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Article ; Online: Stereotactic beam radiotherapy for prostate cancer: is less, more?

Miralbell, Raymond

2019 Volume 20, Issue 11, Page(s) 1471–1472

MeSH term(s)	Dose Fractionation, Radiation ; Etoposide ; Humans ; Male ; Prostatic Neoplasms/surgery ; Radiosurgery ; Radiotherapy, Intensity-Modulated
Chemical Substances	Etoposide (6PLQ3CP4P3)
Language	English
Publishing date	2019-11-01
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(19)30652-7
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Zs.MO 460: Show issues

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Article: Stereotactic body radiotherapy for prostate cancer: treatment approaches and clinical outcomes.

Miralbell, Raymond

Journal of radiosurgery and SBRT

2017 Volume 1, Issue 2, Page(s) 147–154

Abstract: Extreme hypofractionation may be a radiobiologically sound strategy against prostate cancer cells with presumed low radiosensitivity (α) and high repair capacity (β) to small treatment fractions. In this case, large doses per fraction may be more ... ...

Abstract	Extreme hypofractionation may be a radiobiologically sound strategy against prostate cancer cells with presumed low radiosensitivity (α) and high repair capacity (β) to small treatment fractions. In this case, large doses per fraction may be more effective in the tumor cell killing. Hence, the fractionation sensitivity differential (tumor/normal tissue) favors the use of hypofractionated radiotherapy (RT) as tumor α/β values are lower than the values considered for late normal-tissue morbidity. High-dose rate brachytherapy (HDR-BT) and stereotactic body RT (SBRT) are competing extreme hypofractionated treatment methods aiming to efficiently escalate the dose against prostate cancer. Focal treatment strategies to the dominant and non-dominant tumor nodules inside the prostate have been considered with both treatment approaches.The present status of SBRT for prostate cancer is presented as well as a comparative summary of the existing studies on partial prostate boost irradiation either with HDR-BT or SBRT. Extreme hypofractionation (i.e., >6 Gy/fraction) still deserves investigation in prospective trials provided that the precaution is taken to assure an homogeneous tumor dose distribution, a short overall treament time (<5 weeks), and an optimally short fraction duration.
Language	English
Publishing date	2017-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2647020-2
ISSN	2156-4639
ISSN	2156-4639
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Article: Urinary toxicity after salvage re-irradiation for prostate cancer local failure after definitive radiotherapy: a clinical and dosimetric prognostic factors analysis.

Dipasquale, Giovanna / Zilli, Thomas / Fiorino, Claudio / Achard, Vérane / Rouzaud, Michel / Miralbell, Raymond

Journal of contemporary brachytherapy

2022 Volume 14, Issue 3, Page(s) 222–226

Abstract: Purpose: Predictors of long-term toxicity after prostate cancer re-irradiation are scarce. In this study, we retrospectively assessed the impact of clinical/dosimetric data on late genitourinary (GU) toxicity on fourteen radio-recurrent prostate cancer ... ...

Abstract	Purpose: Predictors of long-term toxicity after prostate cancer re-irradiation are scarce. In this study, we retrospectively assessed the impact of clinical/dosimetric data on late genitourinary (GU) toxicity on fourteen radio-recurrent prostate cancer patients treated with salvage radiotherapy (RT). Material and methods: To identify dose parameters and clinical factors potentially associated to severe long-term GU toxicity, study population was stratified in two groups according to toxicity, including one low-grade group (grade ≤ 2, Results: At salvage-RT, the median EQD Conclusions: Our analysis shows that the delivery of doses up to 75-80 Gy (EQD
Language	English
Publishing date	2022-06-14
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2627721-9
ISSN	2081-2841 ; 1689-832X
ISSN (online)	2081-2841
ISSN	1689-832X
DOI	10.5114/jcb.2022.117124
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Article ; Online: ONE SHOT - single shot radiotherapy for localized prostate cancer: 18-month results of a single arm, multicenter phase I/II trial.

Zilli, Thomas / Franzese, Ciro / Guckenberger, Matthias / Giaj-Levra, Niccolò / Mach, Nicolas / Koutsouvelis, Nikolaos / Achard, Verane / Mcdonald, Andrew / Alongi, Filippo / Scorsetti, Marta / Constantin, Guillaume / Bertaut, Aurelie / Miralbell, Raymond

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2024 Volume 194, Page(s) 110181

Abstract: Purpose: To assess in a prospective, multicenter, single-arm phase I/II study the early safety and efficacy profile of single fraction urethra-sparing stereotactic body radiotherapy (SBRT) for men with localized prostate cancer.: Material and methods!# ...

Abstract	Purpose: To assess in a prospective, multicenter, single-arm phase I/II study the early safety and efficacy profile of single fraction urethra-sparing stereotactic body radiotherapy (SBRT) for men with localized prostate cancer. Material and methods: Patients with low- and intermediate-risk localized prostate cancer without significant tumor in the transitional zone were recruited. A single-fraction of 19 Gy was delivered to the prostate, with 17 Gy dose-reduction to the urethra. Intrafraction motion was monitored using intraprostatic electromagnetic transponders with intra-fraction correction of displacements exceeding 3 mm. Genitourinary (GU), gastrointestinal (GI), and sexual toxicity during the first 18 months were evaluated using the CTCAE v4.0 grading scale. Quality of life was assessed using the International Prostate Symptom Score, the Expanded Prostate Cancer Index composite 26 score, and the International Index of Erectile Function score. Results: Among the 45 patients recruited in 5 centers between 2017 and 2022, 43 received the single fraction without protocol deviations, and 34 had a minimal follow-up of 18 months. The worst GU toxicity was observed at day-5 after SBRT (42.5 % and 20 % with grade 1 and 2, respectively), returning to baseline at week-12 and month-6 (<3% with grade 2), with a 12 % grade 2 flare at month 18. Gl toxicity was mild in the acute phase, with no grade ≥ 2 events (12 % grade 1 at month 6). Grade-3 proctitis was observed in one patient at month 12, with < 3 % grade 2 toxicity at month 18. Mean GU and GI bother scores showed a decline at day 5, a complete recovery at month 6, and a flare between month 12 and 18. Mean PSA dropped from 6.2 ng/ml to 1.2 ng/ml at month 18 and 0.7 ng/ml at month 24. After a median follow-up time of 26 months, 3 biochemical failures (7 %) were observed at month 17, 21 and 30. Conclusions: In this multicenter phase I/II trial, we demonstrated that a 19 Gy single-fraction urethra-sparing SBRT is feasible and associated with an acceptable toxicity rate, mostly returning to the baseline at week-12 and with a symptoms flare between months 12 and 18. Longer follow-up is needed to assess the potential long-term adverse effects and the disease control efficacy.
MeSH term(s)	Humans ; Male ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Aged ; Middle Aged ; Prospective Studies ; Radiosurgery/methods ; Radiosurgery/adverse effects ; Aged, 80 and over ; Quality of Life ; Urethra/radiation effects ; Organ Sparing Treatments/methods ; Radiation Injuries/etiology
Language	English
Publishing date	2024-02-24
Publishing country	Ireland
Document type	Journal Article ; Clinical Trial, Phase II ; Multicenter Study ; Clinical Trial, Phase I ; Research Support, Non-U.S. Gov't
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2024.110181
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Article ; Online: Re: Prophylactic Sildenafil Citrate Improves Select Aspects of Sexual Function in Men Treated with Radiotherapy for Prostate Cancer: M. J. Zelefsky, D. Shasha, R. D. Branco, M. Kollmeier, R. E. Baser, X. Pei, R. Ennis, R. Stock, N. Bar-Chama and J. P. Mulhall J Urol 2014; 192: 868-874.

Zilli, Thomas / Miralbell, Raymond

The Journal of urology

2015 Volume 194, Issue 2, Page(s) 600–601

MeSH term(s)	Erectile Dysfunction/prevention & control ; Humans ; Male ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Piperazines/therapeutic use ; Prostatic Neoplasms/radiotherapy ; Sulfones/therapeutic use
Chemical Substances	Phosphodiesterase 5 Inhibitors ; Piperazines ; Sulfones
Language	English
Publishing date	2015-08
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2014.12.104
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Article ; Online: High-dose salvage radiation therapy for prostate cancer after relapse: in regard to D'Angelillo et al.

Zilli, Thomas / Miralbell, Raymond

International journal of radiation oncology, biology, physics

2015 Volume 91, Issue 3, Page(s) 681–682

MeSH term(s)	Choline/analogs & derivatives ; Fluorine Radioisotopes ; Humans ; Male ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/radiotherapy ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Radionuclide Imaging ; Salvage Therapy/methods
Chemical Substances	Fluorine Radioisotopes ; Choline (N91BDP6H0X)
Language	English
Publishing date	2015-03-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2014.10.057
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Article ; Online: Editorial Comment from Dr Zilli and Dr Miralbell to Early radiotherapy after radical prostatectomy improves cancer-specific survival only in patients with highly aggressive prostate cancer: validation of recently released criteria.

Zilli, Thomas / Miralbell, Raymond

International journal of urology : official journal of the Japanese Urological Association

2015 Volume 22, Issue 1, Page(s) 96

MeSH term(s)	Humans ; Male ; Prostate/pathology ; Prostatectomy/methods ; Prostatic Neoplasms/radiotherapy
Language	English
Publishing date	2015-01
Publishing country	Australia
Document type	Comment ; Journal Article
ZDB-ID	1328401-0
ISSN	1442-2042 ; 0919-8172
ISSN (online)	1442-2042
ISSN	0919-8172
DOI	10.1111/iju.12614
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Zs.A 4460: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: PET/CT imaging and the oligometastatic prostate cancer patient: an opportunity for a curative approach with high-dose radiotherapy?

Miralbell, Raymond / Buchegger, Franz

European journal of nuclear medicine and molecular imaging

2014 Volume 41, Issue 7, Page(s) 1267–1269

MeSH term(s)	Humans ; Male ; Multimodal Imaging ; Neoplasm Metastasis ; Positron-Emission Tomography ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/radiotherapy ; Radiation Dosage ; Radiotherapy Dosage ; Tomography, X-Ray Computed
Language	English
Publishing date	2014-05-13
Publishing country	Germany
Document type	Editorial
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-014-2793-8
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Article: Five-Fraction Proton Therapy for the Treatment of Skull Base Chordomas and Chondrosarcomas: Early Results of a Prospective Series and Description of a Clinical Trial.

Sallabanda, Morena / Vera, Juan Antonio / Pérez, Juan María / Matute, Raúl / Montero, Marta / de Pablo, Ana / Cerrón, Fernando / Valero, Mireia / Castro, Juan / Mazal, Alejandro / Miralbell, Raymond

Cancers

2023 Volume 15, Issue 23

Abstract: 1) Background: Our purpose is to describe the design of a phase II clinical trial on 5-fraction proton therapy for chordomas and chondrosarcomas of the skull base and to present early results in terms of local control and clinical tolerance of the first ...

Abstract	(1) Background: Our purpose is to describe the design of a phase II clinical trial on 5-fraction proton therapy for chordomas and chondrosarcomas of the skull base and to present early results in terms of local control and clinical tolerance of the first prospective series. (2) Methods: A dose of 37.5 GyRBE in five fractions was proposed for chordomas and 35 GyRBE in five fractions for chondrosarcomas. The established inclusion criteria are age ≥ 18 years, Karnofsky Performance Status ≥ 70%, clinical target volume up to 50 cc, and compliance with dose restrictions to the critical organs. Pencil beam scanning was used for treatment planning, employing four to six beams. (3) Results: A total of 11 patients (6 chordomas and 5 chondrosarcomas) were included. The median follow-up was 12 months (9-15 months) with 100% local control. Acute grade I-II headache (64%), grade I asthenia and alopecia (45%), grade I nausea (27%), and grade I dysphagia (18%) were described. Late toxicity was present in two patients with grade 3 temporal lobe necrosis. (4) Conclusions: Hypofractionated proton therapy is showing encouraging preliminary results. However, to fully assess the efficacy of this therapeutic approach, future trials with adequate sample sizes and extended follow-ups are necessary.
Language	English
Publishing date	2023-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15235579
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Article ; Online: Electromagnetic Transponder Localization and Real-Time Tracking for Prostate Cancer Radiation Therapy: Clinical Impact of Metallic Hip Prostheses.

Bottero, Marta / Dipasquale, Giovanna / Lancia, Andrea / Miralbell, Raymond / Jaccard, Maud / Zilli, Thomas

Practical radiation oncology

2020 Volume 10, Issue 6, Page(s) e538–e542

Abstract: Purpose: Our purpose was to assess the ability of electromagnetic transponders (EMTs) to localize and track movements in patients with prostate cancer (PCa) with metallic hip prostheses (MHPs) treated with curative radiation therapy (RT).: Methods and ...

Abstract	Purpose: Our purpose was to assess the ability of electromagnetic transponders (EMTs) to localize and track movements in patients with prostate cancer (PCa) with metallic hip prostheses (MHPs) treated with curative radiation therapy (RT). Methods and materials: Data sets of 8 PCa patients with MHPs (3 bilateral and 5 unilateral) treated between 2016 and 2018 with RT and EMT tracking were retrospectively assessed. The distances between the 3 EMTs (apex to left, left to right, right to apex) and the isocenter were calculated both on planning computed tomography (CT) and cone beam CT (CBCT) at the first treatment fraction and compared with data reported by Calypso. EMT position and treatment interruptions triggered by Calypso were analyzed for all evaluable treatment fractions (n = 120). Localization accuracy was quantified by recording the geometric residual value (expected limit ≤0.2 cm) at the RT setup. Results: The Calypso system was able to localize and track prostate position without any detectable interference from MHP. For every treatment fraction, the agreement between the CBCT images and Calypso guidance was optimal, with EMTs always within the defined tolerance (ie, CT-Calypso or CBCT-Calypso measured differences in inter-EMT distances within 0.3 cm). EMT to isocenter distances measured by Calypso reproduced CT data and were confirmed on CBCT scans. During RT, the EMT centroid exceeded the threshold 24 times (20% of all fractions): 5 times in the left-right, 15 times in the anteroposterior, and 4 times in the superoinferior directions. The largest motions recorded were in the anteroposterior axis: 0.6 cm anteriorly and 0.5 cm posteriorly in patients with unilateral and bilateral MHP, respectively. Conclusions: Our study represents the first clinical experience assessing the localization and tracking accuracy of Calypso EMTs during curative RT of patients with PCa with unilateral or bilateral MHP.
MeSH term(s)	Electromagnetic Phenomena ; Hip Prosthesis ; Humans ; Male ; Movement ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Retrospective Studies
Language	English
Publishing date	2020-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2655748-4
ISSN	1879-8519 ; 1879-8500
ISSN (online)	1879-8519
ISSN	1879-8500
DOI	10.1016/j.prro.2020.03.003
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