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Book ; Online ; E-Book: Biopesticides handbook

Mir, Showkat Rasool / Nollet, Leo M. L.

2024

Author's details	edited by Leo M.L. Nollet, Showkat Rasool Mir
Subject code	632/.95
Language	English
Size	1 Online-Ressource (xvii, 316 Seiten)
Edition	Second edition
Publisher	CRC Press, Taylor & Francis Group
Publishing place	Boca Raton, Fla
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT030355312
ISBN	978-1-00-093511-0 ; 978-1-003-26513-9 ; 9781032206288 ; 9781032207674 ; 1-00-093511-6 ; 1-003-26513-8 ; 1032206284 ; 1032207671
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Purification and characterization of Taxol and 10‐Deacetyl baccatin III from the bark, needles, and endophytes of Taxus baccata by preparative high‐performance liquid chromatography, ultra‐high‐performance liquid chromatography‐mass spectrometry, and nuclear magnetic resonance

Nurullah, Md / Usmani, Zakiya / Ahmad, Sheeraz / Panda, Bibhu Prasad / Amin, Saima / Mir, Showkat Rasool

Journal of Separation Science. 2023 Mar., v. 46, no. 6 p.e2200841-

2023

Abstract: Taxol and 10‐Deacetyl baccatin III are major taxanes in the bark, needles, and endophytes of Taxus baccata. The current study aimed to develop a process for their separation from different matrices. Crude taxoid was prepared by extraction of samples with ...

Abstract	Taxol and 10‐Deacetyl baccatin III are major taxanes in the bark, needles, and endophytes of Taxus baccata. The current study aimed to develop a process for their separation from different matrices. Crude taxoid was prepared by extraction of samples with methanol, followed by partitioning with dichloromethane and precipitation with hexane. Analytical high‐performance liquid chromatography involved isocratic elution on C18 column (4.6 × 250 mm, 5 μm) with methanol‐water (70:30 v/v) at a flow rate of 1 ml/min. Injection volume was 20 μl and detection was carried out at 227 nm. The content of Taxol and 10‐Deacetyl baccatin III in bark, needles and endophytic culture broth was 11.19 and 1.75 μg/mg; 11.19 and 1.75 μg/mg; and 2.80 and 0.22 μg/L, respectively. Preparative high‐performance liquid chromatography was done on C18 column (10 × 250 mm, 5 μm) at a flow rate of 10 ml/min. About 20 g crude taxoid was processed in < 3 h with a recovery of about 90% for both the analytes. The purity of recovered Taxol and 10‐Deacetyl baccatin III determined by ultra‐high‐performance liquid chromatography‐mass spectrometry was found to be 95.78 ± 3.63% and 99.72 ± 0.18%, respectively. The structure of recovered Taxol was confirmed by nuclear magnetic resonance. The method can find use in biotransformation studies.
Keywords	Taxus baccata ; bark ; biotransformation ; chemical species ; culture media ; endophytes ; hexane ; high performance liquid chromatography ; mass spectrometry ; methanol ; methylene chloride ; nuclear magnetic resonance spectroscopy ; paclitaxel ; separation ; taxanes
Language	English
Dates of publication	2023-03
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202200841
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Purification and characterization of Taxol and 10-Deacetyl baccatin III from the bark, needles, and endophytes of Taxus baccata by preparative high-performance liquid chromatography, ultra-high-performance liquid chromatography-mass spectrometry, and nuclear magnetic resonance.

Nurullah, Md / Usmani, Zakiya / Ahmad, Sheeraz / Panda, Bibhu Prasad / Amin, Saima / Mir, Showkat Rasool

Journal of separation science

2023 Volume 46, Issue 6, Page(s) e2200841

Abstract: Taxol and 10-Deacetyl baccatin III are major taxanes in the bark, needles, and endophytes of Taxus baccata. The current study aimed to develop a process for their separation from different matrices. Crude taxoid was prepared by extraction of samples with ...

Abstract	Taxol and 10-Deacetyl baccatin III are major taxanes in the bark, needles, and endophytes of Taxus baccata. The current study aimed to develop a process for their separation from different matrices. Crude taxoid was prepared by extraction of samples with methanol, followed by partitioning with dichloromethane and precipitation with hexane. Analytical high-performance liquid chromatography involved isocratic elution on C18 column (4.6 × 250 mm, 5 μm) with methanol-water (70:30 v/v) at a flow rate of 1 ml/min. Injection volume was 20 μl and detection was carried out at 227 nm. The content of Taxol and 10-Deacetyl baccatin III in bark, needles and endophytic culture broth was 11.19 and 1.75 μg/mg; 11.19 and 1.75 μg/mg; and 2.80 and 0.22 μg/L, respectively. Preparative high-performance liquid chromatography was done on C18 column (10 × 250 mm, 5 μm) at a flow rate of 10 ml/min. About 20 g crude taxoid was processed in < 3 h with a recovery of about 90% for both the analytes. The purity of recovered Taxol and 10-Deacetyl baccatin III determined by ultra-high-performance liquid chromatography-mass spectrometry was found to be 95.78 ± 3.63% and 99.72 ± 0.18%, respectively. The structure of recovered Taxol was confirmed by nuclear magnetic resonance. The method can find use in biotransformation studies.
MeSH term(s)	Paclitaxel/chemistry ; Chromatography, High Pressure Liquid ; Taxus ; Endophytes/metabolism ; Needles ; Plant Bark/chemistry ; Methanol/metabolism ; Taxoids/analysis ; Mass Spectrometry ; Magnetic Resonance Spectroscopy
Chemical Substances	Paclitaxel (P88XT4IS4D) ; baccatin III (40K5PZ0K67) ; Methanol (Y4S76JWI15) ; Taxoids ; 10-deacetylbaccatine III (4K6EWW2Z45)
Language	English
Publishing date	2023-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202200841
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chemical constituents from the seed husks of Oryza sativa L

Ali, Mohammed / Ahmad, Ateeque / Sultana, Shahnaz / Mir, Showkat Rasool

Natural Product Research. 2022 Nov. 1, v. 36, no. 21 p.5530-5538

2022

Abstract: Oryza sativa L. (Family Poaceae) is cultivated in tropical regions as a staple food all over the world. The rice grain husk is considered as a tonic and administered orally to relieve dysentery. The air-dried seeds husks of O. sativa were exhaustively ... ...

Abstract	Oryza sativa L. (Family Poaceae) is cultivated in tropical regions as a staple food all over the world. The rice grain husk is considered as a tonic and administered orally to relieve dysentery. The air-dried seeds husks of O. sativa were exhaustively extracted with methanol in a Soxhlet apparatus. The concentrated methanol extract was adsorbed on silica gel and chromatographed on a silica gel column. The column was eluted with petroleum ether, chloroform and methanol successively to isolate four phytoconstituents characterised as 7-ketostigmasterol (1), 3β-benzyloxy-stigmast-7-one-22-en-19-oic acid 29-ethyleneglycol ether (2), sesquaurs-11-en- 2β, 3β,5α-triol (3) and 2′-(1′′β-hydroxypropyl)-7,4′-dimethoxyapigenin (4). These phytoconstituents were identified on the basis of spectral data analysis.
Keywords	Oryza sativa ; air drying ; chemical constituents of plants ; chloroform ; dysentery ; hulls ; methanol ; petroleum ; research ; rice ; silica gel ; spectral analysis ; staple foods ; Oryza sativa husk ; phytoconstituents ; isolation ; structural elucidation
Language	English
Dates of publication	2022-1101
Size	p. 5530-5538.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.2019733
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Chemical constituents from the seed husks of

Ali, Mohammed / Ahmad, Ateeque / Sultana, Shahnaz / Mir, Showkat Rasool

Natural product research

2021 Volume 36, Issue 21, Page(s) 5530–5538

Abstract: ... Oryza ... ...

Abstract	Oryza sativa
MeSH term(s)	Oryza ; Methanol ; Silica Gel ; Seeds ; Poaceae
Chemical Substances	Methanol (Y4S76JWI15) ; Silica Gel (60650-90-0)
Language	English
Publishing date	2021-12-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.2019733
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluation of the Antidiabetic Potential of an Isolated Hydroalcoholic Fraction from the Fruit of

Waris, Md / Shahzad, Naiyer / Al-Ghamdi, Saeed Saeed / Mir, Showkat Rasool / Tanuja

Journal of pharmacy & bioallied sciences

2022 Volume 13, Issue 4, Page(s) 367–372

Abstract: The hydro-alcoholic extract ... ...

Abstract	The hydro-alcoholic extract of
Language	English
Publishing date	2022-03-04
Publishing country	India
Document type	Journal Article
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.JPBS_423_20
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Article ; Online: Development of cannabidiol nanoemulsion for direct nose to brain delivery: statistical optimization,<i>in vitro</i>and<i>in vivo</i>evaluation.

Ahmed, Bakr / Rizwanullah, Md / Mir, Showkat Rasool / Akhtar, M Shaheer / Amin, Saima

Biomedical materials (Bristol, England)

2022 Volume 17, Issue 6

Abstract: Cannabidiol (CBD) is a prescribed drug for epilepsy but has low oral bioavailability and gastric instability. Because of the direct link between the nasal cavity and the central nervous system, intranasal administration of CBD as nanoemulsions which are ... ...

Abstract	Cannabidiol (CBD) is a prescribed drug for epilepsy but has low oral bioavailability and gastric instability. Because of the direct link between the nasal cavity and the central nervous system, intranasal administration of CBD as nanoemulsions which are the small sized lipid carriers seem to improve the bioavailability. CBD-nanoemulsions (NEs) were made using Capryol 90, Tween 80, and Transcutol P as oil, surfactant, and co-surfactant, respectively, following aqueous titration approach. Then, using the Box-Behnken design, CBD-NE was statistically optimised for the selection of desirable excipient concentrations in order to create the optimal CBD-NE formulation. As independent variables in the statistical design, Capryol 90 (oil; coded asA), Tween 80 (surfactant; coded asB), and Transcutol P (co-surfactant; coded asC) were used. The dependent variables were droplet size (DS; coded asR<sub>1</sub>) and polydispersity index (PDI; coded asR<sub>2</sub>). The average DS, PDI, and the zeta potential of the optimized CBD-NEs were observed to be 88.73 ± 2.67 nm, 0.311 ± 0.015, and -2.71 ± 0.52 mV respectively. Pure CBD and lyophilized CBD-NEFourier-transform infraredspectra demonstrated no physicochemical interaction between excipients and the drug. Furthermore, differential scanning calorimetry and x-ray diffraction measurements revealed the amorphous CBD in the NE. As compared to pure CBD, the optimised CBD-NE showed considerably betterin vitrodrug release as well asex vivonasal permeability. The drug targeting efficiency and direct transport percentage of the optimised CBD-NEs were found to be 419.64% and 76.17%, respectively, in this research. Additionally, pharmacokinetic investigations after intranasal administration of CBD-NE revealed considerably higher drug concentrations in the brain with better brain targeting efficiency. As a result, the development of CBD-NE may be an excellent alternative for better intranasal delivery.
MeSH term(s)	Brain ; Cannabidiol ; Drug Delivery Systems ; Emulsions/chemistry ; Ethylene Glycols ; Excipients/chemistry ; Lipids ; Nanoparticles/chemistry ; Particle Size ; Polymers ; Polysorbates/chemistry ; Propylene Glycols ; Surface-Active Agents/chemistry
Chemical Substances	Emulsions ; Ethylene Glycols ; Excipients ; Lipids ; Polymers ; Polysorbates ; Propylene Glycols ; Surface-Active Agents ; capryol propylene glycol monocaprylate ; Cannabidiol (19GBJ60SN5) ; carbitol (A1A1I8X02B)
Language	English
Publishing date	2022-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2265222-X
ISSN	1748-605X ; 1748-6041
ISSN (online)	1748-605X
ISSN	1748-6041
DOI	10.1088/1748-605X/ac9267
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Article ; Online: Polymer-lipid hybrid nanoparticles of exemestane for improved oral bioavailability and anti-tumor efficacy: An extensive preclinical investigation.

Rizwanullah, Md / Perwez, Ahmad / Alam, Meraj / Ahmad, Shahnawaz / Mir, Showkat Rasool / Rizvi, Mohd Moshahid Alam / Amin, Saima

International journal of pharmaceutics

2023 Volume 642, Page(s) 123136

Abstract: Exemestane (EXE), an irreversible aromatase inhibitor, is primarily used as a first-line therapy for estrogen receptor-positive breast cancer patients. However, complex physicochemical characteristics of EXE limit its oral bioavailability (<10%) and anti- ...

Abstract	Exemestane (EXE), an irreversible aromatase inhibitor, is primarily used as a first-line therapy for estrogen receptor-positive breast cancer patients. However, complex physicochemical characteristics of EXE limit its oral bioavailability (<10%) and anti-breast cancer efficacy. The present study aimed to develop a novel nanocarrier system to improve the oral bioavailability and anti-breast cancer efficacy of EXE. In this perspective, EXE-loaded TPGS-based polymer lipid hybrid nanoparticles (EXE-TPGS-PLHNPs) were prepared by the nanoprecipitation method and evaluated for their potential in improving oral bioavailability, safety, and therapeutic efficacy in the animal model. EXE-TPGS-PLHNPs showed significantly higher intestinal permeation in comparison to EXE-PLHNPs (without TPGS) and free EXE. After oral administration, EXE-TPGS-PLHNPs and EXE-PLHNPs revealed 3.58 and 4.69 times higher oral bioavailability in Wistar rats compared to the conventional EXE suspension. The results of the acute toxicity experiment suggested that the developed nanocarrier was safe for oral administration. Furthermore, EXE-TPGS-PLHNPs and EXE-PLHNPs represented much better anti-breast cancer activity in Balb/c mice bearing MCF-7 tumor xenograft with tumor inhibition rate of 72.72% and 61.94% respectively in comparison with the conventional EXE suspension (30.79%) after 21 days of oral chemotherapy. In addition, insignificant changes in the histopathological examination of vital organs and hematological analysis further confirm the safety of the developed PLHNPs. Therefore, the findings of the present investigation advocated that the encapsulation of EXE in PLHNPs can be a promising approach for oral chemotherapy of breast cancer.
MeSH term(s)	Humans ; Rats ; Animals ; Mice ; Female ; Polymers/therapeutic use ; Biological Availability ; Rats, Wistar ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Androstadienes/pharmacology ; Androstadienes/therapeutic use ; Nanoparticles ; Lipids
Chemical Substances	exemestane (NY22HMQ4BX) ; Polymers ; Androstadienes ; Lipids
Language	English
Publishing date	2023-06-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.123136
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Article ; Online: Exemestane encapsulated polymer-lipid hybrid nanoparticles for improved efficacy against breast cancer: optimization,

Rizwanullah, Md / Perwez, Ahmad / Mir, Showkat Rasool / Alam Rizvi, Mohd Moshahid / Amin, Saima

Nanotechnology

2021 Volume 32, Issue 41

Abstract: Polymer-lipid hybrid nanoparticles (PLHNPs) are novel nanoplatforms for the effective delivery of a lipophilic drug in the management of a variety of solid tumors. The present work was designed to develop exemestane (EXE) encapsulated D-alpha-tocopheryl ... ...

Abstract	Polymer-lipid hybrid nanoparticles (PLHNPs) are novel nanoplatforms for the effective delivery of a lipophilic drug in the management of a variety of solid tumors. The present work was designed to develop exemestane (EXE) encapsulated D-alpha-tocopheryl polyethylene glycol succinate (TPGS) based PLHNPs (EXE-TPGS-PLHNPs) for controlled delivery of EXE for breast cancer management. EXE-TPGS-PLHNPs were formulated by single-step nano-precipitation technique and statistically optimized by a 3
MeSH term(s)	Androstadienes/metabolism ; Androstadienes/pharmacology ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Biomimetic Materials/chemistry ; Cell Survival/drug effects ; Drug Carriers/chemical synthesis ; Drug Compounding/methods ; Drug Liberation ; Drug Stability ; Factor Analysis, Statistical ; Fluorescent Dyes/chemistry ; Gastric Juice/chemistry ; Humans ; Kinetics ; Liposomes/chemistry ; Liposomes/ultrastructure ; MCF-7 Cells ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Phosphatidylcholines/chemistry ; Polyesters/chemistry ; Rhodamines/chemistry ; Vitamin E/chemistry
Chemical Substances	Androstadienes ; Antineoplastic Agents ; Drug Carriers ; Fluorescent Dyes ; Lipid Nanoparticles ; Liposomes ; Phosphatidylcholines ; Polyesters ; Rhodamines ; phospholipon 90G ; Vitamin E (1406-18-4) ; polycaprolactone (24980-41-4) ; rhodamine B (K7G5SCF8IL) ; exemestane (NY22HMQ4BX) ; tocophersolan (O03S90U1F2)
Language	English
Publishing date	2021-07-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/ac1098
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Combinatorial delivery of Ribociclib and green tea extract mediated nanostructured lipid carrier for oral delivery for the treatment of breast cancer synchronising

Sartaj, Ali / Alam, Meraj / Biswas, Largee / Yar, Mohammad Shahar / Mir, Showkat Rasool / Verma, Anita Kamra / Baboota, Sanjula / Ali, Javed

Journal of drug targeting

2022 Volume 30, Issue 10, Page(s) 1113–1134

Abstract: Purpose: The current research investigated the development and evaluation of dual drug-loaded nanostructure lipidic carriers (NLCs) of green tea extract and Ribociclib.: Method: In silico: Results: In silico: Conclusion: The prominent potential ...

Abstract	Purpose: The current research investigated the development and evaluation of dual drug-loaded nanostructure lipidic carriers (NLCs) of green tea extract and Ribociclib. Method: In silico Results: In silico Conclusion: The prominent potential of green tea extract and RBO-loaded NLCs in enhancing their therapeutic efficacy for better treatment of breast cancer.
MeSH term(s)	Rats ; Animals ; Female ; Antioxidants ; Lipids/chemistry ; Hemolysis ; Rats, Wistar ; Nanostructures/chemistry ; Drug Carriers/chemistry ; Particle Size ; Excipients ; Tea ; Neoplasms
Chemical Substances	ribociclib (TK8ERE8P56) ; Antioxidants ; Lipids ; Drug Carriers ; Excipients ; Tea
Language	English
Publishing date	2022-08-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1187110-6
ISSN	1029-2330 ; 1061-186X
ISSN (online)	1029-2330
ISSN	1061-186X
DOI	10.1080/1061186X.2022.2104292
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