Article ; Online: Emerging trends in the treatment of rectal cancer.
Acta oncologica (Stockholm, Sweden)
2019 Volume 58, Issue 10, Page(s) 1343–1351
Abstract: The conventional treatment for cT3-T4 or node-positive clinically resectable rectal cancer is long course preoperative chemoradiation followed by surgery and postoperative adjuvant chemotherapy. Disadvantages of this approach include possible ... ...
Abstract | The conventional treatment for cT3-T4 or node-positive clinically resectable rectal cancer is long course preoperative chemoradiation followed by surgery and postoperative adjuvant chemotherapy. Disadvantages of this approach include possible overtreatment of patients, 6 weeks of daily radiation treatment, and undetected metastatic disease. There are a number of emerging trends which are changing this approach to treatment. Selected topics included in this manuscript include the selective use of pelvic radiation, the role of radiation for a positive radial margin, the interval between radiation and surgery, non-operative management, new chemoradiation regimens, short vs. long course radiation, and the role of postoperative adjuvant chemotherapy. |
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MeSH term(s) | Chemoradiotherapy/methods ; Chemotherapy, Adjuvant/methods ; Clinical Trials, Phase III as Topic ; Disease-Free Survival ; Humans ; Neoadjuvant Therapy/methods ; Neoplasm Staging ; Patient Selection ; Proctectomy ; Radiotherapy Dosage ; Rectal Neoplasms/mortality ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy ; Time Factors |
Language | English |
Publishing date | 2019-07-04 |
Publishing country | England |
Document type | Journal Article ; Review |
ZDB-ID | 896449-x |
ISSN | 1651-226X ; 0349-652X ; 0284-186X ; 1100-1704 |
ISSN (online) | 1651-226X |
ISSN | 0349-652X ; 0284-186X ; 1100-1704 |
DOI | 10.1080/0284186X.2019.1629009 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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