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Book ; Online ; E-Book: Phytonutrients and Neurological Disorders

Khan, Haroon / Aschner, Michael / Mirzaei, Hamed

Therapeutic and Toxicological Aspects

2023

Abstract: Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects provides and assesses the latest research and developments surrounding the use of phytonutrients for the treatment of neurological disorders. The volume analyzes advances in ...

Abstract	Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects provides and assesses the latest research and developments surrounding the use of phytonutrients for the treatment of neurological disorders. The volume analyzes advances in phytonutrient isolation, characterization and therapeutic applications, giving particular emphasis to mechanisms and safety profiles. The book takes toxicological considerations into account, including adverse drug reactions, toxicokinetics and toxicodynamics. Sections cover bioactive compound classes and biosynthesis pathways, general considerations, including quality control, standardization, and technology, and toxicology. This title is a comprehensive work on the latest research in phytonutrients and neurological disorders that will be useful to researchers and medical practitioners.Presents a comprehensive resource on phytonutrients and their relationship to neurological disordersAnalyzes the isolation, characterization and mechanisms of phytonutrients in neurologyFocuses on various signaling pathways followed by phytonutrients in neuroprotectionGives the latest thinking on quality control parameters and specifications for phytonutrient studyConsiders the toxicology of phytonutrients, including adverse drug reactions, toxicokinetics and toxicodynamics
Keywords	Pharmacology ; Medical
Subject code	616.804
Language	English
Size	1 online resource (418 pages)
Publisher	Elsevier Science & Technology
Publishing place	San Diego
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-323-85978-X ; 9780128244678 ; 978-0-323-85978-3 ; 0128244674
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Kidney Injury: Focus on Molecular Signaling Pathways.

Liu, Wei / Hu, MengDi / Wang, Le / Mirzaei, Hamed

Current medicinal chemistry

2024

Abstract: Acute kidney injury (AKI) is a syndrome in which kidney function reduces suddenly. This syndrome which includes both structural changes and loss of function may lead to chronic kidney disease (CKD). Kidney regeneration capacity depends on the cell type ... ...

Abstract	Acute kidney injury (AKI) is a syndrome in which kidney function reduces suddenly. This syndrome which includes both structural changes and loss of function may lead to chronic kidney disease (CKD). Kidney regeneration capacity depends on the cell type and severity of the injury. However, novel studies indicated that regeneration mostly relies on endogenous tubular cells that survive after AKI. Regenerative pharmacology requires a great knowledge of fundamental processes involved in the development and endogenous regeneration, leading to a necessity for investigating related signaling molecules in this process. Regulatory non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) are currently known as critical regulators of gene expression in various cellular processes, and this regulatory function is also observed in nephrotic tissue, following damaging insults, which may promote or inhibit the progression of damage. Thus, studying signaling molecules and pathways involved in renal injury and repair results in a comprehensive prospect of these processes. Moreover, these studies can lead to new opportunities for discovering and enhancing therapeutic approaches to renal diseases. Herein, we review studies dealing with the role of different signaling pathways involved in renal injury. Besides, we discuss how some signaling pathways are useful for the repair process following AKI.
Language	English
Publishing date	2024-01-17
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0109298673271547231108060805
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Article ; Online: The Combination of 5-FU and Resveratrol Can Suppress the Growth of Glioblastoma Cells Through Downregulation of TRPM2 and β-Catenin.

Aghababaei, Farzaneh / Nejati, Majid / Karami, Hadi / Darvish, Maryam / Mirzaei, Hamed

Journal of molecular neuroscience : MN

2024 Volume 74, Issue 1, Page(s) 7

Abstract: Glioblastoma multiforme (GBM) is the most common as well as the most fatal primary malignant tumor of the central nervous system (CNS), which still lacks a definitive cure. 5-FU is an anti-metabolite anti-cancer agent which has shown promising results ... ...

Abstract	Glioblastoma multiforme (GBM) is the most common as well as the most fatal primary malignant tumor of the central nervous system (CNS), which still lacks a definitive cure. 5-FU is an anti-metabolite anti-cancer agent which has shown promising results for GBM treatment. Resveratrol (Res) is a phytochemical anti-oxidant that has also been effective in suppressing the progression of GBM. The combination of 5-FU and Res has been studied in a variety of cancers, but no study has assessed this combination in GBM. In this study, we investigated how 5-FU and Res, in combination and alone, may affect the growth and apoptosis of GBM cells and also the potential of TRPM2 and β-catenin as the mediator of their effects. U87 cells were cultured as the in vitro model. MTT assay was used for measuring cellular growth, and RT-qPCR was used to measure the level of caspase-3, TRPM2, and β-catenin; caspase-3 level served as the indicator of apoptotic rate. 5-FU and Res, in combination and alone, suppressed the growth while promoting the apoptosis of U87 cells; these effects were significantly greater when they were used in combination. RT-qPCR showed downregulation of TRPM-2 and β-catenin in response to this combination, which suggested that these two molecules may mediate the cited anti-oncogenic effects. In conclusion, our study confirmed the synergism between 5-FU and Res in suppressing the progression of GBM and suggested the putative axis of TRPM2/ β-catenin as the downstream mediator of this therapeutic regime. Future studies may be able to approve the eligibility of this therapeutic regime for GBM treatment and also the underlying mechanism.
MeSH term(s)	Humans ; beta Catenin/genetics ; Caspase 3 ; Down-Regulation ; Fluorouracil/pharmacology ; Glioblastoma/drug therapy ; Resveratrol/pharmacology ; TRPM Cation Channels/genetics
Chemical Substances	beta Catenin ; Caspase 3 (EC 3.4.22.-) ; Fluorouracil (U3P01618RT) ; Resveratrol (Q369O8926L) ; TRPM Cation Channels ; TRPM2 protein, human
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1043392-2
ISSN	1559-1166 ; 0895-8696
ISSN (online)	1559-1166
ISSN	0895-8696
DOI	10.1007/s12031-023-02174-3
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Article ; Online: Correction: The Combination of 5-FU and Resveratrol Can Suppress the Growth of Glioblastoma Cells through Downregulation of TRPM2 and β-Catenin.

Aghababaei, Farzaneh / Nejati, Majid / Karami, Hadi / Darvish, Maryam / Mirzaei, Hamed

Journal of molecular neuroscience : MN

2024 Volume 74, Issue 1, Page(s) 20

Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1043392-2
ISSN	1559-1166 ; 0895-8696
ISSN (online)	1559-1166
ISSN	0895-8696
DOI	10.1007/s12031-024-02198-3
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Article: Role of fermented goat milk as a nutritional product to improve anemia

Mirzaei, Hamed / Sharafati Chaleshtori, Reza

Journal of food biochemistry. 2022 June, v. 46, no. 6

2022

Abstract: Goat milk, like cow milk, needs some modifications to be used as the sole source of nutrition during early infancy. For goat milk to be more like human milk and more nutritionally complete, sugar, vitamins and minerals need to be added to it and for ... ...

Abstract	Goat milk, like cow milk, needs some modifications to be used as the sole source of nutrition during early infancy. For goat milk to be more like human milk and more nutritionally complete, sugar, vitamins and minerals need to be added to it and for reduction of renal solute load, it needs to be diluted. To prevent megaloblastic anemia in infants fed exclusively on goat milk, folic acid should be supplied either by adding it to goat milk or by an oral folic acid supplement. In fortification of milk products, thermal processing, fermentation, and species differences in milk folate bioavailability are three additional factors that should be considered besides absolute difference in folate concentration between goat and human milk. Whether different feeding regimes (e.g., iron and folate content of diets) influence milk folate content needs to be elucidated by more research. Our findings showed that fermented goat milk during anemia recovery can be improve antioxidant status, protection from oxidative damage to biomolecules, protective effects on testis, improve Fe and skeletal muscle homeostasis as well as improve cardiovascular health. PRACTICAL APPLICATIONS: To be used as part of a postweaning nutritionally well‐balanced diet, fermented goat milk is most likely an excellent source of nutrition for the human.
Keywords	anemia ; antioxidants ; bioavailability ; breast milk ; diet ; fermentation ; folic acid ; goat milk ; goats ; homeostasis ; humans ; infancy ; iron ; milk ; skeletal muscle ; solutes ; sugars ; testes
Language	English
Dates of publication	2022-06
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.13969
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Stroke in Women: Risk Factors and Clinical Biomarkers.

Mirzaei, Hamed

Journal of cellular biochemistry

2017 Volume 118, Issue 12, Page(s) 4191–4202

Abstract: Stroke has been emerged as one of major health problems for women worldwide. Increasing of knowledge in this field has provided new data in this area which contribute to finding of new risk factors and could improve stroke treatment. A large number ... ...

Abstract	Stroke has been emerged as one of major health problems for women worldwide. Increasing of knowledge in this field has provided new data in this area which contribute to finding of new risk factors and could improve stroke treatment. A large number studies indicated a variety of risk factors including sex, age, race, smoking, diabetes, and physical inactivity could be involved in stroke in women. The understanding of various aspects involved in women stroke including risk factors, outcomes, stroke recovery, and prevention could provide new therapeutic platforms which could likely lead to better treatment in women stroke. Diagnosis is one of important steps in stroke therapy. It has been showed that a variety of biomarkers such as microRNAs (miRNAs), tPA, and von willebrand factor could be used as therapeutic and diagnostic biomarkers in stroke therapy. Here, we summarized various aspects of stroke in women which could help to recognition risk factors, outcomes, care, treatment, and novel biomarkers involve in treatment of stroke. J. Cell. Biochem. 118: 4191-4202, 2017. © 2017 Wiley Periodicals, Inc.
MeSH term(s)	Age Factors ; Biomarkers/analysis ; Diabetes Complications ; Female ; Humans ; MicroRNAs/analysis ; Motor Activity ; Risk Factors ; Sex Factors ; Smoking/adverse effects ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/etiology ; Stroke/metabolism ; von Willebrand Factor/analysis
Chemical Substances	Biomarkers ; MicroRNAs ; von Willebrand Factor
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.26130
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Role of fermented goat milk as a nutritional product to improve anemia.

Mirzaei, Hamed / Sharafati Chaleshtori, Reza

Journal of food biochemistry

2021 Volume 46, Issue 6, Page(s) e13969

Abstract	Goat milk, like cow milk, needs some modifications to be used as the sole source of nutrition during early infancy. For goat milk to be more like human milk and more nutritionally complete, sugar, vitamins and minerals need to be added to it and for reduction of renal solute load, it needs to be diluted. To prevent megaloblastic anemia in infants fed exclusively on goat milk, folic acid should be supplied either by adding it to goat milk or by an oral folic acid supplement. In fortification of milk products, thermal processing, fermentation, and species differences in milk folate bioavailability are three additional factors that should be considered besides absolute difference in folate concentration between goat and human milk. Whether different feeding regimes (e.g., iron and folate content of diets) influence milk folate content needs to be elucidated by more research. Our findings showed that fermented goat milk during anemia recovery can be improve antioxidant status, protection from oxidative damage to biomolecules, protective effects on testis, improve Fe and skeletal muscle homeostasis as well as improve cardiovascular health. PRACTICAL APPLICATIONS: To be used as part of a postweaning nutritionally well-balanced diet, fermented goat milk is most likely an excellent source of nutrition for the human.
MeSH term(s)	Anemia ; Animals ; Folic Acid ; Goats ; Humans ; Male ; Milk ; Rats ; Rats, Wistar
Chemical Substances	Folic Acid (935E97BOY8)
Language	English
Publishing date	2021-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.13969
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Nanoemulsion and nanoencapsulation of a hydroethanolic extract of Nettle (

Rahmani, Zeinab / Karimi, Merat / Saffari, Iman / Mirzaei, Hamed / Nejati, Majid / Sharafati Chaleshtori, Reza

Frontiers in chemistry

2024 Volume 12, Page(s) 1266573

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2024.1266573
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: MicroRNA-155 and exosomal microRNA-155: Small pieces in the cardiovascular diseases puzzle.

Eshraghi, Reza / Rafiei, Moein / Hadian Jazi, Zahra / Shafie, Davood / Raisi, Arash / Mirzaei, Hamed

Pathology, research and practice

2024 Volume 257, Page(s) 155274

Abstract: MicroRNAs (miRs, miRNAs) are known to have a part in various human illnesses, such as those related to the heart. One particular miRNA, miR-155, has been extensively studied and has been found to be involved in hematopoietic lineage differentiation, ... ...

Abstract	MicroRNAs (miRs, miRNAs) are known to have a part in various human illnesses, such as those related to the heart. One particular miRNA, miR-155, has been extensively studied and has been found to be involved in hematopoietic lineage differentiation, immunity, viral infections, inflammation, as well as vascular remodeling. These processes have all been connected to cardiovascular diseases, including heart failure, diabetic heart disease, coronary artery disease, and abdominal aortic aneurysm. The impacts of miR-155 depend on the type of cell it is acting on and the specific target genes involved, resulting in different mechanisms of disease. Although, the exact part of miR-155 in cardiovascular illnesses is yet not fully comprehended, as some studies have shown it to promote the development of atherosclerosis while others have shown it to prevent it. As a result, to comprehend the underlying processes of miR-155 in cardiovascular disorders, further thorough study is required. It has been discovered that exosomes that could be absorbed by adjacent or distant cells, control post-transcriptional regulation of gene expression by focusing on mRNA. Exosomal miRNAs have been found to have a range of functions, including participating in inflammatory reactions, cell movement, growth, death, autophagy, as well as epithelial-mesenchymal transition. An increasing amount of research indicates that exosomal miRNAs are important for cardiovascular health and have a major role in the development of a number of cardiovascular disorders, including pulmonary hypertension, atherosclerosis, acute coronary syndrome, heart failure, and myocardial ischemia-reperfusion injury. Herein the role of miR-155 and its exosomal form in heart diseases are summarized.
Language	English
Publishing date	2024-04-01
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2024.155274
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Article ; Online: Epigenetic modifications and obsessive-compulsive disorder: what do we know?

Mohammadi, Amir Hossein / Karimian, Mohammad / Mirzaei, Hamed / Milajerdi, Alireza

Brain structure & function

2023 Volume 228, Issue 5, Page(s) 1295–1305

Abstract: Obsessive-Compulsive Disorder (OCD) is a chronic, severe disabling neuropsychiatric disorder whose pathophysiology is not yet well defined. Generally, the symptom onset occurs during pre-adult life and affects subjects in different life aspects, ... ...

Abstract	Obsessive-Compulsive Disorder (OCD) is a chronic, severe disabling neuropsychiatric disorder whose pathophysiology is not yet well defined. Generally, the symptom onset occurs during pre-adult life and affects subjects in different life aspects, including professional and social relationships. Although robust evidence indicates the presence of genetic factors in the etiopathology of OCD, the entirely mechanisms are not totally clarified. Thus, the possible interactions between genes and environmental risk factors mediated by epigenetic mechanisms should be sought. Therefore, we provide a review of genetic and epigenetic mechanisms related to OCD with a deep focus on the regulation of critical genes of the central nervous system seeking possible potential biomarkers.
MeSH term(s)	Humans ; Obsessive-Compulsive Disorder/genetics ; Obsessive-Compulsive Disorder/psychology ; Epigenesis, Genetic
Language	English
Publishing date	2023-05-19
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2273162-3
ISSN	1863-2661 ; 1863-2653
ISSN (online)	1863-2661
ISSN	1863-2653
DOI	10.1007/s00429-023-02649-4
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