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  1. Article ; Online: Designing Biomimetic 3D-Printed Osteochondral Scaffolds for Enhanced Load-Bearing Capacity.

    Choe, Robert H / Kuzemchak, Blake C / Kotsanos, George J / Mirdamadi, Eman / Sherry, Mary / Devoy, Eoin / Lowe, Tao / Packer, Jonathan D / Fisher, John P

    Tissue engineering. Part A

    2024  

    Abstract: Osteoarthritis is a debilitating chronic joint disorder that affects millions of people worldwide. Since palliative and surgical treatments cannot completely regenerate hyaline cartilage within the articulating joint, osteochondral (OC) tissue ... ...

    Abstract Osteoarthritis is a debilitating chronic joint disorder that affects millions of people worldwide. Since palliative and surgical treatments cannot completely regenerate hyaline cartilage within the articulating joint, osteochondral (OC) tissue engineering has been explored to heal OC defects. Utilizing computational simulations and three-dimensional (3D) printing, we aimed to build rationale around fabricating OC scaffolds with enhanced biomechanics. First, computational simulations revealed that interfacial fibrils within a bilayer alter OC scaffold deformation patterns by redirecting load-induced stresses toward the top of the cartilage layer. Principal component analysis revealed that scaffolds with 800 μm long fibrils (scaffolds 8A-8H) possessed optimal biomechanical properties to withstand compression and shear forces. While compression testing indicated that OC scaffolds with 800 μm fibrils did not have greater compressive moduli than other scaffolds, interfacial shear tests indicated that scaffold 8H possessed the greatest shear strength. Lastly, failure analysis demonstrated that yielding or buckling models describe interfacial fibril failure depending on fibril slenderness
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2420582-5
    ISSN 1937-335X ; 1937-3341
    ISSN (online) 1937-335X
    ISSN 1937-3341
    DOI 10.1089/ten.TEA.2023.0217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5500/A: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: 3D bioprinting optimization of human mesenchymal stromal cell laden gelatin-alginate-collagen bioink.

    Sawyer, Stephen W / Takeda, Kazuyo / Alayoubi, Alaadin / Mirdamadi, Eman / Zidan, Ahmed / Bauer, Steven R / Degheidy, Heba

    Biomedical materials (Bristol, England)

    2022  Volume 18, Issue 1

    Abstract: 3D bioprinting technology has gained increased attention in the regenerative medicine and tissue engineering communities over the past decade with their attempts to create functional living tissues and ... ...

    Abstract 3D bioprinting technology has gained increased attention in the regenerative medicine and tissue engineering communities over the past decade with their attempts to create functional living tissues and organs
    MeSH term(s) Humans ; Gelatin ; Alginates ; Reproducibility of Results ; Collagen ; Mesenchymal Stem Cells
    Chemical Substances Gelatin (9000-70-8) ; Alginates ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-12-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2265222-X
    ISSN 1748-605X ; 1748-6041
    ISSN (online) 1748-605X
    ISSN 1748-6041
    DOI 10.1088/1748-605X/aca3e7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6626: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Agarose Slurry as a Support Medium for Bioprinting and Culturing Freestanding Cell-Laden Hydrogel Constructs

    Mirdamadi, Eman / Muselimyan, Narine / Koti, Priyanka / Asfour, Huda / Sarvazyan, Narine

    3D printing and additive manufacturing

    2019  Volume 6, Issue 3, Page(s) 158–164

    Language English
    Publishing date 2019-03-28
    Publishing country United States
    Document type Journal Article
    ISSN 2329-7662
    ISSN 2329-7662
    DOI 10.1089/3dp.2018.0175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: FRESH 3D Bioprinting a Full-Size Model of the Human Heart.

    Mirdamadi, Eman / Tashman, Joshua W / Shiwarski, Daniel J / Palchesko, Rachelle N / Feinberg, Adam W

    ACS biomaterials science & engineering

    2020  Volume 6, Issue 11, Page(s) 6453–6459

    Abstract: Recent advances in embedded three-dimensional (3D) bioprinting have expanded the design space for fabricating geometrically complex tissue scaffolds using hydrogels with mechanical properties comparable to native tissues and organs in the human body. The ...

    Abstract Recent advances in embedded three-dimensional (3D) bioprinting have expanded the design space for fabricating geometrically complex tissue scaffolds using hydrogels with mechanical properties comparable to native tissues and organs in the human body. The advantage of approaches such as Freeform Reversible Embedding of Suspended Hydrogels (FRESH) printing is the ability to embed soft biomaterials in a thermoreversible support bath at sizes ranging from a few millimeters to centimeters. In this study, we were able to expand this printable size range by FRESH bioprinting a full-size model of an adult human heart from patient-derived magnetic resonance imaging (MRI) data sets. We used alginate as the printing biomaterial to mimic the elastic modulus of cardiac tissue. In addition to achieving high print fidelity on a low-cost printer platform, FRESH-printed alginate proved to create mechanically tunable and suturable models. This demonstrates that large-scale 3D bioprinting of soft hydrogels is possible using FRESH and that cardiac tissue constructs can be produced with potential future applications in surgical training and planning.
    MeSH term(s) Alginates ; Bioprinting ; Humans ; Hydrogels ; Printing, Three-Dimensional ; Tissue Scaffolds
    Chemical Substances Alginates ; Hydrogels
    Language English
    Publishing date 2020-10-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.0c01133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Use of GelMA for 3D printing of cardiac myocytes and fibroblasts.

    Koti, Priyanka / Muselimyan, Narine / Mirdamadi, Eman / Asfour, Huda / Sarvazyan, Narine A

    Journal of 3D printing in medicine

    2019  Volume 3, Issue 1, Page(s) 11–22

    Abstract: Aim: To 3D print heart tissue, one must understand how the main two types of cardiac cells are affected by the printing process.: Materials & methods: Effects of gelatin methacryloyl (GelMA) concentration, extruder pressure and duration of UV ... ...

    Abstract Aim: To 3D print heart tissue, one must understand how the main two types of cardiac cells are affected by the printing process.
    Materials & methods: Effects of gelatin methacryloyl (GelMA) concentration, extruder pressure and duration of UV exposure on survival of cardiac myocytes and fibroblasts were examined using lactate dehydrogenase and LIVE/DEAD assays, bioluminescence imaging and morphological assessment.
    Results & conclusion: Cell survival within 3D printed cardiomyocyte-laden GelMA constructs was more sensitive to extruder pressure and GelMA concentrations than within 3D fibroblast-laden GelMA constructs. Cells within both types of constructs were adversely impacted by the UV curing step. Use of mixed cell populations and enrichment of bioink formulation with fibronectin led to an improvement of cardiomyocyte survival and spreading.
    Language English
    Publishing date 2019-01-15
    Publishing country England
    Document type Journal Article
    ISSN 2059-4763
    ISSN (online) 2059-4763
    DOI 10.2217/3dp-2018-0017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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