluid-fluid interface under gravity. The proposed technique combines the improved smoothed profile-lattice Boltzmann method (iSP-LBM) for the treatment of moving solid-fluid boundaries and the free-energy LBM for the description of isodensity immiscible two-phase flows. We considered five benchmark problems in two-dimensional systems, including a stationary drop, a wettable particle trapped at a fluid-fluid interface in the absence or presence of gravity, two freely moving particles at a fluid-fluid interface in the presence of gravity (i.e., capillary floatation forces), and two vertically constrained particles at a fluid-fluid interface (i.e., capillary immersion forces). The simulation results agreed well with theoretical estimations, demonstrating the efficacy of the proposed technique.
Language	English
Publishing date	2020-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.101.033304
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Article: Simulation on Pore Formation from Polymer Solution at Surface in Contact with Solid Substrate via Thermally Induced Phase Separation.

Mino, Yasushi / Fukukawa, Naruki / Matsuyama, Hideto

Membranes

2021 Volume 11, Issue 7

Abstract: The formation of porous structures from polymer solutions at the surface in contact with various solid surfaces via a thermally-induced phase separation (TIPS) process is investigated. The pore formation process at the bulk and the surface of the poly( ... ...

Abstract	The formation of porous structures from polymer solutions at the surface in contact with various solid surfaces via a thermally-induced phase separation (TIPS) process is investigated. The pore formation process at the bulk and the surface of the poly(methyl methacrylate)/cyclohexanol solution is simulated with a model based on the phase field method. When the compatibilities between the polymer-rich phase formed by the phase separation and the solid surface are high or low, surface porosity decreases. In contrast, for the solid surface having similar compatibilities with the polymer and solvent, high surface porosity is achieved. This indicates that the compatibility between the solid surface and polymer solution is important, and that optimal compatibility results in high surface porosity. The knowledge obtained in this work is useful to design the coagulation bath component in the membrane preparation process by TIPS for achieving high surface porosity.
Language	English
Publishing date	2021-07-13
Publishing country	Switzerland
Document type	Journal Article
ISSN	2077-0375
ISSN	2077-0375
DOI	10.3390/membranes11070527
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Article ; Online: Lattice Boltzmann model for capillary interactions between particles at a liquid-vapor interface under gravity.

Mino, Yasushi / Tanaka, Hazuki / Nakaso, Koichi / Gotoh, Kuniaki / Shinto, Hiroyuki

Physical review. E

2022 Volume 105, Issue 4-2, Page(s) 45316

Abstract: A computational technique based on the lattice Boltzmann method (LBM) is developed to simulate the wettable particles adsorbed to a liquid-vapor interface under gravity. The proposed technique combines the improved smoothed-profile LBM for the treatment ... ...

Abstract	A computational technique based on the lattice Boltzmann method (LBM) is developed to simulate the wettable particles adsorbed to a liquid-vapor interface under gravity. The proposed technique combines the improved smoothed-profile LBM for the treatment of moving solid particles in a fluid and the free-energy LBM for the description of a liquid-vapor system. Five benchmark two-dimensional problems are examined: (A) a stationary liquid drop in the vapor phase; a wettable particle adsorbed to a liquid-vapor interface in (B) the absence and (C) the presence of gravity; (D) two freely moving particles at a liquid-vapor interface in the presence of gravity (i.e., capillary flotation forces); and (E) two vertically constrained particles at a liquid-vapor interface (i.e., capillary immersion forces). The simulation results are in good quantitative agreement with theoretical estimations, demonstrating that the proposed technique can reproduce the capillary interactions between wettable particles at a liquid-vapor interface under gravity.
Language	English
Publishing date	2022-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.105.045316
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Article: Investigation of the boxed warnings in package inserts of prescription medicines for medical professionals in Japan.

Mino, Yasuaki / Naito, Takafumi / Ohshiro, Junya / Yamada, Takahiro / Kawakami, Junichi

Pharmacy practice

2022 Volume 20, Issue 4, Page(s) 2733

Abstract: Objective: In the Japanese Pharmacists Act, article 25-2, revised in 2013, it states that pharmacists shall provide the necessary information and guidance to the patient based on pharmaceutical knowledge and experience for ensuring the proper use of the ...

Abstract	Objective: In the Japanese Pharmacists Act, article 25-2, revised in 2013, it states that pharmacists shall provide the necessary information and guidance to the patient based on pharmaceutical knowledge and experience for ensuring the proper use of the medicine dispensed. The package insert is one of the documents to be referred to when providing the information and guidance. The boxed warnings in package inserts that include the precautions and responses are the most significant parts, however, the suitability of boxed warnings for pharmaceutical practice has not been evaluated. The aim of this study was to investigate the boxed warning descriptions in package inserts of prescription medicines for medical professionals in Japan. Methods: Package inserts of prescription medicines listed in the Japanese National Health Insurance drug price list on March 1st 2015 were collected one by one by hand from the website of the Japanese Pharmaceuticals and Medical Devices Agency (https://www.pmda.go.jp/english/). Package inserts with boxed warnings were classified according to the Standard Commodity Classification Number of Japan based on the pharmacological activity of each medicine. They were also compiled according to their formulations. The boxed warnings were divided into the precautions and responses parts, and their characteristics were compared among medicines. Results: The number of package inserts found on the website of the Pharmaceuticals and Medical Devices Agency was 15,828. Boxed warnings were present in 8.1% of the package inserts. A description of adverse drug reactions accounted for 74% of all precautions. Most of the precautions were observed in the warning boxes of antineoplastic agents. Blood and lymphatic system disorders were the most common precaution. Responses in the boxed warnings directed toward medical doctors, pharmacists, and other healthcare professionals accounted for 100, 77, and 8% of all package inserts with a boxed warning, respectively. Explanations for patients were the second most frequent response. Conclusions: The majority of boxed warnings request therapeutic contribution by pharmacists, and the descriptions of these explanations and guidance by pharmacists to patients were found to be consistent with the Pharmacists Act.
Language	English
Publishing date	2022-10-12
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2414565-8
ISSN	1886-3655 ; 1885-642X
ISSN (online)	1886-3655
ISSN	1885-642X
DOI	10.18549/PharmPract.2022.4.2733
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Article ; Online: Temporal variation of particulate organic carbon flux at the mouth of Tokyo Bay.

Sukigara, Chiho / Otosaka, Shigeyoshi / Horimoto-Miyazaki, Naho / Mino, Yoshihisa

Journal of oceanography

2022 Volume 79, Issue 3, Page(s) 199–209

Abstract: A sediment trap experiment was conducted at a depth of 750 m at the mouth of Tokyo Bay to clarify the quantity and transport process of particles from the bay to the open ocean. The high total mass flux (8.7 ± 4.5 g ... ...

Abstract	A sediment trap experiment was conducted at a depth of 750 m at the mouth of Tokyo Bay to clarify the quantity and transport process of particles from the bay to the open ocean. The high total mass flux (8.7 ± 4.5 g m
Language	English
Publishing date	2022-08-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2017037-3
ISSN	1573-868X ; 0916-8370
ISSN (online)	1573-868X
ISSN	0916-8370
DOI	10.1007/s10872-022-00660-7
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Article ; Online: Impact of clinical clerkship integrated with clinical ladder on attending physicians' teaching self-efficacy.

Arai, Yuto / Yoshino, Go / Ohta, Kento / Okanishi, Tohru / Kakee, Sosuke / Mino, Yoichi / Komatsu, Hiroaki / Yamada, Nanako / Ueki, Masaru / Maegaki, Yoshihiro

BMC medical education

2024 Volume 24, Issue 1, Page(s) 400

Abstract: Background: Self-efficacy plays an important role in enhancing the teaching capabilities of attending physicians (APs). The clinical ladder (CL) is an educational approach developed in the field of nursing education that increases difficulty in an ... ...

Abstract	Background: Self-efficacy plays an important role in enhancing the teaching capabilities of attending physicians (APs). The clinical ladder (CL) is an educational approach developed in the field of nursing education that increases difficulty in an incremental manner. However, no previous study has confirmed the effectiveness of CL in medical education. Therefore, this study aimed to examine the effect of clinical clerkship integrated with clinical ladder (CC-CL) on the self-efficacy of APs. Methods: Sixth-year medical students participated in CC-CL for 6 months starting from April 2023, and the changes in the self-efficacy of APs were retrospectively evaluated. The students were trained by the APs concurrently, and the achievement levels of each student were shared. The primary outcome measure was the physician teaching self-efficacy questionnaire (PTSQ) score. The PTSQ scores before and after CC-CL were analyzed using the Wilcoxon matched-pair signed-rank test. Results: Fifteen APs from the Department of Pediatric and Child Neurology were included in this study. No significant difference was observed in the total PTSQ scores of the APs before and after CC-CL. However, a significant increase was observed in the PTSQ score of APs who participated for at least 2 h per week over a period of more than 3 months (n = 8) after CC-CL (p = 0.022). Furthermore, APs who had received their pediatrician certification < 10 years ago (n = 8) showed a significant increase in the total PTSQ score after CC-CL (p = 0.022). Conclusions: CC-CL may play an important role in cultivating the self-efficacy of less experienced APs. Further comparative studies must be conducted in the future to validate the findings of this study.
MeSH term(s)	Humans ; Child ; Clinical Clerkship ; Career Mobility ; Retrospective Studies ; Self Efficacy ; Physicians ; Students, Medical ; Teaching
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-024-05396-0
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