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Article ; Online: Daphnia magna as a Model Organism to Predict the Teratogenic Effect of Different Compounds.

Mishra, Monalisa

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2753, Page(s) 261–281

Abstract: For aquatic ecosystem Daphnia magna is evolving as a model organism to check the teratogenicity of numerous compounds. D. magna can be easily cultured in the laboratory, and the teratogen effect of several compounds can be easily studied. The ... ...

Abstract	For aquatic ecosystem Daphnia magna is evolving as a model organism to check the teratogenicity of numerous compounds. D. magna can be easily cultured in the laboratory, and the teratogen effect of several compounds can be easily studied. The developmental stages are well studied in D. magna. All the developmental stages are transparent so the defect can be easily accessed. So, the postembryonic developmental changes can be easily studied after the exposure with teratogen. More importantly, D. magna also have a swimming behavioral phenotype. The behavioral defect can be easily accessed after teratogen exposure. The current chapter summarizes numerous protocols associated with embryo and adult staining and adult behavioral assays that can be used to access the teratogenicity of any unknown compound.
MeSH term(s)	Animals ; Teratogens/toxicity ; Daphnia magna ; Ecosystem ; Teratogenesis ; Biological Assay
Chemical Substances	Teratogens
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3625-1_13
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploration of Teratogenic and Genotoxic Effects on Model Organism Drosophila melanogaster.

Naik, Seekha / Mishra, Monalisa

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2753, Page(s) 317–330

Abstract: Drosophila melanogaster is one of the crucial in vivo models in terms of analyzing the toxicity of various unknown chemicals. Every part of the fly serves as a model in metabolic and therapeutic approaches. Genotoxic and teratogenic compounds are exposed ...

Abstract	Drosophila melanogaster is one of the crucial in vivo models in terms of analyzing the toxicity of various unknown chemicals. Every part of the fly serves as a model in metabolic and therapeutic approaches. Genotoxic and teratogenic compounds are exposed to Drosophila through the oral route. Further, the toxicity of genotoxic compounds is analyzed in Drosophila's gut, hemolymph, and phenotype. The toxicity of teratogen compounds is also analyzed using a Drosophila embryo. The current chapter summarizes several techniques that are used to detect the genotoxicity and teratogenicity of any unknown compound in this model.
MeSH term(s)	Animals ; Teratogens/toxicity ; Drosophila melanogaster/genetics ; Teratogenesis ; Drosophila ; DNA Damage
Chemical Substances	Teratogens
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3625-1_16
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Article ; Online: Ca@Cu-CD nanoprobe for dual detection of glycine and

Behera, Lingaraj / Mishra, Lopamudra / Mishra, Monalisa / Mohapatra, Sasmita

Journal of materials chemistry. B

2024

Abstract: Hydrothermally prepared copper-doped carbon dots (Cu-CDs) were modified with ... ...

Abstract	Hydrothermally prepared copper-doped carbon dots (Cu-CDs) were modified with Ca
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d4tb00060a
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Article: Drosophila melanogaster

Nayak, Nibedita / Mishra, Monalisa

Journal of integrative neuroscience

2022 Volume 21, Issue 2, Page(s) 66

Abstract: The innate immune system primarily gets triggered by microbe infiltration, injury, stress, aging, and brain disorders. The hyperactivation of the innate immune system and neuroinflammatory reactions contributes to chronic age-related neurodegeneration. ... ...

Abstract	The innate immune system primarily gets triggered by microbe infiltration, injury, stress, aging, and brain disorders. The hyperactivation of the innate immune system and neuroinflammatory reactions contributes to chronic age-related neurodegeneration. The mechanism for activation of the immune pathway is conserved between
MeSH term(s)	Animals ; Disease Models, Animal ; Drosophila melanogaster ; Inflammation ; Microglia/metabolism ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/metabolism ; Neuroinflammatory Diseases/etiology ; Neuroinflammatory Diseases/metabolism
Language	English
Publishing date	2022-03-18
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2136427-8
ISSN	0219-6352
ISSN	0219-6352
DOI	10.31083/j.jin2102066
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Article ; Online: High fat diet induced abnormalities in metabolism, growth, behavior, and circadian clock in Drosophila melanogaster.

Nayak, Nibedita / Mishra, Monalisa

Life sciences

2021 Volume 281, Page(s) 119758

Abstract: Aims: The current lifestyle trend has made people vulnerable to diabetes and related diseases. Years of scientific research have not been able to yield a cure to the disease completely. The current study aims to investigate a link between high-fat diet ... ...

Abstract	Aims: The current lifestyle trend has made people vulnerable to diabetes and related diseases. Years of scientific research have not been able to yield a cure to the disease completely. The current study aims to investigate a link between high-fat diet mediated diabesity and circadian rhythm in the Drosophila model and inferences that might help in establishing a cure to the dreaded disease. Main methods: Several experimental methods including phenotypical, histological, biochemical, molecular, and behavioral assays were used in the study to detect obesity, diabetes, and changes in the circadian clock in the fly model. Key findings: The larva and adults of Drosophila melanogaster exposed to high-fat diet (HFD) displayed excess deposition of fat as lipid droplets and micronuclei formation in the gut, fat body, and crop. Larva and adults of HFD showed behavioral defects. The higher amount of triglyceride, glucose, trehalose in the whole body of larva and adult fly confirmed obesity-induced hyperglycemia. The overexpression of insulin gene (Dilp2) and tribble (trbl) gene expression confirmed insulin resistance in HFD adults. We also observed elevated ROS level, developmental delay, altered metal level, growth defects, locomotory rhythms, sleep fragmentation, and expression of circadian genes (per, tim, and clock) in HFD larva and adults. Thus, HFD impairs the metabolism to produce obesity, insulin resistance, disruption of clock, and circadian clock related co-mordities in D. melanogaster. Significance: The circadian gene expression provides an innovative perspective to understand and find a new treatment for type-II diabetes and circadian anomalies.
MeSH term(s)	Adipose Tissue/metabolism ; Animals ; Behavior, Animal ; Circadian Clocks/genetics ; Diet, High-Fat ; Drosophila melanogaster/growth & development ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/physiology ; Female ; Glucose/metabolism ; Hyperglycemia/metabolism ; Insulin Resistance ; Larva/metabolism ; Male ; Metals/metabolism ; Obesity/ethnology ; Oxidative Stress ; Tissue Distribution ; Trehalose/metabolism
Chemical Substances	Metals ; Trehalose (B8WCK70T7I) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2021-06-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119758
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Article ; Online: Reactive oxygen species: the root cause of nanoparticle-induced toxicity in

Mishra, Monalisa / Panda, Mrutyunjaya

Free radical research

2021 Volume 55, Issue 6, Page(s) 671–687

Abstract: Nanotechnology is a rapidly developing technology in the twenty-first century. Nanomaterials are extensively used in numerous industries including cosmetics, food, medicines, industries, agriculture, etc. Along with its wide application toxicity is also ... ...

Abstract	Nanotechnology is a rapidly developing technology in the twenty-first century. Nanomaterials are extensively used in numerous industries including cosmetics, food, medicines, industries, agriculture, etc. Along with its wide application toxicity is also reported from studies of various model organisms including
MeSH term(s)	Animals ; Drosophila melanogaster/metabolism ; Nanoparticles/toxicity ; Reactive Oxygen Species/metabolism
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2021-04-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1194130-3
ISSN	1029-2470 ; 1071-5762
ISSN (online)	1029-2470
ISSN	1071-5762
DOI	10.1080/10715762.2021.1914335
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Zs.A 2236: Show issues

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Article: High fat diet induced abnormalities in metabolism, growth, behavior, and circadian clock in Drosophila melanogaster

Nayak, Nibedita / Mishra, Monalisa

Life sciences. 2021 Sept. 15, v. 281

2021

Abstract: The current lifestyle trend has made people vulnerable to diabetes and related diseases. Years of scientific research have not been able to yield a cure to the disease completely. The current study aims to investigate a link between high-fat diet ... ...

Abstract	The current lifestyle trend has made people vulnerable to diabetes and related diseases. Years of scientific research have not been able to yield a cure to the disease completely. The current study aims to investigate a link between high-fat diet mediated diabesity and circadian rhythm in the Drosophila model and inferences that might help in establishing a cure to the dreaded disease.Several experimental methods including phenotypical, histological, biochemical, molecular, and behavioral assays were used in the study to detect obesity, diabetes, and changes in the circadian clock in the fly model.The larva and adults of Drosophila melanogaster exposed to high-fat diet (HFD) displayed excess deposition of fat as lipid droplets and micronuclei formation in the gut, fat body, and crop. Larva and adults of HFD showed behavioral defects. The higher amount of triglyceride, glucose, trehalose in the whole body of larva and adult fly confirmed obesity-induced hyperglycemia. The overexpression of insulin gene (Dilp2) and tribble (trbl) gene expression confirmed insulin resistance in HFD adults. We also observed elevated ROS level, developmental delay, altered metal level, growth defects, locomotory rhythms, sleep fragmentation, and expression of circadian genes (per, tim, and clock) in HFD larva and adults. Thus, HFD impairs the metabolism to produce obesity, insulin resistance, disruption of clock, and circadian clock related co-mordities in D. melanogaster.The circadian gene expression provides an innovative perspective to understand and find a new treatment for type-II diabetes and circadian anomalies.
Keywords	Drosophila melanogaster ; circadian clocks ; circadian rhythm ; digestive system ; fat body ; genes ; glucose ; high fat diet ; histology ; hyperglycemia ; insulin ; insulin resistance ; lifestyle ; metabolism ; models ; obesity ; sleep ; trehalose ; triacylglycerols
Language	English
Dates of publication	2021-0915
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119758
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Polymeric curcumin nanospheres for lysozyme aggregation inhibition, antibacterial, and wound healing applications.

Rananaware, Pranita / Bauri, Samir / Keri, Rangappa / Mishra, Monalisa / Brahmkhatri, Varsha

Environmental science and pollution research international

2023

Abstract: The present study reports highly stable polymeric nanoparticles comprising curcumin and polyvinylpyrrolidone, and then conjugated with gold nanoparticles, resulting in C-PVP and C-PVP-Au, respectively. The synthesized conjugates C-PVP and C-PVP-Au were ... ...

Abstract	The present study reports highly stable polymeric nanoparticles comprising curcumin and polyvinylpyrrolidone, and then conjugated with gold nanoparticles, resulting in C-PVP and C-PVP-Au, respectively. The synthesized conjugates C-PVP and C-PVP-Au were investigated for amyloid aggregation inhibition activity, antimicrobial activity, and wound healing applications. The anti-amyloidogenic capacity of nanoconjugates were studied for model protein, hen egg-white lysozyme (HEWL). The ThT binding assay, fibril size measurement, and electron microscopy results revealed that conjugates suppress fibrillogenesis in HEWL. The highest amyloid inhibition activity obtained against C-PVP and C-PVP-Au was 31 μg.mL
Language	English
Publishing date	2023-09-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-29160-x
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Article ; Online: A quick and laidback way to detect the internal structure of the Drosophila eye: An alternative to cryosectioning.

Sahu, Swetapadma / Karmakar, Puja / Saha, Jayasree / Bhattacharyya, Sankar / Mishra, Monalisa

Reproductive toxicology (Elmsford, N.Y.)

2023 Volume 117, Page(s) 108361

Abstract: Immunofluorescence techniques have been a great tool to chase the structure, localization, and function of many proteins within a cell. Drosophila eye is widely used as a model to answer various questions. However, the complex sample preparation and ... ...

Abstract	Immunofluorescence techniques have been a great tool to chase the structure, localization, and function of many proteins within a cell. Drosophila eye is widely used as a model to answer various questions. However, the complex sample preparation and visualization methods restrict its use only with an expert's hand. Thus, an easy and hassle-free method is in need to broaden the use of this model even with an amateur's hand. The current protocol describes an easy sample preparation method using DMSO to image the adult fly eye. The brief description of sample collection, preparation, dissection, staining, imaging, storage, and handling has been described over here. For readers, the possible problems that might arise during the execution of the experiment have been described with their possible reason and solutions. The overall protocol reduces the use of chemicals and shortens the sample preparation time to only 3 h, which is significantly less in comparison to other protocols.
MeSH term(s)	Animals ; Drosophila/physiology ; Dissection/methods ; Cryoultramicrotomy ; Eye
Language	English
Publishing date	2023-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639342-1
ISSN	1873-1708 ; 0890-6238
ISSN (online)	1873-1708
ISSN	0890-6238
DOI	10.1016/j.reprotox.2023.108361
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Zs.A 2316: Show issues

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Article ; Online: Inulin-A polysaccharide: Review on its functional and prebiotic efficacy.

Bhanja, Amrita / Sutar, Parag Prakash / Mishra, Monalisa

Journal of food biochemistry

2022 , Page(s) e14386

Abstract: The intake of dietary fibers in the regular diet results in boosting the gut microbiome and health of the host in several ways. The misapprehension about such dietary fibers of being only an indigestible product has changed into indispensable ingredient ... ...

Abstract	The intake of dietary fibers in the regular diet results in boosting the gut microbiome and health of the host in several ways. The misapprehension about such dietary fibers of being only an indigestible product has changed into indispensable ingredient that has to be included in every healthy diet. Inulin is considered to be an important naturally occurring fructan classified under such dietary fibers. The present review intends to provide a thorough knowledge on inulin in maintaining the gut microbiome of the human, supported by several studies conducted on the Drosophila melanogaster, mice, rat models as well as effect on human being. The extraction process of inulin has also been described in this review that would provide a brief knowledge about its stability and the conditions that have been optimized by the researchers in order to obtain a stable product. PRACTICAL APPLICATIONS: In order to meet the consumers demand, the food industries are trying to come up with new products that could eventually replace or lower the utilization of medically avail drugs and satisfy consumers by providing them with health benefits. The availability of functional food is the new trend that can improve health of the consumers with minimal use of the drugs. Therefore, inulin as a prebiotic can be utilized to produce several functional food products that could promote health benefits to the consumers. Apart from this, the review also justifies the efficacy of inulin as a fat replacer, stabilizer, and humectant in cosmetic industries. Research also suggests that inulin has also been used as nanoparticles in pharmaceutical industries. The overall review also depicts the different extraction process of inulin from different sources.
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.14386
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