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Article: A five-day-old child with lipid hemihypertrophy: A case report.

Mirnia, Kayvan / Saeedi, Maryam / Sangsari, Razieh / Kazemzadeh, Kimia

2024 Volume 12, Issue 2, Page(s) e8476

Abstract: Key clinical message: Lipid hemihypertrophy should be considered in the differential diagnosis of neonatal asymmetry. Early recognition and further evaluation for associated disorders are important for appropriate management and surveillance of ... ...

Abstract	Key clinical message: Lipid hemihypertrophy should be considered in the differential diagnosis of neonatal asymmetry. Early recognition and further evaluation for associated disorders are important for appropriate management and surveillance of potential complications. Abstract: We present the case of a 5-day-old female neonate who presented with a visibly enlarged right thigh, right labia majora, and below the right mandible. This case report highlights the importance of early identification, comprehensive evaluation, and multidisciplinary management in neonates with lipid hemihypertrophy to optimize their long-term outcomes and quality of life.
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.8476
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Article ; Online: Amniotic membrane dressings for treatment of aplasia cutis in newborns.

Kadivar, Maliheh / Sangsari, Razieh / Rostamli, Somayeh / Sotoudeh, Soheila / Mirnia, Kayvan

Pediatric dermatology

2024 Volume 41, Issue 3, Page(s) 445–450

Abstract: Background: Aplasia cutis congenita (ACC) is a rare congenital skin defect characterized by a focal or extensive absence of the epidermis, dermis, and occasionally, subcutaneous tissue. When the wound caused by this defect is wide or deep, various ... ...

Abstract	Background: Aplasia cutis congenita (ACC) is a rare congenital skin defect characterized by a focal or extensive absence of the epidermis, dermis, and occasionally, subcutaneous tissue. When the wound caused by this defect is wide or deep, various treatments are used, including skin grafting. The amniotic membrane (AM) is a biological dressing that facilitates re-epithelialization as it contains mesenchymal cells and numerous growth factors. Objective: To report the efficacy of AM dressings in treating the skin defects of ACC. Method: This study was conducted on five neonates diagnosed with ACC born between 2018 and 2022, referred to the Children's Medical Center in Tehran, Iran. AM dressings were applied on wounds larger than 1 cm Results: The skin defects gradually re-epithelialized after application of the AM. The complete healing process took around 3.5 weeks on average. No hypertrophic scarring was observed. Conclusion: The application of AM dressing resulted in satisfactory cosmetic outcomes, with no hypertrophic scar formation. Complete healing occurred in all cases except one. The length of the hospital stay ranged from 2 to 6 weeks, depending on the size of the wound.
MeSH term(s)	Humans ; Infant, Newborn ; Ectodermal Dysplasia/therapy ; Male ; Biological Dressings ; Female ; Amnion/transplantation ; Wound Healing ; Treatment Outcome ; Re-Epithelialization
Language	English
Publishing date	2024-02-26
Publishing country	United States
Document type	Journal Article ; Case Reports
ZDB-ID	605539-4
ISSN	1525-1470 ; 0736-8046
ISSN (online)	1525-1470
ISSN	0736-8046
DOI	10.1111/pde.15540
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Article ; Online: Evaluating the Efficacy of Amniotic Membrane in Treating Neonatal Extravasation.

Kadivar, Maliheh / Bitaraf, Masoud / Nasrabadi, Seyed Ali Hashemi / Mirnia, Kayvan

Advances in skin & wound care

2023 Volume 36, Issue 6, Page(s) 1–6

Abstract: Objective: Extravasation is leakage of material from a peripheral venous access into adjacent tissue, which results in tissue damage ranging from local irritation to necrosis and scar formation. Neonates are at extravasation risk with IV treatment ... ...

Abstract	Objective: Extravasation is leakage of material from a peripheral venous access into adjacent tissue, which results in tissue damage ranging from local irritation to necrosis and scar formation. Neonates are at extravasation risk with IV treatment because of their small, fragile veins and the long treatment period required. In this report, investigators assessed the efficacy of amniotic membrane (AM) as a biological dressing to heal extravasation wounds in neonates. Methods: This case series includes six neonates who presented with extravasation injuries from February 2020 to April 2022. Neonates born at any gestational age diagnosed with a wound secondary to extravasation were recruited. Neonates with skin disorders and those who had stage 1 or 2 wounds were excluded. Providers covered infection- and necrosis-free wounds with AM and assessed the wounds after 48 hours. Five days after placement, providers removed and replaced the AM; they continued to replace the bandages every 5 to 7 days until healed. Results: The average gestational age of included neonates was 33.6 weeks. Average healing time was 12.5 days (range, 10-20 days), and no adverse reactions were observed. All neonates healed completely without scar formation. Conclusions: This preliminary report suggests that the application of AM in treating extravasation in neonates is safe and effective. However, controlled trials with larger sample sizes are needed to evaluate this outcome and determine implications for practice.
MeSH term(s)	Infant, Newborn ; Humans ; Infant ; Cicatrix ; Amnion ; Wound Healing ; Bandages ; Skin Diseases
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012792-3
ISSN	1538-8654 ; 1527-7941
ISSN (online)	1538-8654
ISSN	1527-7941
DOI	10.1097/01.ASW.0000926620.27523.a4
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Article ; Online: A suggested screening method for hypothyroidism in very preterm and/or very low birth weight neonates.

Mirnia, Kayvan / Dindarian, Sina / Mohammadi, Sedra / Rostami, Parastoo / Mohammadi, Hozan

Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo

2022 Volume 40, Page(s) e2020376

Abstract: Objective: To assess thyroid function in very preterm or very low birth weight (VLBW) neonates by measuring combination levels of thyroid-stimulating hormone TSH and free T4 (FT4).: Methods: Inclusion criteria were defined as all very preterm ( ... ...

Abstract	Objective: To assess thyroid function in very preterm or very low birth weight (VLBW) neonates by measuring combination levels of thyroid-stimulating hormone TSH and free T4 (FT4). Methods: Inclusion criteria were defined as all very preterm (gestational age <32 weeks) or VLBW (birth weight ≤1500g) neonates with initial Thyroid Function Test (TFT) who were admitted to the Neonatal Intense Care Unit (NICU) of Taleghani Hospital, Tabriz, Iran, from March 2015 to March 2016. Exclusion criteria were the absence of initial TFT with any major congenital anomaly. The primary value of TSH was evaluated at 3-5 days, and mean levels of TSH with FT4 were measured at 2, 4, and 8-weeks. Results: Ninety-five neonates with a mean gestational age of 29.5 weeks were included, and the mean levels of thyrotropin and FT4 at postnatal week two were 4.4mIU/L and 1.4ng/dL, respectively. Two of the patients had serum TSH concentration >25mIU/L that was considered as permanent primary hypothyroidism. Among nine hypothyroxinemia cases, two had elevated TSH levels (10.8±0.4mIU/L at the end of 8 weeks) and normal FT4 concentration, and were considered transient hypothyroidism. Seven cases had normal TSH levels (1.6±1.0mIU/L at 2 weeks, 3.5±2.8mIU/L at 8 weeks) and low FT4 concentrations. Conclusions: Combined venous TSH and FT4 concentration at the end of the first postnatal month can be an efficient approach for detecting neonatal hypothyroidism.
MeSH term(s)	Humans ; Hypothyroidism/diagnosis ; Infant ; Infant, Extremely Premature ; Infant, Newborn ; Infant, Very Low Birth Weight ; Neonatal Screening/methods ; Thyrotropin ; Thyroxine
Chemical Substances	Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
Language	Portuguese
Publishing date	2022-05-06
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2560228-7
ISSN	1984-0462 ; 1984-0462
ISSN (online)	1984-0462
ISSN	1984-0462
DOI	10.1590/1984-0462/2022/40/2020376IN
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Article: Comparing the Efficacy and Safety of Levetiracetam Versus Phenytoin for Treating the Acute Phase of Neonatal Seizures.

Mohammadi, Mahmoud / Kadivar, Maliheh / Sangsari, Razieh / Mirnia, Kayvan / Saeedi, Maryam / Adhami, Pegah

Iranian journal of child neurology

2023 Volume 17, Issue 1, Page(s) 65–71

Abstract: Objectives: Neonatal seizure is a significant problem in this life course, and its timely and effective treatment is crucial. In this study, we compared the efficacy of levetiracetam versus phenytoin for treating the acute phase of neonatal seizures.: ...

Abstract	Objectives: Neonatal seizure is a significant problem in this life course, and its timely and effective treatment is crucial. In this study, we compared the efficacy of levetiracetam versus phenytoin for treating the acute phase of neonatal seizures. Materials & methods: In this single-blind case-control study, 60 consecutive children with neonatal seizures referred to the Children's medical center in Tehran, Iran, in 2018 were studied. Those neonates who had at least 30 minutes of seizure after Phenobarbital treatment were assigned to receive either phenytoin (20 mg/kg) or levetiracetam (initial dose of 40-60 mg/kg) through block randomization. The efficacy and safety of the two drugs were compared between the groups. Results: The response rate was 83.3% and 86.7% in phenytoin and Levetiracetam groups, respectively, which was not significantly different between groups (P=1.000). Adverse effects were nearly similar between groups (6.7% in the phenytoin group and 3.3% in the Levetiracetam group, P=1.000). Conclusion: Levetiracetam and phenytoin are both practical and safe for treating neonatal seizures.
Language	English
Publishing date	2023-01-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2542305-8
ISSN	2008-0700 ; 1735-4668
ISSN (online)	2008-0700
ISSN	1735-4668
DOI	10.22037/ijcn.v17i1.36008
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Article: Developing a model to predict neonatal respiratory distress syndrome and affecting factors using data mining: A cross-sectional study.

Farshid, Parisa / Mirnia, Kayvan / Rezaei-Hachesu, Peyman / Maserat, Elham / Samad-Soltani, Taha

International journal of reproductive biomedicine

2023 Volume 21, Issue 11, Page(s) 909–920

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-12-19
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2898387-7
ISSN	2476-3772 ; 2476-4108
ISSN (online)	2476-3772
ISSN	2476-4108
DOI	10.18502/ijrm.v21i11.14654
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Article ; Online: Short-term side effects of COVID-19 vaccines among healthcare workers: a multicenter study in Iran.

Mirnia, Kayvan / Haji Esmaeil Memar, Elmira / Kamran, Niyoosha / Yeganedoost, Saadollah / Nickhah Klashami, Zeynab / Mamishi, Setareh / Mahmoudi, Shima

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4086

Abstract: Since the initiation of the COVID-19 vaccination effort, there has been widespread concern regarding vaccine efficacy and potential side effects. This study aimed to explore the short-term side effects of four available COVID-19 vaccines (Sputnik V, ... ...

Abstract	Since the initiation of the COVID-19 vaccination effort, there has been widespread concern regarding vaccine efficacy and potential side effects. This study aimed to explore the short-term side effects of four available COVID-19 vaccines (Sputnik V, Sinopharm, Oxford-AstraZeneca, and Covaxin) among healthcare workers (HCWs) in Iran. The multicenter study involved 1575 HCWs, with the majority received Sputnik V (74.1%), followed by Covaxin (15.6%), Sinopharm (6.4%), and Oxford-AstraZeneca (3.8%). The prevalence of at least one side effect after the first and second dose COVID-19 vaccine was 84.6% and 72.9%, respectively. The common side effects (presented in > 50% of the study participants) after the first dose of the vaccine were injection site pain (61.7%), myalgia (51.8%), and muscle pain (50.9%). The most reported side effects after the second dose of the vaccine were injection site pain (26.8%), myalgia (15.8%), fever (10.3%), headache (9.9%), and chills (9.2%). In conclusion, according to the COVID-19 vaccine type, different side effects might occur following the first and second doses of vaccination. These findings assist in addressing the ongoing problems of vaccination hesitancy which has been driven by widespread worries about the vaccine safety profile.
MeSH term(s)	Humans ; COVID-19 Vaccines/adverse effects ; Iran/epidemiology ; Myalgia/chemically induced ; Myalgia/epidemiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; Health Personnel
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54450-w
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Article ; Online: Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium.

Salek Maghsoudi, Armin / Hassani, Shokoufeh / Mirnia, Kayvan / Abdollahi, Mohammad

International journal of nanomedicine

2021 Volume 16, Page(s) 803–832

Abstract: Heavy metals cause considerable environmental pollution due to their extent and non-degradability in the environment. Analysis and trace levels of arsenic, lead, mercury, and cadmium as the most toxic heavy metals show that they can cause various hazards ...

Abstract	Heavy metals cause considerable environmental pollution due to their extent and non-degradability in the environment. Analysis and trace levels of arsenic, lead, mercury, and cadmium as the most toxic heavy metals show that they can cause various hazards in humans' health. To achieve rapid, high-sensitivity methods for analyzing ultra-trace amounts of heavy metals in different environmental and biological samples, novel biosensors have been designed with the participation of strategies applied in nanotechnology. This review attempted to investigate the novel, sensitive, efficient, cost-benefit, point of care, and user-friendly biosensors designed to detect these heavy metals based on functional mechanisms. The study's search strategies included examining the primary databases from 2015 onwards and various keywords focusing on heavy metal biosensors' performance and toxicity mechanisms. The use of aptamers and whole cells as two important bio-functional nanomaterials is remarkable in heavy metal diagnostic biosensors' bioreceptor design. The application of hybridized nanomaterials containing a specific physicochemical function in the presence of a suitable transducer can improve the sensing performance to achieve an integrated detection system. Our study showed that in addition to both labeled and label-free detection strategies, a wide range of nanoparticles and nanocomposites were used to modify the biosensor surface platform in the detection of heavy metals. The detection limit and linear dynamic range as an essential characteristic of superior biosensors for the primary toxic metals are studied. Furthermore, the perspectives and challenges facing the design of heavy metal biosensors are outlined. The development of novel biosensors and the application of nanotechnology, especially in real samples, face challenges such as the capability to simultaneously detect multiple heavy metals, the interference process in complex matrices, the efficiency and stability of nanomaterials implemented in various laboratory conditions.
MeSH term(s)	Biosensing Techniques/methods ; Environmental Pollution/analysis ; Humans ; Metals, Heavy/analysis ; Nanostructures/chemistry ; Nanotechnology/trends
Chemical Substances	Metals, Heavy
Language	English
Publishing date	2021-02-04
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S294417
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Article ; Online: Weaning and extubation from neonatal mechanical ventilation: an evidenced-based review.

Sangsari, Razieh / Saeedi, Maryam / Maddah, Marzieh / Mirnia, Kayvan / Goldsmith, Jay P

BMC pulmonary medicine

2022 Volume 22, Issue 1, Page(s) 421

Abstract: Mechanical ventilation is a lifesaving treatment used to treat critical neonatal patients. It facilitates gas exchange, oxygenation, and CO2 removal. Despite advances in non-invasive ventilatory support methods in neonates, invasive ventilation (i.e., ... ...

Abstract	Mechanical ventilation is a lifesaving treatment used to treat critical neonatal patients. It facilitates gas exchange, oxygenation, and CO2 removal. Despite advances in non-invasive ventilatory support methods in neonates, invasive ventilation (i.e., ventilation via an endotracheal tube) is still a standard treatment in NICUs. This ventilation approach may cause injury despite its advantages, especially in preterm neonates. Therefore, it is recommended that neonatologists consider weaning neonates from invasive mechanical ventilation as soon as possible. This review examines the steps required for the neonate's appropriate weaning and safe extubation from mechanical ventilation.
MeSH term(s)	Infant, Newborn ; Humans ; Airway Extubation ; Respiration, Artificial ; Ventilator Weaning ; Intubation, Intratracheal ; Respiration
Language	English
Publishing date	2022-11-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-022-02223-4
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Article ; Online: Prevalence of gram-negative bacteria and their antibiotic resistance in neonatal sepsis in Iran: a systematic review and meta-analysis.

Moftian, Nazila / Rezaei-Hachesu, Peyman / Arab-Zozani, Morteza / Samad-Soltani, Taha / Esfandiari, Atefeh / Tabib, Mohammad Saleh / Mirnia, Kayvan

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 534

Abstract: Background: Neonatal sepsis, particularly gram-negative (GN) bacteria-induced, is a significant cause of morbidity and mortality in newborns. Healthcare professionals find this issue challenging because of antibiotic resistance. This study aims to ... ...

Abstract	Background: Neonatal sepsis, particularly gram-negative (GN) bacteria-induced, is a significant cause of morbidity and mortality in newborns. Healthcare professionals find this issue challenging because of antibiotic resistance. This study aims to combine findings to identify the prevalence of GN bacteria and their antibiotic resistance in Iranian neonates with sepsis. Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). The literature search was performed through international databases, including (PubMed/MEDLINE, EMBASE, Scopus, and Web of Science), Iranian local databases (Magiran, Iranmedex, Irandoc, Scimed, and SID), and the first 100 records of Google Scholar. Analytical cross-sectional study checklist from the Joanna Briggs Institute (JBI) was used for the quality assessment of included studies. Comprehensive Meta-Analysis Software Version 2 was used to conduct the meta-analysis. The between-study heterogeneity was investigated by I Results: The prevalence of GN bacteria was estimated to be 53.6% [95% CI: 45.9- 61.1: P = 0.362] in Iranian neonates with sepsis, based on 31 studies with a sample size of 104,566. klebsiella pneumoniae (K.pneumonia) (23.2% [95% CI: 17.5-30.0, P < 0.001]) followed by Escherichia coli (E.coli) (13.5% [95% CI: 9.4-18.9, P < 0.001]) were more prevalent among GN bacteria. The highest resistance in K.pneumoniae was observed in Cefixime (80.6%, [95% CI: 56.3-93.1, P = 0.018]). E.coli showed greater resistance to Ampicillin (61.8%, [95% CI: 44.2-76.5, P = 0.188]. The prevalence of GN bacteria in Iranian neonates with sepsis has a decreasing trend based on the year, as shown by a meta-regression model (P < 0.0004). Conclusion: GN pathogens, particularly K.pneumoniae, and E.coli, are the leading cause of neonatal sepsis in Iran. GN bacteria showed the highest resistance to Third-generation cephalosporin and Aminoglycosides.
MeSH term(s)	Humans ; Infant, Newborn ; Iran/epidemiology ; Neonatal Sepsis/drug therapy ; Neonatal Sepsis/epidemiology ; Prevalence ; Cross-Sectional Studies ; Gram-Negative Bacteria ; Drug Resistance, Microbial ; Klebsiella pneumoniae ; Escherichia coli
Language	English
Publishing date	2023-08-15
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08508-1
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