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  1. Article ; Online: Thoracic duct identification with indocyanine green fluorescence to prevent chyle leaks during minimally invasive esophagectomy.

    Mahmoodzadeh, Habibollah / Farahzadi, Athena / Omranipour, Ramesh / Harirchi, Iraj / Jalaeefar, Amirmohsen / Shirkhoda, Mohammad / Miri, Seyed Rouhollah / Hadjilooei, Farimah

    Cancer reports (Hoboken, N.J.)

    2024  Volume 7, Issue 4, Page(s) e2053

    Abstract: Introduction: Chylothorax (CT) is a rare yet serious complication after esophagectomy. Identification of the thoracic duct (TD) during esophagectomy is challenging due to its anatomical variation. Real-time identification of TD may help to prevent its ... ...

    Abstract Introduction: Chylothorax (CT) is a rare yet serious complication after esophagectomy. Identification of the thoracic duct (TD) during esophagectomy is challenging due to its anatomical variation. Real-time identification of TD may help to prevent its injury. Near infra-red imaging with Indocyanine green (ICG) is a novel technique that recently has been used to overcome this issue.
    Methods: Patients who underwent minimally invasive esophagectomy for esophageal cancer were divided into two groups with and without ICG. We injected ICG into bilateral superficial inguinal lymph nodes. Identification of TD and its injuries during the operation was evaluated and compared with the non-ICG group.
    Results: Eighteen patients received ICG, and 18 patients underwent surgery without ICG. Each group had one (5.5%) TD ligation. In the ICG group injury was detected intraoperative, and ligation was done at the site of injury. In all cases, the entire thoracic course of TD was visualized intraoperatively after a mean time of 81.39 min from ICG injection to visualization. The Mean extra time for ICG injection was 11.94 min. In the ICG group, no patient suffered from CT. One patient in the non-ICG group developed CT after surgery that was managed conservatively. According to Fisher's exact test, there was no significant association between CT development and ICG use, possibly due to the small sample size.
    Conclusions: This study confirms that ICG administration into bilateral superficial inguinal lymph nodes can highlight the TD and reduce its damage during esophagectomy. It can be a standard method for the prevention of postoperative CT.
    MeSH term(s) Humans ; Indocyanine Green ; Thoracic Duct/diagnostic imaging ; Thoracic Duct/surgery ; Thoracic Duct/pathology ; Esophagectomy/adverse effects ; Fluorescence ; Chyle
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2024-03-31
    Publishing country United States
    Document type Journal Article
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.2053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intra Operative Mild Cooling of Large Tumors Reduces Their Invasive and Metastatic Functions While Increasing Their Resistance to Apoptosis.

    Tavassoli, Noureddin / Ghahremani, Alireza / Namakin, Kosar / Naserghandi, Alvand / Miri, Seyed Rouhollah / Abdolahad, Mohammad

    Therapeutic hypothermia and temperature management

    2023  

    Abstract: Cancer treatment often involves excisional surgery, but this approach may leave behind minimal residual disease, leading to tumor regrowth. Proinflammatory cytokines and their role in altering residual cancerous cells postsurgery have garnered attention. ...

    Abstract Cancer treatment often involves excisional surgery, but this approach may leave behind minimal residual disease, leading to tumor regrowth. Proinflammatory cytokines and their role in altering residual cancerous cells postsurgery have garnered attention. The study examines how mild intraoperative cooling affects cancer cells and their gene expression. It aims to discover strategies for reducing tumor growth after surgery. Nine cases of solid tumor were included in the study, nine samples were cooled with the Peltier-Seebeck device down to12°C, and cooled and noncooled regions of tumors were analyzed using reverse transcription-polymerase chain reaction. Key transcriptomes, including neural-cadherin, cadherins (
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609342-X
    ISSN 2153-7933 ; 2153-7658
    ISSN (online) 2153-7933
    ISSN 2153-7658
    DOI 10.1089/ther.2023.0060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Application of Breast Scintigraphy for Patients with Suspicious (Breast Imaging-Reporting and Data System IV) Breast Lesions.

    Azarpeikan, Ali Reza / Omranipour, Ramesh / Mahmoodzadeh, Habibollah / Miri, Seyed Rouhollah / Mohammadzadeh, Narjes / Derakhshan, Farhang / Farzanefar, Saeed / Abbasi, Mehrshad

    Advanced biomedical research

    2023  Volume 12, Page(s) 86

    Abstract: Background: The surgery for a breast imaging-reporting and data system (BIRADS) IV lesions needs imaging or pathology supporting data. The roll of breast scintigraphy for this purpose is unclear.: Materials and methods: In a prospective design, 16 ... ...

    Abstract Background: The surgery for a breast imaging-reporting and data system (BIRADS) IV lesions needs imaging or pathology supporting data. The roll of breast scintigraphy for this purpose is unclear.
    Materials and methods: In a prospective design, 16 patients with 25 BIRADS IV lesions who were scheduled for surgery were included. Before the surgery, breast scintigraphy was done using a nondedicated dual head gamma camera in the prone position employing a shaped foam pad providing imaging at breast pendulous position. Twenty mCi
    Results: Out of all lesions, 12 were malignant (invasive ductal and lobular carcinoma ductal carcinoma
    Conclusions: Breast scintigraphy with general purpose gamma camera employing SPECT imaging may assist the selection of BIRADS IV lesions in need for surgery. All uptake positive cases should undergo surgery and decision for uptake negative cases should be made based on other data.
    Language English
    Publishing date 2023-04-25
    Publishing country India
    Document type Journal Article
    ZDB-ID 2672524-1
    ISSN 2277-9175
    ISSN 2277-9175
    DOI 10.4103/abr.abr_347_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evaluation of

    Adelipour, Maryam / Naghashpour, Mahshid / Roshanazadeh, Mohammad Reza / Chenaneh, Hadi / Mohammadi, Asma / Pourangi, Pegah / Miri, Seyed Rouhollah / Zahedi, Atefeh / Haghighatnezhad, Mahmood / Golabi, Sahar

    Molecular biology research communications

    2024  Volume 13, Issue 1, Page(s) 11–19

    Abstract: Autophagy is a cellular process that plays a major role in the fate of tumor cells. Understanding the role of autophagy in cancer therapy is a major challenge, particularly for breast cancer as the sole top cause of mortality among women. In this study, ... ...

    Abstract Autophagy is a cellular process that plays a major role in the fate of tumor cells. Understanding the role of autophagy in cancer therapy is a major challenge, particularly for breast cancer as the sole top cause of mortality among women. In this study, we evaluated the gene expression of
    Language English
    Publishing date 2024-01-01
    Publishing country Iran
    Document type Journal Article
    ISSN 2345-2005
    ISSN (online) 2345-2005
    DOI 10.22099/mbrc.2023.47597.1837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Neuroendocrine tumor of the common bile duct: A case report of extremely rare cause for obstructive jaundice.

    Miri, Seyed Rouhollah / Movaghar, Ehsanollah Rahimi / Safaei, Masoomeh / Sharifi, Amirsina

    International journal of surgery case reports

    2020  Volume 77, Page(s) 303–306

    Abstract: Introduction: Neuroendocrine tumors (NET) of common bile duct are rare. There have been less than 100 cases reported worldwide.: Presentation of case: A 37-year-old female patient was referred to our center after six months of abdominal pain with no ... ...

    Abstract Introduction: Neuroendocrine tumors (NET) of common bile duct are rare. There have been less than 100 cases reported worldwide.
    Presentation of case: A 37-year-old female patient was referred to our center after six months of abdominal pain with no definite diagnosis. At initial presentation, she complained of increased abdominal pain, nausea, vomiting, oral intolerance to food and icteric sclera. Physical examination and laboratory tests were indicative of pancreatitis. At day four, she took retrograde cholangiopancreatography (ERCP) and a mid CBD stenosis or impacted stone was found. In order to locally investigate the lesion, Endoscopic Ultrasound (EUS) examination was performed which reported 16 × 12 mm isoechoic tumoral lesion at the middle of the CBD. In this regard we decided to perform ERCP-guided brushing biopsy of the lesion. The pathology report was highly suggestive for malignancy. She underwent resection of the mid portion of the CBD with Roux-en-Y hepaticojejunostomy, cholecystectomy and portahepatis lymph node dissection. The pathology report indicated that the CBD lesion was well-differentiated neuroendocrine tumor grade II.
    Discussion: The exact etiology of developing NET in the bile duct tissues is not clear however cholelithiasis and congenital malformation of the biliary tract has been proposed to cause chronic inflammation with subsequent metaplasia which ultimately transforms into NET.
    Conclusion: As there are very few cases of NETs of the CBD, no definite surgical or medical treatment is proposed. Currently, combination of radical surgical resection and lymph node dissection followed by chemotherapy is the treatment of choice.
    Language English
    Publishing date 2020-11-08
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2020.11.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Systematic Review on Overall Survival and Disease-Free Survival Following Total Pelvic Exenteration.

    Miri, Seyed Rouhollah / Akhavan, Setareh / Mousavi, Azam Sadat / Hashemi, Seyedeh Razieh / Sheikhhasan, Shahrzad / Almasi-Hashiani, Amir / Sadegh Fakhari, Mohammad / Esmailzadeh, Arezoo

    Asian Pacific journal of cancer prevention : APJCP

    2022  Volume 23, Issue 4, Page(s) 1137–1145

    Abstract: Backgrounds: Total Pelvic Exenteration (TPE) is a radical operation for malignancies in which all of the organs inside the pelvic cavity, including the female reproductive organs, the lower urinary tract, and a part of the rectosigmoid are removed. In ... ...

    Abstract Backgrounds: Total Pelvic Exenteration (TPE) is a radical operation for malignancies in which all of the organs inside the pelvic cavity, including the female reproductive organs, the lower urinary tract, and a part of the rectosigmoid are removed. In this study, we aimed to conduct a systematic review to assess the overall survival (OS) and disease-free survival (DFS) following TPE.
    Methods: This systematic review is composed of a comprehensive review of PubMed and Scopus databases with various related keywords to synthesis the overall survival and disease-free survival following TPE. The Synthesis Without Meta-analysis guideline was used to summarize the results.
    Results: We included the results of 39 primary studies and the results revealed that one-year OS of gynecological cancer in patients who have undergone TPE ranged from 50.0% to 72.0% and the 5-years OS ranged from 6.0% to 64.6%. The one-year survival rate of colorectal cancer patients was reported to be over 80% in almost all studies. The 3-year survival rate of patients varied from 25% to 75% and the lowest 5-year survival rate was 8% and the highest survival rate was 92%. To synthesis the disease-free survival rate in colorectal cancer, ten studies were included and one-year recurrence rate was 9.1% and the one-year DFS was reported as 61.0%. Three-year recurrence rate study was 20.4% and 3 and 5-year DFS ranged from 22.0% to 78.0%.
    Conclusions: The results suggested that DFS in primary advanced cancers is higher than locally recurrence tumors. This review showed that patient overall survival and disease-free survival rates have increased over time, especially at high volume centers that are more experienced and possibly better equipped. Therefore, it can be suggested that the attitude towards PE as a palliative surgery can be turned into curative surgery.
    MeSH term(s) Colorectal Neoplasms/pathology ; Disease-Free Survival ; Female ; Humans ; Neoplasm Recurrence, Local/pathology ; Pelvic Exenteration/methods ; Retrospective Studies
    Language English
    Publishing date 2022-04-01
    Publishing country Thailand
    Document type Journal Article ; Systematic Review
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.31557/APJCP.2022.23.4.1137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: SARS-CoV-2 Omicron (B.1.1.529) Variant: A Challenge with COVID-19.

    Mohseni Afshar, Zeinab / Tavakoli Pirzaman, Ali / Karim, Bardia / Rahimipour Anaraki, Shiva / Hosseinzadeh, Rezvan / Sanjari Pireivatlou, Elaheh / Babazadeh, Arefeh / Hosseinzadeh, Dariush / Miri, Seyed Rouhollah / Sio, Terence T / Sullman, Mark J M / Barary, Mohammad / Ebrahimpour, Soheil

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 3

    Abstract: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there have been multiple peaks of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus virus 2) infection, mainly due to the emergence of new variants, each with a new set ... ...

    Abstract Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there have been multiple peaks of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus virus 2) infection, mainly due to the emergence of new variants, each with a new set of mutations in the viral genome, which have led to changes in the pathogenicity, transmissibility, and morbidity. The Omicron variant is the most recent variant of concern (VOC) to emerge and was recognized by the World Health Organization (WHO) on 26 November 2021. The Omicron lineage is phylogenetically distinct from earlier variants, including the previously dominant Delta SARS-CoV-2 variant. The reverse transcription-polymerase chain reaction (RT-PCR) test, rapid antigen assays, and chest computed tomography (CT) scans can help diagnose the Omicron variant. Furthermore, many agents are expected to have therapeutic benefits for those infected with the Omicron variant, including TriSb92, molnupiravir, nirmatrelvir, and their combination, corticosteroids, and interleukin-6 (IL-6) receptor blockers. Despite being milder than previous variants, the Omicron variant threatens many lives, particularly among the unvaccinated, due to its higher transmissibility, pathogenicity, and infectivity. Mounting evidence has reported the most common clinical manifestations of the Omicron variant to be fever, runny nose, sore throat, severe headache, and fatigue. This review summarizes the essential features of the Omicron variant, including its history, genome, transmissibility, clinical manifestations, diagnosis, management, and the effectiveness of existing vaccines against this VOC.
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13030559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Anticoagulant therapy in COVID-19: A narrative review.

    Mohseni Afshar, Zeinab / Tavakoli Pirzaman, Ali / Hosseinzadeh, Rezvan / Babazadeh, Arefeh / Taghizadeh Moghadam, Mohamad Ali / Miri, Seyed Rouhollah / Sio, Terence T / Sullman, Mark J M / Barary, Mohammad / Ebrahimpour, Soheil

    Clinical and translational science

    2023  Volume 16, Issue 9, Page(s) 1510–1525

    Abstract: Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can manifest itself in several ways, including coagulopathy and thrombosis. These complications can be the first and sometimes only ... ...

    Abstract Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can manifest itself in several ways, including coagulopathy and thrombosis. These complications can be the first and sometimes only manifestations of SARS-CoV-2 infection and can occur early or late in the course of the disease. However, these symptoms are more prevalent in hospitalized patients with venous thromboembolism, particularly those admitted to intensive care units. Moreover, various forms of arterial and venous thrombosis, or micro- or macro-vasculature embolisms, have been reported during the current pandemic. They have led to harmful consequences, such as neurological and cardiac events, nearly all resulting from the hypercoagulable state caused by this viral infection. The severe hypercoagulability observed in patients with COVID-19 accounts for most cases of the disease that become critical. Therefore, anticoagulants seem to be one of the most vital therapeutics for treating this potentially life-threatening condition. In the current paper, we present a thorough review of the pathophysiology of COVID-19-induced hypercoagulable state and the use of anticoagulants to treat SARS-CoV-2 infections in different patient groups, as well as their pros and cons.
    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Anticoagulants/adverse effects ; Blood Coagulation Disorders/complications ; Thrombosis/drug therapy ; Thrombosis/etiology ; Thrombosis/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2433157-0
    ISSN 1752-8062 ; 1752-8054
    ISSN (online) 1752-8062
    ISSN 1752-8054
    DOI 10.1111/cts.13569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Potential of Circulating miR-193b, miR-146b-3p and miR-483-3p as Noninvasive Biomarkers in Cutaneous Melanoma Patients.

    Mohammadloo, Atefeh / Asgari, Yazdan / Esmaeili-Bandboni, Aghil / Mazloomi, Mohammad Ali / Ghasemi, Seyedeh Fatemeh / Ameri, Sima / Miri, Seyed Rouhollah / Hamzelou, Shahin / Mahmoudi, Hamid Reza / Veisi-Malekshahi, Ziba

    Molecular biotechnology

    2023  

    Abstract: Melanoma is a destructive skin disease with few therapeutic options in the developed stage and therefore there is a critical need for reliable biomarkers for early diagnosis. In this context, microRNAs could play an important role as diagnostic ... ...

    Abstract Melanoma is a destructive skin disease with few therapeutic options in the developed stage and therefore there is a critical need for reliable biomarkers for early diagnosis. In this context, microRNAs could play an important role as diagnostic biomarkers. Three datasets with accession numbers GSE31568, GSE61741 and GSE20994 were downloaded from the Gene Expression Omnibus (GEO) database. MATLAB software was used to analyze differentially expressed miRNAs between cutaneous melanoma plasma samples and normal plasma samples (control). Plasma levels of miR-193b, miR-146b-3p and miR-483-3p were evaluated by the RT-PCR method. Furthermore, linear regression followed by receiver operating characteristic analyses was performed to estimate whether selected plasma miRNAs were able to distinguish between cases and controls. Finally, the data were analyzed by unpaired Mann-Whitney U test using Graph pad prism 8 computer software. Specifically, miR-193b and miR-146b-3p were downregulated in the plasma of melanoma patients compared with control groups which were decreased 5 × [Formula: see text]-fold in miR-193b and 58-fold in miR-146b-3p, while miR-483-3p was upregulated 3.5-fold. After receiver operating characteristic (ROC) curve analysis, miR-193b with the most area under the curve (AUC: 1.00, 95% confidence interval 1.00-1.00, p < 0.0001) had the best discriminatory power, and miR-146b-3p had the large area under the curve (AUC: 0.96, 95% confidence interval 0.96-1.00, p < 0.0001) and consequently the high discriminatory power. Between these three miRNAs, miR-193b and miR-146b-3p had a high capacity to distinguish between melanoma patients and control groups that are appropriate to be applied in melanoma diagnosis as an early and noninvasive method.
    Language English
    Publishing date 2023-11-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1193057-3
    ISSN 1559-0305 ; 1073-6085
    ISSN (online) 1559-0305
    ISSN 1073-6085
    DOI 10.1007/s12033-023-00893-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A Raman-based serum constituents’ analysis for gastric cancer diagnosis: In vitro study

    Bahreini, Maryam / Hajian, Parastoo / Hosseinzadegan, Ahmad / Miri, Seyed Rouhollah / Mirzaei, Hamid Reza / Rashidi, Arian

    Talanta. 2019 Nov. 01, v. 204

    2019  

    Abstract: The importance of blood serum testing in most medical diagnosis has led researchers to seek for a reliable analysis method. Raman spectroscopy is a potential tool for probing serum components due to its real-time and non-destructive measurements without ... ...

    Abstract The importance of blood serum testing in most medical diagnosis has led researchers to seek for a reliable analysis method. Raman spectroscopy is a potential tool for probing serum components due to its real-time and non-destructive measurements without need to any additional reagents. So, Raman spectroscopy for the analysis and discrimination of human serum of healthy and gastric cancer subjects is investigated in this work. In order to find the correlation between Raman spectra and enzymatic test results of glucose, cholesterol, HDL, LDL and triglycerides of serum samples, the partial least squares regression (PLSR) method is utilized. Moreover, the Raman spectroscopy is used to distinguish between serum samples of healthy people and gastric cancer patients using partial least square discriminant analysis (PLS-DA) method. Correlation results reveal that for all serum components, the correlation coefficients between Raman spectra and all enzymatic test results are above 94% significantly. Discrimination results of healthy subjects and gastric cancer patients show that 87.5 ± 2.5% of healthy and gastric cancer subjects are diagnosed properly. Our preliminary results can confirm the Raman method in analysis of serum and also as a diagnostic tool in screening of gastric cancer.
    Keywords blood serum ; cholesterol ; diagnostic techniques ; discriminant analysis ; glucose ; high density lipoprotein ; humans ; in vitro studies ; least squares ; low density lipoprotein ; patients ; Raman spectroscopy ; screening ; stomach neoplasms ; triacylglycerols
    Language English
    Dates of publication 2019-1101
    Size p. 826-832.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2019.06.068
    Database NAL-Catalogue (AGRICOLA)

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