LIVIVO - Search results -

Search results

Result 1 - 10 of total 200

Search options

Article ; Online: A Randomized Controlled Trial Comparing Face-to-Face Versus Remote Delivery of Low-Tech Augmentative and Alternative Communication in Nonspeaking Children With Autism Spectrum Disorder.

Mishra, Avinash

Journal of speech, language, and hearing research : JSLHR

2024 Volume 67, Issue 5, Page(s) 1478–1489

Abstract: Purpose: Thirty percent of children diagnosed with autism spectrum disorder (ASD) do not develop spoken language. To provide a means of communication for this subset of the population, augmentative and alternative communication (AAC) systems are often ... ...

Abstract	Purpose: Thirty percent of children diagnosed with autism spectrum disorder (ASD) do not develop spoken language. To provide a means of communication for this subset of the population, augmentative and alternative communication (AAC) systems are often utilized. Low-tech options have traditionally been delivered through the in-person modality. However, due to the COVID-19 pandemic, changes to service delivery models have been required. This randomized controlled trial was conducted in order to assess the efficacy of low-tech AAC delivered face-to-face versus remotely on communication outcomes in nonspeaking children with ASD. Conclusions: Both participant groups demonstrated similar gains in AAC proficiency, number and type of nonspeaking acts, and number of spoken communication acts. Remote delivery of low-tech AAC treatment is a viable alternative to face-to-face instruction.
MeSH term(s)	Humans ; Autism Spectrum Disorder/therapy ; Child ; Male ; Female ; Communication Aids for Disabled ; COVID-19 ; Child, Preschool ; Treatment Outcome
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Comparative Study
ZDB-ID	1364086-0
ISSN	1558-9102 ; 1092-4388
ISSN (online)	1558-9102
ISSN	1092-4388
DOI	10.1044/2024_JSLHR-23-00390
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 606: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Universal slit-lamp mounted indentation gonioscopy tool for angle evaluation: An innovative device.

Bhirud, Atul / Tripathi, Anchal / Agarwal, Mohini / Mishra, Avinash

Indian journal of ophthalmology

2024

Abstract: In the field of ophthalmology, slit-lamp gonioscopy has long been a cornerstone for examining anterior chamber angles and diagnosing conditions such as angle closure, secondary causes of raised intraocular pressure, neovascularization of angle, angle ... ...

Abstract	In the field of ophthalmology, slit-lamp gonioscopy has long been a cornerstone for examining anterior chamber angles and diagnosing conditions such as angle closure, secondary causes of raised intraocular pressure, neovascularization of angle, angle recession, angle tumors, and foreign bodies. However, the conventional approach for goniophotography is a demanding procedure requiring juggling a gonioscopy lens in one hand and a smartphone in the other. Balancing a gonioscopy lens with one hand makes it difficult to adjust and focus the image in busy clinical settings. This article introduces a groundbreaking solution to this problem - a universal slit-lamp-mounted gonioscope ingeniously repurposed from discarded materials, that is, indirect goniophotography (IndiGo). This novel system simplifies the process of both gonioscopy and goniophotography, allowing ophthalmologists to easily assess anterior chamber angles and capture high-quality images. These images can be swiftly shared with glaucoma specialists worldwide for digital analysis. Not only does this approach enhance examination efficiency, but also it fosters sustainability in ophthalmic diagnostics.
Language	English
Publishing date	2024-04-16
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/IJO.IJO_3035_23
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 329: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 598: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Pharmacophore screening to identify natural origin compounds to target RNA-dependent RNA polymerase (RdRp) of SARS-CoV2.

Mishra, Avinash / Rathore, Anurag S

Molecular diversity

2022 Volume 26, Issue 5, Page(s) 2613–2629

Abstract: Several existing drugs have gained initial consideration due to their therapeutic characteristics against COVID-19 (Corona Virus Disease 2019). Hydroxychloroquine (HCQ) was proposed as possible therapy for shortening the duration of COVID-19, but soon ... ...

Abstract	Several existing drugs have gained initial consideration due to their therapeutic characteristics against COVID-19 (Corona Virus Disease 2019). Hydroxychloroquine (HCQ) was proposed as possible therapy for shortening the duration of COVID-19, but soon after this, it was discarded. Similarly, known antiviral compounds were also proposed and investigated to treat COVID-19. We report a pharmacophore screening using essential chemical groups derived from HCQ and known antivirals to search a natural compound chemical space. Molecular docking of HCQ under physiological condition with spike protein, 3C-like protease (3CLpro), and RNA-dependent RNA polymerase (RdRp) of SARS-CoV2 showed - 8.52 kcal/mole binding score with RdRp, while the other two proteins showed relatively weaker binding affinity. Docked complex of RdRp-HCQ is further examined using 100 ns molecular dynamic simulation. Docking and simulation study confirmed active chemical moieties of HCQ, treated as 6-point pharmacophore to screen ZINC natural compound database. Pharmacophore screening resulted in the identification of potent hit molecule [(3S,3aR,6R,6aS)-3-(5-phenylsulfanyltetrazol-1-yl)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl]N-naphthalen-ylcarbamate from natural compound library. Additionally, a set of antiviral compounds with similar chemical scaffolds are also used to design a separate ligand-based pharmacophore screening. Antiviral pharmacophore screening produced a potent hit 4-[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-(2-hydroxyphenyl)methyl]-1,5-dimethyl-2-phenylpyrazol-3-one containing essential moieties that showed affinity towards RdRp. Further, both these screened compounds are docked (- 8.69 and - 8.86 kcal/mol) and simulated with RdRp protein for 100 ns in explicit solvent medium. They bind at the active site of RdRp and form direct/indirect interaction with ASP618, ASP760, and ASP761 catalytic residues of the protein. Successively, their molecular mechanics Poisson Boltzmann surface area (MMPBSA) binding energies are calculated over the simulation trajectory to determine the dynamic atomistic interaction details. Overall, this study proposes two key natural chemical moieties: (a) tetrazol and (b) phenylpyrazol that can be investigated as a potential chemical group to design inhibitors against SARS-CoV2 RdRp.
MeSH term(s)	Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; COVID-19 ; Furans ; Humans ; Hydroxychloroquine ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Peptide Hydrolases/metabolism ; RNA, Viral ; RNA-Dependent RNA Polymerase ; SARS-CoV-2 ; Solvents ; Spike Glycoprotein, Coronavirus ; Zinc
Chemical Substances	Antiviral Agents ; Furans ; Ligands ; RNA, Viral ; Solvents ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Hydroxychloroquine (4QWG6N8QKH) ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Peptide Hydrolases (EC 3.4.-) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2022-01-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1376507-3
ISSN	1573-501X ; 1381-1991
ISSN (online)	1573-501X
ISSN	1381-1991
DOI	10.1007/s11030-021-10358-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4946: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Metabolite Profiling, Biological and Molecular Analyses Validate the Nutraceutical Potential of Green Seaweed

Tanna, Bhakti / Yadav, Sonam / Patel, Manish Kumar / Mishra, Avinash

Nutrients

2024 Volume 16, Issue 8

Abstract: Seaweeds have proven to be nutrient-dense and are rich in antioxidants, like phenolics, flavonoids, and other essential metabolites that help to provide their medicinal benefits. Non-targeted metabolite profiling of the tropical green ... ...

Abstract	Seaweeds have proven to be nutrient-dense and are rich in antioxidants, like phenolics, flavonoids, and other essential metabolites that help to provide their medicinal benefits. Non-targeted metabolite profiling of the tropical green seaweed
MeSH term(s)	Humans ; Dietary Supplements ; Seaweed/chemistry ; Antioxidants/pharmacology ; Plant Extracts/pharmacology ; HeLa Cells ; Metabolomics/methods ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Flavonoids/pharmacology ; Flavonoids/analysis
Chemical Substances	Antioxidants ; Plant Extracts ; Flavonoids
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16081222
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Differentiating stable and unstable protein using convolution neural network and molecular dynamics simulations.

Suyash, Shreyansh / Jha, Akshat / Maitra, Priyasha / Punia, Parveen / Mishra, Avinash

Computational biology and chemistry

2024 Volume 110, Page(s) 108081

Abstract: Protein stability is a critical aspect of molecular biology and biochemistry, hinges on an intricate balance of thermodynamic and structural factors. Determining protein stability is crucial for understanding and manipulating biological machineries, as ... ...

Abstract	Protein stability is a critical aspect of molecular biology and biochemistry, hinges on an intricate balance of thermodynamic and structural factors. Determining protein stability is crucial for understanding and manipulating biological machineries, as it directly correlated with the protein function. Thus, this study delves into the intricacies of protein stability, highlighting its dependence on various factors, including thermodynamics, thermal conditions, and structural properties. Moreover, a notable focus is placed on the free energy change of unfolding (ΔG
Language	English
Publishing date	2024-04-20
Publishing country	England
Document type	Journal Article
ISSN	1476-928X
ISSN (online)	1476-928X
DOI	10.1016/j.compbiolchem.2024.108081
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: Intrastromal voriconazole as successful adjunctive approach for recalcitrant deep fungal keratitis.

Bhirud, Atul / Mishra, Avinash / Agrawal, Mohini / Sharma, Jyoti

Romanian journal of ophthalmology

2023 Volume 67, Issue 1, Page(s) 7–13

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Voriconazole/therapeutic use ; Antifungal Agents/therapeutic use ; Ulcer/drug therapy ; Keratitis/diagnosis ; Keratitis/drug therapy ; Keratitis/microbiology ; Treatment Outcome ; Corneal Ulcer/diagnosis ; Corneal Ulcer/drug therapy ; Corneal Ulcer/microbiology ; Eye Infections, Fungal/diagnosis ; Eye Infections, Fungal/drug therapy ; Eye Infections, Fungal/microbiology
Chemical Substances	Voriconazole (JFU09I87TR) ; Antifungal Agents
Language	English
Publishing date	2023-04-05
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2842202-8
ISSN	2501-2533 ; 2457-4325
ISSN (online)	2501-2533
ISSN	2457-4325
DOI	10.22336/rjo.2023.3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Universal slit-lamp-mounted mobile adapter with 20 D lens for fundus photography:

Bhirud, Atul / Chandrakanth, Prithvi / Agrawal, Mohini / Mishra, Avinash

Indian journal of ophthalmology

2023 Volume 71, Issue 5, Page(s) 2222–2224

Abstract: Fundus photography is an arduous task as it involves using 90 D in one hand and a smartphone attached on an eyepiece of a slit-lamp biomicroscope in the other hand. Similarly, with a 20 D lens, the filming distance is adjusted by moving the lens or ... ...

Abstract	Fundus photography is an arduous task as it involves using 90 D in one hand and a smartphone attached on an eyepiece of a slit-lamp biomicroscope in the other hand. Similarly, with a 20 D lens, the filming distance is adjusted by moving the lens or mobile forward or backward, which makes it difficult to adjust and focus the image in busy ophthalmology outpatient departments (OPDs). Moreover, fundus camera costs thousands of dollars. Authors describe a novel technique of performing fundus photography with a 20 D lens and a universal slit-lamp-mounted mobile adapter made from trash. By the use of this simple, yet frugal innovation, primary care physicians or ophthalmologists without a fundus camera can easily snap a fundus photo and subject it to digital analysis by retina specialists across the world. This will help in simultaneous ocular examination and fundus photos taken via mounted 20 D on a slit lamp itself and also reduce the need for unnecessary retina referrals to tertiary eye care centers.
MeSH term(s)	Humans ; Slit Lamp ; Diagnostic Techniques, Ophthalmological ; Eye Diseases/diagnosis ; Fundus Oculi ; Photography
Language	English
Publishing date	2023-05-18
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/IJO.IJO_3226_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 329: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 598: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Introgression of

Jha, Rajesh Kumar / Mishra, Avinash

Cells

2021 Volume 11, Issue 1

Abstract: Salicornia ... ...

Abstract	Salicornia brachiata
MeSH term(s)	Adaptation, Physiological/genetics ; Chenopodiaceae/genetics ; Dehydration ; Gene Expression Regulation, Plant ; Heat-Shock Proteins/genetics ; Homeostasis ; Ions ; Membrane Proteins/metabolism ; Osmosis ; Plant Development/genetics ; Plant Proteins/genetics ; Plants, Genetically Modified ; Reactive Oxygen Species/metabolism ; Stress, Physiological/genetics ; Subcellular Fractions/metabolism ; Nicotiana/genetics ; Nicotiana/physiology ; Transformation, Genetic
Chemical Substances	Heat-Shock Proteins ; Ions ; Membrane Proteins ; Plant Proteins ; Reactive Oxygen Species
Language	English
Publishing date	2021-12-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11010062
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: RNA dependent RNA polymerase (RdRp) as a drug target for SARS-CoV2.

Mishra, Avinash / Rathore, Anurag S

Journal of biomolecular structure & dynamics

2021 Volume 40, Issue 13, Page(s) 6039–6051

Abstract: RNA-dependent RNA polymerase (RdRp), also called nsp12, is considered a promising but challenging drug target for inhibiting replication and hence, the growth of various RNA-viruses. In this report, a computational study is performed to offer insights on ...

Abstract	RNA-dependent RNA polymerase (RdRp), also called nsp12, is considered a promising but challenging drug target for inhibiting replication and hence, the growth of various RNA-viruses. In this report, a computational study is performed to offer insights on the binding of Remdesivir and Galidesivir with SARS-CoV2 RdRp with natural substrate, ATP, as the control. It was observed that Remdesivir and Galidesivir exhibited similar binding energies for their best docked poses, -6.6 kcal/mole and -6.2 kcal/mole, respectively. ATP also displayed comparative and strong binding free energy of -6.3 kcal/mole in the catalytic site of RdRp. However, their binding locations within the active site are distinct. Further, the interaction of catalytic site residues (Asp760, Asp761, and Asp618) with Remdesivir and Galidesivir is comprehensively examined. Conformational changes of RdRp and bound molecules are demonstrated using 100 ns explicit solvent simulation of the protein-ligand complex. Simulation suggests that Galidesivir binds at the non-catalytic location and its binding strength is relatively weaker than ATP and Remdesivir. Remdesivir also binds at the catalytic site and showed high potency to inhibit the function of RdRp. Binding of co-factor units nsp7 and nsp8 with RdRp (nsp12) complexed with Remdesivir and Galidesivir was also examined. MMPBSA binding energy for all three complexes has been computed across the 100 ns simulation trajectory. Overall, this study suggests, Remdesivir has anti-RdRp activity
MeSH term(s)	Adenosine Triphosphate/metabolism ; Antiviral Agents/chemistry ; RNA-Dependent RNA Polymerase/antagonists & inhibitors ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology
Chemical Substances	Antiviral Agents ; Adenosine Triphosphate (8L70Q75FXE) ; RNA-Dependent RNA Polymerase (EC 2.7.7.48)
Language	English
Publishing date	2021-01-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2021.1875886
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2093: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Plant aquaporins alleviate drought tolerance in plants by modulating cellular biochemistry, root-architecture, and photosynthesis.

Patel, Jaykumar / Mishra, Avinash

Physiologia plantarum

2021 Volume 172, Issue 2, Page(s) 1030–1044

Abstract: Water is a vital resource for plants to grow, thrive, and complete their life cycle. In recent years, drastic changes in the climate, especially drought frequency and severity, have increased, which reduces agricultural productivity worldwide. Aquaporins ...

Abstract	Water is a vital resource for plants to grow, thrive, and complete their life cycle. In recent years, drastic changes in the climate, especially drought frequency and severity, have increased, which reduces agricultural productivity worldwide. Aquaporins are membrane channels belonging to the major intrinsic protein superfamily, which play an essential role in cellular water and osmotic homeostasis of plants under both control and water deficit conditions. A genome-wide search reveals the vast availability of aquaporin isoforms, phylogenetic relationships, different families, conserved residues, chromosomal locations, and gene structure of aquaporins. Furthermore, aquaporins gating and subcellular trafficking are commonly controlled by phosphorylation, cytosolic pH, divalent cations, reactive oxygen species, and stoichiometry. Researchers have identified their involvement in regulating hydraulic conductance, root system architecture, modulation of abiotic stress-related genes, seed viability and germination, phloem loading, xylem water exit, photosynthetic parameters, and post-drought recovery. Remarkable effects following the change in aquaporin activity and/or gene expression have been observed on root water transport properties, nutrient acquisition, physiology, transpiration, stomatal aperture, gas exchange, and water use efficiency. The present review highlights the role of different aquaporin homologs under water-deficit stress condition in model and crop plants. Moreover, the opportunity and challenges encountered to explore aquaporins for engineering drought-tolerant crop plants are also discussed here.
MeSH term(s)	Aquaporins/genetics ; Aquaporins/metabolism ; Droughts ; Gene Expression Regulation, Plant ; Photosynthesis ; Phylogeny ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plant Roots/genetics ; Plant Roots/metabolism ; Water/metabolism
Chemical Substances	Aquaporins ; Plant Proteins ; Water (059QF0KO0R)
Language	English
Publishing date	2021-01-19
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	2020837-6
ISSN	1399-3054 ; 0031-9317
ISSN (online)	1399-3054
ISSN	0031-9317
DOI	10.1111/ppl.13324
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito