Article: Biased Coupling to β-Arrestin of Two Common Variants of the CB
2021 Volume 12, Page(s) 714561
Abstract: β-arrestins are partners of the G protein-coupled receptors (GPCRs), regulating their intracellular trafficking and signaling. Development of biased GPCR agonists, selectively targeting either G protein or β-arrestin pathways, are in the focus of ... ...
| Abstract | β-arrestins are partners of the G protein-coupled receptors (GPCRs), regulating their intracellular trafficking and signaling. Development of biased GPCR agonists, selectively targeting either G protein or β-arrestin pathways, are in the focus of interest due to their therapeutic potential in different pathological conditions. The CB |
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| MeSH term(s) | HEK293 Cells ; Humans ; Mutation, Missense ; Protein Binding ; Protein Transport ; Receptor, Cannabinoid, CB2/chemistry ; Receptor, Cannabinoid, CB2/genetics ; Receptor, Cannabinoid, CB2/metabolism ; beta-Arrestins/genetics ; beta-Arrestins/metabolism |
| Chemical Substances | Receptor, Cannabinoid, CB2 ; beta-Arrestins |
| Language | English |
| Publishing date | 2021-08-16 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2592084-4 |
| ISSN | 1664-2392 |
| ISSN | 1664-2392 |
| DOI | 10.3389/fendo.2021.714561 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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