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  1. Book ; Online ; E-Book: Novel Approaches in Metronomic Chemotherapy for Breast Cancer Treatment

    Mir, Manzoor Ahmad

    2024  

    Abstract: This book provides latest research and developments in the field of metronomic chemotherapy for breast cancer. It presents the principles and mechanisms of metronomic chemotherapy, preclinical and clinical studies, and the latest developments in drug ... ...

    Abstract This book provides latest research and developments in the field of metronomic chemotherapy for breast cancer. It presents the principles and mechanisms of metronomic chemotherapy, preclinical and clinical studies, and the latest developments in drug delivery systems and nano formulations.
    Language English
    Size 1 online resource (191 pages)
    Edition 1st ed.
    Publisher Taylor & Francis Group
    Publishing place Milton
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9781040013717 ; 9781032620459 ; 1040013716 ; 1032620455
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Human pathogenic microbes

    Mir, Manzoor Ahmad

    diseases and concerns

    (Developments in microbiology)

    2022  

    Author's details Manzoor Ahmad Mir
    Series title Developments in microbiology
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxiii, 266 Seiten), Illustrationen, Diagramme
    Publisher Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021299603
    ISBN 978-0-323-95426-6 ; 9780323961271 ; 0-323-95426-X ; 0323961274
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: Combinational therapy in triple negative breast cancer

    Mir, Manzoor Ahmad

    2022  

    Author's details Manzoor Ahmad Mir
    Keywords Breast/Cancer/Treatment
    Subject code 616.9944906
    Language English
    Size 1 online resource (335 pages)
    Publisher Academic Press
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-96137-1 ; 9780323961363 ; 978-0-323-96137-0 ; 0323961363
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: Developing costimulatory molecules for immunotherapy of diseases

    Mir, Manzoor Ahmad

    2015  

    Author's details Manzoor Ahmad Mir
    Keywords Immunotherapy ; Immunologic diseases/Molecular aspects ; CD antigens
    Subject code 616.079
    Language English
    Size XX, 299 S. : Ill., graph. Darst., 23 cm
    Publisher Elsevier Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018683419
    ISBN 978-0-12-802585-7 ; 0-12-802585-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 2405 available for loan (reading room) Lesesaal EG

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  5. Article ; Online: Antimicrobial resistance: new insights and therapeutic implications.

    Sheikh, Bashir Ahmad / Bhat, Basharat Ahmad / Mir, Manzoor Ahmad

    Applied microbiology and biotechnology

    2022  Volume 106, Issue 19-20, Page(s) 6427–6440

    Abstract: Antimicrobial resistance has not been a new phenomenon. Still, the number of resistant organisms, the geographic areas affected by emerging drug resistance, and the magnitude of resistance in a single organism are enormous and mounting. Disease and ... ...

    Abstract Antimicrobial resistance has not been a new phenomenon. Still, the number of resistant organisms, the geographic areas affected by emerging drug resistance, and the magnitude of resistance in a single organism are enormous and mounting. Disease and disease-causing agents formerly thought to be contained by antibiotics are now returning in new forms resistant to existing therapies. Antimicrobial resistance is one of the most severe and complicated health issues globally, driven by interrelated dynamics in humans, animals, and environmental health sectors. Coupled with various epidemiological factors and a limited pipeline for new antimicrobials, all these misappropriations allow the transmission of drug-resistant organisms. The problem is likely to worsen soon. Antimicrobial resistance in general and antibiotic resistance in particular is a shared global problem. Actions taken by any single country can adversely or positively affect the other country. Targeted coordination and prevention strategies are critical in stopping the spread of antibiotic-resistant organisms and hence its overall management. This article has provided in-depth knowledge about various methods that can help mitigate the emergence and spread of antimicrobial resistance globally. KEY POINTS: • Overview of antimicrobial resistance as a global challenge and explain various reasons for its rapid progression. • Brief about the intrinsic and acquired resistance to antimicrobials and development of antibiotic resistance in bacteria. • Systematically organized information is provided on different strategies for tackling antimicrobial resistance for the welfare of human health.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteria ; Drug Resistance, Bacterial ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-09-19
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-022-12175-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2229: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Ginger extract ameliorates endocrine-metabolic disturbances in letrozole-induced PCOS mice model by altering androgen-adiponectin status

    Shah, Mohd Zahoor ul haq / Shrivastava, Vinoy Kumar / Mir, Manzoor Ahmad

    Obesity Medicine. 2023 May, v. 39 p.100485-

    2023  

    Abstract: Polycystic ovarian syndrome (PCOS) has an impact on numerous women's health issues worldwide. Since the specific aetiology is unknown, the diagnostic criteria are currently insufficient, which contributes to the under diagnosis and under treatment of ... ...

    Abstract Polycystic ovarian syndrome (PCOS) has an impact on numerous women's health issues worldwide. Since the specific aetiology is unknown, the diagnostic criteria are currently insufficient, which contributes to the under diagnosis and under treatment of PCOS in many women. Eighteen mature Parkes strain mice (4–5 weeks old) weighing 18–21 g were at random separated to three groups with six mice each: Group I served as the control; Group II was given Letrozole (LET) dissolved in normal saline water (0.9%) orally by using oral gavage at the dose of (6 mg/kg bw) for twenty one days to induce PCOS followed by 60 days without treatment; Group III was given LET (6 mg/kg) for the twenty one days, followed by the oral gavage treatment of ginger (350 mg/kg bw orally daily) for 60 days. In our study we observed that mice with PCOS had increased body weight, ovary mass, blood glucose, insulin, Homa insulin resistance (IR), cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and interleukin-6 (IL-6) as well as increase in testosterone, and luteinizing hormone (LH). We observed decline in estrogen, follicle stimulating hormone (FSH) and decreased antioxidant capacity in the ovary. These alterations were linked to decreased adiponectin in mice. However after ginger administration these changes were reversed. The findings from our research suggested that adiponectin has direct impact on metabolic and endocrine facets of PCOS, & its drop can cause women infertility. Therefore, boosting the circulation of adiponectin may be employed as a remedy to metabolic, and perhaps endocrine, conditions in polycystic ovarian syndrome-affected individuals.
    Keywords adiponectin ; antioxidant activity ; blood glucose ; cholesterol ; estrogens ; etiology ; ginger ; insulin ; insulin resistance ; interleukin-6 ; low density lipoprotein ; luteinizing hormone ; medicine ; models ; obesity ; polycystic ovary syndrome ; saline water ; testosterone ; very low density lipoprotein ; Oxidative stress
    Language English
    Dates of publication 2023-05
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 2451-8476
    DOI 10.1016/j.obmed.2023.100485
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Mechanistic elucidation of Juglanthraquinone C targeting breast Cancer: A network Pharmacology-based investigation.

    Qayoom, Hina / Alkhanani, Mustfa / Almilaibary, Abdullah / Alsagaby, Suliman A / Mir, Manzoor Ahmad

    Saudi journal of biological sciences

    2023  Volume 30, Issue 7, Page(s) 103705

    Abstract: Breast cancer is the leading cause of death among women worldwide. Despite the recent treatment options like surgery, chemotherapy etc. the lethality of breast cancer is alarming. Natural compounds are considered a better treatment option against breast ... ...

    Abstract Breast cancer is the leading cause of death among women worldwide. Despite the recent treatment options like surgery, chemotherapy etc. the lethality of breast cancer is alarming. Natural compounds are considered a better treatment option against breast carcinoma because of their lower side effects and specificity in targeting important proteins involved in the aberrant activation of pathways in breast cancer. A recently discovered compound called Juglanthraquinone C, which is found in the bark of the
    Language English
    Publishing date 2023-06-15
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2023.103705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Immunotherapies against human bacterial and fungal infectious diseases: A review.

    Qadri, Hafsa / Shah, Abdul Haseeb / Alkhanani, Mustfa / Almilaibary, Abdullah / Mir, Manzoor Ahmad

    Frontiers in medicine

    2023  Volume 10, Page(s) 1135541

    Abstract: Nations' ongoing struggles with a number of novel and reemerging infectious diseases, including the ongoing global health issue, the SARS-Co-V2 (severe acute respiratory syndrome coronavirus 2) outbreak, serve as proof that infectious diseases constitute ...

    Abstract Nations' ongoing struggles with a number of novel and reemerging infectious diseases, including the ongoing global health issue, the SARS-Co-V2 (severe acute respiratory syndrome coronavirus 2) outbreak, serve as proof that infectious diseases constitute a serious threat to the global public health. Moreover, the fatality rate in humans is rising as a result of the development of severe infectious diseases brought about by multiple drug-tolerant pathogenic microorganisms. The widespread use of traditional antimicrobial drugs, immunosuppressive medications, and other related factors led to the establishment of such drug resistant pathogenic microbial species. To overcome the difficulties commonly encountered by current infectious disease management and control processes, like inadequate effectiveness, toxicities, and the evolution of drug tolerance, new treatment solutions are required. Fortunately, immunotherapies already hold great potential for reducing these restrictions while simultaneously expanding the boundaries of healthcare and medicine, as shown by the latest discoveries and the success of drugs including monoclonal antibodies (MAbs), vaccinations, etc. Immunotherapies comprise methods for treating diseases that specifically target or affect the body's immune system and such immunological procedures/therapies strengthen the host's defenses to fight those infections. The immunotherapy-based treatments control the host's innate and adaptive immune responses, which are effective in treating different pathogenic microbial infections. As a result, diverse immunotherapeutic strategies are being researched more and more as alternative treatments for infectious diseases, leading to substantial improvements in our comprehension of the associations between pathogens and host immune system. In this review we will explore different immunotherapies and their usage for the assistance of a broad spectrum of infectious ailments caused by various human bacterial and fungal pathogenic microbes. We will discuss about the recent developments in the therapeutics against the growing human pathogenic microbial diseases and focus on the present and future of using immunotherapies to overcome these diseases. Graphical AbstractThe graphical abstract shows the therapeutic potential of different types of immunotherapies like vaccines, monoclonal antibodies-based therapies, etc., against different kinds of human Bacterial and Fungal microbial infections.
    Language English
    Publishing date 2023-04-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1135541
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  9. Article ; Online: Molecular Prediction and Correlation of the Structure and Function of Universal Stress Protein A (UspA) from Salmonella Typhimurium.

    Nabi, Bilkees / Kumawat, Manoj / Yadav, Pramod Kumar / Ahlawat, Neeraj / Mir, Manzoor Ahmad / Kumar, Vivek / Kumar, Manoj / Ahlawat, Sushma

    Biochemical genetics

    2024  

    Abstract: Salmonella Typhimurium (ST) is a zoonotic pathogen that can cause gastroenteritis in humans when they consume contaminated food or water. When exposed to various stressors, both from living organisms (biotic) and the environment (abiotic), Salmonella ... ...

    Abstract Salmonella Typhimurium (ST) is a zoonotic pathogen that can cause gastroenteritis in humans when they consume contaminated food or water. When exposed to various stressors, both from living organisms (biotic) and the environment (abiotic), Salmonella Typhimurium produces Universal Stress Proteins (USPs). These proteins are gaining recognition for their crucial role in bacterial stress resistance and the ability to enter a prolonged state of growth arrest. Additionally, USPs exhibit diverse structures due to the fusion of the USP domain with different catalytic motifs, enabling them to participate in various reactions and cellular activities during stressful conditions. In this particular study, researchers cloned and analyzed the uspA gene obtained from poultry-derived strains of Salmonella Typhimurium. The gene comprises 435 base pairs, encoding a USP family protein consisting of 144 amino acids. Phylogenetic analysis demonstrated a close relationship between the uspA genes of Salmonella Typhimurium and those found in other bacterial species. We used molecular dynamics simulations and 3D structure prediction to ensure that the USPA protein was stable. Furthermore, we also carried out motif search and network analysis of protein-protein interactions. The findings from this study offer valuable insights for the development of inhibitors targeted against Salmonella Typhimurium.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2168-4
    ISSN 1573-4927 ; 0006-2928
    ISSN (online) 1573-4927
    ISSN 0006-2928
    DOI 10.1007/s10528-024-10699-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Metronomic chemotherapy and drug repurposing: A paradigm shift in oncology.

    Jan, Nusrat / Sofi, Shazia / Qayoom, Hina / Shabir, Aisha / Haq, Burhan Ul / Macha, Muzaffar A / Almilaibary, Abdullah / Mir, Manzoor Ahmad

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e24670

    Abstract: Cancer represents a significant global health and economic burden due to its high mortality rates. While effective in some instances, traditional chemotherapy often falls short of entirely eradicating various types of cancer. It can cause severe side ... ...

    Abstract Cancer represents a significant global health and economic burden due to its high mortality rates. While effective in some instances, traditional chemotherapy often falls short of entirely eradicating various types of cancer. It can cause severe side effects due to harm to healthy cells. Two therapeutic approaches have risen to the forefront to address these limitations: metronomic chemotherapy (MCT) and drug repurposing. Metronomic chemotherapy is an innovative approach that breaks from traditional models. It involves the administration of chemotherapeutic regimens at lower doses, without long drug-free intervals that have previously been a hallmark of such treatments. This method offers a significant reduction in side effects and improved disease management. Simultaneously, drug repurposing has gained considerable attraction in cancer treatment. This approach involves utilizing existing drugs, initially developed for other therapeutic purposes, as potential cancer treatments. The application of known drugs in a new context accelerates the timeline from laboratory to patient due to pre-existing safety and dosage data. The intersection of these two strategies gives rise to a novel therapeutic approach named 'Metronomics.' This approach encapsulates the benefits of both MCT and drug repurposing, leading to reduced toxicity, potential for oral administration, improved patient quality of life, accelerated clinical implementation, and enhanced affordability. Numerous clinical studies have endorsed the efficacy of metronomic chemotherapy with tolerable side effects, underlining the potential of Metronomics in better cancer management, particularly in low- and middle-income countries. This review underscores the benefits and applications of metronomic chemotherapy and drug repurposing, specifically in the context of breast cancer, showcasing the promising results of pre-clinical and clinical studies. However, we acknowledge the necessity of additional clinical investigations to definitively establish the role of metronomic chemotherapy in conjunction with other treatments in comprehensive cancer management.
    Language English
    Publishing date 2024-01-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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