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  1. Article: Asymptomatic giant ascending aortic aneurysm: a challenging surgical strategy for a silent bicuspid aortopathy.

    Romeo, Maria Grazia / Pilato, Emanuele / Giordano, Raffaele / Comentale, Giuseppe / Iannelli, Gabriele / Romeo, Domenico / Miserrafiti, Bruna / Di Tommaso, Luigi

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2024  

    Abstract: We report the case of an incidental finding of a huge aneurysm of the ascending aorta with a congenital bicuspid aortic valve type 0-lateral. This severe condition was totally unknown to the patient, who was asymptomatic for cardiovascular disease. The ... ...

    Abstract We report the case of an incidental finding of a huge aneurysm of the ascending aorta with a congenital bicuspid aortic valve type 0-lateral. This severe condition was totally unknown to the patient, who was asymptomatic for cardiovascular disease. The aneurysmal mass involved the entire mediastinum, altering the normal anatomical relations, so the operative strategy was modified intraoperatively, tailoring the surgical technique to the anatomical conditions found. Despite a delayed awakening, the patient had an uncomplicated postoperative course. Therefore, this case highlights the importance of not underestimating nonspecific, seemingly harmless symptoms and signs that may reveal potentially catastrophic pathologies, while also focusing on the surgical technique used. The modified Cabrol procedure, while an underutilized technique, if present in the cardiac surgeon's "arsenal," can represent a life-saving strategy in complex cases requiring an aortic valve and ascending aorta replacement.
    Language English
    Publishing date 2024-03-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2024.2936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparing the Prognostic Impact of Prediabetes with Diabetes in a Nationwide Cohort of Patients with Chronic Coronary Syndromes: An Analysis of the START Registry.

    De Luca, Leonardo / Gabrielli, Domenico / Gonzini, Lucio / Riccio, Carmine / Arena, Giuseppe / Miserrafiti, Bruna / Mortara, Andrea / Colivicchi, Furio / Gulizia, Michele Massimo / Temporelli, Pier Luigi

    Cardiology

    2021  Volume 146, Issue 5, Page(s) 547–555

    Abstract: Aims: Using data from the nationwide prospective START registry that enrolled a large cohort of patients with chronic coronary syndromes (CCS), we aimed to investigate whether the presence of diabetes mellitus (DM) and pre-DM independently affected the ... ...

    Abstract Aims: Using data from the nationwide prospective START registry that enrolled a large cohort of patients with chronic coronary syndromes (CCS), we aimed to investigate whether the presence of diabetes mellitus (DM) and pre-DM independently affected the risk of cardiovascular events at 1-year follow-up.
    Methods: We assessed the impact of DM and pre-DM on all-cause mortality and a composite of all-cause mortality and hospitalization for cardiovascular causes at 1-year follow-up.
    Results: Among the 3,778 patients with available fasting plasma glucose data at study entry, 37% were classified as DM, 25% as pre-DM, and 38% as no DM. At 1 year, patients with DM had higher rates of all-cause death (p = 0.004) and death/cardiovascular hospitalization (p = 0.003) than those with pre-DM or without DM. Conversely, no significant differences in the adverse event rate were found between patients with pre-DM and those without DM. At unadjusted Cox analysis, DM resulted as a predictor of both death for any cause (hazard ratio [HR]: 2.41; 95% confidence intervals [CI]: 1.34-4.34; p = 0.003) and all-cause death/hospitalization for cardiovascular causes (HR: 1.29; 95% CI: 1.02-1.62; p = 0.03). However, DM did not result as an independent predictor of either endpoint at multivariate analysis.
    Conclusions: The risk of 1-year major events among patients with CCS and pre-DM is comparable to that of patients with CCS and normoglycemic status and is lower than that of patients with DM.
    MeSH term(s) Humans ; Prediabetic State ; Prognosis ; Prospective Studies ; Registries ; Syndrome
    Language English
    Publishing date 2021-07-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 80092-2
    ISSN 1421-9751 ; 0008-6312
    ISSN (online) 1421-9751
    ISSN 0008-6312
    DOI 10.1159/000517122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevalence and predictive role of hypertriglyceridemia in statin-treated patients at very high risk: insights from the START Study

    De Luca, Leonardo / Temporelli, Pier Luigi / Gulizia, Michele Massimo / Gonzini, Lucio / Ammaturo, Tiziana Anita / Tedesco, Luigi / Pede, Silvia / Oliva, Fabrizio / Gabrielli, Domenico / Colivicchi, Furio / Averna, Maurizio R. / Maggioni, A.P. / Lucci, D. / Lorimer, A. / Orsini, G. / Gonzini, L. / Fabbri, G. / Priami, P. / Maras, P. /
    Ramani, F. / Falcone, C. / Passarelli, I. / Mauri, S. / Calabrò, P. / Bianchi, R. / Di Palma, G. / Mascia, F. / Vetrano, A. / Fusco, A. / Proia, E. / Colivicchi, F. / Aiello, A. / Tomai, F. / Licitra, R. / Petrolini, A. / Bosco, B. / Magliari, F. / Callerame, M. / Mazzella, T. / Lettica, G.V. / Coco, G. / Incao, F. / Marinacci, L. / D'Addario, S. / Tartaglione, S.N. / Ubaldi, S. / Sanchez, F.A. / Costa, P. / Manca, G. / Failla, M. / Scherillo, M. / Procaccini, V. / Formigli, D. / Senni, M. / Luminita, E.M. / Bonomo, P. / Mossa, C. / Corda, S. / Colavita, A.R. / Trevisonno, G. / Vizzari, G. / Cosentino, N. / Formaro, C. / Paolillo, C. / Nalin, I.L. / De Rosa, F.M. / Fontana, F. / Fuscaldo, G.F. / Passamonti, E. / Bertella, E. / Calvaruso, E.V. / Varani, E. / Tani, F. / Cicchitelli, G. / Gabrielli, D. / Paoloni, P. / Marziali, A. / Campo, G. / Tebaldi, M. / Biscaglia, S. / Biase, M Di / Brunetti, N.D. / Gallotta, A.M. / Mattei, L. / Marini, R. / Balsemin, F. / Urbano, M.D. / Naio, R. / Vicinelli, P. / Arena, G. / Mazzini, M. / Gigli, N. / Miserrafiti, B. / Monopoli, A. / Mortara, A. / Delfino, P. / Chioffi, M.M. / Mariño, P. / Gravellone, M. / Barbieri, L. / Ledda, A. / Geraci, G. / Carmina, M.G. / Raisaro, A.E. / Di Giacomo, C. / Somaschini, A. / Fasano, M.L. / Sannazzaro, M. / Arcieri, R. / Pantaleoni, M. / Leuzzi, C. / Gorlato, G. / Greco, G. / Chiera, A. / Ammaturo, T.A. / Malanchini, G. / Del Corral, M.P. / Tedesco, L. / Pede, S. / Urso, L.G. / Piscione, F. / Galasso, G. / Provasoli, S. / Fattore, L. / Lucca, G. / Cresti, A. / Cardillo, A. / Fera, M.S. / Vennettilli, F. / Gaudio, C. / Paravati, V. / Caldarola, P. / Locuratolo, N. / Verlato, R. / De Conti, F. / Turiano, G. / Preti, G. / Moretti, L. / Silenzi, S. / Colonna, G. / Picciolo, A. / Nicosia, A. / Cascone, C. / Di Sciascio, G. / Mangiacapra, F. / Russo, A. / Mastroianno, S. / Esposito, G. / Cosmi, F. / D'Orazio, S. / Costantini, C. / Lanari, A. / De Rosa, P. / Esposito, L. / Bilato, C. / Valle, C Dalla / Ceresa, M. / Colombo, E. / Pennisi, V. / Casciola, G. / Driussi, M. / Bisceglia, T. / Scalvini, S. / Rivadossi, F. / Volpe, M. / Comito, F. / Scorzoni, D. / Grimoldi, P. / Lagioia, R. / Santoro, D. / De Cesare, N. / Comotti, T. / Poli, A. / Martina, P. / Musolino, M.F. / Multari, E.I. / Bilardo, G. / Scalchi, G. / Olivieri, C. / Caranci, F. / Pavan, D. / Ganci, G. / Mariani, A. / Falchetti, E. / Lanzillo, T. / Caccavale, A. / Bongo, A.S. / Rizzi, A. / Favilli, R. / Maffei, S. / Mallardo, M. / Fulgione, C. / Bordin, F. / Bonmassari, R. / Battaia, E. / Puzzo, A. / Vianello, G. / D'Arpino, A. / Romei, M. / Pajes, G. / Petronzelli, S. / Ghezzi, F. / Brigido, S. / Pignatelli, L. / Brscic, E. / Sori, P. / Russo, M. / Biancolillo, E. / Ignone, G. / De Giorgio, N.A. / Campaniello, C. / Ponticelli, P. / Margonato, A. / Gerosa, S. / Cutaia, A. / Casalicchio, C. / Bartolomucci, F. / Larosa, C. / Spadafina, T. / Putignano, A. / De Cristofaro, R. / Bernardi, L. / Sommariva, L. / Celestini, A. / Bertucci, C.M. / Marchetti, M. / Grisolia, E Franceschini / Ammendolea, C. / Carini, M. / Scipione, P. / Politano, M. / Rubino, G. / Reina, C. / Peccerillo, N. / Paloscia, L. / D'Alleva, A. / Petacchi, R. / Pignalosa, M. / Lucchetti, D. / Di Palma, F. / La Mastra, R.A. / Amico, A.F. / Filippis, M De / Fontanella, B. / Zanini, G. / Casolo, G. / Del Meglio, J. / Parato, V.M. / Genovesi, E. / D'Alimonte, A. / Miglioranza, A. / Alessandri, N. / Moscariello, F. / Mauro, C. / Sasso, A. / Caso, P. / Petrillo, C. / Napoletano, C. / Paparoni, S.R. / Bernardo, V. / Serdoz, R. / Rotunno, R. / Oppo, I. / Aloisio, A. / Aurelio, A. / Licciardello, G. / Cassaniti, L. / Gulizia, M.M. / Francese, G.M. / Marcassa, C. / Temporelli, P.L. / Villani, R. / Zorzoli, F. / Mileto, F. / Vecchis, M De / Scolozzi, D. / Lupi, G. / Caruso, D. / Rebulla, E. / La Fata, B. / Anselmi, M. / Girardi, P. / Borruso, E. / Ferrantelli, G. / Sassone, B. / Bressan, S. / Capriolo, M. / Pelissero, E. / Piancastelli, M. / Gobbi, M. / Cocco, F. / Bruno, M.G. / Berti, S. / Lo Surdo, G. / Tanzi, P. / De Rosa, R. / Vilei, E. / De Iaco, M.R. / Grassi, G. / Zanella, C. / Marullo, L. / Alfano, G. / Pelaggi, P. / Talarico, R. / Tuccillo, B. / Irace, L. / Proietti, F. / Di Croce, G. / Di Lorenzo, L. / Zarrilli, A. / Bongini, M. / Ranise, A. / Aprile, A. / Fornengo, C. / Capogrosso, V. / Tranghese, A. / Golia, B. / Marziano, A. / Roncon, L. / Picariello, C. / Bagni, E. / Leci, E. / Gregorio, G. / Gatto, F. / Piemonte, F. / Gervasio, F. / Navazio, A. / Guerri, E. / Belmonte, E. / Marino, F. / Di Belardino, N. / Di Nuzzo, M.R. / Epifani, M. / Comolatti, G. / Conconi, B. / Benea, D. / Casu, G. / Merella, P. / Ammirati, M.A. / Corrado, V.M. / Spagnolo, D. / Caico, S.I. / Bonizzato, S. / Margheri, M. / Corrado, L. / Antonicelli, R. / Ferrigno, C. / Merlino, A. / Nassiacos, D. / Antonelli, A. / Marchese, A. / Uguccioni, M. / Villella, A. / Bechi, S. / Lo Bianco, F. / Bedogni, F. / Negro, L. / Donato, L. / Statile, D. / Cassin, M. / Fedele, F. / Granatelli, A. / Calcagno, S. / Politi, A. / Pani., A.

    Nutrition, Metabolism and Cardiovascular Diseases. 2023 Aug. 07

    2023  

    Abstract: Elevated triglyceride (TG) levels seem to identify subjects at increased cardiovascular risk, independent of LDL-C levels. We sought to evaluate the predictive role of hypertriglyceridemia, defined as TG levels ≥150 mg/dl, in very high risk (VHR) ... ...

    Abstract Elevated triglyceride (TG) levels seem to identify subjects at increased cardiovascular risk, independent of LDL-C levels. We sought to evaluate the predictive role of hypertriglyceridemia, defined as TG levels ≥150 mg/dl, in very high risk (VHR) patients with chronic coronary syndromes (CCS) treated with statins. Using the data from the STable Coronary Artery Diseases RegisTry (START) study, an Italian nationwide registry, we assessed the association between the TG levels and baseline clinical characteristics, pharmacological treatment and major adverse cardio-cerebrovascular events (MACCE) at 1 year in a large cohort of statin-treated patients at VHR. Of the 4751 consecutive patients with CCS enrolled in the registry and classified as VHR, 2652 (55.8%) had TG values available (mean 120.6±54.9) and were treated with at least a statin at baseline: 2019 (76.1%) with TG <150 and 633 (23.9%) with TG ≥150 mg/dl. At 1 year from enrolment, MACCE occurred in 168 (6.3%) patients, without differences between the two groups of TG (5.9 vs 7.6%; p=0.14). At multivariable analysis, hypertriglyceridemia did not result as independent predictor of the MACCE (hazard ratio: 1.16; 95% confidence intervals: 0.82-1.64; p=0.42). In the present large, nationwide cohort of consecutive CCS patients at VHR with statin-controlled LDL-C levels, hypertriglyceridemia was present in around 24% of cases and did not result as predictor of MACCE at 1 year. Further studies with a longer follow-up and larger sample size are needed to better define the prognostic role of TG levels when intensive LDL lowering therapies are used.
    Keywords coronary vessels ; hazard ratio ; hypertriglyceridemia ; metabolism ; nutrition ; risk ; sample size ; triacylglycerols ; LDL-C ; management ; treatment ; statin ; ezetimibe
    Language English
    Dates of publication 2023-0807
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 1067704-5
    ISSN 0939-4753
    ISSN 0939-4753
    DOI 10.1016/j.numecd.2023.07.036
    Database NAL-Catalogue (AGRICOLA)

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