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Article ; Online: Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and Metastasis.

Miranda-Galvis, Marisol / Teng, Yong

International journal of molecular sciences

2020 Volume 21, Issue 15

Abstract: Hypoxia in locally advanced solid tumors develops due to uncontrollable cell proliferation, altered metabolism, and the severe structural and functional abnormality of the tumor vasculature, leading to an imbalance between oxygen supply and consumption ... ...

Abstract	Hypoxia in locally advanced solid tumors develops due to uncontrollable cell proliferation, altered metabolism, and the severe structural and functional abnormality of the tumor vasculature, leading to an imbalance between oxygen supply and consumption in the fast-growing tumors and negative impact on the therapeutic outcome. Several hypoxia-responsive molecular determinants, such as hypoxia-inducible factors, guide the cellular adaptation to hypoxia by gene activation, which is critical for promoting malignant progression in the hostile tumor microenvironment. Over time, a large body of evidence exists to suggest that tumor hypoxia also influences the tumor metabolic reprogramming, resulting in neoangiogenesis, metastasis, and immune evasion. In this respect, our review aims to understand the biological processes, key events, and consequences regarding the hypoxia-driven metabolic adaptation of tumor cells. We also assess the potential therapeutic impact of hypoxia and highlight our review by discussing possible therapeutic strategies targeting hypoxia, which would advance the current understanding of hypoxia-associated tumor propagation and malignant progression and improve the management of tumor hypoxia.
MeSH term(s)	Cell Proliferation ; Disease Progression ; Humans ; Neoplasms/metabolism ; Neovascularization, Pathologic ; Tumor Hypoxia ; Tumor Microenvironment
Language	English
Publishing date	2020-07-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21155487
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Article ; Online: Disparities in survival of hematologic malignancies in the context of social determinants of health: a systematic review.

Miranda-Galvis, Marisol / Tjioe, Kellen C / Balas, E Andrew / Agrawal, Gagan / Cortes, Jorge E

Blood advances

2023 Volume 7, Issue 21, Page(s) 6466–6491

Abstract: Social determinants of health (SDHs) have been reported as relevant factors responsible for health inequity. We sought to assess clinical data from observational studies conducted in the United States evaluating the impact of SDHs on the outcomes of ... ...

Abstract	Social determinants of health (SDHs) have been reported as relevant factors responsible for health inequity. We sought to assess clinical data from observational studies conducted in the United States evaluating the impact of SDHs on the outcomes of patients with hematologic malignancies. Thus, we performed a systematic review in 6 databases on 1 September 2021, in which paired reviewers independently screened studies and included data from 41 studies. We assessed the risk of bias using the Joanna Briggs Institute appraisal tools and analyzed the data using a descriptive synthesis. The most common SDH domains explored were health care access and quality (54.3%) and economic stability (25.6%); others investigated were education (19%) and social and community context (7.8%). We identified strong evidence of 5 variables significantly affecting survival: lack of health insurance coverage or having Medicare or Medicaid insurance, receiving cancer treatment at a nonacademic facility, low household income, low education level, and being unmarried. In contrast, the reports on the effect of distance traveled to the treatment center are contradictory. Other SDHs examined were facility volume, provider expertise, poverty, and employment rates. We identified a lack of data in the literature in terms of transportation, debt, higher education, diet, social integration, environmental factors, or stress. Our results underscore the complex nature of social, financial, and health care barriers as intercorrelated variables. Therefore, the management of hematologic malignancies needs concerted efforts to incorporate SDHs into clinical care, research, and public health policies, identifying and addressing the barriers at a patient-based level to enhance outcome equity (PROSPERO CRD42022346854).
MeSH term(s)	Humans ; Hematologic Neoplasms/epidemiology ; Hematologic Neoplasms/therapy ; Poverty ; Social Determinants of Health ; Health Status Disparities ; Survival Rate
Language	English
Publishing date	2023-08-29
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023010690
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Article ; Online: Impacts of Environmental Factors on Head and Neck Cancer Pathogenesis and Progression.

Miranda-Galvis, Marisol / Loveless, Reid / Kowalski, Luiz Paulo / Teng, Yong

Cells

2021 Volume 10, Issue 2

Abstract: Epidemiological and clinical studies over the past two decades have provided strong evidence that genetic elements interacting with environmental components can individually and collectively influence one's susceptibility to cancer. In addition to ... ...

Abstract	Epidemiological and clinical studies over the past two decades have provided strong evidence that genetic elements interacting with environmental components can individually and collectively influence one's susceptibility to cancer. In addition to tumorigenic properties, numerous environmental factors, such as nutrition, chemical carcinogens, and tobacco/alcohol consumption, possess pro-invasive and pro-metastatic cancer features. In contrast to traditional cancer treatment, modern therapeutics not only take into account an individual's genetic makeup but also consider gene-environment interactions. The current review sharpens the focus by elaborating on the impact that environmental factors have on the pathogenesis and progression of head and neck cancer and the underlying molecular mechanisms involved. Recent advances, challenges, and future perspectives in this area of research are also discussed. Inhibiting key environmental drivers of tumor progression should yield survival benefits for patients at any stage of head and neck cancer.
MeSH term(s)	Disease Progression ; Environment ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/pathology ; Humans ; Microbiota ; Risk Factors ; Smoking/adverse effects
Language	English
Publishing date	2021-02-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10020389
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Article ; Online: The interaction between social determinants of health and cervical cancer survival: A systematic review.

Tjioe, Kellen Cristine / Miranda-Galvis, Marisol / Johnson, Marian Symmes / Agrawal, Gagan / Balas, E Andrew / Cortes, Jorge E

Gynecologic oncology

2023 Volume 181, Page(s) 141–154

Abstract: Objective: This systematic review aimed to investigate what are the most relevant social determinants of health (SDH), how they are measured, how they interact among themselves and what is their impact on the outcomes of cervical cancer patients.: ... ...

Abstract	Objective: This systematic review aimed to investigate what are the most relevant social determinants of health (SDH), how they are measured, how they interact among themselves and what is their impact on the outcomes of cervical cancer patients. Methods: Search was performed in PubMed, Scopus, Web of Science, Embase, Cochrane, and Google Scholar databases from January 2001 to September 2022. The protocol was registered at PROSPERO (CRD42022346854). We followed the PICOS strategy: Population- Patients treated for cervical cancer in the United States; Intervention - Any SDH; Comparison- None; Outcome measures- Cancer treatment outcomes related to the survival of the patients; Types of studies- Observational studies. Two reviewers extracted the data following the PRISMA guidelines. Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies was used for risk of bias (ROB) assessment. Results: Twenty-four studies were included (22 had low and 2 had moderate ROB). Most manuscripts analyzed data from public registries (83.3%) and only one SDH (54.17%). The SDH category of Neighborhood was not included in any study. Although the SDH were measured differently across the studies, not being married, receiving treatment at a low-volume hospital, and having public insurance (Medicaid or Medicare) or not being insured was associated with shorter survival of cervical cancer patients in most studies. Conclusions: There is a deficit in the number of studies comprehensively assessing the impact of SDH on cervical cancer treatment-related outcomes. Marital status, hospital volume and health insurance status are potential predictors of worse outcome.
MeSH term(s)	Female ; Humans ; Aged ; United States/epidemiology ; Uterine Cervical Neoplasms/therapy ; Social Determinants of Health ; Cross-Sectional Studies ; Medicare ; Hospitals, Low-Volume
Language	English
Publishing date	2023-12-31
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2023.12.020
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Article ; Online: Teledermatology for skin cancer screening in rural Georgia utilizing teledermoscopy and distance learning: An ongoing report.

Maloney, McKenzie E / Miranda-Galvis, Marisol / Juarez, Brenda Santellano / Mamouni, Kenza / Odhiambo, Lorriane / Ibrahim, Samah / Islam, K M Monirul / Markowitz, Rhea-Beth / Desai, Koosh / Rabinovitz, Harold / Buchanan, Kendall / Patten, Douglas / Davis, Loretta S / Cortes, Jorge E

JAAD international

2023 Volume 11, Page(s) 140–142

Language	English
Publishing date	2023-03-02
Publishing country	United States
Document type	Journal Article
ISSN	2666-3287
ISSN (online)	2666-3287
DOI	10.1016/j.jdin.2023.02.010
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Article ; Online: New Insights into the Impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8.

Miranda-Galvis, Marisol / Carneiro Soares, Carolina / Moretto Carnielli, Carolina / Ramalho Buttura, Jaqueline / Sales de Sá, Raisa / Kaminagakura, Estela / Marchi, Fabio Albuquerque / Paes Leme, Adriana Franco / Lópes Pinto, Clóvis A / Santos-Silva, Alan Roger / Moraes Castilho, Rogerio / Kowalski, Luiz Paulo / Squarize, Cristiane Helena

Cells

2023 Volume 12, Issue 9

Abstract: Human papillomavirus (HPV) infection has recently been linked to a subset of cancers affecting the oral cavity. However, the molecular mechanisms underlying HPV-driven oral squamous cell carcinoma (OSCC) onset and progression are poorly understood.: ... ...

Abstract	Human papillomavirus (HPV) infection has recently been linked to a subset of cancers affecting the oral cavity. However, the molecular mechanisms underlying HPV-driven oral squamous cell carcinoma (OSCC) onset and progression are poorly understood. Methods: We performed MS-based proteomics profiling based on HPV status in OSCC in young patients, following biological characterization and cell assays to explore the proteome functional landscape. Results: Thirty-nine proteins are differentially abundant between HPV (+) and HPV (-) OSCC. Among them, COPS3, DYHC1, and S100A8 are unfavorable for tumor recurrence and survival, in contrast to A2M and Serpine1, low levels of which show an association with better DFS. Remarkably, S100A8 is considered an independent prognostic factor for lower survival rates, and at high levels, it alters tumor-associated immune profiling, showing a lower proportion of M1 macrophages and dendritic cells. HPV (+) OSCC also displayed the pathogen-associated patterns receptor that, when activated, triggered the S100A8 and NFκB inflammatory responses. Conclusion: HPV (+) OSCC has a peculiar microenvironment pattern distinctive from HPV (-), involving the expression of pathogen-associated pattern receptors, S100A8 overexpression, and NFκB activation and responses, which has important consequences in prognosis and may guide therapeutic decisions.
MeSH term(s)	Humans ; Carcinoma, Squamous Cell/pathology ; Head and Neck Neoplasms/complications ; Human Papillomavirus Viruses ; Mouth Neoplasms/pathology ; Neoplasm Recurrence, Local ; Papillomavirus Infections/pathology ; Proteomics ; Squamous Cell Carcinoma of Head and Neck/complications ; Tumor Microenvironment
Chemical Substances	S100A8 protein, human
Language	English
Publishing date	2023-05-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12091323
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Article ; Online: Orthodontic treatment in a patient with cherubism: Benefits and limitations.

Miranda Galvis, Marisol / Faustino, Isabel Schausltz Pereira / Ferraz, Francisco Carlos / Castelli Sanchez, Flavio José / Santos-Silva, Alan Roger / Lopes, Marcio Ajudarte

Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

2020 Volume 40, Issue 3, Page(s) 291–297

Abstract: Aim: Cherubism is an uncommon hereditary disease that leads to the development of giant cell lesions in the jaws, alterations in the dentition, and malocclusion. The biological behavior of bones to orthodontic forces in these patients is not described ... ...

Abstract	Aim: Cherubism is an uncommon hereditary disease that leads to the development of giant cell lesions in the jaws, alterations in the dentition, and malocclusion. The biological behavior of bones to orthodontic forces in these patients is not described in the literature, leading dentists to avoid this management. The aim of this article was to describe a case report of management with orthodontics. We present details regarding clinicoradiographic features, diagnosis, treatment, and follow-up. Case report: A 12-year-old male patient diagnosed with cherubism presented to our service with complaints about his esthetic facial and dental appearance. Management was interdisciplinary, including careful and controlled orthodontic treatment. The results were satisfactory; alignment, dental leveling, and correction of the malocclusion were achieved. Conclusion: Patients with cherubism may benefit from orthodontics, improving oral function, and esthetic and psychosocial well-being. The orthodontic treatment might be performed according to the severity of clinical manifestation, expectations of the patients, and limitations of each case.
MeSH term(s)	Cherubism ; Child ; Esthetics, Dental ; Humans ; Male ; Malocclusion ; Orthodontics, Corrective ; Tooth
Language	English
Publishing date	2020-04-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	604118-8
ISSN	1754-4505 ; 0275-1879
ISSN (online)	1754-4505
ISSN	0275-1879
DOI	10.1111/scd.12457
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Article: Increased Tumor Immune Microenvironment CD3+ and CD20+ Lymphocytes Predict a Better Prognosis in Oral Tongue Squamous Cell Carcinoma.

Sales de Sá, Raísa / Miranda Galvis, Marisol / Mariz, Bruno Augusto Linhares Almeida / Leite, Amanda Almeida / Schultz, Luciana / Almeida, Oslei Paes / Santos-Silva, Alan Roger / Pinto, Clovis Antonio Lopes / Vargas, Pablo Agustin / Gollob, Kenneth John / Kowalski, Luiz Paulo

Frontiers in cell and developmental biology

2021 Volume 8, Page(s) 622161

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-02-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2020.622161
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Article ; Online: Oral cancer adjacent to dental implants mimicking benign lesions: a case series study.

Miranda Galvis, Marisol / Schausltz Pereira Faustino, Isabel / Cabral Ramos, Joab / Dos Santos Silva, Alan Roger / de Abreu Alves, Fábio / Kowalski, Luiz Paulo / Ajudarte Lopes, Marcio

Australian dental journal

2020 Volume 66, Issue 1, Page(s) 112–118

Abstract: Despite the long-term survival rates of osseointegrated dental implants, several biological complications are known to affect the peri-implant tissues, such as peri-implant mucositis and peri-implantitis. Occasionally, the clinical features of these more ...

Abstract	Despite the long-term survival rates of osseointegrated dental implants, several biological complications are known to affect the peri-implant tissues, such as peri-implant mucositis and peri-implantitis. Occasionally, the clinical features of these more common benign lesions, or others nonrelated to implants, might be similar to oral malignancies, leading to misdiagnosis. The objective of this study was to present a case series of oral cancer located adjacent to dental implants, aimed to identify the reasons for initial misinterpretation of diagnosis. Thirteen patients, 10 females and 3 males, aged 59 to 90, were assessed. Among the differential diagnoses established, a malignant or premalignant lesion was not considered in 10 out of the 13 patients. Peri-implantitis was the most common preliminary diagnosis, followed by fungal infection, viral infections, and traumatic ulcers. The meantime for the diagnosis of oral cancer was 21.5 months. The clinical presentation of peri-implant malignancy, such as ulceration, white and red plaques, and exophytic lesions, might mimic benign diseases that are more common in the oral cavity. Suspicious lesions with treatment failure that persist for more than 2 weeks require biopsy and histopathological analysis to establish an early definitive diagnosis to improve the prognosis and quality of life of the patients.
MeSH term(s)	Aged ; Aged, 80 and over ; Dental Implants/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Mouth Neoplasms/diagnosis ; Peri-Implantitis/diagnosis ; Peri-Implantitis/etiology ; Quality of Life ; Stomatitis/diagnosis ; Stomatitis/etiology
Chemical Substances	Dental Implants
Keywords	covid19
Language	English
Publishing date	2020-10-04
Publishing country	Australia
Document type	Case Reports
ZDB-ID	603965-0
ISSN	1834-7819 ; 0045-0421
ISSN (online)	1834-7819
ISSN	0045-0421
DOI	10.1111/adj.12793
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Article ; Online: PD-L1 expression patterns in oral cancer as an integrated approach for further prognostic classification.

Miranda-Galvis, Marisol / Rumayor Piña, Alicia / Sales de Sá, Raísa / Almeida Leite, Amanda / Agustin Vargas, Pablo / Calsavara, Vinicius Fernando / Lópes Pinto, Clóvis A / Teng, Yong / Kowalski, Luiz Paulo

Oral diseases

2020 Volume 27, Issue 7, Page(s) 1699–1710

Abstract: Background: Despite the well-known role of programmed cell death ligand 1 (PD-L1) in promoting immune resistance in oral squamous cell carcinoma (OSCC), its potential utility as a prognostic biomarker is undetermined. We evaluated PD-L1 expression as ... ...

Abstract	Background: Despite the well-known role of programmed cell death ligand 1 (PD-L1) in promoting immune resistance in oral squamous cell carcinoma (OSCC), its potential utility as a prognostic biomarker is undetermined. We evaluated PD-L1 expression as predictor of survival in patients with OSCC and explored PD-L1 expression patterns. Methods: We conducted a retrospective cohort study that assessed PD-L1 expression through immunohistochemistry in 123 surgical specimens of OSCC. A first approach evaluated tumor proportion scores (TPS) and combined proportion scores (CPS). Next, expression patterns were examined by evaluating PD-L1 localization in tumor nests, as well as the interfaces of tumor cells (TC) and immune cells (IC) in the tumor microenvironment. Results: High-level PD-L1 expression determined by TPS and CPS using variable cutoffs was not associated with survival. Immunohistochemistry revealed that TC expressed PD-L1 in either patchy or diffuse patterns. The patchy pattern was an independent risk factor for overall survival. Furthermore, expression patterns in the tumor immune microenvironment showed that most cases expressed PD-L1 on both TC and IC, while PD-L1 non-expressors had the lowest overall survival. Conclusion: PD-L1 expression patterns in the context of localization in tumor nests and TC-IC interactions represent antitumor immune responses better than either TPS or CPS. Our suggested classification system may have important implications for the characterization of OSCC and for the use of PD-L1 as a prognostic biomarker.
MeSH term(s)	B7-H1 Antigen ; Carcinoma, Squamous Cell ; Head and Neck Neoplasms ; Humans ; Mouth Neoplasms ; Prognosis ; Retrospective Studies ; Tumor Microenvironment
Chemical Substances	B7-H1 Antigen ; CD274 protein, human
Language	English
Publishing date	2020-11-26
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.13714
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